Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | CHE-14 protein | 0.0047 | 0.0005 | 0.0005 |
Trypanosoma brucei | 3-methylcrotonyl-CoA carboxylase alpha subunit, putative | 0.5661 | 0.3792 | 0.3584 |
Schistosoma mansoni | hypothetical protein | 0.0045 | 0.0004 | 0.0004 |
Giardia lamblia | Acetyl-CoA carboxylase/pyruvate carboxylase fusion protein, putative | 0.2535 | 0.1683 | 0.5 |
Trypanosoma brucei | 3-methylcrotonoyl-CoA carboxylase beta subunit, putative | 0.2014 | 0.1332 | 0.1041 |
Schistosoma mansoni | hypothetical protein | 0.0045 | 0.0004 | 0.0004 |
Leishmania major | methylcrotonoyl-coa carboxylase biotinylated subunitprotein-like protein | 0.5661 | 0.3792 | 0.3584 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0065 | 0.0017 | 0.0017 |
Loa Loa (eye worm) | hypothetical protein | 0.0262 | 0.015 | 0.0151 |
Echinococcus granulosus | propionyl coenzyme A carboxylase alpha chain | 0.5661 | 0.3792 | 0.3792 |
Brugia malayi | jmjC domain containing protein | 0.0065 | 0.0017 | 0.0018 |
Mycobacterium ulcerans | propionyl-CoA carboxylase beta chain 4 AccD4 | 0.2014 | 0.1332 | 0.2905 |
Mycobacterium tuberculosis | Acetyl/propionyl-CoA carboxylase (beta subunit) AccD6 | 0.2014 | 0.1332 | 0.2905 |
Entamoeba histolytica | acetyl-coA carboxylase, putative | 0.2535 | 0.1683 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0055 | 0.001 | 0.0006 |
Schistosoma mansoni | dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase | 0.0521 | 0.0324 | 0.0324 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0053 | 0.0009 | 0.001 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0065 | 0.0017 | 0.0017 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.1793 | 0.1183 | 0.1183 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0047 | 0.0005 | 0.5 |
Mycobacterium leprae | Probable bifunctional protein acetyl-/propionyl-coenzyme A carboxylase, alpha chain AccA3 (BccP) | 0.5661 | 0.3792 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0521 | 0.0324 | 0.0331 |
Echinococcus multilocularis | protein dispatched 1 | 0.0053 | 0.0009 | 0.0009 |
Schistosoma mansoni | pyruvate carboxylase | 0.5661 | 0.3792 | 0.3792 |
Loa Loa (eye worm) | hypothetical protein | 0.0521 | 0.0324 | 0.0331 |
Mycobacterium leprae | ACETYL/PROPIONYL-CoA CARBOXYLASE (BETA SUBUNIT) ACCD6 | 0.2014 | 0.1332 | 0.2905 |
Trypanosoma cruzi | acetyl-CoA carboxylase, putative | 0.2014 | 0.1332 | 0.172 |
Schistosoma mansoni | hypothetical protein | 0.0187 | 0.0099 | 0.0099 |
Schistosoma mansoni | hypothetical protein | 0.0187 | 0.0099 | 0.0099 |
Brugia malayi | hypothetical protein | 0.0136 | 0.0065 | 0.0067 |
Schistosoma mansoni | carbamoyl-phosphate synthetase | 0.128 | 0.0836 | 0.0836 |
Echinococcus granulosus | dihydrolipoyllysine residue acetyltransferase | 0.0521 | 0.0324 | 0.0324 |
Leishmania major | acetyl-CoA carboxylase, putative | 1.4863 | 1 | 1 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0262 | 0.015 | 0.015 |
Loa Loa (eye worm) | hypothetical protein | 0.0136 | 0.0065 | 0.0062 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0065 | 0.0017 | 0.0017 |
Schistosoma mansoni | aspartate carbamoyltransferase | 0.128 | 0.0836 | 0.0836 |
Trypanosoma cruzi | 3-methylcrotonoyl-CoA carboxylase beta subunit, putative | 0.2014 | 0.1332 | 0.172 |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.0047 | 0.0005 | 0.0005 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0156 | 0.0078 | 0.0078 |
