Detailed information for compound 1603750

Basic information

Technical information
  • TDR Targets ID: 1603750
  • Name: 9-(2,6-dimethyl-4,4a,8,8a-tetrahydro-[1,3]dio xino[4,5-e][1,3]dioxin-8-yl)-3,3,6,6-tetramet hyl-4,5,7,9-tetrahydro-2H-xanthene-1,8-dione
  • MW: 446.533 | Formula: C25H34O7
  • H donors: 0 H acceptors: 2 LogP: 2.52 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC1OC2COC(OC2C(O1)C1C2=C(OC3=C1C(=O)CC(C3)(C)C)CC(CC2=O)(C)C)C
  • InChi: 1S/C25H34O7/c1-12-28-11-18-22(30-12)23(31-13(2)29-18)21-19-14(26)7-24(3,4)9-16(19)32-17-10-25(5,6)8-15(27)20(17)21/h12-13,18,21-23H,7-11H2,1-6H3
  • InChiKey: NUIBXLWXNAKBGU-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 9-(2,6-dimethyl-4,4a,8,8a-tetrahydro-[1,3]dioxino[4,5-e][1,3]dioxin-8-yl)-3,3,6,6-tetramethyl-4,5,7,9-tetrahydro-2H-xanthene-1,8-quinone
  • 7512-02-9
  • NCI60_003734
  • 9-(2,6-Dimethyltetrahydro[1,3]dioxino[5,4-d][1,3]dioxin-4-yl)-3,3,6,6-tetramethyl-3,4,5,6,7,9-hexahydro-1H-xanthene-1,8(2H)-dione
  • 9-(2,6-Dimethyltetrahydro(1,3)dioxino(5,4-d)(1,3)dioxin-4-yl)-3,3,6,6-tetramethyl-3,4,5,6,7,9-hexahydro-1H-xanthene-1,8(2H)-dione
  • NSC 400290
  • AIDS-130224
  • AIDS130224
  • NSC400290

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0057 0.0104 0.0115
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0314 0.1182 0.3289
Loa Loa (eye worm) hypothetical protein 0.0661 0.2635 0.2635
Loa Loa (eye worm) hypothetical protein 0.0661 0.2635 0.2635
Echinococcus multilocularis neuropeptide Y receptor 0.0661 0.2635 0.2886
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0061 0.0123 0.0134
Trypanosoma brucei Replication factor A protein 1 0.005 0.0075 0.0098
Onchocerca volvulus 0.0661 0.2635 0.6001
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0042 0.0041 0.0041
Echinococcus multilocularis Furin 1 0.0314 0.1182 0.1295
Loa Loa (eye worm) hypothetical protein 0.0041 0.0037 0.0037
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0095 0.0263 0.0288
Schistosoma mansoni subfamily S8B non-peptidase homologue (S08 family) 0.0314 0.1182 0.1285
Loa Loa (eye worm) steroid hormone receptor 0.0041 0.0037 0.0037
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0041 0.0037 0.0037
Loa Loa (eye worm) hypothetical protein 0.0661 0.2635 0.2635
Schistosoma mansoni hypothetical protein 0.0033 0.0005 0.0005
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0042 0.0041 0.0041
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0661 0.2635 0.2886
Echinococcus multilocularis SWI:SNF matrix associated 0.0117 0.0358 0.0392
Echinococcus granulosus Upstream activation factor subunit UAF30 0.0117 0.0358 0.0392
Schistosoma mansoni tyrosine kinase 0.0086 0.0228 0.0248
Echinococcus granulosus neuropeptides capa receptor 0.0661 0.2635 0.2886
Loa Loa (eye worm) TK/CSK protein kinase 0.0038 0.0026 0.0026
Brugia malayi Nuclear hormone receptor-like 1 0.0041 0.0037 0.0037
Trichomonas vaginalis replication factor A 1, rfa1, putative 0.0099 0.0279 0.063
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0041 0.0037 0.0041
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0099 0.0281 0.0281
Brugia malayi Guanylate kinase family protein 0.004 0.0032 0.0032
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0061 0.0123 0.0134
Echinococcus multilocularis Upstream activation factor subunit UAF30 0.0117 0.0358 0.0392
Echinococcus multilocularis segment polarity protein dishevelled 0.0099 0.0281 0.0308
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0057 0.0104 0.0115
Schistosoma mansoni hypothetical protein 0.0117 0.0358 0.0389
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0057 0.0104 0.0115
Schistosoma mansoni glutamate receptor NMDA 0.0279 0.1034 0.1124
Schistosoma mansoni tubulin subunit beta 0.0858 0.346 0.3763
Echinococcus multilocularis nardilysin 0.0046 0.006 0.0066
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0041 0.0037 0.0041
Echinococcus granulosus SWI:SNF matrix associated 0.0117 0.0358 0.0392
Brugia malayi hypothetical protein 0.004 0.0033 0.0033
Loa Loa (eye worm) TK protein kinase 0.0081 0.0205 0.0205
Trypanosoma cruzi peptidase, putative 0.0046 0.006 0.0056
Echinococcus granulosus tyrosine protein kinase Blk 0.0081 0.0205 0.0224
Leishmania major C-8 sterol isomerase-like protein 0.0374 0.1432 0.4069
Plasmodium vivax subtilisin-like protease 1 0.0057 0.0104 0.0115
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0041 0.0037 0.0041
Trichomonas vaginalis deoxyribonuclease II, putative 0.007 0.0159 0.0276
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0314 0.1182 0.3289
Onchocerca volvulus 0.0038 0.0025 0.0058
Schistosoma mansoni tyrosine kinase 0.0095 0.0263 0.0286
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0041 0.0037 0.0037
Leishmania major beta tubulin 0.0858 0.346 1
Echinococcus multilocularis g protein coupled receptor 0.0661 0.2635 0.2886
Trichomonas vaginalis conserved hypothetical protein 0.0257 0.0944 0.2588
Trypanosoma brucei beta tubulin 0.0858 0.346 1
Trypanosoma brucei hypothetical protein 0.0118 0.0358 0.0927
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0118 0.0358 0.0927
Echinococcus multilocularis 0.0073 0.0172 0.0188
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0661 0.2635 0.2886
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0041 0.0037 0.0037
Brugia malayi hypothetical protein 0.0661 0.2635 0.2635
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0763 0.3059 0.8819
Loa Loa (eye worm) tubulin beta-1 chain 0.0858 0.346 0.346
Onchocerca volvulus 0.0049 0.0071 0.0162
Loa Loa (eye worm) BEN-1 protein 0.0858 0.346 0.346
Echinococcus granulosus rhodopsin orphan GPCR 0.0661 0.2635 0.2886
Echinococcus granulosus furin 0.1236 0.504 0.552
Schistosoma mansoni neuropeptide receptor 0.0661 0.2635 0.2866
Onchocerca volvulus 0.0661 0.2635 0.6001
Echinococcus granulosus rhodopsin orphan GPCR 0.0661 0.2635 0.2886
Trypanosoma brucei subtilisin peptidase 0.0057 0.0104 0.0185
Loa Loa (eye worm) hypothetical protein 0.0661 0.2635 0.2635
Loa Loa (eye worm) hypothetical protein 0.0117 0.0355 0.0355
Trichomonas vaginalis conserved hypothetical protein 0.0257 0.0944 0.2588
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0035 0.0014 0.0016
Onchocerca volvulus Matrix metalloproteinase homolog 0.0062 0.0127 0.0289
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.0062 0.0127 0.0139
Schistosoma mansoni integrin alpha-ps 0.0035 0.0012 0.0013
Trichomonas vaginalis leucine-rich repeat protein, BspA family 0.0257 0.0944 0.2588
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.005 0.0076 0.0083
Loa Loa (eye worm) glutamate receptor 2 0.0033 0.0005 0.0005
Toxoplasma gondii insulysin, putative 0.0044 0.0051 0.0074
Schistosoma mansoni serine-type protease inhibitor 0.2229 0.9196 1
Giardia lamblia High cysteine membrane protein Group 2 0.0448 0.1743 0.3177
Leishmania major beta tubulin 0.0858 0.346 1
Echinococcus granulosus tyrosine protein kinase HCK 0.0066 0.0145 0.0158
Loa Loa (eye worm) integrin alpha pat-2 0.0229 0.0827 0.0827
Brugia malayi Tyrosine-protein kinase abl-1 0.0125 0.039 0.039
Echinococcus granulosus beta tubulin 0.0858 0.346 0.379
Schistosoma mansoni membrane associated guanylate kinase inverted related 0.0073 0.0172 0.0187
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0041 0.0037 0.0041
Loa Loa (eye worm) hypothetical protein 0.0661 0.2635 0.2635
Loa Loa (eye worm) hypothetical protein 0.0661 0.2635 0.2635
Loa Loa (eye worm) hypothetical protein 0.0473 0.1847 0.1847
Echinococcus multilocularis rhodopsin orphan GPCR 0.0661 0.2635 0.2886
Trichomonas vaginalis conserved hypothetical protein 0.0057 0.0104 0.0115
Echinococcus granulosus tyrosine protein kinase Src42A 0.0074 0.0175 0.0192
Loa Loa (eye worm) G-protein coupled receptor 0.0661 0.2635 0.2635
Echinococcus multilocularis neuropeptide s receptor 0.0661 0.2635 0.2886
Echinococcus multilocularis tubulin beta 1 chain 0.0858 0.346 0.379
Echinococcus multilocularis tyrosine protein kinase csk 0.0038 0.0026 0.0028
Echinococcus multilocularis ring and YY1 binding protein 0.0042 0.0041 0.0045
Echinococcus multilocularis segment polarity protein dishevelled 0.0099 0.0281 0.0308
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0041 0.0037 0.0037
Onchocerca volvulus 0.0038 0.0025 0.0058
Brugia malayi G-protein coupled receptor 0.0661 0.2635 0.2635
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0035 0.0014 0.0015
Leishmania major beta tubulin 0.0858 0.346 1
Loa Loa (eye worm) melatonin receptor type 1A 0.0661 0.2635 0.2635
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0057 0.0104 0.0115
Echinococcus granulosus membrane associated guanylate kinase, WW and PDZ 0.0053 0.0087 0.0095
