Detailed information for compound 1603857

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 343.332 | Formula: C21H13NO4
  • H donors: 0 H acceptors: 1 LogP: 4.15 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=c1oc2cc(/N=C/c3ccc4c(c3)OCO4)ccc2c2c1cccc2
  • InChi: 1S/C21H13NO4/c23-21-17-4-2-1-3-15(17)16-7-6-14(10-19(16)26-21)22-11-13-5-8-18-20(9-13)25-12-24-18/h1-11H,12H2/b22-11+
  • InChiKey: VQEBKHUPMSDMKM-SSDVNMTOSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0082 0.0279 0.0315
Entamoeba histolytica NADP-dependent alcohol dehydrogenase, putative 0.0082 0.0279 0.5618
Loa Loa (eye worm) phosphopantetheine attachment site family protein 0.0133 0.0485 0.0548
Echinococcus granulosus tm gpcr rhodopsin 0.0812 0.3209 0.5981
Echinococcus granulosus acyl carrier protein mitochondrial 0.0133 0.0485 0.0904
Wolbachia endosymbiont of Brugia malayi acyl carrier protein 0.0133 0.0485 0.3303
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0054 0.0049
Schistosoma mansoni cpg binding protein 0.0028 0.0061 0.0303
Trypanosoma brucei oxidoreductase, putative 0.0082 0.0279 0.2014
Leishmania major hypothetical protein, conserved 0.0398 0.1547 1
Trypanosoma brucei beta-ketoacyl-ACP synthase 0.0331 0.128 1
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0133 0.0485 0.0522
Trypanosoma cruzi NADP-dependent alcohol hydrogenase, putative 0.0082 0.0279 0.2088
Plasmodium vivax acyl carrier protein, putative 0.0133 0.0485 0.3717
Brugia malayi Papain family cysteine protease containing protein 0.0016 0.0014 0.0009
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0093 0.0511
Mycobacterium tuberculosis Probable polyketide synthase Pks17 0.0323 0.1245 0.1497
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0082 0.0279 0.0273
Trypanosoma cruzi major cysteine proteinase, putative 0.0048 0.0144 0.1024
Echinococcus granulosus cathepsin l cysteine peptidase 0.0016 0.0014 0.0027
Trichomonas vaginalis penicillin-binding protein, putative 0.0042 0.0118 0.0673
Onchocerca volvulus 0.0019 0.0026 0.0012
Onchocerca volvulus 0.0264 0.1011 0.105
Echinococcus multilocularis lamin dm0 0.0026 0.0054 0.0102
Loa Loa (eye worm) hypothetical protein 0.0082 0.0279 0.0315
Schistosoma mansoni rab6-interacting 0.0019 0.0026 0.0075
Schistosoma mansoni cpg binding protein 0.0029 0.0067 0.0345
Schistosoma mansoni hypothetical protein 0.0133 0.0485 0.3071
Echinococcus granulosus cpg binding protein 0.0029 0.0067 0.0125
Mycobacterium leprae Polyketide synthase Pks13 0.1973 0.7875 1
Echinococcus multilocularis lamin 0.0026 0.0054 0.0102
Mycobacterium tuberculosis Probable alcohol dehydrogenase AdhA 0.0082 0.0279 0.0258
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0667 0.2629 0.4697
Echinococcus granulosus dnaJ subfamily B 0.0395 0.1537 0.2864
Brugia malayi hypothetical protein 0.0019 0.0026 0.002
Plasmodium falciparum acyl carrier protein 0.0133 0.0485 0.3717
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0073 0.0244 0.0455
Trichomonas vaginalis inositol monophosphatase, putative 0.0036 0.0093 0.0511
Mycobacterium tuberculosis Conserved protein 0.0042 0.0118 0.0051
Brugia malayi Cathepsin L-like precursor 0.0016 0.0014 0.0009
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.0873 0.3456 0.437
Loa Loa (eye worm) hypothetical protein 0.0016 0.0014 0.0016
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0034 0.0085 0.0127
Loa Loa (eye worm) acyl carrier protein 0.0133 0.0485 0.0548
Mycobacterium tuberculosis Probable polyketide beta-ketoacyl synthase Pks4 0.0202 0.0763 0.0879
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0053 0.0164 0.0305
Loa Loa (eye worm) ctsf protein 0.0016 0.0014 0.0016
Loa Loa (eye worm) hypothetical protein 0.0019 0.0026 0.0029
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0034 0.0085 0.0161
Leishmania major nuclear receptor binding factor-like protein 0.0082 0.0279 0.1725
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.0244 0.1498
Loa Loa (eye worm) hypothetical protein 0.0082 0.0279 0.0315
Trichomonas vaginalis D-aminoacylase, putative 0.0042 0.0118 0.0673
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0197 0.1361
Echinococcus multilocularis conserved hypothetical protein 0.1337 0.532 1
Loa Loa (eye worm) hypothetical protein 0.0083 0.0284 0.0321
