Detailed information for compound 1603857

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 343.332 | Formula: C21H13NO4
  • H donors: 0 H acceptors: 1 LogP: 4.15 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=c1oc2cc(/N=C/c3ccc4c(c3)OCO4)ccc2c2c1cccc2
  • InChi: 1S/C21H13NO4/c23-21-17-4-2-1-3-15(17)16-7-6-14(10-19(16)26-21)22-11-13-5-8-18-20(9-13)25-12-24-18/h1-11H,12H2/b22-11+
  • InChiKey: VQEBKHUPMSDMKM-SSDVNMTOSA-N  

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Mycobacterium ulcerans 3-oxoacyl-(acyl carrier protein) synthase II 0.0331 0.128 0.1598
Echinococcus granulosus cpg binding protein 0.0029 0.0067 0.0125
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.11 0.4368 0.5503
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0042 0.0118 0.0051
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.132 0.5252 0.5249
Mycobacterium ulcerans polyketide synthase Pks9 0.0873 0.3456 0.437
Schistosoma mansoni [ACP] S-malonyltransferase 0.0083 0.0284 0.176
Onchocerca volvulus 0.1233 0.4904 0.515
Mycobacterium ulcerans oxidoreductase 0.0082 0.0279 0.0322
Echinococcus multilocularis ubiquitin specific protease 41 0.0036 0.0093 0.0175
Schistosoma mansoni lamin 0.0026 0.0054 0.0259
Brugia malayi Methyltransferase-like protein 4 0.0398 0.1547 0.1542
Trypanosoma cruzi oxidoreductase, putative 0.0082 0.0279 0.2088
Plasmodium falciparum LCCL domain-containing protein 0.0019 0.0026 0.0091
Loa Loa (eye worm) hypothetical protein 0.0082 0.0279 0.0315
Mycobacterium ulcerans polyketide synthase Pks13 0.1973 0.7875 1
Trichomonas vaginalis D-aminoacylase, putative 0.0042 0.0118 0.0673
Trypanosoma cruzi nuclear receptor binding factor, putative 0.0082 0.0279 0.2088
Toxoplasma gondii Zn-containing alcohol dehydrogenase 0.0082 0.0279 0.0475
Brugia malayi ADP-specific Phosphofructokinase/Glucokinase conserved region family protein 0.0083 0.0284 0.0279
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0197 0.1361
Mycobacterium tuberculosis Probable thioesterase TesA 0.11 0.4368 0.5503
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0036 0.0093 0.0175
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0093 0.062
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0133 0.0485 0.0522
Plasmodium vivax hypothetical protein, conserved 0.0042 0.0118 0.0814
Echinococcus multilocularis survival motor neuron protein 1 0.0263 0.1007 0.1892
Plasmodium falciparum malonyl CoA-acyl carrier protein transacylase 0.0083 0.0284 0.2131
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0133 0.0485 0.0522
Trypanosoma cruzi nuclear receptor binding factor, putative 0.0082 0.0279 0.2088
Loa Loa (eye worm) hypothetical protein 0.0034 0.0085 0.0096
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 0.0133 0.0485 0.0585
Schistosoma mansoni 3-oxoacyl-[ACP] synthase 0.0331 0.128 0.8261
Brugia malayi Cytochrome P450 family protein 0.0019 0.0026 0.0021
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0085 0.0463
Plasmodium vivax acyl carrier protein, putative 0.0133 0.0485 0.3717
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0197 0.1361
Leishmania major cathepsin L-like protease 0.0062 0.0197 0.1191
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0054 0.0061
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0133 0.0485 0.0522
Echinococcus granulosus mitochondrial trans 2 enoyl coenzyme A reductase 0.0082 0.0279 0.052
Loa Loa (eye worm) alcohol dehydrogenase class III 0.0082 0.0279 0.0315
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0026 0.0048
Echinococcus granulosus NADH dehydrogenase 0.0133 0.0485 0.0904
Loa Loa (eye worm) hypothetical protein 0.0042 0.0118 0.0133
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0016 0.0014 0.0016
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.1402 0.5581 0.7059
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0042 0.0118 0.0051
Trypanosoma brucei Acyl carrier protein, mitochondrial 0.0133 0.0485 0.3658
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0244 0.0277
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.1062 0.4216 0.5338
Plasmodium falciparum 3-oxoacyl-acyl-carrier protein synthase I/II 0.0331 0.128 1
Brugia malayi hypothetical protein 0.0019 0.0026 0.002
Echinococcus multilocularis 3 oxoacyl (acyl carrier protein) synthase 0.0331 0.128 0.2407