Loa Loa (eye worm) endoprotease bli-4 0.1236 0.504 0.504
Plasmodium vivax hypothetical protein, conserved 0.0117 0.0358 0.0862
Chlamydia trachomatis ribonucleoside-diphosphate reductase subunit alpha 0.0181 0.0622 1
Brugia malayi Transforming growth factor beta like domain containing protein 0.0125 0.0389 0.0389
Loa Loa (eye worm) hypothetical protein 0.0661 0.2635 0.2635
Echinococcus granulosus neuropeptide FF receptor 2 0.1129 0.4591 0.5028
Brugia malayi PAN domain containing protein 0.0038 0.0025 0.0025
Echinococcus multilocularis neuroendocrine convertase 2 0.0788 0.3163 0.3465
Echinococcus granulosus insulin degrading enzyme 0.0046 0.006 0.0066
Schistosoma mansoni amine GPCR 0.0661 0.2635 0.2866
Echinococcus multilocularis fmrfamide receptor 0.0661 0.2635 0.2886
Echinococcus granulosus neuropeptide receptor 0.0661 0.2635 0.2886
Toxoplasma gondii subtilisin SUB10 0.0057 0.0104 0.023
Loa Loa (eye worm) hypothetical protein 0.0049 0.0071 0.0071
Loa Loa (eye worm) hypothetical protein 0.0661 0.2635 0.2635
Schistosoma mansoni cell polarity protein 0.0034 0.0009 0.001
Trichomonas vaginalis replication factor A 1, rfa1, putative 0.005 0.0075 0.0027
Schistosoma mansoni tubulin subunit beta 0.0858 0.346 0.3763
Leishmania major beta tubulin 0.0858 0.346 1
Echinococcus granulosus tubulin beta 1 chain 0.0858 0.346 0.379
Toxoplasma gondii rhoptry metalloprotease toxolysin TLN1 0.0046 0.006 0.0102
Onchocerca volvulus Bile acid receptor homolog 0.0041 0.0037 0.0085
Schistosoma mansoni neuropeptide receptor 0.0661 0.2635 0.2866
Chlamydia trachomatis DNA topoisomerase I 0.0117 0.0358 0.5299
Echinococcus multilocularis proprotein convertase subtilisin:kexin type 5 0.0763 0.3059 0.335
Schistosoma mansoni nuclear hormone receptor 0.0041 0.0037 0.0041
Echinococcus granulosus neuropeptide Y receptor 0.0661 0.2635 0.2886
Schistosoma mansoni amine GPCR 0.0661 0.2635 0.2866
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.0587 0.1536
Onchocerca volvulus 0.0661 0.2635 0.6001
Loa Loa (eye worm) hypothetical protein 0.0041 0.0037 0.0037
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0314 0.1182 0.3289
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0661 0.2635 0.2635
Leishmania major beta tubulin 0.0858 0.346 1
Brugia malayi proprotein convertase 2 0.0788 0.3163 0.3163
Echinococcus multilocularis g-protein coupled receptor 0.0661 0.2635 0.2886
Echinococcus granulosus glutamate receptor ionotropic kainate 3 0.0033 0.0005 0.0005
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0095 0.0263 0.0288
Toxoplasma gondii subtilisin SUB8 0.0057 0.0104 0.023
Echinococcus granulosus GPCR family 2 0.0033 0.0005 0.0005
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0661 0.2635 0.2635
Toxoplasma gondii aspartyl protease ASP1 0.0048 0.0065 0.0117
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0661 0.2635 0.2866
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0118 0.0358 0.0927
Loa Loa (eye worm) hypothetical protein 0.0661 0.2635 0.2635
Echinococcus granulosus rhodopsin orphan GPCR 0.0661 0.2635 0.2886
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0661 0.2635 0.2635
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0661 0.2635 0.2886
Leishmania major beta tubulin 0.0858 0.346 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0041 0.0037 0.0037
Onchocerca volvulus Putative replication factor A 73 kDa subunit 0.0093 0.0255 0.0581
Giardia lamblia Beta tubulin 0.0858 0.346 1
Schistosoma mansoni myosin xvIII 0.0661 0.2635 0.2866
Schistosoma mansoni thyroid hormone receptor 0.0041 0.0037 0.0041
Loa Loa (eye worm) camk/mapkapk/mapkapk protein kinase 0.0181 0.0624 0.0624
Trichomonas vaginalis tubulin epsilon chain, putative 0.0858 0.346 1
Schistosoma mansoni hypothetical protein 0.1243 0.5071 0.5515
Brugia malayi Tachykinin-like peptides receptor 99D 0.1129 0.4591 0.4591
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0041 0.0037 0.0037
Onchocerca volvulus 0.0038 0.0025 0.0058
Loa Loa (eye worm) BEN-1 protein 0.0858 0.346 0.346
Entamoeba histolytica protein kinase, putative 0.0066 0.0145 0.0326
Echinococcus granulosus neuropeptide Y receptor 0.0661 0.2635 0.2886
Loa Loa (eye worm) hypothetical protein 0.0057 0.0104 0.0104
Echinococcus multilocularis tumor protein p63 0.0334 0.1265 0.1385
Schistosoma mansoni ATP-binding cassette transporter 0.0033 0.0005 0.0006
Brugia malayi AKH receptor 0.0661 0.2635 0.2635
Schistosoma mansoni glutamate receptor AMPA 0.0033 0.0005 0.0005
Echinococcus granulosus Furin 1 0.0314 0.1182 0.1295
Echinococcus multilocularis neuropeptide receptor 0.0661 0.2635 0.2886
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0048 0.0065 0.0072
Brugia malayi PAN domain containing protein 0.0038 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.0661 0.2635 0.2635
Loa Loa (eye worm) hypothetical protein 0.0661 0.2635 0.2635
Echinococcus granulosus ecdysone induced protein 78C 0.0041 0.0037 0.0041
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0763 0.3059 0.8819
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0037 0.002 0.0021
Trypanosoma cruzi peptidase, putative 0.0046 0.006 0.0056
Echinococcus multilocularis allatostatin A receptor 0.1081 0.4391 0.481
Loa Loa (eye worm) bone morphogenic protein 6 0.0125 0.0389 0.0389
Echinococcus granulosus epidermal growth factor receptor 0.0086 0.0228 0.025
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0041 0.0037 0.0037
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0041 0.0037 0.0041
Onchocerca volvulus Neuropeptide F receptor homolog 0.0661 0.2635 0.6001
Leishmania major beta tubulin 0.0858 0.346 1
Onchocerca volvulus Putative endochitinase 0.0074 0.0177 0.0402
Loa Loa (eye worm) hypothetical protein 0.0099 0.0281 0.0281
Loa Loa (eye worm) angiotensin-converting enzyme family protein 0.2421 1 1
Echinococcus granulosus tyrosine protein kinase Fyn 0.0095 0.0263 0.0288
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0279 0.1034 0.1132
Loa Loa (eye worm) TK/INSR protein kinase 0.0054 0.0092 0.0092
Schistosoma mansoni glutamate receptor AMPA 0.0033 0.0005 0.0005
Onchocerca volvulus Matrilysin homolog 0.0062 0.0127 0.0289
Trichomonas vaginalis proprotein convertase subtilisin/kexin type, putative 0.0257 0.0944 0.2588
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0661 0.2635 0.2866
Schistosoma mansoni cathepsin D (A01 family) 0.014 0.0453 0.0493
Entamoeba histolytica tubulin family protein 0.0858 0.346 1
Schistosoma mansoni cellular tumor antigen P53 0.0049 0.0071 0.0077
Leishmania major phosphoglycan beta 1,3 galactosyltransferase 5 0.0046 0.006 0.0056
Echinococcus multilocularis g protein coupled receptor 0.0661 0.2635 0.2886
Echinococcus granulosus integrin beta 2 0.0937 0.3787 0.4148
Brugia malayi Calcitonin receptor-like protein seb-1 0.0069 0.0156 0.0156
Schistosoma mansoni integrin alpha-ps 0.0067 0.0146 0.0158
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.0117 0.0358 0.0927
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.0034 0.0009 0.001
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.005 0.0076 0.0083
Loa Loa (eye worm) latrophilin receptor protein 2 0.0033 0.0005 0.0005
Echinococcus granulosus tm gpcr rhodopsin 0.0661 0.2635 0.2886
Schistosoma mansoni insulysin unit 3 (M16 family) 0.0046 0.006 0.0066
Loa Loa (eye worm) integrin beta-2 0.1268 0.5176 0.5176
Trichomonas vaginalis replication factor A 1, rfa1, putative 0.0104 0.0301 0.0694
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0057 0.0104 0.0115
Loa Loa (eye worm) hypothetical protein 0.0661 0.2635 0.2635
Echinococcus granulosus tyrosine protein kinase csk 0.0038 0.0026 0.0028
Echinococcus granulosus neuropeptide receptor A26 0.0661 0.2635 0.2886
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0057 0.0104 0.0115
Loa Loa (eye worm) hypothetical protein 0.0661 0.2635 0.2635
Schistosoma mansoni biogenic amine (5HT) receptor 0.0661 0.2635 0.2866
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0118 0.0358 0.0927
Brugia malayi PAN domain containing protein 0.0038 0.0025 0.0025
Brugia malayi Hypothetical subtilase-type proteinase F21H12.6 in chromosome II 0.0057 0.0104 0.0104
Brugia malayi hypothetical protein 0.0661 0.2635 0.2635
Echinococcus multilocularis NMDA receptor 0.0033 0.0005 0.0005
Echinococcus multilocularis ribonucleoside diphosphate reductase large 0.0181 0.0622 0.0681
Schistosoma mansoni RAR-like nuclear receptor 0.0041 0.0037 0.0041
Schistosoma mansoni fusion 0.0042 0.0041 0.0045
Echinococcus granulosus fmrfamide receptor 0.0661 0.2635 0.2886
Echinococcus granulosus tyrosine protein kinase Src64B 0.0095 0.0263 0.0288
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.1236 0.504 0.5481