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0093 0.062
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0082 0.0279 0.0273
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.132 0.5252 0.5249
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.0093 0.0174
Mycobacterium ulcerans thioesterase 0.11 0.4368 0.5532
Mycobacterium tuberculosis Polyketide synthetase MbtC (polyketide synthase) 0.0454 0.1772 0.2173
Entamoeba histolytica NADP-dependent alcohol dehydrogenase 0.0082 0.0279 0.5618
Mycobacterium tuberculosis Polyketide synthase Pks12 0.1402 0.5581 0.7059
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0042 0.0118 0.0112
Trypanosoma cruzi beta-ketoacyl synthase family protein, putative 0.0331 0.128 1
Schistosoma mansoni hypothetical protein 0.0054 0.0165 0.0983
Mycobacterium tuberculosis Probable quinone reductase Qor (NADPH:quinone reductase) (zeta-crystallin homolog protein) 0.0082 0.0279 0.0258
Onchocerca volvulus 0.0028 0.0061 0.0049
Echinococcus multilocularis 3 oxoacyl (acyl carrier protein) synthase 0.0331 0.128 0.2407
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0093 0.0512
Mycobacterium tuberculosis Probable polyketide beta-ketoacyl synthase Pks3 0.0202 0.0763 0.0879
Plasmodium vivax malonyl CoA-acyl carrier protein transacylase precursor, putative 0.0083 0.0284 0.2131
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.1402 0.5581 0.7059
Brugia malayi Pre-SET motif family protein 0.0232 0.0882 0.0877
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0085 0.0463
Schistosoma mansoni inositol monophosphatase 0.0036 0.0093 0.0511
Mycobacterium ulcerans Type I modular polyketide synthase 0.132 0.5252 0.6658
Brugia malayi hypothetical protein 0.0263 0.1007 0.1002
Brugia malayi beta-lactamase family protein 0.0042 0.0118 0.0112
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0034 0.0085 0.0463
Schistosoma mansoni lamin 0.0026 0.0054 0.0259
Brugia malayi intermediate filament protein 0.0026 0.0054 0.0049
Mycobacterium ulcerans polyketide synthase 0.1402 0.5581 0.7078
Brugia malayi Pre-SET motif family protein 0.0034 0.0085 0.008
Onchocerca volvulus 0.0042 0.0118 0.0109
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0085 0.0463
Trypanosoma brucei Acyl carrier protein, mitochondrial 0.0133 0.0485 0.3658
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0036 0.0093 0.0512
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0197 0.1361
Toxoplasma gondii ABC1 family protein 0.0042 0.0118 0.0185
Mycobacterium ulcerans zinc-dependent alcohol dehydrogenase 0.0082 0.0279 0.0322
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0093 0.0619
Onchocerca volvulus 0.1233 0.4904 0.515
Mycobacterium tuberculosis S-nitrosomycothiol reductase MscR 0.0082 0.0279 0.0258
Mycobacterium tuberculosis Probable NADPH quinone oxidoreductase FadB4 (NADPH:quinone reductase) (zeta-crystallin) 0.0082 0.0279 0.0258
Plasmodium vivax SET domain protein, putative 0.0034 0.0085 0.056
Mycobacterium tuberculosis Probable alcohol dehydrogenase Adh 0.0082 0.0279 0.0258
Entamoeba histolytica acyl-CoA synthetase, putative 0.0133 0.0485 1
Echinococcus multilocularis cysteine protease 0.0016 0.0014 0.0027
Mycobacterium tuberculosis Probable hydrolase 0.0042 0.0118 0.0051
Brugia malayi Cytochrome P450 family protein 0.0019 0.0026 0.0021
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.0202 0.0763 0.0879
Brugia malayi beta-lactamase 0.0042 0.0118 0.0112
Onchocerca volvulus 0.0034 0.0085 0.0075
Loa Loa (eye worm) hypothetical protein 0.0042 0.0118 0.0133
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0133 0.0485 0.048
Schistosoma mansoni methyltransferase-related 0.0398 0.1547 1
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0042 0.0118 0.0133
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0133 0.0485 0.0522
Toxoplasma gondii acyl transferase domain-containing protein 0.0083 0.0284 0.0485
Brugia malayi CXXC zinc finger family protein 0.0028 0.0061 0.0055
Leishmania major cathepsin L-like protease 0.0062 0.0197 0.1191
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0036 0.0093 0.1669
Mycobacterium ulcerans esterase/lipase LipP 0.0042 0.0118 0.0116
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0006 0.0006
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0042 0.0118 0.0673
