Detailed information for compound 1603882

Basic information

Technical information
  • TDR Targets ID: 1603882
  • Name: 2-methyl-4-(4-nitrophenyl)-2,3-dihydro-1,5-be nzothiazepine
  • MW: 298.36 | Formula: C16H14N2O2S
  • H donors: 0 H acceptors: 2 LogP: 3.81 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC1CC(=Nc2c(S1)cccc2)c1ccc(cc1)[N+](=O)[O-]
  • InChi: 1S/C16H14N2O2S/c1-11-10-15(12-6-8-13(9-7-12)18(19)20)17-14-4-2-3-5-16(14)21-11/h2-9,11H,10H2,1H3
  • InChiKey: OEUXANLCGPEYQZ-UHFFFAOYSA-N  

Network

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Synonyms

  • N-hydroxy-4-(2-methyl-2,3-dihydro-1,5-benzothiazepin-4-yl)benzeneamine oxide
  • N-[4-(2-methyl-2,3-dihydro-1,5-benzothiazepin-4-yl)phenyl]-N-oxidohydroxylamine
  • N-[4-(2-methyl-2,3-dihydro-1,5-benzothiazepin-4-yl)phenyl]-N-oxido-hydroxylamine
  • NSC637000
  • NCI60_012264
  • 4-(4-(Hydroxy(oxido)amino)phenyl)-2-methyl-2,3-dihydro-1,5-benzothiazepine
  • AIDS-136064
  • AIDS136064

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Trypanosoma brucei chrX additional, unordered contigs 0.0014 0.0021 0.0163
Onchocerca volvulus Putative alcohol dehydrogenase 0.0035 0.022 0.0219
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0035 0.022 0.0676
Leishmania major DNA polymerase kappa, putative 0.0045 0.0313 0.2087
Onchocerca volvulus 0.0019 0.0073 0.0064
Trypanosoma brucei DNA polymerase kappa, putative 0.0031 0.0181 0.1472
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0068 0.0528 0.43
Brugia malayi Papain family cysteine protease containing protein 0.0019 0.0073 0.0061
Mycobacterium ulcerans aldehyde dehydrogenase 0.007 0.0555 0.0682
Brugia malayi Cathepsin L-like precursor 0.0019 0.0073 0.0061
Leishmania major cysteine peptidase A (CPA) 0.0019 0.0073 0.0483
Schistosoma mansoni cathepsin F (C01 family) 0.0019 0.0073 0.0098
Leishmania major zinc binding dehydrogenase-like protein 0.0035 0.022 0.147
Mycobacterium tuberculosis Probable polyketide beta-ketoacyl synthase Pks3 0.0087 0.0707 0.0637
Brugia malayi serine/threonine-protein kinase plk-2 0.011 0.0926 0.0915
Mycobacterium ulcerans polyketide synthase 0.0564 0.5224 0.6635
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0057 0.0428 0.0271
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.007 0.0555 0.371
Echinococcus granulosus mitochondrial trans 2 enoyl coenzyme A reductase 0.0035 0.022 0.028
Loa Loa (eye worm) hypothetical protein 0.0035 0.022 0.0236
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0053 0.0391 0.0446
Loa Loa (eye worm) hypothetical protein 0.0019 0.0073 0.0069
Echinococcus multilocularis dna polymerase kappa 0.0045 0.0313 0.034
Schistosoma mansoni cathepsin F (C01 family) 0.0019 0.0073 0.0098
Mycobacterium leprae PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) 0.0177 0.1565 0.1759
Schistosoma mansoni jumonji domain containing protein 0.0018 0.0061 0.0082
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.011 0.0926 0.6186
Mycobacterium ulcerans aldehyde dehydrogenase 0.007 0.0555 0.0682
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0073 0.0197
Schistosoma mansoni terminal deoxycytidyl transferase 0.0045 0.0313 0.0419
Loa Loa (eye worm) hypothetical protein 0.0035 0.022 0.0236
Echinococcus multilocularis mannose 6 phosphate isomerase 0.0113 0.0956 0.1209
Loa Loa (eye worm) alcohol dehydrogenase class III 0.0035 0.022 0.0236
Loa Loa (eye worm) hypothetical protein 0.0014 0.0021 0.001
Loa Loa (eye worm) DEAH box polypeptide 35 0.0188 0.1671 0.1877
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0035 0.022 0.0676
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0285 0.2585 0.4654
Plasmodium falciparum JmjC domain-containing protein, putative 0.0018 0.0061 0.0337
Onchocerca volvulus 0.0982 0.9174 0.9651
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0023 0.0107 0.0192
Mycobacterium leprae PROBABLE POLYKETIDE BETA-KETOACYL SYNTHASE PKS4 0.0087 0.0707 0.0637
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0589 0.4795
Entamoeba histolytica phosphomannose isomerase, putative 0.0113 0.0956 0.3088
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0313 0.2543
Trichomonas vaginalis DNA helicase recq, putative 0.0023 0.0107 0.0306
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0073 0.0197
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0035 0.022 0.0209
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0073 0.0197