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.0197 0.1442
Mycobacterium tuberculosis Possible oxidoreductase FadB5 0.0082 0.0279 0.0258
Brugia malayi AMP-binding enzyme family protein 0.1233 0.4904 0.4901
Mycobacterium ulcerans polyketide synthase 0.1402 0.5581 0.7078
Trichomonas vaginalis set domain proteins, putative 0.0264 0.1011 0.6503
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0036 0.0093 0.0512
Toxoplasma gondii 3-oxoacyl-acyl-carrier protein synthase I/II, putative 0.0331 0.128 0.2274
Leishmania major beta-ketoacyl synthase family protein, putative,3-oxoacyl-acyl carrier protein synthase ii, putative 0.0331 0.128 0.8261
Toxoplasma gondii ABC1 family protein 0.0042 0.0118 0.0185
Onchocerca volvulus 0.0019 0.0026 0.0012
Mycobacterium ulcerans short-chain dehydrogenase 0.0082 0.0279 0.0322
Brugia malayi beta-lactamase family protein 0.0042 0.0118 0.0112
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0133 0.0485 0.0585
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0085 0.0463
Mycobacterium ulcerans thioesterase 0.11 0.4368 0.5532
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0133 0.0485 0.0585
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0056 0.0176 0.1273
Toxoplasma gondii aldehyde dehydrogenase 0.0073 0.0244 0.0412
Leishmania major zinc binding dehydrogenase-like protein 0.0082 0.0279 0.1725
Toxoplasma gondii quinone oxidoreductase, putative 0.0082 0.0279 0.0475
Mycobacterium tuberculosis Conserved protein 0.0042 0.0118 0.0051
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0133 0.0485 0.0522
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0232 0.0882 0.0996
Brugia malayi hypothetical protein 0.0263 0.1007 0.1002
Mycobacterium ulcerans thioesterase TesA 0.11 0.4368 0.5532
Loa Loa (eye worm) fatty acid synthase 0.1303 0.5181 0.585
Entamoeba histolytica NADP-dependent alcohol dehydrogenase, putative 0.0082 0.0279 0.5618
Mycobacterium leprae PROBABLE NADP-DEPENDENT ALCOHOL DEHYDROGENASE ADHC 0.0082 0.0279 0.0258
Trichomonas vaginalis penicillin-binding protein, putative 0.0042 0.0118 0.0673
Brugia malayi Cathepsin L-like precursor 0.0016 0.0014 0.0009
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.1062 0.4216 0.5338
Leishmania major hypothetical protein, conserved 0.0398 0.1547 1
Loa Loa (eye worm) hypothetical protein 0.0083 0.0284 0.0321
Brugia malayi Papain family cysteine protease containing protein 0.0016 0.0014 0.0009
Mycobacterium tuberculosis Acyl carrier protein (ACP) MbtL 0.0133 0.0485 0.0522
Schistosoma mansoni polycystin 1-related 0.0019 0.0026 0.0075
Trypanosoma cruzi NADP-dependent alcohol hydrogenase, putative 0.0082 0.0279 0.2088
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0042 0.0118 0.0051
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0093 0.0511
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0034 0.0085 0.0127
Onchocerca volvulus 0.0026 0.0054 0.0042
Loa Loa (eye worm) hypothetical protein 0.0016 0.0014 0.0016
Mycobacterium tuberculosis Probable polyketide beta-ketoacyl synthase Pks3 0.0202 0.0763 0.0879
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0948 0.3759 0.4721
Loa Loa (eye worm) acyl carrier protein 0.0133 0.0485 0.0548
Plasmodium vivax multidomain scavenger receptor, putative 0.0019 0.0026 0.0091
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE 0.0873 0.3456 0.4333
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0197 0.1361
Onchocerca volvulus 0.0042 0.0118 0.0109
Echinococcus multilocularis lamin 0.0026 0.0054 0.0102
Toxoplasma gondii acyl transferase domain-containing protein 0.0083 0.0284 0.0485
Mycobacterium ulcerans quinone oxidoreductase 0.0082 0.0279 0.0322
Mycobacterium ulcerans zinc-dependent alcohol dehydrogenase 0.0082 0.0279 0.0322
Trypanosoma cruzi NADP-dependent alcohol hydrogenase, putative 0.0082 0.0279 0.2088
Mycobacterium ulcerans acyl carrier protein 0.0133 0.0485 0.0585
Loa Loa (eye worm) hypothetical protein 0.0042 0.0118 0.0133
Echinococcus multilocularis lamin dm0 0.0026 0.0054 0.0102
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0812 0.3209 0.6033
Mycobacterium ulcerans zinc-dependent alcohol dehydrogenase AdhE2 0.0082 0.0279 0.0322
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.0191 0.1151