Mycobacterium ulcerans lipase LipD 0.0042 0.0118 0.0116
Toxoplasma gondii aldehyde dehydrogenase 0.0073 0.0244 0.0412
Loa Loa (eye worm) hypothetical protein 0.0026 0.0054 0.0061
Trypanosoma cruzi oxidoreductase, putative 0.0082 0.0279 0.2088
Mycobacterium ulcerans NADP-dependent alcohol dehydrogenase Adh 0.0082 0.0279 0.0322
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.0197 0.1442
Trypanosoma brucei acyl transferase-like protein 0.0083 0.0284 0.2056
Loa Loa (eye worm) CYP4Cod1 0.0019 0.0026 0.003
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0054 0.0165 0.016
Mycobacterium leprae Probable lipase LipE 0.0042 0.0118 0.0051
Mycobacterium ulcerans acyl carrier protein 0.0133 0.0485 0.0585
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0133 0.0485 0.0522
Trypanosoma cruzi acyl transferase-like protein 0.0083 0.0284 0.2131
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0197 0.1361
Leishmania major zinc-binding dehydrogenase-like protein 0.0082 0.0279 0.1725
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0133 0.0485 0.0522
Loa Loa (eye worm) hypothetical protein 0.074 0.292 0.3297
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0133 0.0485 0.0585
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0133 0.0485 0.0585
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0036 0.0093 0.0175
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0093 0.0619
Echinococcus granulosus 3 oxoacyl acyl carrier protein synthase 0.0331 0.128 0.2386
Mycobacterium ulcerans 3-oxoacyl-(acyl carrier protein) synthase II 0.0331 0.128 0.1598
Toxoplasma gondii type I fatty acid synthase, putative 0.094 0.3724 0.6664
Loa Loa (eye worm) TK/FAK protein kinase 0.0247 0.0942 0.1063
Trichomonas vaginalis conserved hypothetical protein 0.0398 0.1547 1
Echinococcus granulosus RUN 0.0019 0.0026 0.0048
Loa Loa (eye worm) acyl carrier protein 0.0607 0.2388 0.2696
Mycobacterium ulcerans hypothetical protein 0.0042 0.0118 0.0116
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0036 0.0093 0.0173
Wolbachia endosymbiont of Brugia malayi 3-oxoacyl-ACP synthase 0.0331 0.128 1
Echinococcus multilocularis protein tyrosine kinase 0.0244 0.093 0.1749
Loa Loa (eye worm) hypothetical protein 0.0042 0.0118 0.0133
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0016 0.0014 0.0027
Brugia malayi Cytochrome P450 family protein 0.0019 0.0026 0.0021
Schistosoma mansoni survival motor neuron protein 0.0054 0.0165 0.0983
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.1402 0.5581 0.7078
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0197 0.1361
Loa Loa (eye worm) hypothetical protein 0.0042 0.0118 0.0133
Mycobacterium tuberculosis Probable lipase LipD 0.0042 0.0118 0.0051
Trichomonas vaginalis penicillin-binding protein, putative 0.0042 0.0118 0.0673
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0073 0.0244 0.0213
Mycobacterium ulcerans polyketide synthase MbtD 0.0406 0.158 0.1979
Schistosoma mansoni rab6-interacting 0.0019 0.0026 0.0075
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0244 0.0277
Trypanosoma cruzi oxidoreductase, putative 0.0082 0.0279 0.2088
Trypanosoma cruzi cytochrome P450, putative 0.0019 0.0026 0.0094
Echinococcus multilocularis mitochondrial trans 2 enoyl coenzyme A reductase 0.0082 0.0279 0.0524
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0036 0.0093 0.0512
Echinococcus granulosus lamin 0.0026 0.0054 0.0101
Schistosoma mansoni 3-oxoacyl-[ACP] synthase 0.0331 0.128 0.8261
Mycobacterium ulcerans NADPH quinone oxidoreductase FadB4 0.0082 0.0279 0.0322
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0042 0.0118 0.0673
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.0197 0.1442
Mycobacterium tuberculosis Conserved protein 0.0042 0.0118 0.0051
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0053 0.0164 0.0308
Echinococcus multilocularis Malonyl coenzyme A acyl carrier protein transacylase 0.0083 0.0284 0.0534
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.1062 0.4216 0.5338
Loa Loa (eye worm) hypothetical protein 0.0026 0.0052 0.0059
Echinococcus granulosus survival motor neuron protein 1 0.0263 0.1007 0.1876
Mycobacterium ulcerans polyketide synthase MbtC 0.0331 0.128 0.1598