Entamoeba histolytica | Niemann-Pick C1 protein, putative | 0.0109 | 0.0047 | 0.0278 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0264 | 0.0151 | 0.0152 |
Schistosoma mansoni | dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase | 0.0521 | 0.0324 | 0.0324 |
Loa Loa (eye worm) | hypothetical protein | 0.0109 | 0.0047 | 0.0044 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0262 | 0.015 | 0.015 |
Echinococcus granulosus | geminin | 0.0187 | 0.0099 | 0.0099 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0156 | 0.0078 | 0.0078 |
Schistosoma mansoni | carbamoyl-phosphate synthetase | 0.128 | 0.0836 | 0.0836 |
Mycobacterium ulcerans | acetyl-/propionyl-coenzyme a carboxylase alpha chain, AccA2 | 0.5661 | 0.3792 | 1 |
Plasmodium falciparum | carbamoyl phosphate synthetase | 0.128 | 0.0836 | 0.0742 |
Echinococcus multilocularis | propionyl coenzyme A carboxylase alpha chain | 0.5661 | 0.3792 | 0.3792 |
Trypanosoma cruzi | 3-methylcrotonoyl-CoA carboxylase beta subunit, putative | 0.2014 | 0.1332 | 0.172 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.001 | 0.0006 |
Schistosoma mansoni | hypothetical protein | 0.0045 | 0.0004 | 0.0004 |
Mycobacterium ulcerans | propionyl-CoA carboxylase beta chain 5 AccD5 | 0.2014 | 0.1332 | 0.2905 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0055 | 0.001 | 0.0011 |
Echinococcus granulosus | microtubule associated protein 2 | 0.0765 | 0.0489 | 0.0489 |
Echinococcus granulosus | Biotin lipoyl attachment | 0.0521 | 0.0324 | 0.0324 |
Schistosoma mansoni | acetyl-CoA carboxylase | 1.4863 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0136 | 0.0065 | 0.0062 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.0047 | 0.0005 | 0.0005 |
Schistosoma mansoni | dihydrolipoamide S-acetyltransferase | 0.0521 | 0.0324 | 0.0324 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0109 | 0.0047 | 0.0047 |
Echinococcus granulosus | Protein patched homolog 1 | 0.0047 | 0.0005 | 0.0005 |
Chlamydia trachomatis | biotin carboxylase | 0.5141 | 0.3441 | 1 |
Leishmania major | propionyl-coa carboxylase beta chain, putative | 0.2014 | 0.1332 | 0.1041 |
Schistosoma mansoni | patched 1 | 0.0047 | 0.0005 | 0.0005 |
Mycobacterium ulcerans | acetyl-coenzyme a carboxylase carboxyl transferase (subunit beta) AccD3 | 0.2014 | 0.1332 | 0.2905 |
Brugia malayi | hypothetical protein | 0.0262 | 0.015 | 0.0156 |
Brugia malayi | dihydrolipoamide S-acetyltransferase precursor, putative | 0.0521 | 0.0324 | 0.0336 |
Mycobacterium ulcerans | acetyl-/propionyl-CoA carboxylase subunit beta | 0.2014 | 0.1332 | 0.2905 |
Mycobacterium ulcerans | propionyl-CoA carboxylase beta chain 4 AccD4_2 | 0.2014 | 0.1332 | 0.2905 |
Brugia malayi | Carboxyl transferase domain containing protein | 1.4342 | 0.9649 | 1 |
Echinococcus granulosus | expressed conserved protein | 0.0103 | 0.0042 | 0.0042 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.0012 | 0.0007 |
Wolbachia endosymbiont of Brugia malayi | Acetyl/propionyl-CoA carboxylase, alpha subunit | 0.5661 | 0.3792 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0055 | 0.001 | 0.0011 |
Treponema pallidum | pyruvate carboxylase subunit B | 0.0521 | 0.0324 | 0.5 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0264 | 0.0151 | 0.0152 |
Mycobacterium leprae | Probable propionyl-CoA carboxylase beta chain 5 AccD5 (PCCASE) (PROPANOYL-COA:CARBON DIOXIDE LIGASE) | 0.2014 | 0.1332 | 0.2905 |