Trypanosoma cruzi major cysteine proteinase, putative 0.0048 0.0144 0.1024
Schistosoma mansoni hypothetical protein 0.0019 0.0026 0.0075
Mycobacterium ulcerans Zn-dependent alcohol dehydrogenase, AdhX 0.0082 0.0279 0.0322
Mycobacterium tuberculosis Probable polyketide synthase Pks9 0.075 0.2964 0.3702
Mycobacterium ulcerans NADP-dependent alcohol dehydrogenase Adh 0.0082 0.0279 0.0322
Schistosoma mansoni zinc binding dehydrogenase 0.0082 0.0279 0.1725
Brugia malayi Cathepsin L-like precursor 0.0016 0.0014 0.0009
Mycobacterium tuberculosis Possible quinone oxidoreductase (NADPH:quinone oxidoreductase) (zeta-crystallin) 0.0082 0.0279 0.0258
Loa Loa (eye worm) hypothetical protein 0.2218 0.8857 1
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0073 0.0244 0.0213
Loa Loa (eye worm) hypothetical protein 0.0026 0.0052 0.0059
Echinococcus multilocularis Polycystic kidney disease protein 0.0019 0.0026 0.0049
Toxoplasma gondii acyl carrier protein ACP 0.0133 0.0485 0.0845
Plasmodium falciparum acyl carrier protein 0.0133 0.0485 0.3717
Trichomonas vaginalis inositol monophosphatase, putative 0.0036 0.0093 0.0511
Mycobacterium ulcerans zinc-containing alcohol dehydrogenase NAD dependent AdhB 0.0082 0.0279 0.0322
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0197 0.1361
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0856 0.3389 0.6062
Loa Loa (eye worm) AMP-binding enzyme family protein 0.1233 0.4904 0.5536
Toxoplasma gondii type I fatty acid synthase, putative 0.094 0.3724 0.6664
Leishmania major nuclear receptor binding factor-like protein 0.0082 0.0279 0.1725
Brugia malayi Cathepsin L-like precursor 0.0016 0.0014 0.0009
Mycobacterium tuberculosis Probable polyketide synthase Pks17 0.0323 0.1245 0.1497
Brugia malayi Pre-SET motif family protein 0.0232 0.0882 0.0877
Loa Loa (eye worm) hypothetical protein 0.0042 0.0118 0.0133
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0053 0.0164 0.0308
Leishmania major hypothetical protein, conserved 0.0042 0.0118 0.0673
Echinococcus granulosus beta LACTamase domain containing family member 0.0042 0.0118 0.0219
Mycobacterium tuberculosis Polyketide synthetase MbtD (polyketide synthase) 0.0406 0.158 0.1926
Brugia malayi Cathepsin L-like precursor 0.0016 0.0014 0.0009
Mycobacterium tuberculosis Polyketide synthase Pks12 0.1402 0.5581 0.7059
Brugia malayi CXXC zinc finger family protein 0.0028 0.0061 0.0055
Loa Loa (eye worm) TK/FAK protein kinase 0.0247 0.0942 0.1063
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0042 0.0118 0.0116
Echinococcus granulosus cathepsin l cysteine peptidase 0.0016 0.0014 0.0027
Schistosoma mansoni cpg binding protein 0.0029 0.0067 0.0345
Mycobacterium tuberculosis Possible dehydrogenase 0.0082 0.0279 0.0258
Loa Loa (eye worm) hypothetical protein 0.0019 0.0026 0.0029
Schistosoma mansoni rab6-interacting 0.0019 0.0026 0.0075
Loa Loa (eye worm) hypothetical protein 0.0042 0.0118 0.0133
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0118 0.0814
Mycobacterium ulcerans NADPH quinone oxidoreductase FadB4 0.0082 0.0279 0.0322
Echinococcus multilocularis beta LACTamase domain containing family member 0.0042 0.0118 0.0221
Schistosoma mansoni inositol monophosphatase 0.0036 0.0093 0.0511
Echinococcus granulosus dnaJ subfamily B 0.0395 0.1537 0.2864
Loa Loa (eye worm) hypothetical protein 0.0202 0.0763 0.0861
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.128 0.5089 0.6428
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0202 0.0763 0.0879
Trichomonas vaginalis penicillin-binding protein, putative 0.0042 0.0118 0.0673
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0053 0.0164 0.0305
Mycobacterium tuberculosis Probable zinc-type alcohol dehydrogenase AdhD (aldehyde reductase) 0.0082 0.0279 0.0258
Trypanosoma brucei beta-ketoacyl-ACP synthase 0.0331 0.128 1
Mycobacterium ulcerans Type I modular polyketide synthase 0.132 0.5252 0.6658
Mycobacterium leprae Polyketide synthase Pks13 0.1973 0.7875 1
Mycobacterium ulcerans esterase/lipase LipP 0.0042 0.0118 0.0116
Mycobacterium ulcerans acyl-CoA synthetase 0.0133 0.0485 0.0585
Mycobacterium tuberculosis S-nitrosomycothiol reductase MscR 0.0082 0.0279 0.0258
Mycobacterium tuberculosis Conserved protein 0.0042 0.0118 0.0051
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0197 0.1361