Schistosoma mansoni cpg binding protein 0.0029 0.0067 0.0345
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.132 0.5252 0.6658
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0093 0.062
Echinococcus multilocularis beta LACTamase domain containing family member 0.0042 0.0118 0.0221
Mycobacterium ulcerans beta-lactamase 0.0042 0.0118 0.0116
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0856 0.3389 0.6062
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0036 0.0093 0.0087
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0016 0.0014 0.0027
Plasmodium falciparum 3-oxoacyl-acyl-carrier protein synthase I/II 0.0331 0.128 1
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.0197 0.1442
Mycobacterium leprae conserved hypothetical protein 0.0042 0.0118 0.0051
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.1402 0.5581 0.7059
Loa Loa (eye worm) hypothetical protein 0.2218 0.8857 1
Mycobacterium ulcerans 3-oxoacyl-(acyl carrier protein) synthase II 0.0331 0.128 0.1598
Plasmodium vivax hypothetical protein, conserved 0.0189 0.071 0.549
Wolbachia endosymbiont of Brugia malayi ACP S-malonyltransferase 0.0083 0.0284 0.1611
Toxoplasma gondii type I fatty acid synthase, putative 0.1402 0.5581 1
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0118 0.0814
Mycobacterium ulcerans oxidoreductase FadB5 0.0082 0.0279 0.0322
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0073 0.0244 0.1498
Onchocerca volvulus 0.0054 0.0165 0.0159
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0118 0.0814
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0093 0.0511
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0042 0.0118 0.0116
Schistosoma mansoni zinc binding dehydrogenase 0.0082 0.0279 0.1725
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE 0.0873 0.3456 0.4333
Schistosoma mansoni lipoxygenase 0.0053 0.0164 0.0974
Onchocerca volvulus 0.0042 0.0118 0.0109
Trypanosoma cruzi NADP-dependent alcohol hydrogenase, putative 0.0082 0.0279 0.2088
Loa Loa (eye worm) hypothetical protein 0.0042 0.0118 0.0133
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0036 0.0093 0.1665
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.128 0.5089 0.6428
Loa Loa (eye worm) cysteine protease 0.0016 0.0014 0.0016
Mycobacterium tuberculosis Conserved hypothetical protein 0.0133 0.0485 0.0522
Mycobacterium ulcerans non-ribosomal peptide synthetase 0.0133 0.0485 0.0585
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0197 0.1361
Echinococcus granulosus Malonyl coenzyme A acyl carrier protein transacylase 0.0083 0.0284 0.053
Echinococcus granulosus protein tyrosine kinase 0.0244 0.093 0.1734
Onchocerca volvulus Acyl carrier protein, mitochondrial homolog 0.0133 0.0485 0.0496
Leishmania major zinc binding dehydrogenase-like protein 0.0082 0.0279 0.1725
Brugia malayi Cathepsin L-like precursor 0.0016 0.0014 0.0009
Echinococcus multilocularis AMP dependent ligase 0.0133 0.0485 0.0912
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0056 0.0176 0.1273
Schistosoma mansoni [ACP] S-malonyltransferase 0.0083 0.0284 0.176
Mycobacterium ulcerans Type I modular polyketide synthase 0.132 0.5252 0.6658
Trichomonas vaginalis D-aminoacylase, putative 0.0042 0.0118 0.0673
Echinococcus granulosus ubiquitin specific protease 41 0.0036 0.0093 0.0173
Loa Loa (eye worm) hypothetical protein 0.0034 0.0085 0.0096
Brugia malayi Methyltransferase-like protein 4 0.0398 0.1547 0.1542
Plasmodium falciparum malonyl CoA-acyl carrier protein transacylase 0.0083 0.0284 0.2131
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0061 0.0069
Echinococcus granulosus cathepsin L cysteine proteinase 0.0016 0.0014 0.0027
Schistosoma mansoni alcohol dehydrogenase 0.0082 0.0279 0.1725
Mycobacterium ulcerans oxidoreductase 0.0082 0.0279 0.0322
Mycobacterium leprae Probable polyketide synthase Pks1 0.1402 0.5581 0.7059
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.1062 0.4216 0.5308
Onchocerca volvulus 0.0026 0.0054 0.0042
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0133 0.0485 0.0585
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0189 0.071 0.549
Mycobacterium ulcerans NADP-dependent alcohol dehydrogenase AdhC 0.0082 0.0279 0.0322
Echinococcus granulosus hypothetical protein 0.1348 0.5366 1