Loa Loa (eye worm) hypothetical protein 0.0096 0.0798 0.0889
Trichomonas vaginalis rotamase, putative 0.0039 0.0256 0.079
Trypanosoma brucei DNA damage repair protein, putative 0.0014 0.0021 0.0163
Echinococcus granulosus NADH dehydrogenase 0.0057 0.0428 0.0558
Toxoplasma gondii 3-oxoacyl-acyl-carrier protein synthase I/II, putative 0.0142 0.1228 0.2211
Leishmania major oxidoreductase-like protein 0.0035 0.022 0.147
Echinococcus multilocularis lysine specific demethylase 5A 0.0068 0.0535 0.064
Trypanosoma cruzi cysteine peptidase, putative 0.0074 0.0589 0.4795
Trichomonas vaginalis rotamase, putative 0.0038 0.0247 0.0762
Trypanosoma brucei phosphomannose isomerase 0.0113 0.0956 0.7785
Loa Loa (eye worm) hypothetical protein 0.0035 0.022 0.0236
Echinococcus multilocularis cathepsin L cysteine protease 0.0019 0.0073 0.0016
Mycobacterium tuberculosis Probable polyketide synthase Pks9 0.0321 0.2922 0.3535
Mycobacterium ulcerans oxidoreductase FadB5 0.0035 0.022 0.0255
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0057 0.0428 0.0416
Onchocerca volvulus 0.0514 0.475 0.499
Echinococcus multilocularis Acyl carrier protein, mitochondrial 0.0057 0.0428 0.0496
Leishmania major hypothetical protein, conserved 0.017 0.1496 1
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0142 0.1228 0.1217
Brugia malayi Pre-SET motif family protein 0.0035 0.0224 0.0212
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0045 0.0313 0.0974
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.0564 0.5224 0.6547
Brugia malayi jmjC domain containing protein 0.0018 0.0061 0.0049
Schistosoma mansoni zinc binding dehydrogenase 0.0035 0.022 0.0295
Trypanosoma cruzi phosphomannose isomerase, putative 0.0113 0.0956 0.7785
Mycobacterium tuberculosis Probable mannose-6-phosphate isomerase ManA (phosphomannose isomerase) (phosphomannoisomerase) (PMI) (phosphohexoisomerase) (pho 0.0061 0.0468 0.0323
Echinococcus granulosus dna polymerase kappa 0.0045 0.0313 0.0403
Brugia malayi Alcohol dehydrogenase class III 0.0035 0.022 0.0209
Mycobacterium tuberculosis Polyketide synthetase MbtC (polyketide synthase) 0.0194 0.1723 0.1966
Mycobacterium ulcerans polyketide synthase MbtC 0.0142 0.1228 0.154
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0019 0.0073 0.0069
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0039 0.0256 0.0276
Mycobacterium ulcerans acyl carrier protein 0.0057 0.0428 0.0519
Trichomonas vaginalis CAMK family protein kinase 0.011 0.0926 0.2962
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0014 0.0021 0.0037
Mycobacterium ulcerans acyl-CoA synthetase 0.0057 0.0428 0.0519
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0339 0.3096 1
Echinococcus granulosus jumonji domain containing 1A 0.0018 0.0061 0.0066
Schistosoma mansoni hypothetical protein 0.0096 0.0798 0.1069
Schistosoma mansoni hypothetical protein 0.0336 0.3071 0.4116
Plasmodium vivax vivapain-2 0.0019 0.0073 0.0594
Plasmodium vivax SET domain protein, putative 0.0035 0.0224 0.1821
Onchocerca volvulus 0.0035 0.022 0.0219
Trypanosoma cruzi DNA polymerase kappa, putative 0.0045 0.0313 0.2543
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0224 0.03
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0038 0.0247 0.2008
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0053 0.0391 0.0446
Brugia malayi Methyltransferase-like protein 4 0.017 0.1496 0.1486
Trypanosoma brucei DNA polymerase IV, putative 0.0045 0.0313 0.2543
Echinococcus granulosus histone acetyltransferase MYST2 0.0063 0.0485 0.0635
Trypanosoma cruzi NADP-dependent alcohol hydrogenase, putative 0.0035 0.022 0.1791
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.002 0.0079 0.009
Schistosoma mansoni phd/f-box containing protein 0.0018 0.0061 0.0082
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0053 0.0391 0.0429
Loa Loa (eye worm) apoptosis regulator protein 0.0096 0.0798 0.0889
Echinococcus multilocularis histone acetyltransferase MYST2 0.0063 0.0485 0.0573
Loa Loa (eye worm) hypothetical protein 0.0316 0.2878 0.3242
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0019 0.0073 0.0433
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0019 0.0073 0.0069
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.0087 0.0707 0.0637
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0057 0.0428 0.0271
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0454 0.4181 0.5306
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0038 0.0247 0.0798
