Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsB | 0.0927 | 0.3367 | 0.4452 |
Loa Loa (eye worm) | acyl carrier protein | 0.053 | 0.127 | 0.1462 |
Trypanosoma cruzi | beta-ketoacyl synthase family protein, putative | 0.0289 | 0 | 0.5 |
Mycobacterium leprae | Polyketide synthase Pks13 | 0.1722 | 0.7562 | 1 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks15 | 0.0466 | 0.0933 | 0.0864 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsE | 0.0762 | 0.2495 | 0.3299 |
Brugia malayi | Methyltransferase-like protein 4 | 0.0347 | 0.0306 | 0.0306 |
Onchocerca volvulus | 0.2005 | 0.9058 | 0.9285 | |
Mycobacterium ulcerans | fatty acid synthase Fas | 0.0362 | 0.0384 | 0.0508 |
Mycobacterium ulcerans | thioesterase TesA | 0.096 | 0.3541 | 0.4682 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks7 | 0.1224 | 0.4933 | 0.6376 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.1152 | 0.4555 | 0.5856 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC | 0.1224 | 0.4933 | 0.6337 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.1224 | 0.4933 | 0.6522 |
Trypanosoma brucei | beta-ketoacyl-ACP synthase | 0.0289 | 0 | 0.5 |
Schistosoma mansoni | methyltransferase-related | 0.0347 | 0.0306 | 1 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.082 | 0.2802 | 0.5682 |
Brugia malayi | AMP-binding enzyme family protein | 0.1076 | 0.4155 | 0.4155 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks1 | 0.0828 | 0.2842 | 0.3495 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.1152 | 0.4555 | 0.6023 |
Loa Loa (eye worm) | hypothetical protein | 0.1936 | 0.869 | 1 |
Mycobacterium ulcerans | multifunctional mycocerosic acid synthase membrane-associated Mas | 0.1224 | 0.4933 | 0.6522 |
Plasmodium vivax | 3-oxoacyl-[acyl-carrier-protein] synthase i/ii, putative | 0.0289 | 0 | 0.5 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.1152 | 0.4555 | 0.6023 |
Toxoplasma gondii | beta-ketoacyl synthase, N-terminal domain-containing protein | 0.0747 | 0.2419 | 0.4903 |
Chlamydia trachomatis | 3-oxoacyl-ACP synthase | 0.0289 | 0 | 0.5 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA | 0.1152 | 0.4555 | 0.581 |
Brugia malayi | AMP-binding enzyme family protein | 0.0354 | 0.0343 | 0.0343 |
Toxoplasma gondii | AMP-binding enzyme domain-containing protein | 0.0582 | 0.1547 | 0.3136 |
Mycobacterium ulcerans | thioesterase | 0.096 | 0.3541 | 0.4682 |
Mycobacterium tuberculosis | Polyketide synthetase MbtD (polyketide synthase) | 0.0354 | 0.0343 | 0.0052 |
Loa Loa (eye worm) | fatty acid synthase | 0.1137 | 0.4474 | 0.5149 |
Mycobacterium ulcerans | polyketide synthase MbtD | 0.0354 | 0.0343 | 0.0454 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.0927 | 0.3367 | 0.4452 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.1152 | 0.4555 | 0.5856 |
Mycobacterium tuberculosis | Probable multifunctional mycocerosic acid synthase membrane-associated Mas | 0.1224 | 0.4933 | 0.6376 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0347 | 0.0306 | 0.5 |
Mycobacterium ulcerans | polyketide synthase | 0.1224 | 0.4933 | 0.6522 |
Mycobacterium tuberculosis | Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) | 0.1076 | 0.4155 | 0.5305 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks5 | 0.1117 | 0.4368 | 0.5599 |
Loa Loa (eye worm) | hypothetical protein | 0.0646 | 0.1881 | 0.2164 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB | 0.0927 | 0.3367 | 0.4155 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks9 | 0.0655 | 0.1931 | 0.224 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.1152 | 0.4555 | 0.5856 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD | 0.1152 | 0.4555 | 0.581 |
Mycobacterium leprae | PROBABLE THIOESTERASE TESA | 0.096 | 0.3541 | 0.4398 |
Echinococcus multilocularis | 3 oxoacyl (acyl carrier protein) synthase | 0.0289 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable fatty acid synthase Fas (fatty acid synthetase) | 0.0362 | 0.0384 | 0.0108 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.1224 | 0.4933 | 1 |
Mycobacterium ulcerans | polyketide synthase Pks13 | 0.1722 | 0.7562 | 1 |
Mycobacterium leprae | Probable polyketide synthase Pks1 | 0.1224 | 0.4933 | 0.6337 |
Mycobacterium tuberculosis | Polyketide synthase Pks13 | 0.1722 | 0.7562 | 1 |
Mycobacterium tuberculosis | Probable membrane bound polyketide synthase Pks6 | 0.1722 | 0.7562 | 1 |
Loa Loa (eye worm) | AMP-binding enzyme family protein | 0.1076 | 0.4155 | 0.4782 |
Giardia lamblia | Methyltransferase like 2 | 0.0347 | 0.0306 | 0.5 |
Mycobacterium tuberculosis | Polyketide synthetase MbtC (polyketide synthase) | 0.0396 | 0.0564 | 0.0356 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE | 0.0762 | 0.2495 | 0.2941 |
Mycobacterium leprae | Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas | 0.1224 | 0.4933 | 0.6337 |
Echinococcus granulosus | 3 oxoacyl acyl carrier protein synthase | 0.0289 | 0 | 0.5 |
Mycobacterium tuberculosis | Polyketide synthase Pks12 | 0.1224 | 0.4933 | 0.6376 |
Leishmania major | hypothetical protein, conserved | 0.0347 | 0.0306 | 1 |
Plasmodium falciparum | 3-oxoacyl-acyl-carrier protein synthase I/II | 0.0289 | 0 | 0.5 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.1152 | 0.4555 | 0.6023 |
Mycobacterium ulcerans | polyketide synthase | 0.1152 | 0.4555 | 0.6023 |
Trypanosoma cruzi | beta-ketoacyl synthase family protein, putative | 0.0289 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable thioesterase TesA | 0.096 | 0.3541 | 0.4459 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.1152 | 0.4555 | 0.6023 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks8 | 0.0942 | 0.3447 | 0.4329 |
Mycobacterium ulcerans | polyketide synthase Pks9 | 0.0762 | 0.2495 | 0.3299 |
Onchocerca volvulus | Fatty acid synthase homolog | 0.2077 | 0.9436 | 1 |
Brugia malayi | Beta-ketoacyl synthase, N-terminal domain containing protein | 0.1152 | 0.4555 | 0.4555 |
Mycobacterium tuberculosis | Polyketide synthase Pks2 | 0.1117 | 0.4368 | 0.5599 |
Wolbachia endosymbiont of Brugia malayi | 3-oxoacyl-ACP synthase | 0.0289 | 0 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.