Mycobacterium tuberculosis Polyketide synthase Pks2 0.128 0.5089 0.6428
Leishmania major cytochrome p450-like protein 0.0019 0.0026 0.0077
Trichomonas vaginalis esterase, putative 0.0042 0.0118 0.0673
Toxoplasma gondii Zn-containing alcohol dehydrogenase 0.0082 0.0279 0.0475
Mycobacterium leprae Probable alcohol dehydrogenase AdhA 0.0082 0.0279 0.0258
Loa Loa (eye worm) hypothetical protein 0.0042 0.0118 0.0133
Echinococcus multilocularis musashi 0.0026 0.0054 0.0102
Echinococcus granulosus lamin dm0 0.0026 0.0054 0.0101
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.0093 0.0173
Loa Loa (eye worm) hypothetical protein 0.0263 0.1007 0.1137
Loa Loa (eye worm) hypothetical protein 0.0202 0.0763 0.0861
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.132 0.5252 0.6636
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0082 0.0279 0.0273
Echinococcus multilocularis cysteine protease 0.0016 0.0014 0.0027
Mycobacterium tuberculosis Probable NADP-dependent alcohol dehydrogenase AdhC 0.0082 0.0279 0.0258
Onchocerca volvulus Fatty acid synthase homolog 0.238 0.9508 1
Echinococcus multilocularis cpg binding protein 0.0029 0.0067 0.0127
Trichomonas vaginalis set domain proteins, putative 0.0264 0.1011 0.6503
Loa Loa (eye worm) cytochrome P450 family protein 0.0019 0.0026 0.003
Mycobacterium tuberculosis Probable oxidoreductase 0.0082 0.0279 0.0258
Trypanosoma cruzi oxidoreductase, putative 0.0082 0.0279 0.2088
Mycobacterium ulcerans NADP-dependent oxidoreductase 0.0082 0.0279 0.0322
Mycobacterium ulcerans polyketide synthase Pks13 0.1973 0.7875 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0034 0.0085 0.0161
Loa Loa (eye worm) hypothetical protein 0.0042 0.0118 0.0133
Toxoplasma gondii 3-oxoacyl-acyl-carrier protein synthase I/II, putative 0.0331 0.128 0.2274
Onchocerca volvulus 0.0133 0.0485 0.0496
Mycobacterium ulcerans dehydrogenase 0.0082 0.0279 0.0322
Giardia lamblia Methyltransferase like 2 0.0398 0.1547 1
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0054 0.0061
Leishmania major d-xylulose reductase, putative 0.0082 0.0279 0.1725
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0812 0.3209 0.6033
Mycobacterium tuberculosis Hypothetical protein 0.0398 0.1547 0.1884
Mycobacterium tuberculosis Possible oxidoreductase FadB5 0.0082 0.0279 0.0258
Echinococcus multilocularis survival motor neuron protein 1 0.0263 0.1007 0.1892
Entamoeba histolytica acyl-CoA synthetase, putative 0.0133 0.0485 1
Mycobacterium leprae Probable oxidireductase 0.0082 0.0279 0.0258
Onchocerca volvulus 0.0019 0.0026 0.0012
Echinococcus multilocularis NADH dehydrogenase 0.0133 0.0485 0.0912
Treponema pallidum acyl carrier protein 0.0133 0.0485 0.5
Onchocerca volvulus 0.2298 0.9179 0.9653
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0036 0.0093 0.0173
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0202 0.0763 0.0879
Echinococcus granulosus NADH dehydrogenase 0.0133 0.0485 0.0904
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.1233 0.4904 0.619
Brugia malayi AMP-binding enzyme family protein 0.1233 0.4904 0.4901
Loa Loa (eye worm) beta-lactamase 0.0042 0.0118 0.0133
Brugia malayi ADP-specific Phosphofructokinase/Glucokinase conserved region family protein 0.0083 0.0284 0.0279
Echinococcus granulosus intermediate filament protein 0.0026 0.0054 0.0101
Mycobacterium leprae conserved hypothetical protein 0.0133 0.0485 0.0522
Schistosoma mansoni lipoxygenase 0.0019 0.0026 0.0075
Mycobacterium tuberculosis Conserved protein 0.0398 0.1547 0.1884
Toxoplasma gondii quinone oxidoreductase, putative 0.0082 0.0279 0.0475
Onchocerca volvulus 0.0026 0.0054 0.0042
Mycobacterium ulcerans quinone reductase Qor 0.0082 0.0279 0.0322
Mycobacterium tuberculosis Probable fatty acid synthase Fas (fatty acid synthetase) 0.0415 0.1615 0.1972
Brugia malayi acyl carrier protein, mitochondrial precursor, putative 0.0133 0.0485 0.048
Mycobacterium leprae PROBABLE POLYKETIDE BETA-KETOACYL SYNTHASE PKS4 0.0202 0.0763 0.0879
Echinococcus granulosus mitochondrial trans 2 enoyl coenzyme A reductase 0.0082 0.0279 0.052
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0036 0.0093 0.0512
Mycobacterium tuberculosis Possible dehydrogenase 0.0082 0.0279 0.0258
Brugia malayi Cathepsin L-like precursor 0.0016 0.0014 0.0009