Schistosoma mansoni jumonji/arid domain-containing protein 0.007 0.0552 0.074
Trypanosoma cruzi hypothetical protein, conserved 0.0014 0.0021 0.0163
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0057 0.0428 0.0271
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0045 0.0313 0.0403
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0035 0.0224 0.03
Trichomonas vaginalis CAMK family protein kinase 0.011 0.0926 0.2962
Leishmania major cathepsin L-like protease 0.0019 0.0073 0.0483
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.0096 0.0798 0.1055
Schistosoma mansoni hypothetical protein 0.0096 0.0798 0.1069
Echinococcus multilocularis Malonyl coenzyme A acyl carrier protein transacylase 0.0036 0.0226 0.0222
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0843 0.7862 1
Entamoeba histolytica serine/threonine protein kinase, putative 0.011 0.0926 0.299
Toxoplasma gondii type I fatty acid synthase, putative 0.0599 0.5555 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0021 0.0163
Plasmodium vivax hypothetical protein, conserved 0.0081 0.0654 0.5323
Trypanosoma brucei Acyl carrier protein, mitochondrial 0.0057 0.0428 0.3482
Trypanosoma cruzi DNA damage repair protein, putative 0.0014 0.0021 0.0163
Schistosoma mansoni aldehyde dehydrogenase 0.007 0.0555 0.0744
Trichomonas vaginalis CAMK family protein kinase 0.011 0.0926 0.2962
Mycobacterium ulcerans thioesterase 0.047 0.4334 0.5501
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0589 0.4795
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0057 0.0428 0.0519
Leishmania major cathepsin L-like protease 0.0019 0.0073 0.0483
Wolbachia endosymbiont of Brugia malayi acyl carrier protein 0.0057 0.0428 0.3482
Mycobacterium ulcerans non-ribosomal peptide synthetase 0.0057 0.0428 0.0519
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0035 0.022 0.0209
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0339 0.3096 1
Trichomonas vaginalis CAMK family protein kinase 0.011 0.0926 0.2962
Echinococcus multilocularis cathepsin L cysteine protease 0.0019 0.0073 0.0016
Brugia malayi Cathepsin L-like precursor 0.0019 0.0073 0.0061
Brugia malayi ADP-specific Phosphofructokinase/Glucokinase conserved region family protein 0.0036 0.0226 0.0214
Entamoeba histolytica recQ family helicase, putative 0.0023 0.0107 0.0344
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0339 0.3096 1
Mycobacterium ulcerans polyketide synthase Pks13 0.0843 0.7862 1
Brugia malayi jmjC domain containing protein 0.0018 0.0061 0.0049
Trypanosoma cruzi oxidoreductase, putative 0.0035 0.022 0.1791
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0038 0.0247 0.1648
Mycobacterium ulcerans DNA polymerase IV 0.0045 0.0313 0.0373
Schistosoma mansoni DNA helicase recq1 0.0023 0.0107 0.0143
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0068 0.0535 0.0701
Brugia malayi Pre-SET motif family protein 0.0242 0.218 0.217
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0256 0.079
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.007 0.0555 0.0668
Onchocerca volvulus 0.0527 0.4873 0.5121
Loa Loa (eye worm) jmjC domain-containing protein 0.0018 0.0061 0.0056
Trypanosoma brucei oxidoreductase, putative 0.0035 0.022 0.1791
Onchocerca volvulus Cathepsin L homolog 0.0019 0.0073 0.0064
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.007 0.0555 0.0438
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0166 0.1456 0.1617
Brugia malayi hypothetical protein 0.0514 0.475 0.4743
Leishmania major cathepsin L-like protease 0.0019 0.0073 0.0483
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0019 0.0073 0.0433
Plasmodium vivax 3-oxoacyl-[acyl-carrier-protein] synthase i/ii, putative 0.0142 0.1228 1
Mycobacterium tuberculosis Meromycolate extension acyl carrier protein AcpM 0.0057 0.0428 0.0271
Entamoeba histolytica cysteine protease, putative 0.0019 0.0073 0.0235
Schistosoma mansoni apoptosis regulator bax 0.0096 0.0798 0.1069
Trypanosoma brucei hypothetical protein, conserved 0.0014 0.0021 0.0163
Trypanosoma cruzi polo-like protein kinase, putative 0.011 0.0926 0.7537
Loa Loa (eye worm) mannose-6-phosphate isomerase 0.0113 0.0956 0.1068
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0073 0.0197
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0589 0.4795
Giardia lamblia Fructose-bisphosphate aldolase 0.0339 0.3096 1
Giardia lamblia Sgs1 DNA helicase, putative 0.0023 0.0107 0.028