Brugia malayi Inositol-1 0.0036 0.0093 0.0087
Wolbachia endosymbiont of Brugia malayi acyl carrier protein 0.0133 0.0485 0.3303
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0093 0.0532
Mycobacterium ulcerans beta-lactamase 0.0042 0.0118 0.0116
Trypanosoma cruzi Acyl carrier protein, mitochondrial, putative 0.0133 0.0485 0.3717
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0133 0.0485 0.0585
Echinococcus multilocularis cathepsin L cysteine protease 0.0016 0.0014 0.0027
Toxoplasma gondii type I fatty acid synthase 0.0202 0.0763 0.1344
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.0166 0.0271
Loa Loa (eye worm) hypothetical protein 0.0082 0.0279 0.0315
Schistosoma mansoni alcohol dehydrogenase 0.0082 0.0279 0.1725
Mycobacterium ulcerans malonyl CoA-acyl carrier protein transacylase FabD 0.0083 0.0284 0.0329
Mycobacterium tuberculosis Possible dehydrogenase 0.0082 0.0279 0.0258
Brugia malayi hypothetical protein 0.0019 0.0026 0.002
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0133 0.0485 0.0522
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.0197 0.1442
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0093 0.0619
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.132 0.5252 0.6658
Echinococcus granulosus survival motor neuron protein 1 0.0263 0.1007 0.1876
Mycobacterium tuberculosis Hypothetical protein 0.0398 0.1547 0.1884
Brugia malayi Pre-SET motif family protein 0.0034 0.0085 0.008
Loa Loa (eye worm) CYP4Cod1 0.0019 0.0026 0.003
Brugia malayi Doublecortin family protein 0.0019 0.0026 0.002
Loa Loa (eye worm) hypothetical protein 0.0042 0.0118 0.0133
Schistosoma mansoni survival motor neuron protein 0.0054 0.0165 0.0983
Mycobacterium leprae Probable S-nitrosomycothiol reductase MscR 0.0082 0.0279 0.0258
Echinococcus granulosus tm gpcr rhodopsin 0.0812 0.3209 0.5981
Echinococcus multilocularis conserved hypothetical protein 0.1337 0.532 1
Schistosoma mansoni loxhd1 0.0019 0.0026 0.0075
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.132 0.5252 0.6636
Schistosoma mansoni intermediate filament proteins 0.0026 0.0054 0.0259
Trypanosoma cruzi NADP-dependent alcohol hydrogenase, putative 0.0082 0.0279 0.2088
Wolbachia endosymbiont of Brugia malayi ACP S-malonyltransferase 0.0083 0.0284 0.1611
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0082 0.0279 0.1725
Mycobacterium ulcerans zinc-containing alcohol dehydrogenase NAD-dependent AdhB 0.0082 0.0279 0.0322
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.1402 0.5581 0.7059
Schistosoma mansoni acyl carrier protein 0.0133 0.0485 0.3071
Mycobacterium ulcerans hypothetical protein 0.0133 0.0485 0.0585
Echinococcus multilocularis cpg binding protein 0.0029 0.0067 0.0127
Chlamydia trachomatis acyl carrier protein 0.0133 0.0485 0.2016
Mycobacterium ulcerans zinc-type alcohol dehydrogenase AdhD 0.0082 0.0279 0.0322
Onchocerca volvulus 0.0082 0.0279 0.0278
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0133 0.0485 0.0522
Echinococcus multilocularis Malonyl coenzyme A acyl carrier protein transacylase 0.0083 0.0284 0.0534
Mycobacterium tuberculosis Probable polyketide synthase Pks15 0.0534 0.2094 0.2586
Mycobacterium tuberculosis Conserved protein 0.0042 0.0118 0.0051
Echinococcus granulosus lamin dm0 0.0026 0.0054 0.0101
Mycobacterium tuberculosis Meromycolate extension acyl carrier protein AcpM 0.0133 0.0485 0.0522
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0026 0.0049
Echinococcus granulosus acyl carrier protein mitochondrial 0.0133 0.0485 0.0904
Leishmania major zinc-binding dehydrogenase-like protein 0.0082 0.0279 0.1725
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0042 0.0118 0.0133
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0085 0.0463
Mycobacterium leprae Probable alcohol dehydrogenase AdhA 0.0082 0.0279 0.0258
Entamoeba histolytica NADP-dependent alcohol dehydrogenase 0.0082 0.0279 0.5618
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.132 0.5252 0.6636
Entamoeba histolytica NADP-dependent alcohol dehydrogenase, putative 0.0082 0.0279 0.5618
Leishmania major oxidoreductase-like protein 0.0082 0.0279 0.1725
Echinococcus granulosus protein tyrosine kinase 0.0244 0.093 0.1734
Schistosoma mansoni rab6-interacting 0.0019 0.0026 0.0075