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0026 0.0048
Mycobacterium ulcerans hypothetical protein 0.0133 0.0485 0.0585
Plasmodium vivax hypothetical protein, conserved 0.0042 0.0118 0.0814
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0036 0.0093 0.0175
Wolbachia endosymbiont of Brugia malayi NADPH:quinone reductase 0.0082 0.0279 0.1566
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0197 0.1361
Loa Loa (eye worm) hypothetical protein 0.0019 0.0026 0.0029
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0026 0.0049
Onchocerca volvulus 0.0082 0.0279 0.0278
Trypanosoma cruzi nuclear receptor binding factor, putative 0.0082 0.0279 0.2088
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.108 0.4286 0.5397
Mycobacterium ulcerans short-chain dehydrogenase 0.0082 0.0279 0.0322
Mycobacterium tuberculosis Possible quinone oxidoreductase (NADPH:quinone oxidoreductase) (zeta-crystallin) 0.0082 0.0279 0.0258
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0042 0.0118 0.0051
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0082 0.0279 0.1725
Echinococcus multilocularis cathepsin L cysteine protease 0.0016 0.0014 0.0027
Brugia malayi Serotonin receptor 0.0458 0.1791 0.1786
Schistosoma mansoni tyrosine kinase 0.0244 0.093 0.5976
Leishmania major hypothetical protein, conserved 0.0083 0.0284 0.176
Mycobacterium ulcerans Type I modular polyketide synthase 0.132 0.5252 0.6658
Mycobacterium tuberculosis Probable polyketide synthase Pks15 0.0534 0.2094 0.2586
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0232 0.0882 0.0996
Echinococcus multilocularis RUN 0.0019 0.0026 0.0049
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0197 0.1361
Trypanosoma brucei Trans-2-enoyl-ACP reductase 2, putative 0.0082 0.0279 0.2014
Mycobacterium ulcerans zinc-containing alcohol dehydrogenase NAD-dependent AdhB 0.0082 0.0279 0.0322
Loa Loa (eye worm) fatty acid synthase 0.1303 0.5181 0.585
Mycobacterium tuberculosis Polyketide synthase Pks13 0.1973 0.7875 1
Mycobacterium ulcerans zinc-type alcohol dehydrogenase AdhD 0.0082 0.0279 0.0322
Mycobacterium ulcerans thioesterase TesA 0.11 0.4368 0.5532
Mycobacterium ulcerans polyketide synthase 0.132 0.5252 0.6658
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0197 0.1361
Brugia malayi beta-lactamase family protein 0.0042 0.0118 0.0112
Plasmodium vivax multidomain scavenger receptor, putative 0.0019 0.0026 0.0091
Echinococcus multilocularis dnaJ subfamily B 0.0395 0.1537 0.2889
Loa Loa (eye worm) hypothetical protein 0.0082 0.0279 0.0315
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.1402 0.5581 0.7059
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0085 0.0463
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0016 0.0014 0.0016
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0948 0.3759 0.4721
Schistosoma mansoni intermediate filament proteins 0.0026 0.0054 0.0259
Trypanosoma cruzi Acyl carrier protein, mitochondrial, putative 0.0133 0.0485 0.3717
Chlamydia trachomatis 3-oxoacyl-ACP synthase 0.0331 0.128 1
Loa Loa (eye worm) alcohol dehydrogenase class III 0.0082 0.0279 0.0315
Brugia malayi hypothetical protein 0.0019 0.0026 0.002
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.0166 0.0271
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.0244 0.1498
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.1973 0.7875 1
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0093 0.0532
Mycobacterium ulcerans zinc-containing alcohol dehydrogenase NAD dependent AdhB 0.0082 0.0279 0.0322
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0197 0.1361
Onchocerca volvulus Putative alcohol dehydrogenase 0.0082 0.0279 0.0278
Echinococcus multilocularis ubiquitin specific protease 41 0.0036 0.0093 0.0175
Schistosoma mansoni acyl carrier protein 0.0133 0.0485 0.3071
Mycobacterium leprae Probable S-nitrosomycothiol reductase MscR 0.0082 0.0279 0.0258
Onchocerca volvulus 0.0042 0.0118 0.0109
Loa Loa (eye worm) hypothetical protein 0.0036 0.0093 0.0105
Schistosoma mansoni hypothetical protein 0.0395 0.1537 0.9934
Leishmania major acyl carrier protein, putative 0.0133 0.0485 0.3071
Leishmania major cathepsin L-like protease 0.0062 0.0197 0.1191
Toxoplasma gondii type I fatty acid synthase 0.0202 0.0763 0.1344