Loa Loa (eye worm) hypothetical protein 0.0063 0.0485 0.0535
Mycobacterium ulcerans zinc-dependent alcohol dehydrogenase AdhE2 0.0035 0.022 0.0255
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0527 0.4873 0.55
Echinococcus multilocularis dna polymerase eta 0.0074 0.0592 0.0717
Entamoeba histolytica mannose-6-phosphate isomerase, putative 0.0052 0.0378 0.122
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.0391 0.0524
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0023 0.0107 0.0095
Mycobacterium ulcerans Type I modular polyketide synthase 0.0564 0.5224 0.6635
Trichomonas vaginalis CAMK family protein kinase 0.0054 0.0402 0.1265
Schistosoma mansoni DNA helicase recq5 0.0023 0.0107 0.0143
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0073 0.0197
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0055 0.0413 0.0422
Mycobacterium ulcerans thioesterase TesA 0.047 0.4334 0.5501
Trypanosoma brucei Trans-2-enoyl-ACP reductase 2, putative 0.0035 0.022 0.1791
Brugia malayi Bloom's syndrome protein homolog 0.0023 0.0107 0.0095
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0045 0.0313 0.034
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0224 0.03
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0018 0.0061 0.011
Mycobacterium ulcerans NADP-dependent oxidoreductase 0.0035 0.022 0.0255
Loa Loa (eye worm) hypothetical protein 0.0018 0.0061 0.0056
Leishmania major DNA polymerase kappa, putative 0.0014 0.0021 0.0134
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0599 0.5555 0.6981
Echinococcus granulosus dnaJ subfamily B 0.0475 0.4378 0.586
Brugia malayi Phosphopantetheine attachment site family protein 0.0057 0.0428 0.0416
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0073 0.0197
Schistosoma mansoni methyltransferase-related 0.017 0.1496 0.2005
Entamoeba histolytica cysteine proteinase, putative 0.0013 0.0012 0.0039
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0096 0.0798 0.0787
Brugia malayi jmjC domain containing protein 0.0068 0.0535 0.0523
Mycobacterium ulcerans polyketide synthase 0.0599 0.5555 0.7058
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0589 0.4795
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0057 0.0428 0.0271
Mycobacterium ulcerans fatty acid synthase Fas 0.0177 0.1565 0.1969
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0057 0.0428 0.0519
Loa Loa (eye worm) CXXC zinc finger family protein 0.0033 0.0204 0.0217
Echinococcus granulosus Malonyl coenzyme A acyl carrier protein transacylase 0.0036 0.0226 0.0287
Mycobacterium ulcerans quinone oxidoreductase 0.0035 0.022 0.0255
Mycobacterium ulcerans zinc-dependent alcohol dehydrogenase 0.0035 0.022 0.0255
Trypanosoma cruzi DNA polymerase kappa, putative 0.0045 0.0313 0.2543
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0023 0.0107 0.0192
Trypanosoma brucei DNA polymerase IV, putative 0.0045 0.0313 0.2543
Echinococcus multilocularis AMP dependent ligase 0.0057 0.0428 0.0496
Entamoeba histolytica NADP-dependent alcohol dehydrogenase, putative 0.0035 0.022 0.0712
Brugia malayi mannose-6-phosphate isomerase, class I family protein 0.0113 0.0956 0.0945
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0023 0.0107 0.0127
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0073 0.0197
Echinococcus multilocularis 3 oxoacyl (acyl carrier protein) synthase 0.0142 0.1228 0.1577
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0313 0.2543
Mycobacterium leprae Polyketide synthase Pks13 0.0843 0.7862 1
Loa Loa (eye worm) mbt repeat family protein 0.0055 0.0413 0.0453
Trypanosoma brucei beta-ketoacyl-ACP synthase 0.0142 0.1228 1
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0081 0.0654 0.5243
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0043 0.03 0.054
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0063 0.0485 0.0473
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0339 0.3096 1
Schistosoma mansoni [ACP] S-malonyltransferase 0.0036 0.0226 0.0303
Brugia malayi mannose-6-phosphate isomerase, class I family protein 0.0113 0.0956 0.0945
Loa Loa (eye worm) hypothetical protein 0.0188 0.1671 0.1877
Loa Loa (eye worm) hypothetical protein 0.0087 0.0707 0.0787
Echinococcus multilocularis mitochondrial trans 2 enoyl coenzyme A reductase 0.0035 0.022 0.0215
Trypanosoma brucei DNA damage repair protein, putative 0.0014 0.0021 0.0163
Schistosoma mansoni serine/threonine protein kinase 0.011 0.0926 0.1241
