Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | Niemann Pick C1 protein | 0.0146 | 0.149 | 0.149 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.0843 | 0.9483 | 0.9483 |
Brugia malayi | hypothetical protein | 0.0026 | 0.0112 | 0.0112 |
Brugia malayi | hypothetical protein | 0.0017 | 0.0006 | 0.0006 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.0567 | 0.0567 |
Schistosoma mansoni | hypothetical protein | 0.0042 | 0.0297 | 0.0297 |
Schistosoma mansoni | tyrosyl-DNA phosphodiesterase | 0.0069 | 0.0599 | 0.0599 |
Entamoeba histolytica | deoxyuridine 5-triphosphate nucleotidohydrolase, mitochondrial precursor, putative | 0.0888 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0888 | 1 | 1 |
Entamoeba histolytica | deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein | 0.0888 | 1 | 1 |
Trichomonas vaginalis | deoxyuridine 5'-triphosphate nucleotidohydrolase, putative | 0.0888 | 1 | 1 |
Chlamydia trachomatis | deoxyuridine 5'-triphosphate nucleotidohydrolase | 0.0888 | 1 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0052 | 0.0406 | 0.0406 |
Mycobacterium ulcerans | deoxyuridine 5'-triphosphate nucleotidohydrolase | 0.0308 | 0.3349 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0042 | 0.0297 | 0.0297 |
Echinococcus multilocularis | protein patched | 0.0044 | 0.0315 | 0.0315 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0026 | 0.0112 | 0.1873 |
Echinococcus granulosus | tyrosyl DNA phosphodiesterase 1 | 0.0069 | 0.0599 | 0.0599 |
Echinococcus multilocularis | expressed conserved protein | 0.0096 | 0.0915 | 0.0915 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.0104 | 0.1004 | 0.1004 |
Entamoeba histolytica | deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein | 0.0888 | 1 | 1 |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.0044 | 0.0315 | 0.0315 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.0218 | 0.0218 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0429 | 0.0429 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.0567 | 0.0567 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0026 | 0.0112 | 0.0112 |
Echinococcus multilocularis | tyrosyl DNA phosphodiesterase 1 | 0.0069 | 0.0599 | 0.0599 |
Treponema pallidum | deoxyuridine 5'-triphosphate nucleotidohydrolase (dut) | 0.0888 | 1 | 0.5 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0066 | 0.0567 | 0.0567 |
Entamoeba histolytica | deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein | 0.0888 | 1 | 1 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0718 | 0.8042 | 0.8042 |
Loa Loa (eye worm) | TAR-binding protein | 0.0066 | 0.0567 | 0.0567 |
Schistosoma mansoni | hypothetical protein | 0.0176 | 0.1833 | 0.1833 |
Brugia malayi | MH2 domain containing protein | 0.0124 | 0.1235 | 0.1235 |
Echinococcus granulosus | microtubule associated protein 2 | 0.0718 | 0.8042 | 0.8042 |
Onchocerca volvulus | Huntingtin homolog | 0.0127 | 0.1273 | 0.5 |
Plasmodium falciparum | deoxyuridine 5'-triphosphate nucleotidohydrolase | 0.0888 | 1 | 1 |
Echinococcus multilocularis | protein dispatched 1 | 0.005 | 0.0387 | 0.0387 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.0567 | 0.0567 |
Entamoeba histolytica | hypothetical protein | 0.058 | 0.6463 | 0.6237 |
Mycobacterium tuberculosis | Probable deoxycytidine triphosphate deaminase Dcd (dCTP deaminase) | 0.0308 | 0.3349 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0066 | 0.0567 | 0.0567 |
Leishmania major | hypothetical protein, conserved | 0.0026 | 0.0112 | 0.1873 |
Echinococcus granulosus | transcription factor Dp 1 | 0.004 | 0.0267 | 0.0267 |
Schistosoma mansoni | hypothetical protein | 0.0042 | 0.0297 | 0.0297 |
Schistosoma mansoni | patched 1 | 0.0044 | 0.0315 | 0.0315 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0026 | 0.0112 | 0.1873 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0026 | 0.0112 | 0.0112 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0052 | 0.0406 | 0.0406 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0218 | 0.0218 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0026 | 0.0112 | 0.0112 |
Onchocerca volvulus | Huntingtin homolog | 0.0127 | 0.1273 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0102 | 0.0986 | 0.0986 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0066 | 0.0567 | 0.0567 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.0044 | 0.0315 | 0.0315 |