Echinococcus granulosus c src tyrosine kinase 0.0066 0.0144 0.0158
Brugia malayi hypothetical protein 0.0661 0.2635 0.2635
Loa Loa (eye worm) hypothetical protein 0.0041 0.0037 0.0037
Loa Loa (eye worm) glutamate receptor 1 0.0033 0.0005 0.0005
Toxoplasma gondii sporozoite developmental protein 0.0046 0.006 0.0102
Trypanosoma brucei calpain, putative 0.0118 0.0358 0.0927
Loa Loa (eye worm) hypothetical protein 0.0041 0.0037 0.0037
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0057 0.0104 0.0115
Loa Loa (eye worm) replication factor A 73 kDa subunit 0.0104 0.0301 0.0301
Trichomonas vaginalis conserved hypothetical protein 0.0117 0.0358 0.0862
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0041 0.0037 0.0037
Echinococcus multilocularis 0.0046 0.006 0.0066
Schistosoma mansoni glutamate receptor kainate 0.0033 0.0005 0.0005
Toxoplasma gondii subtilisin SUB1 0.0057 0.0104 0.023
Echinococcus granulosus 3'partial|membrane associated guanylate kinase ww and pdz 0.0053 0.0087 0.0095
Plasmodium vivax subtilisin-like protease 2, putative 0.0057 0.0104 0.0115
Schistosoma mansoni tyrosine kinase 0.0035 0.0014 0.0015
Schistosoma mansoni brg-1 associated factor 0.0117 0.0358 0.0389
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0145 0.0473 0.0514
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0041 0.0037 0.0041
Loa Loa (eye worm) hypothetical protein 0.0661 0.2635 0.2635
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.2213 0.913 1
Loa Loa (eye worm) hypothetical protein 0.0191 0.0667 0.0667
Giardia lamblia Beta tubulin 0.0858 0.346 1
Trypanosoma cruzi ribonucleoside-diphosphate reductase large chain, putative 0.0181 0.0622 0.1699
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.0085 0.0221 0.1288
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0374 0.1432 0.4069
Onchocerca volvulus 0.0042 0.0041 0.0094
Echinococcus granulosus somatostatin receptor 0.0661 0.2635 0.2886
Loa Loa (eye worm) microfilarial chitinase 0.0063 0.0131 0.0131
Trichomonas vaginalis glucosylceramidase, putative 0.0262 0.0965 0.2649
Mycobacterium leprae Possible secreted protease 0.0057 0.0104 0.0578
Schistosoma mansoni neuropeptide f receptor 76f 0.0661 0.2635 0.2866
Plasmodium vivax SWIB/MDM2 domain-containing protein, putative 0.0117 0.0358 0.0862
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0314 0.1182 0.3289
Loa Loa (eye worm) SWIB/MDM2 domain-containing protein 0.0117 0.0358 0.0358
Schistosoma mansoni transcription factor LCR-F1 0.004 0.0033 0.0036
Plasmodium falciparum subtilisin-like protease 1 0.0057 0.0104 0.0185
Trichomonas vaginalis conserved hypothetical protein 0.0257 0.0944 0.2588
Toxoplasma gondii PAN domain-containing protein 0.059 0.2336 0.6729
Schistosoma mansoni RNA binding protein 0.0042 0.0041 0.0045
Toxoplasma gondii SWIB/MDM2 domain-containing protein 0.0117 0.0358 0.0969
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0661 0.2635 0.2886
Schistosoma mansoni growth hormone secretagogue receptor 0.0661 0.2635 0.2866
Echinococcus multilocularis zinc finger protein Ran binding 0.0042 0.0041 0.0045
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.0034 0.0009 0.0009
Toxoplasma gondii beta-1 tubulin, putative 0.0858 0.346 1
Brugia malayi G protein-coupled receptor 0.0661 0.2635 0.2635
Onchocerca volvulus 0.0042 0.0041 0.0094
Schistosoma mansoni tubulin subunit beta 0.0858 0.346 0.3763
Echinococcus granulosus tyrosine protein kinase Fyn 0.0095 0.0263 0.0288
Schistosoma mansoni hypothetical protein 0.0661 0.2635 0.2866
Echinococcus multilocularis SWI:SNF matrix associated 0.0117 0.0358 0.0392
Echinococcus granulosus MAP kinase activated protein kinase 2 0.0181 0.0624 0.0684
Loa Loa (eye worm) hypothetical protein 0.0041 0.0037 0.0037
Onchocerca volvulus 0.0194 0.068 0.1548
Schistosoma mansoni biogenic amine receptor 0.0661 0.2635 0.2866
Brugia malayi hypothetical protein 0.0661 0.2635 0.2635
Trichomonas vaginalis tubulin beta chain, putative 0.0858 0.346 1
Leishmania major subtilisin-like serine peptidase 0.0057 0.0104 0.0185
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0661 0.2635 0.2886
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.005 0.0076 0.0083
Loa Loa (eye worm) hypothetical protein 0.0661 0.2635 0.2635
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0661 0.2635 0.2635
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0041 0.0037 0.0085
Echinococcus multilocularis G protein coupled receptor 139 0.0661 0.2635 0.2886
Schistosoma mansoni furin-1 (S08 family) 0.053 0.2086 0.2268
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0661 0.2635 0.2866
Brugia malayi ORL1-like opioid receptor 0.0661 0.2635 0.2635
Onchocerca volvulus 0.0057 0.0104 0.0238
Trichomonas vaginalis tubulin, putative 0.0858 0.346 1
Leishmania major beta tubulin 0.0858 0.346 1
Echinococcus multilocularis membrane bound transcription factor site 1 0.0057 0.0104 0.0114
Loa Loa (eye worm) hypothetical protein 0.1081 0.4391 0.4391
Trichomonas vaginalis tubulin gamma chain, putative 0.0858 0.346 1
Echinococcus granulosus ring and YY1 binding protein 0.0042 0.0041 0.0045
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0661 0.2635 0.2886
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0041 0.0037 0.0041
Echinococcus granulosus Tubulin beta 2C chain 0.0858 0.346 0.379
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.005 0.0076 0.0083
Echinococcus granulosus Tubulin beta 2C chain 0.0858 0.346 0.379
Onchocerca volvulus 0.0661 0.2635 0.6001
Onchocerca volvulus 0.0042 0.0041 0.0094
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0661 0.2635 0.2635
Brugia malayi endoprotease bli-4 precursor 0.1236 0.504 0.504
Echinococcus multilocularis neuropeptide receptor A26 0.0661 0.2635 0.2886
Loa Loa (eye worm) hypothetical protein 0.0661 0.2635 0.2635
Brugia malayi Deoxyribonuclease II family protein 0.007 0.0159 0.0159
Echinococcus multilocularis epidermal growth factor receptor 0.0086 0.0228 0.025
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.0827 0.3327 0.3644
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0057 0.0104 0.0115
Loa Loa (eye worm) hypothetical protein 0.0054 0.0092 0.0092
Trichomonas vaginalis tubulin alpha chain, putative 0.0858 0.346 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0661 0.2635 0.2866
Trichomonas vaginalis DNAse2-prov protein, putative 0.007 0.0159 0.0276
Echinococcus multilocularis dro:myosuppressin receptor 0.0661 0.2635 0.2886
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0057 0.0104 0.0115
Loa Loa (eye worm) hypothetical protein 0.0053 0.0087 0.0087
Brugia malayi putative neuropeptide receptor 0.0661 0.2635 0.2635
Loa Loa (eye worm) hypothetical protein 0.0035 0.0012 0.0012
Trypanosoma brucei peptidase, putative 0.0046 0.006 0.0056
Toxoplasma gondii subtilisin SUB7 0.0057 0.0104 0.023
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0033 0.0005 0.0005
Schistosoma mansoni integrin beta subunit 0.0742 0.2973 0.3233
Echinococcus multilocularis rhodopsin orphan GPCR 0.0661 0.2635 0.2886
Brugia malayi Integrin alpha cytoplasmic region family protein 0.0113 0.0338 0.0338
Brugia malayi PAN domain containing protein 0.0038 0.0025 0.0025
Echinococcus granulosus neuropeptide receptor 0.0661 0.2635 0.2886
Echinococcus multilocularis integrin alpha ps 0.0067 0.0146 0.016
Echinococcus granulosus neuropeptides capa receptor 0.0661 0.2635 0.2886
Echinococcus multilocularis glutamate receptor 2 0.0033 0.0005 0.0005
Echinococcus granulosus glutamate receptor subunit protein glur 0.0033 0.0005 0.0005
Schistosoma mansoni hypothetical protein 0.0033 0.0005 0.0005
Brugia malayi Peripheral plasma membrane protein CASK 0.004 0.0032 0.0032
Schistosoma mansoni hypothetical protein 0.0033 0.0005 0.0005
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0661 0.2635 0.2866
Loa Loa (eye worm) neuropeptide F receptor 0.0661 0.2635 0.2635
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0661 0.2635 0.2866
Loa Loa (eye worm) hypothetical protein 0.0099 0.028 0.028
Mycobacterium ulcerans membrane-anchored mycosin MycP3 0.0057 0.0104 0.0578
Schistosoma mansoni amine GPCR 0.0661 0.2635 0.2866
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0041 0.0037 0.0037
Trichomonas vaginalis glucosylceramidase, putative 0.0262 0.0965 0.2649
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0118 0.0358 0.0927
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0041 0.0037 0.0037
Echinococcus multilocularis SWI:SNF matrix associated 0.0117 0.0358 0.0392
Brugia malayi Serotonin receptor 0.0661 0.2635 0.2635
Onchocerca volvulus Putative endochitinase 0.0074 0.0177 0.0402
Loa Loa (eye worm) deoxyribonuclease II family protein 0.007 0.0159 0.0159