Plasmodium vivax malonyl CoA-acyl carrier protein transacylase precursor, putative 0.0036 0.0226 0.1839
Loa Loa (eye worm) ctsf protein 0.0019 0.0073 0.0069
Trypanosoma cruzi DNA polymerase eta, putative 0.0074 0.0592 0.482
Brugia malayi Probable ATP-dependent helicase DHX35 0.0188 0.1671 0.1661
Trypanosoma cruzi DNA polymerase kappa, putative 0.0045 0.0313 0.2543
Mycobacterium ulcerans 3-oxoacyl-(acyl carrier protein) synthase II 0.0142 0.1228 0.154
Echinococcus multilocularis cysteine protease 0.0019 0.0073 0.0016
Schistosoma mansoni jumonji/arid domain-containing protein 0.007 0.0552 0.074
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0166 0.1456 0.183
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.0391 0.0524
Mycobacterium ulcerans zinc-containing alcohol dehydrogenase NAD dependent AdhB 0.0035 0.022 0.0255
Brugia malayi CXXC zinc finger family protein 0.0033 0.0204 0.0192
Loa Loa (eye worm) hypothetical protein 0.0018 0.0061 0.0056
Mycobacterium ulcerans NADPH quinone oxidoreductase FadB4 0.0035 0.022 0.0255
Echinococcus multilocularis SAM and MBT domain containing protein 0.0055 0.0413 0.0475
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0045 0.0313 0.2087
Plasmodium vivax mannose-6-phosphate isomerase, putative 0.0113 0.0956 0.7786
Plasmodium falciparum malonyl CoA-acyl carrier protein transacylase 0.0036 0.0226 0.17
Plasmodium vivax vivapain-2 0.0019 0.0073 0.0594
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0547 0.506 0.6333
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0018 0.0061 0.0494
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.011 0.0926 0.1168
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0599 0.5555 0.6981
Plasmodium falciparum 3-oxoacyl-acyl-carrier protein synthase I/II 0.0142 0.1228 1
Trichomonas vaginalis CAMK family protein kinase 0.0054 0.0402 0.1265
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0218 0.1952 0.2555
Trypanosoma cruzi Acyl carrier protein, mitochondrial, putative 0.0057 0.0428 0.3482
Trypanosoma brucei unspecified product 0.0031 0.0181 0.1472
Leishmania major cathepsin L-like protease 0.0074 0.0589 0.3936
Leishmania major DNA polymerase eta, putative 0.0074 0.0592 0.3956
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0023 0.0107 0.0061
Mycobacterium leprae probable mannose-6-phosphate isomerase ManA (PHOSPHOMANNOSE ISOMERASE) (PHOSPHOMANNOISOMERASE) (PMI) (PHOSPHOHEXOISOMERASE) (PHO 0.0061 0.0468 0.0323
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0599 0.5555 0.7058
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0035 0.0224 0.0219
Brugia malayi Cathepsin L-like precursor 0.0019 0.0073 0.0061
Leishmania major oxidoreductase, putative 0.0035 0.022 0.147
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0589 0.4795
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0073 0.0197
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0055 0.0413 0.0553
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0019 0.0073 0.0197
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0547 0.506 0.6333
Loa Loa (eye worm) jmjC domain-containing protein 0.0018 0.0061 0.0056
Onchocerca volvulus Acyl carrier protein, mitochondrial homolog 0.0057 0.0428 0.0438
Echinococcus multilocularis Protein lozenge 0.0064 0.0499 0.0591
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0063 0.0485 0.0573
Toxoplasma gondii quinone oxidoreductase, putative 0.0035 0.022 0.0397
Leishmania major cathepsin L-like protease 0.0019 0.0073 0.0483
Mycobacterium tuberculosis Hypothetical protein 0.017 0.1496 0.1669
Entamoeba histolytica cysteine proteinase, putative 0.0019 0.0073 0.0235
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0023 0.0107 0.0709
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE 0.0373 0.3417 0.4183
Leishmania major phosphomannose isomerase 0.0113 0.0956 0.639
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0073 0.0197
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0039 0.0256 0.0244
Echinococcus granulosus lysine specific demethylase 6a 0.0018 0.0061 0.0066
Loa Loa (eye worm) hypothetical protein 0.0035 0.022 0.0236
Entamoeba histolytica NADP-dependent alcohol dehydrogenase, putative 0.0035 0.022 0.0712
Leishmania major acyl carrier protein, putative 0.0057 0.0428 0.2858
Mycobacterium ulcerans DNA polymerase IV 0.0045 0.0313 0.0373
Onchocerca volvulus Cathepsin L homolog 0.0019 0.0073 0.0064