Trypanosoma cruzi cytochrome P450, putative 0.0019 0.0026 0.0094
Loa Loa (eye worm) cysteine protease 0.0016 0.0014 0.0016
Schistosoma mansoni hypothetical protein 0.0133 0.0485 0.3071
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0197 0.1361
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0197 0.1361
Echinococcus granulosus Polycystic kidney disease protein 0.0019 0.0026 0.0048
Mycobacterium tuberculosis Probable NADPH quinone oxidoreductase FadB4 (NADPH:quinone reductase) (zeta-crystallin) 0.0082 0.0279 0.0258
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0006 0.0006
Brugia malayi Cytochrome P450 family protein 0.0019 0.0026 0.0021
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.0202 0.0763 0.0879
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0133 0.0485 0.048
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.1402 0.5581 0.7078
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0093 0.0511
Schistosoma mansoni [ACP] S-malonyltransferase 0.0083 0.0284 0.176
Echinococcus granulosus AMP dependent ligase 0.0133 0.0485 0.0904
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0034 0.0085 0.0463
Schistosoma mansoni lipoxygenase 0.0019 0.0026 0.0075
Echinococcus multilocularis protein tyrosine kinase 0.0244 0.093 0.1749
Echinococcus multilocularis NADH dehydrogenase 0.0133 0.0485 0.0912
Echinococcus granulosus RUN 0.0019 0.0026 0.0048
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0054 0.0061
Loa Loa (eye worm) beta-ketoacyl synthase domain-containing protein 0.0331 0.128 0.1446
Loa Loa (eye worm) doublecortin family protein 0.0019 0.0026 0.0029
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0016 0.0014 0.0027
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0082 0.0279 0.1725
Entamoeba histolytica acyl-CoA synthetase, putative 0.0133 0.0485 1
Mycobacterium tuberculosis Probable lipase LipE 0.0042 0.0118 0.0051
Mycobacterium leprae PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) 0.0415 0.1615 0.1972
Mycobacterium tuberculosis Probable alcohol dehydrogenase AdhA 0.0082 0.0279 0.0258
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.0197 0.1442
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.1973 0.7875 1
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.1233 0.4904 0.619
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0082 0.0279 0.1725
Trichomonas vaginalis conserved hypothetical protein 0.0398 0.1547 1
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0032 0.0078 0.0145
Loa Loa (eye worm) beta-lactamase 0.0042 0.0118 0.0133
Mycobacterium ulcerans Type I modular polyketide synthase 0.132 0.5252 0.6658
Echinococcus granulosus cathepsin l1 0.0016 0.0014 0.0027
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0036 0.0093 0.0085
Trypanosoma cruzi oxidoreductase, putative 0.0082 0.0279 0.2088
Mycobacterium ulcerans dehydrogenase 0.0082 0.0279 0.0322
Mycobacterium tuberculosis Polyketide synthase Pks2 0.128 0.5089 0.6428
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0189 0.071 0.549
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0036 0.0093 0.0512
Onchocerca volvulus 0.0042 0.0118 0.0109
Echinococcus granulosus Malonyl coenzyme A acyl carrier protein transacylase 0.0083 0.0284 0.053
Mycobacterium leprae Probable lipase LipE 0.0042 0.0118 0.0051
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0036 0.0093 0.0175
Onchocerca volvulus 0.0082 0.0279 0.0278
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0082 0.0279 0.0273
Mycobacterium tuberculosis Probable NADP-dependent alcohol dehydrogenase AdhC 0.0082 0.0279 0.0258
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.0093 0.0174
Brugia malayi intermediate filament protein 0.0026 0.0054 0.0049
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0093 0.062
Loa Loa (eye worm) ctsf protein 0.0016 0.0014 0.0016
Plasmodium vivax 3-oxoacyl-[acyl-carrier-protein] synthase i/ii, putative 0.0331 0.128 1
Loa Loa (eye worm) fibroinase 0.0016 0.0014 0.0016
Onchocerca volvulus 0.0026 0.0054 0.0042
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0093 0.053
Mycobacterium ulcerans non-ribosomal peptide synthetase 0.0133 0.0485 0.0585
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0093 0.0512
Mycobacterium tuberculosis Conserved protein 0.0398 0.1547 0.1884