Echinococcus multilocularis thyroid hormone receptor alpha 0.0041 0.0037 0.0041
Echinococcus multilocularis 0.0978 0.3962 0.434
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0057 0.0104 0.0115
Loa Loa (eye worm) hypothetical protein 0.0042 0.0041 0.0041
Echinococcus granulosus Tubulin beta 2C chain 0.0858 0.346 0.379
Loa Loa (eye worm) hypothetical protein 0.0661 0.2635 0.2635
Loa Loa (eye worm) TYRA-2 protein 0.0661 0.2635 0.2635
Schistosoma mansoni deoxyribonuclease II-related 0.007 0.0159 0.0173
Brugia malayi Tyrosine-protein kinase abl-1 0.0113 0.0338 0.0338
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0041 0.0037 0.0037
Echinococcus granulosus neuropeptide s receptor 0.0661 0.2635 0.2886
Toxoplasma gondii DNA topoisomerase domain-containing protein 0.0117 0.0358 0.0969
Echinococcus granulosus nmda type glutamate receptor 0.0118 0.036 0.0394
Toxoplasma gondii replication factor-a protein 1 (rpa1) subfamily protein 0.005 0.0075 0.0144
Loa Loa (eye worm) hypothetical protein 0.1236 0.504 0.504
Toxoplasma gondii subtilisin SUB2 0.0057 0.0104 0.023
Mycobacterium ulcerans chitinase/cellulase 0.0063 0.0131 0.074
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0048 0.0065 0.0071
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0057 0.0104 0.0115
Loa Loa (eye worm) tubulin beta chain 0.0858 0.346 0.346
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.0587 0.1536
Trichomonas vaginalis conserved hypothetical protein 0.0257 0.0944 0.2588
Onchocerca volvulus 0.0038 0.0025 0.0058
Schistosoma mansoni neuropeptide receptor 0.0661 0.2635 0.2866
Loa Loa (eye worm) hypothetical protein 0.0374 0.1432 0.1432
Echinococcus granulosus 7TM GPCR rhodopsin 0.0661 0.2635 0.2886
Echinococcus multilocularis neuropeptides capa receptor 0.0661 0.2635 0.2886
Schistosoma mansoni opsin-like receptor 0.0661 0.2635 0.2866
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0118 0.0358 0.0927
Echinococcus granulosus nardilysin 0.0046 0.006 0.0066
Loa Loa (eye worm) hypothetical protein 0.0042 0.0041 0.0041
Echinococcus granulosus orexin receptor type 2 0.0661 0.2635 0.2886
Schistosoma mansoni tyrosine kinase 0.0079 0.0199 0.0216
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0057 0.0104 0.0115
Brugia malayi hypothetical protein 0.0661 0.2635 0.2635
Onchocerca volvulus 0.0052 0.0086 0.0196
Loa Loa (eye worm) deoxyribonuclease II family protein 0.007 0.0159 0.0159
Loa Loa (eye worm) hypothetical protein 0.0194 0.068 0.068
Echinococcus granulosus tyrosine protein kinase Lyn 0.0095 0.0265 0.029
Schistosoma mansoni site-1 peptidase (S08 family) 0.0057 0.0104 0.0114
Schistosoma mansoni hypothetical protein 0.0145 0.0473 0.0514
Plasmodium falciparum tubulin beta chain 0.0858 0.346 1
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0095 0.0263 0.0288
Brugia malayi PAN domain containing protein 0.0038 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.0661 0.2635 0.2635
Mycobacterium ulcerans ribonucleotide-diphosphate reductase subunit alpha 0.0427 0.1652 1
Echinococcus granulosus glutamate receptor 2 0.005 0.0076 0.0083
Schistosoma mansoni glutamate receptor NMDA 0.005 0.0076 0.0082
Leishmania major beta tubulin 0.0858 0.346 1
Schistosoma mansoni tyrosine kinase 0.0054 0.0092 0.01
Onchocerca volvulus 0.0661 0.2635 0.6001
Trypanosoma brucei RNA helicase, putative 0.0729 0.2919 0.8417
Echinococcus multilocularis serotonin receptor 0.0661 0.2635 0.2886
Toxoplasma gondii beta-tubulin, putative 0.0858 0.346 1
Echinococcus granulosus deoxyribonuclease ii 0.007 0.0159 0.0174
Brugia malayi Kelch motif family protein 0.0206 0.0727 0.0727
Onchocerca volvulus 0.008 0.0201 0.0457
Trypanosoma cruzi ribonucleoside-diphosphate reductase large chain, putative 0.0051 0.0079 0.0109
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0118 0.0358 0.0927
Trichomonas vaginalis conserved hypothetical protein 0.0057 0.0104 0.0115
Trypanosoma brucei beta tubulin 0.0858 0.346 1
Loa Loa (eye worm) hypothetical protein 0.0195 0.0681 0.0681
Loa Loa (eye worm) matrixin family protein 0.0062 0.0127 0.0127
Trichomonas vaginalis conserved hypothetical protein 0.0257 0.0944 0.2588
Plasmodium falciparum subtilisin-like protease 2 0.0057 0.0104 0.0185
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0041 0.0037 0.0037
Brugia malayi photoreceptor-specific nuclear receptor 0.0041 0.0037 0.0037
Schistosoma mansoni hypothetical protein 0.0042 0.0041 0.0045
Loa Loa (eye worm) SRC-1 0.0095 0.0263 0.0263
Brugia malayi GnHR receptor homolog 0.2019 0.8319 0.8319
Loa Loa (eye worm) hypothetical protein 0.0034 0.0009 0.0009
Schistosoma mansoni cathepsin D (A01 family) 0.014 0.0453 0.0493
Echinococcus granulosus ribonucleoside diphosphate reductase large 0.0181 0.0622 0.0681
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0033 0.0005 0.0005
Echinococcus granulosus tm gpcr rhodopsin 0.2213 0.913 1
Brugia malayi nuclear receptor NHR-88 0.0041 0.0037 0.0037
Echinococcus granulosus peptide allatostatin:somatostatin 0.0661 0.2635 0.2886
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0057 0.0104 0.0115
Schistosoma mansoni hypothetical protein 0.0033 0.0005 0.0005
Brugia malayi RE15519p 0.0661 0.2635 0.2635
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0661 0.2635 0.2886
Plasmodium falciparum ribonucleoside-diphosphate reductase large subunit, putative 0.0181 0.0622 0.1699
Chlamydia trachomatis SWIB complex protein 0.0117 0.0358 0.5299
Brugia malayi PAN domain containing protein 0.0038 0.0025 0.0025
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.005 0.0076 0.0083
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0095 0.0263 0.0288
Schistosoma mansoni steroid hormone receptor ad4bp 0.0041 0.0037 0.0041
Onchocerca volvulus 0.0661 0.2635 0.6001
Brugia malayi Endochitinase 0.0074 0.0177 0.0177
Onchocerca volvulus 0.0041 0.0037 0.0085
Onchocerca volvulus 0.0661 0.2635 0.6001
Echinococcus granulosus proprotein convertase subtilisin:kexin type 5 0.0763 0.3059 0.335
Loa Loa (eye worm) hypothetical protein 0.0661 0.2635 0.2635
Echinococcus granulosus allatostatin A receptor 0.1081 0.4391 0.481
Loa Loa (eye worm) hypothetical protein 0.0038 0.0025 0.0025
Echinococcus granulosus tubulin beta 4A class IVa 0.0858 0.346 0.379
Treponema pallidum ribonucleotide-diphosphate reductase subunit alpha 0.0181 0.0622 1
Onchocerca volvulus 0.1081 0.4391 1
Schistosoma mansoni neuropeptide F-like receptor 0.0661 0.2635 0.2866
Schistosoma mansoni dishevelled 0.0089 0.0239 0.026
Mycobacterium tuberculosis Probable proline rich membrane-anchored mycosin MycP5 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-5) 0.0057 0.0104 0.0578
Onchocerca volvulus 0.0661 0.2635 0.6001
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0118 0.0358 0.0927
Plasmodium vivax tubulin beta chain, putative 0.0858 0.346 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0314 0.1182 0.3289
Loa Loa (eye worm) hypothetical protein 0.0661 0.2635 0.2635
Echinococcus multilocularis Tubulin beta 2C chain 0.0858 0.346 0.379
Loa Loa (eye worm) hypothetical protein 0.0042 0.0041 0.0041
Schistosoma mansoni tubulin subunit beta 0.0858 0.346 0.3763
Echinococcus granulosus glutamate receptor ionotropic kainate 0.0033 0.0005 0.0005
Schistosoma mansoni serine-type protease inhibitor 0.2229 0.9196 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0661 0.2635 0.2886
Trypanosoma brucei beta tubulin 0.0858 0.346 1
Onchocerca volvulus Putative endochitinase 0.0074 0.0177 0.0402
Loa Loa (eye worm) hypothetical protein 0.0661 0.2635 0.2635
Schistosoma mansoni tyrosine kinase 0.0054 0.0092 0.01
Echinococcus multilocularis serotonin receptor 0.0661 0.2635 0.2886
Echinococcus granulosus dro:myosuppressin receptor 0.0661 0.2635 0.2886
Loa Loa (eye worm) hypothetical protein 0.0661 0.2635 0.2635
Leishmania major beta tubulin 0.0858 0.346 1
Leishmania major beta tubulin 0.0858 0.346 1
Loa Loa (eye worm) PAN domain-containing protein 0.0038 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.0661 0.2635 0.2635
Loa Loa (eye worm) tubulin beta-4 chain 0.0858 0.346 0.346
Brugia malayi endochitinase 0.0074 0.0177 0.0177
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0041 0.0037 0.0041
Trichomonas vaginalis conserved hypothetical protein 0.0257 0.0944 0.2588
Echinococcus multilocularis g protein coupled receptor 0.0661 0.2635 0.2886
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.005 0.0076 0.0083
Echinococcus granulosus serotonin receptor 0.0661 0.2635 0.2886
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0661 0.2635 0.6001
Toxoplasma gondii subtilisin SUB12 0.0095 0.0263 0.0693