Mycobacterium ulcerans aldehyde dehydrogenase 0.007 0.0555 0.0682
Giardia lamblia Kinase, PLK 0.011 0.0926 0.2943
Mycobacterium ulcerans polyketide synthase Pks9 0.0373 0.3417 0.4331
Leishmania major hypothetical protein, conserved 0.0018 0.0061 0.0406
Trypanosoma cruzi NADP-dependent alcohol hydrogenase, putative 0.0035 0.022 0.1791
Onchocerca volvulus Fatty acid synthase homolog 0.1017 0.9505 1
Toxoplasma gondii acyl carrier protein ACP 0.0057 0.0428 0.077
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0023 0.0107 0.0712
Echinococcus granulosus phd:f box containing protein 0.0018 0.0061 0.0066
Loa Loa (eye worm) mannose-6-phosphate isomerase 0.0113 0.0956 0.1068
Loa Loa (eye worm) acyl carrier protein 0.0057 0.0428 0.047
Trypanosoma brucei DNA polymerase eta, putative 0.0074 0.0592 0.482
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0366 0.335 0.603
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0096 0.0798 0.0995
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0096 0.0798 0.1069
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0073 0.0197
Trichomonas vaginalis CAMK family protein kinase 0.011 0.0926 0.2962
Mycobacterium ulcerans Type I modular polyketide synthase 0.0564 0.5224 0.6635
Toxoplasma gondii PPIC-type PPIASE domain-containing protein 0.0012 0.0001 0.0001
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0073 0.0197
Loa Loa (eye worm) transcription factor SMAD2 0.0139 0.1199 0.1343
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0073 0.0197
Brugia malayi Cathepsin L-like precursor 0.0019 0.0073 0.0061
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0564 0.5224 0.6547
Loa Loa (eye worm) jmjC domain-containing protein 0.007 0.0552 0.0611
Onchocerca volvulus 0.0276 0.2495 0.2616
Onchocerca volvulus 0.0019 0.0073 0.0064
Echinococcus granulosus cathepsin l cysteine peptidase 0.0019 0.0073 0.0082
Trypanosoma cruzi beta-ketoacyl synthase family protein, putative 0.0142 0.1228 1
Brugia malayi jmjC domain containing protein 0.007 0.0552 0.0541
Loa Loa (eye worm) hypothetical protein 0.0035 0.0224 0.0239
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0096 0.0798 0.1055
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0073 0.0197
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0339 0.3096 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0057 0.0428 0.1382
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0073 0.0197
Trypanosoma cruzi nuclear receptor binding factor, putative 0.0035 0.022 0.1791
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0224 0.03
Echinococcus granulosus cathepsin L cysteine proteinase 0.0019 0.0073 0.0082
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0023 0.0107 0.0127
Trichomonas vaginalis DNA helicase recq1, putative 0.0023 0.0107 0.0306
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0073 0.0197
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 0.0057 0.0428 0.0519
Schistosoma mansoni hypothetical protein 0.0475 0.4378 0.5867
Giardia lamblia Methyltransferase like 2 0.017 0.1496 0.4797
Mycobacterium ulcerans dehydrogenase 0.0035 0.022 0.0255
Schistosoma mansoni mannose-6-phosphate isomerase 0.0113 0.0956 0.1281
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0057 0.0428 0.0271
Trypanosoma cruzi DNA damage repair protein, putative 0.0014 0.0021 0.0163
Mycobacterium ulcerans hypothetical protein 0.0057 0.0428 0.0519
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0057 0.0428 0.0519
Echinococcus granulosus dna polymerase eta 0.0074 0.0592 0.0779
Echinococcus granulosus histone lysine methyltransferase setb 0.0035 0.0224 0.0284
Trypanosoma cruzi polo-like protein kinase, putative 0.011 0.0926 0.7537
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0589 0.4795
Echinococcus granulosus bloom syndrome protein 0.0023 0.0107 0.0127
Schistosoma mansoni cpg binding protein 0.0035 0.0222 0.0298
Echinococcus granulosus JmjC domain containing protein 4 0.0018 0.0061 0.0066
Trypanosoma cruzi beta-ketoacyl synthase family protein, putative 0.0142 0.1228 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0313 0.2543
Trypanosoma cruzi oxidoreductase, putative 0.0035 0.022 0.1791
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0045 0.0313 0.034
Schistosoma mansoni phosphatidylserine receptor 0.0018 0.0061 0.0082
Echinococcus granulosus cathepsin l1 0.0019 0.0073 0.0082
Chlamydia trachomatis acyl carrier protein 0.0057 0.0428 0.2016