Mycobacterium tuberculosis Probable hydrolase 0.0042 0.0118 0.0051
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0073 0.0244 0.1498
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.0093 0.0173
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.108 0.4286 0.5397
Mycobacterium ulcerans quinone oxidoreductase 0.0082 0.0279 0.0322
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0036 0.0093 0.1669
Giardia lamblia Methyltransferase like 2 0.0398 0.1547 1
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.132 0.5252 0.6636
Brugia malayi acyl carrier protein, mitochondrial precursor, putative 0.0133 0.0485 0.048
Loa Loa (eye worm) hypothetical protein 0.0202 0.0763 0.0861
Brugia malayi Protein kinase domain containing protein 0.0247 0.0942 0.0937
Trypanosoma cruzi cytochrome P450, putative 0.0019 0.0026 0.0094
Entamoeba histolytica acyl-CoA synthetase, putative 0.0133 0.0485 1
Mycobacterium tuberculosis Probable esterase LipL 0.0042 0.0118 0.0051
Trypanosoma cruzi acyl transferase-like protein, putative 0.0083 0.0284 0.2131
Mycobacterium ulcerans NADP-dependent alcohol dehydrogenase AdhC 0.0082 0.0279 0.0322
Echinococcus multilocularis musashi 0.0026 0.0054 0.0102
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0016 0.0014 0.0016
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0197 0.1361
Treponema pallidum acyl carrier protein 0.0133 0.0485 0.5
Loa Loa (eye worm) inositol-1 0.0036 0.0093 0.0105
Schistosoma mansoni tyrosine kinase 0.0244 0.093 0.5976
Mycobacterium leprae conserved hypothetical protein 0.0133 0.0485 0.0522
Leishmania major cathepsin L-like protease 0.0062 0.0197 0.1191
Loa Loa (eye worm) acyl carrier protein 0.0607 0.2388 0.2696
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0036 0.0093 0.0512
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.1402 0.5581 0.7059
Mycobacterium tuberculosis Probable acyl carrier protein AcpA (ACP) 0.0133 0.0485 0.0522
Mycobacterium ulcerans NADP-dependent oxidoreductase 0.0082 0.0279 0.0322
Trypanosoma brucei oxidoreductase, putative 0.0082 0.0279 0.2014
Trichomonas vaginalis D-aminoacylase, putative 0.0042 0.0118 0.0673
Wolbachia endosymbiont of Brugia malayi NADPH:quinone reductase 0.0082 0.0279 0.1566
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0026 0.0048
Mycobacterium tuberculosis Probable oxidoreductase 0.0082 0.0279 0.0258
Echinococcus multilocularis AMP dependent ligase 0.0133 0.0485 0.0912
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0197 0.1361
Trichomonas vaginalis D-aminoacylase, putative 0.0042 0.0118 0.0673
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0667 0.2629 0.4697
Trypanosoma cruzi cruzipain precursor, putative 0.0062 0.0197 0.1442
Mycobacterium leprae conserved hypothetical protein 0.0042 0.0118 0.0051
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0244 0.0277
Mycobacterium leprae PROBABLE POLYKETIDE BETA-KETOACYL SYNTHASE PKS4 0.0202 0.0763 0.0879
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0034 0.0085 0.0161
Onchocerca volvulus Fatty acid synthase homolog 0.238 0.9508 1
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0331 0.128 0.1276
Echinococcus multilocularis dnaJ subfamily B 0.0395 0.1537 0.2889
Echinococcus multilocularis cysteine protease 0.0016 0.0014 0.0027
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0036 0.0093 0.0173
Onchocerca volvulus 0.0264 0.1011 0.105
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.1062 0.4216 0.5308
Leishmania major hypothetical protein, conserved 0.0083 0.0284 0.176
Schistosoma mansoni inositol monophosphatase 0.0036 0.0093 0.0511
Onchocerca volvulus 0.0133 0.0485 0.0496
Leishmania major quinone oxidoreductase, putative 0.0082 0.0279 0.1725
Brugia malayi Phosphopantetheine attachment site family protein 0.0133 0.0485 0.048
Echinococcus granulosus ubiquitin specific protease 41 0.0036 0.0093 0.0173
Leishmania major NADP-dependent alcohol dehydrogenase, putative 0.0082 0.0279 0.1725
Trichomonas vaginalis esterase, putative 0.0042 0.0118 0.0673
Brugia malayi Cathepsin L-like precursor 0.0016 0.0014 0.0009
Onchocerca volvulus 0.0042 0.0118 0.0109
Brugia malayi Alcohol dehydrogenase class III 0.0082 0.0279 0.0273
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0118 0.0814