Mycobacterium ulcerans quinone oxidoreductase 0.0082 0.0279 0.0322
Mycobacterium tuberculosis Polyketide synthetase MbtD (polyketide synthase) 0.0406 0.158 0.1926
Mycobacterium tuberculosis Probable acyl carrier protein AcpA (ACP) 0.0133 0.0485 0.0522
Mycobacterium leprae PROBABLE NADP-DEPENDENT ALCOHOL DEHYDROGENASE ADHC 0.0082 0.0279 0.0258
Trichomonas vaginalis D-aminoacylase, putative 0.0042 0.0118 0.0673
Trypanosoma cruzi NADP-dependent alcohol hydrogenase, putative 0.0082 0.0279 0.2088
Loa Loa (eye worm) fibroinase 0.0016 0.0014 0.0016
Trypanosoma cruzi cytochrome P450, putative 0.0019 0.0026 0.0094
Leishmania major NADP-dependent alcohol dehydrogenase, putative 0.0082 0.0279 0.1725
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0331 0.128 0.1276
Trypanosoma cruzi cruzipain precursor, putative 0.0062 0.0197 0.1442
Entamoeba histolytica NADP-dependent alcohol dehydrogenase, putative 0.0082 0.0279 0.5618
Trypanosoma brucei hypothetical protein, conserved 0.0042 0.0118 0.0727
Mycobacterium tuberculosis Probable zinc-type alcohol dehydrogenase AdhD (aldehyde reductase) 0.0082 0.0279 0.0258
Onchocerca volvulus 0.0082 0.0279 0.0278
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.1062 0.4216 0.5338
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0197 0.1361
Schistosoma mansoni loxhd1 0.0019 0.0026 0.0075
Mycobacterium tuberculosis Probable esterase LipL 0.0042 0.0118 0.0051
Trypanosoma cruzi NADP-dependent alcohol hydrogenase, putative 0.0082 0.0279 0.2088
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0133 0.0485 0.0522
Plasmodium vivax 3-oxoacyl-[acyl-carrier-protein] synthase i/ii, putative 0.0331 0.128 1
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0026 0.0049
Brugia malayi Protein kinase domain containing protein 0.0247 0.0942 0.0937
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.132 0.5252 0.6636
Mycobacterium tuberculosis Probable polyketide synthase Pks9 0.075 0.2964 0.3702
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0133 0.0485 0.0522
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0036 0.0093 0.0512
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0036 0.0093 0.0085
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0197 0.1361
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0073 0.0244 0.0459
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0093 0.053
Mycobacterium ulcerans Zn-dependent alcohol dehydrogenase, AdhX 0.0082 0.0279 0.0322
Plasmodium falciparum LCCL domain-containing protein 0.0019 0.0026 0.0091
Mycobacterium tuberculosis Meromycolate extension acyl carrier protein AcpM 0.0133 0.0485 0.0522
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.0191 0.1151
Brugia malayi Doublecortin family protein 0.0019 0.0026 0.002
Schistosoma mansoni hypothetical protein 0.0019 0.0026 0.0075
Mycobacterium tuberculosis Probable thioesterase TesA 0.11 0.4368 0.5503
Mycobacterium ulcerans malonyl CoA-acyl carrier protein transacylase FabD 0.0083 0.0284 0.0329
Mycobacterium tuberculosis Possible dehydrogenase 0.0082 0.0279 0.0258
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0133 0.0485 0.0522
Brugia malayi Phosphopantetheine attachment site family protein 0.0133 0.0485 0.048
Echinococcus granulosus cathepsin l1 0.0016 0.0014 0.0027
Mycobacterium leprae PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) 0.0415 0.1615 0.1972
Trypanosoma cruzi nuclear receptor binding factor, putative 0.0082 0.0279 0.2088
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.11 0.4368 0.5503
Brugia malayi Inositol-1 0.0036 0.0093 0.0087
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.1402 0.5581 0.7078
Mycobacterium ulcerans acyl carrier protein 0.0133 0.0485 0.0585
Loa Loa (eye worm) hypothetical protein 0.0202 0.0763 0.0861
Loa Loa (eye worm) cytochrome P450 family protein 0.0019 0.0026 0.003
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 0.0133 0.0485 0.0585
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0244 0.0277
Mycobacterium ulcerans oxidoreductase 0.0082 0.0279 0.0322
Chlamydia trachomatis acyl carrier protein 0.0133 0.0485 0.2016
Mycobacterium ulcerans acyl-CoA synthetase 0.0133 0.0485 0.0585
Echinococcus multilocularis Acyl carrier protein, mitochondrial 0.0133 0.0485 0.0912
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0082 0.0279 0.1725