Plasmodium falciparum cysteine proteinase falcipain 3 0.0019 0.0073 0.0433
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.011 0.0926 0.1034
Loa Loa (eye worm) hypothetical protein 0.0514 0.475 0.536
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0589 0.4795
Onchocerca volvulus 0.0055 0.0413 0.0422
Mycobacterium ulcerans mannose-6-phosphate isomerase ManA 0.0113 0.0956 0.1193
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0019 0.0073 0.0016
Schistosoma mansoni rotamase 0.0039 0.0256 0.0343
Trichomonas vaginalis DNA helicase recq, putative 0.0023 0.0107 0.0306
Mycobacterium tuberculosis Probable acyl carrier protein AcpA (ACP) 0.0057 0.0428 0.0271
Trypanosoma cruzi DNA polymerase kappa, putative 0.0045 0.0313 0.2543
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0599 0.5555 0.7058
Trypanosoma brucei DNA polymerase kappa, putative 0.0031 0.0181 0.1472
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0045 0.0313 0.0121
Onchocerca volvulus 0.0019 0.0073 0.0064
Onchocerca volvulus Cathepsin F homolog 0.0019 0.0073 0.0064
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0405 0.3721 0.4581
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0057 0.0428 0.0271
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0313 0.2543
Trypanosoma brucei polo-like protein kinase 0.011 0.0926 0.7537
Onchocerca volvulus Serine\/threonine kinase homolog 0.011 0.0926 0.0962
Mycobacterium leprae Probable polyketide synthase Pks1 0.0599 0.5555 0.6981
Mycobacterium tuberculosis Probable thioesterase TesA 0.047 0.4334 0.5384
Loa Loa (eye worm) hypothetical protein 0.0023 0.0107 0.0107
Trypanosoma cruzi nuclear receptor binding factor, putative 0.0035 0.022 0.1791
Echinococcus multilocularis cysteine protease 0.0019 0.0073 0.0016
Mycobacterium tuberculosis Acyl carrier protein (ACP) MbtL 0.0057 0.0428 0.0271
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0018 0.0061 0.0082
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.002 0.0079 0.0024
Trichomonas vaginalis DNA polymerase eta, putative 0.0045 0.0313 0.0974
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0599 0.5555 0.6981
Wolbachia endosymbiont of Brugia malayi ACP S-malonyltransferase 0.0036 0.0226 0.1835
Leishmania major d-xylulose reductase, putative 0.0035 0.022 0.147
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0035 0.022 0.0209
Echinococcus granulosus acyl carrier protein mitochondrial 0.0057 0.0428 0.0558
Loa Loa (eye worm) hypothetical protein 0.0074 0.0592 0.0656
Toxoplasma gondii acyl transferase domain-containing protein 0.0036 0.0226 0.0407
Trypanosoma cruzi phosphomannose isomerase, putative 0.0113 0.0956 0.7785
Plasmodium vivax JmjC domain containing protein 0.0018 0.0061 0.0499
Schistosoma mansoni acyl carrier protein 0.0057 0.0428 0.0574
Mycobacterium ulcerans Type I modular polyketide synthase 0.0564 0.5224 0.6635
Echinococcus granulosus microtubule associated protein 2 0.0801 0.7462 1
Wolbachia endosymbiont of Brugia malayi 3-oxoacyl-ACP synthase 0.0142 0.1228 1
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.0461 0.4252 0.5275
Echinococcus granulosus serine:threonine protein kinase PLK1 0.011 0.0926 0.1226
Loa Loa (eye worm) MH2 domain-containing protein 0.0139 0.1199 0.1343
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0023 0.0107 0.0095
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0339 0.3096 1
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0454 0.4181 0.5306
Trypanosoma cruzi cysteine peptidase, putative 0.0074 0.0589 0.4795
Trichomonas vaginalis mannose-6-phosphate isomerase, putative 0.0113 0.0956 0.3061
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0073 0.0197
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0339 0.3096 1
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.0564 0.5224 0.6547
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0242 0.218 0.2453
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0073 0.0197
Brugia malayi ImpB/MucB/SamB family protein 0.0045 0.0313 0.0301
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.047 0.4334 0.5384
Schistosoma mansoni alcohol dehydrogenase 0.0035 0.022 0.0295
Schistosoma mansoni sex comb on midleg homolog 0.0055 0.0413 0.0553
Echinococcus granulosus SAM and MBT domain containing protein 0.0055 0.0413 0.0538
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0073 0.0197
Loa Loa (eye worm) RecQ helicase 0.0023 0.0107 0.0107