Mycobacterium tuberculosis Probable quinone reductase Qor (NADPH:quinone reductase) (zeta-crystallin homolog protein) 0.0082 0.0279 0.0258
Toxoplasma gondii type I fatty acid synthase, putative 0.1402 0.5581 1
Echinococcus granulosus 3 oxoacyl acyl carrier protein synthase 0.0331 0.128 0.2386
Onchocerca volvulus Putative alcohol dehydrogenase 0.0082 0.0279 0.0278
Onchocerca volvulus 0.0019 0.0026 0.0012
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0133 0.0485 0.0522
Mycobacterium ulcerans polyketide synthase 0.132 0.5252 0.6658
Mycobacterium leprae Probable polyketide synthase Pks1 0.1402 0.5581 0.7059
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0082 0.0279 0.0273
Echinococcus multilocularis cathepsin L cysteine protease 0.0016 0.0014 0.0027
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0042 0.0118 0.0112
Trypanosoma brucei Trans-2-enoyl-ACP reductase 2, putative 0.0082 0.0279 0.2014
Onchocerca volvulus 0.0028 0.0061 0.0049
Echinococcus multilocularis cysteine protease 0.0016 0.0014 0.0027
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.1402 0.5581 0.7078
Leishmania major acyl carrier protein, putative 0.0133 0.0485 0.3071
Plasmodium vivax hypothetical protein, conserved 0.0189 0.071 0.549
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0093 0.0511
Schistosoma mansoni cpg binding protein 0.0029 0.0067 0.0345
Mycobacterium ulcerans polyketide synthase MbtC 0.0331 0.128 0.1598
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0016 0.0014 0.0027
Leishmania major cathepsin L-like protease 0.0062 0.0197 0.1191
Mycobacterium ulcerans oxidoreductase FadB5 0.0082 0.0279 0.0322
Trypanosoma cruzi NADP-dependent alcohol hydrogenase, putative 0.0082 0.0279 0.2088
Chlamydia trachomatis 3-oxoacyl-ACP synthase 0.0331 0.128 1
Schistosoma mansoni hypothetical protein 0.0395 0.1537 0.9934
Loa Loa (eye worm) phosphopantetheine attachment site family protein 0.0133 0.0485 0.0548
Trypanosoma brucei acyl transferase-like protein 0.0083 0.0284 0.2056
Loa Loa (eye worm) cytochrome P450 family protein 0.0019 0.0026 0.003
Echinococcus multilocularis mitochondrial trans 2 enoyl coenzyme A reductase 0.0082 0.0279 0.0524
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.132 0.5252 0.6636
Trypanosoma cruzi beta-ketoacyl synthase family protein, putative 0.0331 0.128 1
Schistosoma mansoni hypothetical protein 0.0054 0.0165 0.0983
Mycobacterium ulcerans Type I modular polyketide synthase 0.132 0.5252 0.6658
Mycobacterium tuberculosis Polyketide synthase Pks13 0.1973 0.7875 1
Leishmania major d-xylulose reductase, putative 0.0082 0.0279 0.1725
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0244 0.0277
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.0093 0.0141
Brugia malayi beta-lactamase 0.0042 0.0118 0.0112
Plasmodium vivax SET domain protein, putative 0.0034 0.0085 0.056
Echinococcus granulosus histone lysine methyltransferase setb 0.0034 0.0085 0.0159
Loa Loa (eye worm) hypothetical protein 0.0026 0.0054 0.0061
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0036 0.0093 0.0512
Brugia malayi AMP-binding enzyme family protein 0.0406 0.158 0.1575
Loa Loa (eye worm) hypothetical protein 0.0036 0.0093 0.0105
Onchocerca volvulus 0.0034 0.0085 0.0075
Mycobacterium ulcerans polyketide synthase MbtD 0.0406 0.158 0.1979
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0036 0.0093 0.1665
Brugia malayi beta-lactamase family protein 0.0042 0.0118 0.0112
Onchocerca volvulus 0.2298 0.9179 0.9653
Echinococcus multilocularis Acyl carrier protein, mitochondrial 0.0133 0.0485 0.0912
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0036 0.0093 0.0173
Loa Loa (eye worm) hypothetical protein 0.074 0.292 0.3297
Loa Loa (eye worm) hypothetical protein 0.0042 0.0118 0.0133
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0073 0.0244 0.0459
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0197 0.1361
Mycobacterium tuberculosis Probable polyketide beta-ketoacyl synthase Pks4 0.0202 0.0763 0.0879
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.132 0.5252 0.6636
Schistosoma mansoni lamin 0.0026 0.0054 0.0259
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0054 0.0049
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0042 0.0118 0.0673
Mycobacterium ulcerans quinone reductase Qor 0.0082 0.0279 0.0322