Schistosoma mansoni hypothetical protein 0.0033 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0145 0.0473 0.0473
Echinococcus granulosus segment polarity protein dishevelled 0.0099 0.0281 0.0308
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0118 0.0358 0.0927
Trichomonas vaginalis ribonucleoside-diphosphate reductase alpha chain, putative 0.0165 0.0558 0.1451
Loa Loa (eye worm) insulin-degrading enzyme 0.0046 0.006 0.006
Echinococcus multilocularis integrin alpha 3 0.0114 0.0344 0.0377
Loa Loa (eye worm) kelch domain-containing protein family protein 0.0206 0.0727 0.0727
Loa Loa (eye worm) hypothetical protein 0.0038 0.0025 0.0025
Echinococcus multilocularis beta tubulin 0.0858 0.346 0.379
Trichomonas vaginalis conserved hypothetical protein 0.0257 0.0944 0.2588
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.0587 0.1536
Onchocerca volvulus Glucosylceramidase homolog 0.0172 0.0587 0.1337
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0661 0.2635 0.2886
Wolbachia endosymbiont of Brugia malayi ribonucleotide-diphosphate reductase subunit alpha 0.0165 0.0558 0.5
Plasmodium falciparum plasmepsin I 0.0048 0.0065 0.0071
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0033 0.0005 0.0005
Schistosoma mansoni site-1 peptidase (S08 family) 0.0057 0.0104 0.0114
Echinococcus multilocularis Tubulin beta 2C chain 0.0858 0.346 0.379
Echinococcus granulosus g-protein coupled receptor 0.0661 0.2635 0.2886
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0041 0.0037 0.0041
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0314 0.1182 0.3289
Brugia malayi Integrin alpha pat-2 precursor 0.0149 0.0489 0.0489
Echinococcus multilocularis rhodopsin orphan GPCR 0.0661 0.2635 0.2886
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0224 0.0804 0.088
Echinococcus multilocularis dnaJ subfamily B 0.1243 0.5071 0.5555
Schistosoma mansoni nardilysin (M16 family) 0.0046 0.006 0.0066
Schistosoma mansoni tubulin subunit beta 0.0858 0.346 0.3763
Echinococcus multilocularis insulin receptor 0.0054 0.0092 0.0101
Schistosoma mansoni tyrosine kinase 0.0079 0.0199 0.0216
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.0117 0.0358 0.0927
Mycobacterium ulcerans membrane-anchored serine protease (mycosin), MycP4 0.0057 0.0104 0.0578
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0118 0.0358 0.0927
Brugia malayi putative neuropeptide receptor NPR1 0.0661 0.2635 0.2635
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0074 0.0175 0.0192
Loa Loa (eye worm) chitinase I 0.0074 0.0177 0.0177
Schistosoma mansoni tripeptidyl-peptidase II (S08 family) 0.0057 0.0104 0.0114
Loa Loa (eye worm) hypothetical protein 0.0661 0.2635 0.2635
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0661 0.2635 0.2866
Echinococcus granulosus integrin alpha 3 0.0114 0.0344 0.0377
Loa Loa (eye worm) hypothetical protein 0.0033 0.0005 0.0005
Trichomonas vaginalis conserved hypothetical protein 0.0257 0.0944 0.2588
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.005 0.0076 0.0083
Echinococcus granulosus biogenic amine 5HT receptor 0.0661 0.2635 0.2886
Loa Loa (eye worm) beta-tubulin 0.0858 0.346 0.346
Brugia malayi ephrin receptor 1 precursor 0.0099 0.0279 0.0279
Brugia malayi steroid hormone receptor 0.0041 0.0037 0.0037
Brugia malayi replication factor A 73 kDa subunit 0.0104 0.0301 0.0301
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0661 0.2635 0.2886
Onchocerca volvulus 0.0038 0.0025 0.0058
Echinococcus multilocularis replication protein A 70 kDa DNA binding 0.0104 0.0301 0.033
Onchocerca volvulus 0.0661 0.2635 0.6001
Brugia malayi Integrin beta pat-3 precursor 0.1268 0.5176 0.5176
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP4 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-4) 0.0057 0.0104 0.0578
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0035 0.0014 0.0016
Trypanosoma cruzi serine peptidase, clan SB, family S8-like protein 0.0057 0.0104 0.0185
Onchocerca volvulus 0.0038 0.0025 0.0058
Toxoplasma gondii subtilisin SUB5 0.0057 0.0104 0.023
Brugia malayi Steroid receptor seven-up type 2 0.0041 0.0037 0.0037
Onchocerca volvulus Putative endochitinase 0.0074 0.0177 0.0402
Schistosoma mansoni opsin-like receptor 0.0661 0.2635 0.2866
Schistosoma mansoni hypothetical protein 0.0661 0.2635 0.2866
Loa Loa (eye worm) hypothetical protein 0.0036 0.0017 0.0017
Echinococcus granulosus Tubulin beta 2C chain 0.0858 0.346 0.379
Trypanosoma brucei variant surface glycoprotein (VSG), putative 0.0118 0.0358 0.0927
Loa Loa (eye worm) hypothetical protein 0.0661 0.2635 0.2635
Brugia malayi YY1-associated factor 2 0.0042 0.0041 0.0041
Schistosoma mansoni glutamate receptor kainate 0.0033 0.0005 0.0005
Brugia malayi Subtilase family protein 0.0057 0.0104 0.0104
Brugia malayi Membrane-bound transcription factor site-1 protease precursor 0.0057 0.0104 0.0104
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0118 0.0358 0.0927
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0095 0.0263 0.0288
Echinococcus granulosus zinc finger protein Ran binding 0.0042 0.0041 0.0045
Schistosoma mansoni tubulin subunit beta 0.0858 0.346 0.3763
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0057 0.0104 0.0115
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0661 0.2635 0.2866
Loa Loa (eye worm) brahma associated protein 0.0117 0.0358 0.0358
Brugia malayi hypothetical protein 0.0195 0.0681 0.0681
Plasmodium vivax subtilisin-like serine protease, putative 0.0057 0.0104 0.0115
Brugia malayi Latrophilin receptor protein 2 0.0033 0.0005 0.0005
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0661 0.2635 0.2635
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0057 0.0104 0.0115
Echinococcus multilocularis glutamate receptor ionotropic kainate 0.0033 0.0005 0.0005
Echinococcus multilocularis tubulin, beta 4A class IVa 0.0858 0.346 0.379
Echinococcus granulosus membrane associated guanylate kinase ww and pdz 0.0073 0.0172 0.0188
Brugia malayi larval opioid receptor 0.0661 0.2635 0.2635
Echinococcus multilocularis somatostatin receptor 0.0661 0.2635 0.2886
Echinococcus granulosus 3'partial|nardilysin 0.0046 0.006 0.0066
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0118 0.0358 0.0927
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0041 0.0037 0.0041
Toxoplasma gondii beta tubulin 0.0858 0.346 1
Mycobacterium leprae PROBABLE MEMBRANE-ANCHORED MYCOSIN MYCP3 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-3) 0.0057 0.0104 0.0578
Brugia malayi Tubulin beta-1 chain 0.0858 0.346 0.346
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0661 0.2635 0.2866
Mycobacterium leprae RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE (ALPHA CHAIN) NRDE (RIBONUCLEOTIDE REDUCTASE SMALL SUBUNIT) (R1F PROTEIN) 0.0427 0.1652 1
Plasmodium vivax replication protein A1, large subunit, putative 0.005 0.0075 0.0027
Loa Loa (eye worm) cuticular endochitinase 0.0074 0.0177 0.0177
Echinococcus granulosus peptidase s8 s53 subtilisin kexin sedolisin 0.0057 0.0104 0.0114
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0041 0.0037 0.0041
Schistosoma mansoni hypothetical protein 0.0729 0.2919 0.3174
Brugia malayi Protein kinase domain containing protein 0.0054 0.0092 0.0092
Echinococcus multilocularis tubulin subunit beta 0.0858 0.346 0.379
Echinococcus granulosus hypothetical protein 0.0661 0.2635 0.2886
Echinococcus granulosus rhodopsin orphan GPCR 0.0661 0.2635 0.2886
Loa Loa (eye worm) hypothetical protein 0.0661 0.2635 0.2635
Echinococcus multilocularis rhodopsin orphan GPCR 0.0661 0.2635 0.2886
Brugia malayi endochitinase 0.0074 0.0177 0.0177
Trypanosoma cruzi subtilisin peptidase 0.0057 0.0104 0.0185
Trypanosoma brucei ribonucleoside-diphosphate reductase large chain 0.0181 0.0622 0.1699
Schistosoma mansoni hypothetical protein 0.0661 0.2635 0.2866
Toxoplasma gondii ran binding protein 0.0042 0.0041 0.0046
Schistosoma mansoni biogenic amine receptor 0.0661 0.2635 0.2866
Toxoplasma gondii PAN domain-containing protein 0.059 0.2336 0.6729
Schistosoma mansoni hypothetical protein 0.0145 0.0473 0.0514
Schistosoma mansoni peptide (allatostatin)-like receptor 0.1081 0.4391 0.4775
Brugia malayi Dopamine receptor 0.0661 0.2635 0.2635
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0145 0.0473 0.0473
Echinococcus granulosus Tubulin beta 2C chain 0.0858 0.346 0.379
Echinococcus granulosus G protein coupled receptor 139 0.0661 0.2635 0.2886
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0057 0.0104 0.0115
Brugia malayi PAN domain containing protein 0.0038 0.0025 0.0025
Schistosoma mansoni integrin alpha 0.0149 0.0489 0.0532
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0041 0.0037 0.0041
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0041 0.0037 0.0041