Loa Loa (eye worm) | dUTP diphosphatase | 0.0888 | 1 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0124 | 0.1235 | 0.1235 |
Loa Loa (eye worm) | tyrosyl-DNA phosphodiesterase | 0.0069 | 0.0599 | 0.0599 |
Echinococcus granulosus | expressed conserved protein | 0.0096 | 0.0915 | 0.0915 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0026 | 0.0112 | 0.0112 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0035 | 0.0218 | 0.0218 |
Plasmodium vivax | deoxyuridine 5'-triphosphate nucleotidohydrolase, putative | 0.0888 | 1 | 1 |
Brugia malayi | Tyrosyl-DNA phosphodiesterase family protein | 0.0069 | 0.0599 | 0.0599 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0146 | 0.149 | 0.149 |
Entamoeba histolytica | hypothetical protein | 0.0308 | 0.3349 | 0.2925 |
Entamoeba histolytica | deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein | 0.0888 | 1 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0066 | 0.0567 | 0.0567 |
Schistosoma mansoni | deoxyuridine 5'-triphosphate nucleotidohydrolase | 0.0888 | 1 | 1 |
Echinococcus granulosus | dUTP pyrophosphatase | 0.0888 | 1 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0052 | 0.0406 | 0.0406 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.0567 | 0.0567 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0026 | 0.0112 | 0.1873 |
Echinococcus granulosus | geminin | 0.0176 | 0.1833 | 0.1833 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0124 | 0.1235 | 0.1235 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0069 | 0.0599 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0127 | 0.1273 | 0.1273 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.0044 | 0.0315 | 0.0315 |
Entamoeba histolytica | hypothetical protein | 0.0888 | 1 | 1 |
Entamoeba histolytica | deoxyuridine 5-triphosphate nucleotidohydrolase, putative | 0.0308 | 0.3349 | 0.2925 |
Brugia malayi | CHE-14 protein | 0.0044 | 0.0315 | 0.0315 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0112 | 0.0112 |
Toxoplasma gondii | deoxyuridine 5'-triphosphate nucleotidohydrolase, putative | 0.0888 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.0315 | 0.0315 |
Entamoeba histolytica | hypothetical protein | 0.058 | 0.6463 | 0.6237 |
Echinococcus multilocularis | transcription factor Dp 1 | 0.004 | 0.0267 | 0.0267 |
Echinococcus multilocularis | tar DNA binding protein | 0.0066 | 0.0567 | 0.0567 |
Brugia malayi | RNA binding protein | 0.0066 | 0.0567 | 0.0567 |
Entamoeba histolytica | Niemann-Pick C1 protein, putative | 0.0102 | 0.0986 | 0.0412 |
Brugia malayi | Niemann-Pick C1 protein precursor | 0.0102 | 0.0986 | 0.0986 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.0406 | 0.0406 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0069 | 0.0599 | 1 |
Echinococcus multilocularis | dUTP pyrophosphatase | 0.0888 | 1 | 1 |
Echinococcus multilocularis | geminin | 0.0176 | 0.1833 | 0.1833 |
Mycobacterium leprae | PROBABLE DEOXYCYTIDINE TRIPHOSPHATE DEAMINASE DCD (DCTP DEAMINASE) | 0.0308 | 0.3349 | 0.5 |
Leishmania major | tyrosyl-DNA phosphodiesterase 1 | 0.0069 | 0.0599 | 1 |
Brugia malayi | hypothetical protein | 0.0127 | 0.1273 | 0.1273 |
Entamoeba histolytica | deoxycytidine triphosphate deaminase, putative | 0.0308 | 0.3349 | 0.2925 |
Trypanosoma brucei | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0069 | 0.0599 | 1 |
Echinococcus granulosus | Protein patched homolog 1 | 0.0044 | 0.0315 | 0.0315 |
Brugia malayi | TAR-binding protein | 0.0066 | 0.0567 | 0.0567 |
Wolbachia endosymbiont of Brugia malayi | dUTPase | 0.0888 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0176 | 0.1833 | 0.1833 |
Entamoeba histolytica | deoxyuridine 5-triphosphate nucleotidohydrolase, mitochondrial precursor, putative | 0.0888 | 1 | 1 |
Mycobacterium ulcerans | deoxycytidine triphosphate deaminase | 0.0308 | 0.3349 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0127 | 0.1273 | 0.1273 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0102 | 0.0986 | 0.0986 |
Schistosoma mansoni | hypothetical protein | 0.0042 | 0.0297 | 0.0297 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.0567 | 0.0567 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0718 | 0.8042 | 0.8042 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0102 | 0.0986 | 0.0986 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.