Leishmania major | 3-methylcrotonoyl-CoA carboxylase beta subunit, putative | 0.2014 | 0.1332 | 0.1041 |
Mycobacterium ulcerans | acetyl/propionyl CoA carboxylase subunit beta | 0.2014 | 0.1332 | 0.2905 |
Leishmania major | carbamoyl-phosphate synthase, putative | 0.128 | 0.0836 | 0.0529 |
Mycobacterium ulcerans | carbamoyl phosphate synthase large subunit | 0.128 | 0.0836 | 0.1476 |
Schistosoma mansoni | dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase | 0.0521 | 0.0324 | 0.0324 |
Schistosoma mansoni | methylcrotonyl-CoA carboxylase | 0.5661 | 0.3792 | 0.3792 |
Loa Loa (eye worm) | hypothetical protein | 0.0521 | 0.0324 | 0.0331 |
Mycobacterium leprae | Probable propyonyl-CoA carboxylase beta chain 4 AccD4 (Pccase) | 0.2014 | 0.1332 | 0.2905 |
Toxoplasma gondii | pyruvate carboxylase | 0.5661 | 0.3792 | 0.3584 |
Brugia malayi | Niemann-Pick C1 protein precursor | 0.0109 | 0.0047 | 0.0049 |
Mycobacterium tuberculosis | Probable acetyl-/propionyl-coenzyme A carboxylase alpha chain (alpha subunit) AccA2: biotin carboxylase + biotin carboxyl carrie | 0.5661 | 0.3792 | 1 |
Echinococcus granulosus | propionyl coenzyme A carboxylase beta chain | 0.2014 | 0.1332 | 0.1332 |
Trypanosoma cruzi | glutamine dependent carbamoyl-phosphate synthase, putative | 0.128 | 0.0836 | 0.0874 |
Trypanosoma cruzi | 3-methylcrotonyl-CoA carboxylase, putative | 0.5661 | 0.3792 | 0.5922 |
Echinococcus multilocularis | expressed conserved protein | 0.0103 | 0.0042 | 0.0042 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0065 | 0.0017 | 0.0017 |
Mycobacterium tuberculosis | Probable pyruvate carboxylase Pca (pyruvic carboxylase) | 0.5661 | 0.3792 | 1 |
Trypanosoma cruzi | glutamine-dependent carbamoyl-phosphate synthetase, putative | 0.128 | 0.0836 | 0.0874 |
Brugia malayi | jmjC domain containing protein | 0.0065 | 0.0017 | 0.0018 |
Schistosoma mansoni | hypothetical protein | 0.0045 | 0.0004 | 0.0004 |
Mycobacterium ulcerans | pyruvate carboxylase | 0.5661 | 0.3792 | 1 |
Echinococcus granulosus | dihydrolipoyllysine residue succinyltransferase | 0.0521 | 0.0324 | 0.0324 |
Toxoplasma gondii | carbamoylphosphate synthetase | 0.128 | 0.0836 | 0.0529 |
Trypanosoma brucei | unspecified product | 0.3722 | 0.2484 | 0.2232 |
Plasmodium vivax | biotin carboxylase subunit of acetyl CoA carboxylase, putative | 1.0756 | 0.7229 | 1 |
Leishmania major | carboxylase, putative | 0.5661 | 0.3792 | 0.3584 |
Brugia malayi | Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial precursor, puta | 0.0521 | 0.0324 | 0.0336 |
Echinococcus multilocularis | acetyl coenzyme A carboxylase 1 | 1.4863 | 1 | 1 |
Mycobacterium tuberculosis | Probable propionyl-CoA carboxylase beta chain 5 AccD5 (pccase) (propanoyl-CoA:carbon dioxide ligase) | 0.2014 | 0.1332 | 0.2905 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0065 | 0.0017 | 0.0017 |
Schistosoma mansoni | propionyl-CoA carboxylase beta chain mitochondrial precursor | 0.2014 | 0.1332 | 0.1332 |
Toxoplasma gondii | acetyl-coA carboxylase ACC2 | 1.4863 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | Acetyl-CoA carboxylase, carboxyltransferase component | 0.2014 | 0.1332 | 0.2905 |
Toxoplasma gondii | acyl-CoA carboxyltransferase beta chain, putative | 0.2014 | 0.1332 | 0.1041 |
Echinococcus multilocularis | propionyl coenzyme A carboxylase beta chain | 0.2014 | 0.1332 | 0.1332 |
Mycobacterium ulcerans | acetyl-/propionyl-coenzyme a carboxylase alpha chain AccA1 | 0.5661 | 0.3792 | 1 |