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0041 0.0037 0.0041
Loa Loa (eye worm) apoptosis regulator protein 0.0145 0.0473 0.0473
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0661 0.2635 0.2886
Echinococcus multilocularis anti dorsalizing morphogenetic protein 1a 0.0125 0.0389 0.0426
Echinococcus granulosus tyrosine kinase 0.0081 0.0205 0.0224
Trichomonas vaginalis conserved hypothetical protein 0.0257 0.0944 0.2588
Schistosoma mansoni membrane associated guanylate kinase inverted related 0.0053 0.0087 0.0095
Plasmodium falciparum replication protein A1, large subunit 0.005 0.0075 0.0098
Schistosoma mansoni hypothetical protein 0.0117 0.0358 0.0389
Schistosoma mansoni hypothetical protein 0.0661 0.2635 0.2866
Echinococcus granulosus FTZ F1 alpha 0.0041 0.0037 0.0041
Echinococcus multilocularis nardilysin 0.0046 0.006 0.0066
Trichomonas vaginalis replication factor A 1, rfa1, putative 0.0104 0.0301 0.0694
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0374 0.1432 0.1432
Trypanosoma brucei C-8 sterol isomerase, putative 0.0374 0.1432 0.4069
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.0587 0.1536
Echinococcus granulosus Nuclear pore complex protein Nup153 0.0042 0.0041 0.0045
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0118 0.036 0.0394
Echinococcus multilocularis neuropeptide FF receptor 2 0.1129 0.4591 0.5028
Trichomonas vaginalis hypothetical protein 0.0257 0.0944 0.2588
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0661 0.2635 0.2866
Schistosoma mansoni biogenic amine (5HT) receptor 0.0661 0.2635 0.2866
Mycobacterium tuberculosis Probable ribonucleoside-diphosphate reductase (large subunit) NrdZ (ribonucleotide reductase) 0.0059 0.0115 0.0643
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0041 0.0037 0.0037
Echinococcus multilocularis G-protein coupled receptor, putative 0.0661 0.2635 0.2886
Onchocerca volvulus 0.0038 0.0025 0.0058
Brugia malayi latrophilin 2 splice variant baaae 0.0036 0.0017 0.0017
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.0085 0.0221 0.1288
Onchocerca volvulus 0.0038 0.0025 0.0058
Brugia malayi Furin-like cysteine rich region family protein 0.0302 0.1129 0.1129
Toxoplasma gondii subtilisin SUB9 0.0057 0.0104 0.023
Echinococcus multilocularis tyrosine protein kinase HCK 0.0066 0.0145 0.0158
Echinococcus granulosus glutamate NMDA receptor subunit 0.0279 0.1034 0.1132
Echinococcus granulosus replication protein A 70 kDa DNA binding 0.0104 0.0301 0.033
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0661 0.2635 0.2866
Echinococcus multilocularis Tubulin beta 2C chain 0.0858 0.346 0.379
Schistosoma mansoni histamine h1 receptor 0.0661 0.2635 0.2866
Plasmodium vivax ribonucleoside-diphosphate reductase large chain, putative 0.0181 0.0622 0.164
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0118 0.0358 0.0927
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0048 0.0065 0.0117
Echinococcus multilocularis glutamate receptor 2 0.005 0.0076 0.0083
Mycobacterium ulcerans chitinase/cellulase 0.0063 0.0131 0.074
Loa Loa (eye worm) hypothetical protein 0.0661 0.2635 0.2635
Echinococcus multilocularis c src tyrosine kinase 0.0066 0.0144 0.0158
Trypanosoma brucei calpain-like protein, putative 0.0118 0.0358 0.0927
Brugia malayi hypothetical protein 0.0661 0.2635 0.2635
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0057 0.0104 0.0115
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0661 0.2635 0.2886
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0661 0.2635 0.2866
Echinococcus multilocularis tyrosine protein kinase Blk 0.0081 0.0205 0.0224
Echinococcus multilocularis membrane associated guanylate kinase, WW and PDZ 0.0053 0.0087 0.0095
Loa Loa (eye worm) hypothetical protein 0.0661 0.2635 0.2635
Brugia malayi G protein-coupled receptor F59B2.13 0.0661 0.2635 0.2635
Brugia malayi brahma associated protein 60 kDa 0.0117 0.0358 0.0358
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.0827 0.3327 0.3644
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0041 0.0037 0.0041
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0262 0.0965 0.0965
Brugia malayi Deoxyribonuclease II family protein 0.007 0.0159 0.0159
Mycobacterium ulcerans proline rich membrane-anchored mycosin MycP5 0.0057 0.0104 0.0578
Brugia malayi SRC-1 0.0095 0.0263 0.0263
Brugia malayi protein-tyrosine kinase 0.0081 0.0205 0.0205
Echinococcus granulosus rhodopsin orphan GPCR 0.0661 0.2635 0.2886
Chlamydia trachomatis glutamine binding protein 0.0085 0.0221 0.2863
Echinococcus granulosus tachykinin peptides receptor 99D 0.0661 0.2635 0.2886
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0661 0.2635 0.2866
Leishmania major beta tubulin 0.0858 0.346 1
Onchocerca volvulus Protein ultraspiracle homolog 0.0041 0.0037 0.0085
Loa Loa (eye worm) hypothetical protein 0.0113 0.0338 0.0338
Brugia malayi follicle stimulating hormone receptor 0.0661 0.2635 0.2635
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0262 0.0965 0.0965
Schistosoma mansoni amine GPCR 0.0661 0.2635 0.2866
Brugia malayi hypothetical protein 0.0661 0.2635 0.2635
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0041 0.0037 0.0041
Onchocerca volvulus 0.0039 0.0028 0.0064
Loa Loa (eye worm) hypothetical protein 0.0041 0.0037 0.0037
Schistosoma mansoni glutamate receptor kainate 0.0033 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0661 0.2635 0.2635
Brugia malayi hypothetical protein 0.0661 0.2635 0.2635
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0118 0.0358 0.0927
Loa Loa (eye worm) hypothetical protein 0.0038 0.0025 0.0025
Schistosoma mansoni replication factor A 1 rfa1 0.0104 0.0301 0.0327
Loa Loa (eye worm) tubulin beta-2A chain 0.0858 0.346 0.346
Loa Loa (eye worm) TK protein kinase 0.0066 0.0145 0.0145
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0661 0.2635 0.2886
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0057 0.0104 0.0115
Leishmania major beta tubulin 0.0858 0.346 1
Toxoplasma gondii Zn-finger in Ran binding protein and others domain-containing protein 0.0042 0.0041 0.0046
Loa Loa (eye worm) hypothetical protein 0.0042 0.0041 0.0041
Loa Loa (eye worm) hypothetical protein 0.0661 0.2635 0.2635
Onchocerca volvulus Segment polarity protein dishevelled homolog 0.0058 0.0111 0.0252
Schistosoma mansoni serine/threonine protein kinase 0.0181 0.0624 0.0679
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0069 0.0156 0.0156
Echinococcus multilocularis rhodopsin orphan GPCR 0.0661 0.2635 0.2886
Schistosoma mansoni adenoreceptor 0.0661 0.2635 0.2866
Loa Loa (eye worm) hypothetical protein 0.0069 0.0156 0.0156
Schistosoma mansoni coup transcription factor 0.0041 0.0037 0.0041
Schistosoma mansoni thyroid hormone receptor 0.0041 0.0037 0.0041
Brugia malayi neuroendocrine convertase 1 precursor 0.0788 0.3163 0.3163
Loa Loa (eye worm) hypothetical protein 0.0661 0.2635 0.2635
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0048 0.0065 0.0072
Echinococcus multilocularis Nuclear pore complex protein Nup153 0.0042 0.0041 0.0045
Brugia malayi SWIB/MDM2 domain containing protein 0.0117 0.0358 0.0358
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0081 0.0205 0.0224
Echinococcus granulosus anti dorsalizing morphogenetic protein 1a 0.0125 0.0389 0.0426
Onchocerca volvulus 0.0661 0.2635 0.6001
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0661 0.2635 0.2886
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0086 0.0228 0.025
Echinococcus granulosus tyrosine protein kinase csk 0.0038 0.0026 0.0028
Schistosoma mansoni tyrosine kinase 0.0066 0.0144 0.0157
Echinococcus granulosus tyrosine protein kinase csk 0.0038 0.0026 0.0028
Loa Loa (eye worm) TK/EPH protein kinase 0.0255 0.0932 0.0932
Echinococcus granulosus g protein coupled receptor 0.0661 0.2635 0.2886
Brugia malayi PAN domain containing protein 0.0038 0.0025 0.0025
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0661 0.2635 0.2886
Echinococcus granulosus rhodopsin orphan GPCR 0.0661 0.2635 0.2886
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0661 0.2635 0.2866
Echinococcus multilocularis orexin receptor type 2 0.0661 0.2635 0.2886
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0095 0.0263 0.0288
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0661 0.2635 0.2866
Brugia malayi G-protein coupled receptor 0.0661 0.2635 0.2635
Loa Loa (eye worm) hypothetical protein 0.0661 0.2635 0.2635
Schistosoma mansoni hypothetical protein 0.0257 0.0944 0.1027
Echinococcus multilocularis glutamate receptor subunit protein glur 0.0033 0.0005 0.0005
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0095 0.0263 0.0288