Trypanosoma cruzi oxidoreductase, putative 0.0082 0.0279 0.2088
Mycobacterium ulcerans acyl carrier protein 0.0133 0.0485 0.0585
Mycobacterium tuberculosis Conserved hypothetical protein 0.0133 0.0485 0.0522
Trypanosoma cruzi acyl transferase-like protein 0.0083 0.0284 0.2131
Brugia malayi Cathepsin L-like precursor 0.0016 0.0014 0.0009
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0036 0.0093 0.0512
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0042 0.0118 0.0673
Mycobacterium ulcerans hypothetical protein 0.0042 0.0118 0.0116
Onchocerca volvulus Acyl carrier protein, mitochondrial homolog 0.0133 0.0485 0.0496
Trypanosoma cruzi beta-ketoacyl synthase family protein, putative 0.0331 0.128 1
Trypanosoma brucei hypothetical protein, conserved 0.0042 0.0118 0.0727
Mycobacterium tuberculosis Probable lipase LipD 0.0042 0.0118 0.0051
Mycobacterium ulcerans oxidoreductase 0.0082 0.0279 0.0322
Schistosoma mansoni lipoxygenase 0.0053 0.0164 0.0974
Loa Loa (eye worm) hypothetical protein 0.0082 0.0279 0.0315
Trypanosoma brucei oxidoreductase, putative 0.0082 0.0279 0.2014
Loa Loa (eye worm) hypothetical protein 0.0082 0.0279 0.0315
Brugia malayi Serotonin receptor 0.0458 0.1791 0.1786
Mycobacterium ulcerans fatty acid synthase Fas 0.0415 0.1615 0.2024
Loa Loa (eye worm) hypothetical protein 0.0263 0.1007 0.1137
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0267 0.1023 0.1213
Wolbachia endosymbiont of Brugia malayi 3-oxoacyl-ACP synthase 0.0331 0.128 1
Echinococcus granulosus lamin 0.0026 0.0054 0.0101
Loa Loa (eye worm) cytochrome P450 family protein 0.0019 0.0026 0.003
Plasmodium vivax malonyl CoA-acyl carrier protein transacylase precursor, putative 0.0083 0.0284 0.2131
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.1402 0.5581 0.7059
Mycobacterium tuberculosis Polyketide synthetase MbtC (polyketide synthase) 0.0454 0.1772 0.2173
Schistosoma mansoni cpg binding protein 0.0028 0.0061 0.0303
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0082 0.0279 0.0273
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0073 0.0244 0.0455
Echinococcus granulosus cathepsin L cysteine proteinase 0.0016 0.0014 0.0027
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.0244 0.1498
Mycobacterium ulcerans 3-oxoacyl-(acyl carrier protein) synthase II 0.0331 0.128 0.1598
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0054 0.0165 0.016
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0197 0.1361
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0061 0.0069
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.0873 0.3456 0.437
Echinococcus granulosus intermediate filament protein 0.0026 0.0054 0.0101
Onchocerca volvulus 0.0054 0.0165 0.0159
Echinococcus granulosus hypothetical protein 0.1348 0.5366 1
Schistosoma mansoni methyltransferase-related 0.0398 0.1547 1
Leishmania major oxidoreductase, putative 0.0082 0.0279 0.1725
Leishmania major cytochrome p450-like protein 0.0019 0.0026 0.0077
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0093 0.0619
Mycobacterium leprae Probable oxidireductase 0.0082 0.0279 0.0258
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0133 0.0485 0.0585
Mycobacterium tuberculosis Probable fatty acid synthase Fas (fatty acid synthetase) 0.0415 0.1615 0.1972
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0026 0.0049
Mycobacterium ulcerans lipase LipD 0.0042 0.0118 0.0116
Loa Loa (eye worm) hypothetical protein 0.0019 0.0026 0.0029
Echinococcus multilocularis RUN 0.0019 0.0026 0.0049
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.0244 0.1498
Schistosoma mansoni [ACP] S-malonyltransferase 0.0083 0.0284 0.176
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0036 0.0093 0.0087
Mycobacterium tuberculosis Probable alcohol dehydrogenase Adh 0.0082 0.0279 0.0258
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0034 0.0085 0.0161

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -4.328 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.285 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.236 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.155 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.116 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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