Schistosoma mansoni | methylcrotonyl-CoA carboxylase | 0.5661 | 0.3792 | 0.3792 |
Schistosoma mansoni | survival motor neuron protein | 0.0053 | 0.0009 | 0.0009 |
Wolbachia endosymbiont of Brugia malayi | carbamoyl phosphate synthase large subunit | 0.128 | 0.0836 | 0.1476 |
Onchocerca volvulus | Huntingtin homolog | 0.0136 | 0.0065 | 1 |
Echinococcus multilocularis | Biotin lipoyl attachment | 0.0521 | 0.0324 | 0.0324 |
Echinococcus multilocularis | protein patched | 0.0047 | 0.0005 | 0.0005 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0109 | 0.0047 | 0.0047 |
Plasmodium vivax | carbamoyl phosphate synthetase, putative | 0.128 | 0.0836 | 0.0742 |
Mycobacterium ulcerans | bifunctional protein acetyl-/propionyl-coenzyme a carboxylase (alpha chain) AccA3 | 0.5661 | 0.3792 | 1 |
Trypanosoma brucei | 3-methylcrotonyl-CoA carboxylase alpha subunit, putative | 0.5661 | 0.3792 | 0.3584 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0065 | 0.0017 | 0.0017 |
Chlamydia trachomatis | acetyl-coenzyme A carboxylase carboxyl transferase subunit beta | 0.2014 | 0.1332 | 0.3233 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0065 | 0.0017 | 0.0013 |
Echinococcus multilocularis | dihydrolipoyllysine residue succinyltransferase | 0.0521 | 0.0324 | 0.0324 |
Brugia malayi | Lipoamide acyltransferase component of branched-chain alpha-keto aciddehydrogenase complex, mitochondrial precursor | 0.0521 | 0.0324 | 0.0336 |
Trypanosoma cruzi | acetyl-CoA carboxylase | 0.9202 | 0.6181 | 1 |
Trypanosoma brucei | glutamine hydrolysing (not ammonia-dependent) carbomoyl phosphate synthase, putative | 0.128 | 0.0836 | 0.0529 |
Echinococcus multilocularis | geminin | 0.0187 | 0.0099 | 0.0099 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0765 | 0.0489 | 0.0489 |
Echinococcus multilocularis | dihydrolipoyllysine residue acetyltransferase | 0.0521 | 0.0324 | 0.0324 |
Onchocerca volvulus | Huntingtin homolog | 0.0136 | 0.0065 | 1 |
Trypanosoma cruzi | 3-methylcrotonyl-CoA carboxylase, putative | 0.5661 | 0.3792 | 0.5922 |
Schistosoma mansoni | jumonji domain containing protein | 0.0065 | 0.0017 | 0.0017 |
Schistosoma mansoni | hypothetical protein | 0.0053 | 0.0009 | 0.0009 |
Brugia malayi | MH2 domain containing protein | 0.0264 | 0.0151 | 0.0157 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0765 | 0.0489 | 0.0489 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.0111 | 0.0048 | 0.0048 |
Toxoplasma gondii | acetyl-CoA carboxylase ACC1 | 1.4863 | 1 | 1 |
Loa Loa (eye worm) | carboxyl transferase domain-containing protein | 1.4342 | 0.9649 | 1 |
Trypanosoma brucei | acetyl-CoA carboxylase | 1.4863 | 1 | 1 |
Plasmodium falciparum | biotin carboxylase subunit of acetyl CoA carboxylase, putative | 1.0756 | 0.7229 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -6.24 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.757 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.75 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.718 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.516 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.494 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.494 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.376 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.339 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.231 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.