Echinococcus multilocularis sex peptide receptor 0.0661 0.2635 0.2886
Schistosoma mansoni tyrosine kinase 0.0086 0.0228 0.0248
Echinococcus granulosus tyrosine protein kinase ABL1 0.0224 0.0804 0.088
Trypanosoma brucei beta tubulin 0.0858 0.346 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0041 0.0037 0.0041
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0661 0.2635 0.2866
Echinococcus granulosus insulin receptor 0.0054 0.0092 0.0101
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0057 0.0104 0.0115
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0661 0.2635 0.2866
Schistosoma mansoni apoptosis regulator bax 0.0145 0.0473 0.0514
Echinococcus granulosus membrane bound transcription factor site 1 0.0057 0.0104 0.0114
Schistosoma mansoni alpha-1 adrenergic receptor 0.0661 0.2635 0.2866
Loa Loa (eye worm) hypothetical protein 0.0082 0.021 0.021
Brugia malayi ribonucleoside-diphosphate reductase large chain, putative 0.0181 0.0622 0.0622
Echinococcus granulosus segment polarity protein dishevelled 0.0099 0.0281 0.0308
Loa Loa (eye worm) hypothetical protein 0.0661 0.2635 0.2635
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0661 0.2635 0.2866
Onchocerca volvulus Putative endochitinase 0.0074 0.0177 0.0402
Echinococcus granulosus Ribosomal protein S1 RNA binding domain 0.0033 0.0005 0.0005
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.004 0.0033 0.0036
Toxoplasma gondii subtilisin SUB4 0.0057 0.0104 0.023
Echinococcus multilocularis integrin beta 2 0.0937 0.3787 0.4148
Entamoeba histolytica replication factor A protein 1, putative 0.0045 0.0053 0.0059
Brugia malayi insulin-degrading enzyme 0.0046 0.006 0.006
Brugia malayi ecdysteroid receptor 0.0041 0.0037 0.0037
Echinococcus multilocularis Tubulin beta 2C chain 0.0858 0.346 0.379
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0661 0.2635 0.2866
Loa Loa (eye worm) hypothetical protein 0.0041 0.0037 0.0037
Schistosoma mansoni tyrosine kinase 0.021 0.0744 0.0809
Echinococcus multilocularis Peptidase S8 S53, subtilisin kexin sedolisin 0.0057 0.0104 0.0114
Echinococcus multilocularis rhodopsin orphan GPCR 0.0661 0.2635 0.2886
Trichomonas vaginalis neuroendocrine convertase 2 precursor, putative 0.0257 0.0944 0.2588
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0033 0.0005 0.0005
Echinococcus multilocularis insulin degrading enzyme 0.0046 0.006 0.0066
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0062 0.0127 0.0139
Brugia malayi hypothetical protein 0.0661 0.2635 0.2635
Toxoplasma gondii subtilisin SUB11 0.0057 0.0104 0.023
Trichomonas vaginalis deoxyribonuclease II precursor, putative 0.007 0.0159 0.0276
Loa Loa (eye worm) TK/ABL protein kinase 0.0224 0.0804 0.0804
Loa Loa (eye worm) hypothetical protein 0.0041 0.0037 0.0037
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0041 0.0037 0.0041
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0057 0.0104 0.0115
Echinococcus multilocularis beta tubulin 0.0858 0.346 0.379
Echinococcus multilocularis deoxyribonuclease ii 0.007 0.0159 0.0174
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0042 0.0041 0.0041
Echinococcus multilocularis epidermal growth factor receptor 0.0302 0.1129 0.1237
Plasmodium falciparum plasmepsin II 0.0048 0.0065 0.0071
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP3 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-3) 0.0057 0.0104 0.0578
Onchocerca volvulus 0.0661 0.2635 0.6001
Trypanosoma brucei serine peptidase, clan SB, family S8-like protein 0.0068 0.0151 0.0322
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0661 0.2635 0.2886
Loa Loa (eye worm) TK/EGFR protein kinase 0.0302 0.1129 0.1129
Schistosoma mansoni tyrosine kinase 0.0302 0.1129 0.1228
Loa Loa (eye worm) subtilase 0.0057 0.0104 0.0104
Echinococcus granulosus tyrosine protein kinase Src42A 0.0095 0.0263 0.0288
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0041 0.0037 0.0041
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0661 0.2635 0.2635
Leishmania major beta tubulin 0.0858 0.346 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0661 0.2635 0.2886
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.0587 0.1536
Trichomonas vaginalis glucosylceramidase, putative 0.0262 0.0965 0.2649
Echinococcus granulosus epidermal growth factor receptor 0.0302 0.1129 0.1237
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0057 0.0104 0.0115
Echinococcus granulosus g protein coupled receptor 0.0661 0.2635 0.2886
Loa Loa (eye worm) hypothetical protein 0.0661 0.2635 0.2635
Echinococcus granulosus Zinc finger RanBP2 type 0.0042 0.0041 0.0045
Loa Loa (eye worm) hypothetical protein 0.0661 0.2635 0.2635
Onchocerca volvulus 0.0038 0.0025 0.0058
Echinococcus multilocularis rhodopsin orphan GPCR 0.0661 0.2635 0.2886
Trichomonas vaginalis tubulin epsilon chain, putative 0.0858 0.346 1
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0145 0.0473 0.0518
Brugia malayi neuropeptide F receptor 0.0661 0.2635 0.2635
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0048 0.0065 0.0065
Echinococcus granulosus biogenic amine 5HT receptor 0.0661 0.2635 0.2886
Brugia malayi Glutamate receptor 2 precursor 0.0033 0.0005 0.0005
Brugia malayi hypothetical protein 0.0661 0.2635 0.2635
Echinococcus multilocularis Tubulin beta 2C chain 0.0858 0.346 0.379
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0095 0.0263 0.0288
Leishmania major beta tubulin 0.0858 0.346 1
Toxoplasma gondii subtilisin SUB6 0.0057 0.0104 0.023
Mycobacterium tuberculosis Probable alanine and proline rich membrane-anchored mycosin MycP2 (serine protease) (subtilisin-like protease) (subtilase-like) 0.0057 0.0104 0.0578
Entamoeba histolytica tubulin family protein 0.0858 0.346 1
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0661 0.2635 0.2635
Trichomonas vaginalis glucosylceramidase, putative 0.0262 0.0965 0.2649
Trypanosoma cruzi beta tubulin, putative 0.0858 0.346 1
Leishmania major beta tubulin 0.0858 0.346 1
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0145 0.0473 0.0518
Loa Loa (eye worm) hypothetical protein 0.0661 0.2635 0.2635
Brugia malayi Glutamate receptor 1 precursor 0.0033 0.0005 0.0005
Echinococcus multilocularis integrin alpha ps 0.0067 0.0146 0.016
Leishmania major replication factor A, 51kDa subunit, putative 0.005 0.0075 0.0098
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.0587 0.1536
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.004 0.0033 0.0036
Schistosoma mansoni neuropeptide receptor 0.0661 0.2635 0.2866
Echinococcus granulosus ephrin type A receptor 4 A 0.0201 0.0709 0.0777
Echinococcus granulosus alpha 1A adrenergic receptor 0.0661 0.2635 0.2886
Brugia malayi SH2 domain containing protein 0.0052 0.0086 0.0086
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0661 0.2635 0.2886
Schistosoma mansoni amine GPCR 0.0661 0.2635 0.2866
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0661 0.2635 0.2866
Trichomonas vaginalis glucosylceramidase, putative 0.0262 0.0965 0.2649
Schistosoma mansoni hypothetical protein 0.0145 0.0473 0.0514
Schistosoma mansoni ephrin receptor 0.0201 0.0709 0.0771
Chlamydia trachomatis arginine ABC transporter substrate-binding protein ArtJ 0.0085 0.0221 0.2863
Toxoplasma gondii ribonucleoside-diphosphate reductase large chain 0.0181 0.0622 0.1738
Onchocerca volvulus 0.0661 0.2635 0.6001
Loa Loa (eye worm) hypothetical protein 0.0661 0.2635 0.2635
Trichomonas vaginalis conserved hypothetical protein 0.0257 0.0944 0.2588
Loa Loa (eye worm) hypothetical protein 0.0038 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.0661 0.2635 0.2635
Mycobacterium leprae PROBABLE PROLINE RICH MEMBRANE-ANCHORED MYCOSIN MYCP5 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-5) 0.0057 0.0104 0.0578
Loa Loa (eye worm) hypothetical protein 0.0038 0.0025 0.0025
Onchocerca volvulus Ubiquitin thioesterase ZRANB1 homolog 0.0042 0.0041 0.0094
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0095 0.0263 0.0288
Brugia malayi PAN domain containing protein 0.0038 0.0025 0.0025
Brugia malayi PAN domain containing protein 0.0038 0.0025 0.0025
Mycobacterium tuberculosis Ribonucleoside-diphosphate reductase (alpha chain) NrdE (ribonucleotide reductase small subunit) (R1F protein) 0.0427 0.1652 1
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0661 0.2635 0.2635
Schistosoma mansoni zinc finger protein 0.0042 0.0041 0.0045
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0041 0.0037 0.0037
Echinococcus granulosus membrane associated guanylate kinase ww and pdz 0.0053 0.0087 0.0095
Echinococcus multilocularis nmda type glutamate receptor 0.0118 0.036 0.0394
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0041 0.0037 0.0037