Leishmania major quinone oxidoreductase, putative 0.0082 0.0279 0.1725
Brugia malayi Cathepsin L-like precursor 0.0016 0.0014 0.0009
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0267 0.1023 0.1213
Echinococcus granulosus AMP dependent ligase 0.0133 0.0485 0.0904
Brugia malayi Cathepsin L-like precursor 0.0016 0.0014 0.0009
Brugia malayi Alcohol dehydrogenase class III 0.0082 0.0279 0.0273
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0133 0.0485 0.0585
Loa Loa (eye worm) beta-ketoacyl synthase domain-containing protein 0.0331 0.128 0.1446
Trypanosoma cruzi beta-ketoacyl synthase family protein, putative 0.0331 0.128 1
Mycobacterium ulcerans fatty acid synthase Fas 0.0415 0.1615 0.2024
Schistosoma mansoni [ACP] S-malonyltransferase 0.0083 0.0284 0.176
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0042 0.0118 0.0051
Brugia malayi Cathepsin L-like precursor 0.0016 0.0014 0.0009
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.132 0.5252 0.6636
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0244 0.0277
Leishmania major oxidoreductase, putative 0.0082 0.0279 0.1725
Loa Loa (eye worm) AMP-binding enzyme family protein 0.1233 0.4904 0.5536
Mycobacterium ulcerans polyketide synthase Pks9 0.0873 0.3456 0.437
Mycobacterium tuberculosis Acyl carrier protein (ACP) MbtL 0.0133 0.0485 0.0522
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.132 0.5252 0.6636
Schistosoma mansoni inositol monophosphatase 0.0036 0.0093 0.0511
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0036 0.0093 0.0512
Trypanosoma cruzi acyl transferase-like protein, putative 0.0083 0.0284 0.2131
Schistosoma mansoni [ACP] S-malonyltransferase 0.0083 0.0284 0.176
Leishmania major hypothetical protein, conserved 0.0042 0.0118 0.0673
Mycobacterium tuberculosis Conserved protein 0.0042 0.0118 0.0051
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.0093 0.0141
Loa Loa (eye worm) doublecortin family protein 0.0019 0.0026 0.0029
Leishmania major cathepsin L-like protease 0.0062 0.0197 0.1191
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0054 0.0061
Mycobacterium ulcerans zinc-dependent alcohol dehydrogenase AdhE2 0.0082 0.0279 0.0322
Mycobacterium tuberculosis Probable lipase LipE 0.0042 0.0118 0.0051
Echinococcus granulosus beta LACTamase domain containing family member 0.0042 0.0118 0.0219
Brugia malayi AMP-binding enzyme family protein 0.0406 0.158 0.1575
Schistosoma mansoni polycystin 1-related 0.0019 0.0026 0.0075
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0026 0.0048
Mycobacterium ulcerans quinone oxidoreductase 0.0082 0.0279 0.0322
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0093 0.0511
Schistosoma mansoni lamin 0.0026 0.0054 0.0259
Echinococcus multilocularis cathepsin L cysteine protease 0.0016 0.0014 0.0027
Echinococcus multilocularis Polycystic kidney disease protein 0.0019 0.0026 0.0049
Leishmania major beta-ketoacyl synthase family protein, putative,3-oxoacyl-acyl carrier protein synthase ii, putative 0.0331 0.128 0.8261
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.132 0.5252 0.6636
Echinococcus granulosus Polycystic kidney disease protein 0.0019 0.0026 0.0048
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0042 0.0118 0.0051
Toxoplasma gondii acyl carrier protein ACP 0.0133 0.0485 0.0845
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.1402 0.5581 0.7059
Trypanosoma brucei oxidoreductase, putative 0.0082 0.0279 0.2014
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0082 0.0279 0.1725
Echinococcus granulosus histone lysine methyltransferase setb 0.0034 0.0085 0.0159
Loa Loa (eye worm) inositol-1 0.0036 0.0093 0.0105
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0032 0.0078 0.0145
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0016 0.0014 0.0016
Leishmania major oxidoreductase-like protein 0.0082 0.0279 0.1725

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -4.328 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.285 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.236 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.155 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.116 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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