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0041 0.0037 0.0037
Echinococcus granulosus beta tubulin 0.0858 0.346 0.379
Trichomonas vaginalis glucosylceramidase, putative 0.0181 0.0626 0.165
Echinococcus granulosus tyrosine protein kinase Fyn 0.0095 0.0263 0.0288
Schistosoma mansoni ribonucleoside-diphosphate reductase alpha subunit 0.0181 0.0622 0.0677
Echinococcus multilocularis Ribosomal protein S1, RNA binding domain 0.0033 0.0005 0.0005
Brugia malayi neuropeptide F receptor 0.0661 0.2635 0.2635
Loa Loa (eye worm) hypothetical protein 0.0042 0.0041 0.0041
Loa Loa (eye worm) G-protein coupled receptor 0.0661 0.2635 0.2635
Echinococcus granulosus rhodopsin orphan GPCR 0.0661 0.2635 0.2886
Trichomonas vaginalis conserved hypothetical protein 0.0057 0.0104 0.0115
Trypanosoma cruzi Replication factor A protein 1 0.005 0.0075 0.0098
Echinococcus multilocularis membrane associated guanylate kinase ww and pdz 0.0053 0.0087 0.0095
Onchocerca volvulus 0.0038 0.0025 0.0058
Brugia malayi celfurPC protein 0.0978 0.3962 0.3962
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0661 0.2635 0.2635
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.005 0.0076 0.0083
Schistosoma mansoni neuropeptide F-like receptor 0.0661 0.2635 0.2866
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0118 0.0358 0.0927
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0057 0.0104 0.0115
Loa Loa (eye worm) hypothetical protein 0.0038 0.0025 0.0025
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0068 0.0151 0.0322
Brugia malayi nuclear hormone receptor 0.0041 0.0037 0.0037
Giardia lamblia Beta tubulin 0.0858 0.346 1
Loa Loa (eye worm) SH2 domain-containing protein 0.0045 0.0057 0.0057
Brugia malayi Melatonin receptor type 1A 0.0661 0.2635 0.2635
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0081 0.0205 0.0224
Brugia malayi map kinase activated protein kinase protein 2 0.0181 0.0624 0.0624
Schistosoma mansoni TRABID protein (C64 family) 0.0042 0.0041 0.0045
Echinococcus multilocularis ecdysone induced protein 78C 0.0041 0.0037 0.0041
Loa Loa (eye worm) hypothetical protein 0.0661 0.2635 0.2635
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0069 0.0156 0.0156
Echinococcus multilocularis FTZ F1 alpha 0.0041 0.0037 0.0041
Echinococcus granulosus tubulin subunit beta 0.0858 0.346 0.379
Loa Loa (eye worm) hypothetical protein 0.0063 0.0131 0.0131
Onchocerca volvulus 0.0661 0.2635 0.6001
Echinococcus granulosus g protein coupled receptor 0.0661 0.2635 0.2886
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0057 0.0104 0.0115
Onchocerca volvulus 0.0038 0.0025 0.0058
Loa Loa (eye worm) PAN domain-containing protein 0.0038 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.0661 0.2635 0.2635
Echinococcus multilocularis tyrosine protein kinase csk 0.0038 0.0026 0.0028
Trichomonas vaginalis glucosylceramidase, putative 0.0262 0.0965 0.2649
Mycobacterium tuberculosis Possible chitinase 0.0063 0.0131 0.074
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0041 0.0037 0.0037
Echinococcus multilocularis MAP kinase activated protein kinase 2 0.0181 0.0624 0.0684
Schistosoma mansoni hypothetical protein 0.004 0.0033 0.0036
Brugia malayi Dopamine receptor protein 1 0.0661 0.2635 0.2635
Onchocerca volvulus 0.0117 0.0358 0.0815
Echinococcus multilocularis neuropeptides capa receptor 0.0661 0.2635 0.2886
Loa Loa (eye worm) ribonucleoside-diphosphate reductase large subunit 0.0181 0.0622 0.0622
Leishmania major beta tubulin 0.0858 0.346 1
Echinococcus multilocularis tyrosine protein kinase csk 0.0038 0.0026 0.0028
Brugia malayi beta-tubulin, identical 0.0858 0.346 0.346
Loa Loa (eye worm) PAN domain-containing protein 0.0038 0.0025 0.0025
Brugia malayi Serotonin receptor 0.0661 0.2635 0.2635
Loa Loa (eye worm) hypothetical protein 0.0661 0.2635 0.2635
Plasmodium falciparum plasmepsin IV 0.0048 0.0065 0.0071
Schistosoma mansoni retinoic acid receptor RXR 0.0041 0.0037 0.0041
Trichomonas vaginalis glucosylceramidase, putative 0.0181 0.0626 0.165
Trichomonas vaginalis conserved hypothetical protein 0.0057 0.0104 0.0115
Onchocerca volvulus 0.004 0.0034 0.0078
Loa Loa (eye worm) neuropeptide F receptor 0.0661 0.2635 0.2635
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0661 0.2635 0.2866
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0068 0.0151 0.0322
Loa Loa (eye worm) hypothetical protein 0.0048 0.0065 0.0065
Echinococcus multilocularis tyrosine protein kinase csk 0.0038 0.0026 0.0028
Schistosoma mansoni tyrosine kinase 0.0095 0.0263 0.0286
Loa Loa (eye worm) PAN domain-containing protein 0.0038 0.0025 0.0025
Loa Loa (eye worm) PAN domain-containing protein 0.0038 0.0025 0.0025
Echinococcus granulosus tm gpcr rhodopsin 0.0661 0.2635 0.2886
Echinococcus multilocularis fmrfamide receptor 0.0661 0.2635 0.2886
Onchocerca volvulus 0.0661 0.2635 0.6001
Echinococcus granulosus tumor protein p63 0.0334 0.1265 0.1385
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0057 0.0104 0.0114
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0095 0.0263 0.0288
Plasmodium falciparum plasmepsin VI 0.0048 0.0065 0.0071
Brugia malayi brahma associated protein 60 kDa 0.0117 0.0358 0.0358
Echinococcus multilocularis ephrin type A receptor 4 A 0.0201 0.0709 0.0777
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0041 0.0037 0.0037
Trichomonas vaginalis conserved hypothetical protein 0.0257 0.0944 0.2588
Echinococcus multilocularis tyrosine protein kinase Abl 0.0113 0.0338 0.0371
Brugia malayi sulfakinin receptor protein 0.0661 0.2635 0.2635
Onchocerca volvulus 0.0661 0.2635 0.6001
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0661 0.2635 0.2886
Echinococcus granulosus dnaJ subfamily B 0.1243 0.5071 0.5555
Trichomonas vaginalis conserved hypothetical protein 0.0057 0.0104 0.0115
Echinococcus multilocularis tyrosine protein kinase Srms 0.0081 0.0205 0.0224
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0042 0.0041 0.0041
Leishmania major ribonucleoside-diphosphate reductase large chain, putative 0.0181 0.0622 0.1699
Schistosoma mansoni nardilysin (M16 family) 0.0046 0.006 0.0066
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0033 0.0005 0.0005
Schistosoma mansoni insulysin unit 3 (M16 family) 0.0046 0.006 0.0066
Leishmania major beta tubulin 0.0858 0.346 1
Onchocerca volvulus 0.0661 0.2635 0.6001
Schistosoma mansoni dishevelled 0.0099 0.0281 0.0305
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0661 0.2635 0.2886
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0057 0.0104 0.0115
Leishmania major chitinase 0.0074 0.0177 0.0396
Echinococcus multilocularis neuropeptide receptor 0.0661 0.2635 0.2886
Loa Loa (eye worm) hypothetical protein 0.0661 0.2635 0.2635
Schistosoma mansoni biogenic amine receptor 0.0661 0.2635 0.2866
Schistosoma mansoni opsin-like receptor 0.0661 0.2635 0.2866
Brugia malayi PDZ domain containing protein 0.0054 0.0092 0.0092
Echinococcus multilocularis neuropeptide Y receptor 0.0661 0.2635 0.2886
Loa Loa (eye worm) proprotein convertase 2 0.0314 0.1182 0.1182
Echinococcus granulosus integrin alpha ps 0.0067 0.0146 0.016
Entamoeba histolytica chitinase, putative 0.0074 0.0177 0.0419
Echinococcus granulosus sex peptide receptor 0.0661 0.2635 0.2886
Loa Loa (eye worm) hypothetical protein 0.0038 0.0025 0.0025
Echinococcus granulosus neuroendocrine convertase 2 0.0788 0.3163 0.3465
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0095 0.0263 0.0288
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0041 0.0037 0.0037
Schistosoma mansoni hypothetical protein 0.0117 0.0358 0.0389
Onchocerca volvulus 0.0042 0.0041 0.0094
Schistosoma mansoni tyrosine kinase 0.0079 0.0199 0.0216
Brugia malayi Dopamine receptor protein 2 0.0661 0.2635 0.2635
Echinococcus multilocularis Zinc finger, RanBP2 type 0.0042 0.0041 0.0045
Echinococcus granulosus 7tm_1 domain containing protein 0.0661 0.2635 0.2886
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.0587 0.1536
Echinococcus multilocularis GPCR, family 2 0.0033 0.0005 0.0005
Plasmodium falciparum subtilisin-like protease 3 0.0057 0.0104 0.0185
Loa Loa (eye worm) hypothetical protein 0.0661 0.2635 0.2635
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0041 0.0037 0.0037
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0037 0.002 0.0021
Loa Loa (eye worm) hypothetical protein 0.0084 0.022 0.022
Loa Loa (eye worm) hypothetical protein 0.1129 0.4591 0.4591
Schistosoma mansoni hypothetical protein 0.0036 0.0017 0.0019

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the K-562 Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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