Mycobacterium ulcerans NADP-dependent alcohol dehydrogenase Adh 0.0035 0.022 0.0255
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0023 0.0107 0.0864
Trypanosoma cruzi hypothetical protein, conserved 0.0014 0.0021 0.0163
Entamoeba histolytica NADP-dependent alcohol dehydrogenase 0.0035 0.022 0.0712
Echinococcus multilocularis cpg binding protein 0.0035 0.0222 0.0218
Schistosoma mansoni DNA polymerase eta 0.0074 0.0592 0.0794
Leishmania major beta-ketoacyl synthase family protein, putative,3-oxoacyl-acyl carrier protein synthase ii, putative 0.0142 0.1228 0.8208
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0038 0.0247 0.2008
Schistosoma mansoni 3-oxoacyl-[ACP] synthase 0.0142 0.1228 0.1646
Mycobacterium tuberculosis Probable polyketide synthase Pks15 0.0228 0.2046 0.2389
Treponema pallidum fructose-bisphosphate aldolase 0.0339 0.3096 1
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0057 0.0428 0.0271
Leishmania major NADP-dependent alcohol dehydrogenase, putative 0.0035 0.022 0.147
Echinococcus granulosus mannose 6 phosphate isomerase 0.0113 0.0956 0.1267
Chlamydia trachomatis 3-oxoacyl-ACP synthase 0.0142 0.1228 1
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0166 0.1456 0.1617
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0339 0.3096 1
Mycobacterium ulcerans quinone reductase Qor 0.0035 0.022 0.0255
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0045 0.0313 0.0419
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0035 0.0224 0.0219
Mycobacterium tuberculosis Probable fatty acid synthase Fas (fatty acid synthetase) 0.0177 0.1565 0.1759
Onchocerca volvulus 0.0019 0.0073 0.0064
Leishmania major cathepsin L-like protease 0.0074 0.0589 0.3936
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0063 0.0485 0.0635
Onchocerca volvulus 0.0019 0.0073 0.0064
Giardia lamblia DINP protein human, muc B family 0.0045 0.0313 0.095
Onchocerca volvulus 0.0035 0.022 0.0219
Plasmodium falciparum acyl carrier protein 0.0057 0.0428 0.3374
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0599 0.5555 0.6981
Mycobacterium tuberculosis Probable polyketide beta-ketoacyl synthase Pks4 0.0087 0.0707 0.0637
Brugia malayi ImpB/MucB/SamB family protein 0.0074 0.0592 0.0581
Plasmodium vivax acyl carrier protein, putative 0.0057 0.0428 0.3485
Leishmania major quinone oxidoreductase, putative 0.0035 0.022 0.147
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0339 0.3096 1
Loa Loa (eye worm) phosphopantetheine attachment site family protein 0.0057 0.0428 0.047
Wolbachia endosymbiont of Brugia malayi NADPH:quinone reductase 0.0035 0.022 0.1791
Schistosoma mansoni [ACP] S-malonyltransferase 0.0036 0.0226 0.0303
Loa Loa (eye worm) acyl carrier protein 0.0259 0.2342 0.2636
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0313 0.2543
Brugia malayi AMP-binding enzyme family protein 0.0527 0.4873 0.4867
Loa Loa (eye worm) hypothetical protein 0.0018 0.0061 0.0056
Trypanosoma cruzi acyl transferase-like protein, putative 0.0036 0.0226 0.1835
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0019 0.0073 0.0197
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0313 0.2543
Mycobacterium ulcerans acyl carrier protein 0.0057 0.0428 0.0519
Loa Loa (eye worm) runx1 0.0064 0.0499 0.0551
Schistosoma mansoni cpg binding protein 0.0033 0.0204 0.0274
Loa Loa (eye worm) hypothetical protein 0.0036 0.0226 0.0242
Leishmania major cathepsin L-like protease 0.0074 0.0589 0.3936
Mycobacterium ulcerans malonyl CoA-acyl carrier protein transacylase FabD 0.0036 0.0226 0.0262
Loa Loa (eye worm) fatty acid synthase 0.0556 0.5152 0.5816
Echinococcus granulosus expressed protein 0.0039 0.0256 0.0327
Mycobacterium ulcerans 3-oxoacyl-(acyl carrier protein) synthase II 0.0142 0.1228 0.154
Leishmania major DNA polymerase eta, putative 0.0043 0.03 0.2003
Mycobacterium leprae conserved hypothetical protein 0.0057 0.0428 0.0271
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0019 0.0073 0.0016
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0057 0.0428 0.0519
Trypanosoma brucei acyl transferase-like protein 0.0036 0.0226 0.1835
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0339 0.3096 1
Echinococcus granulosus lysine specific demethylase 5A 0.007 0.0552 0.0725
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0087 0.0707 0.0637
Trypanosoma cruzi DNA polymerase eta, putative 0.0043 0.03 0.244
Trypanosoma cruzi oxidoreductase, putative 0.0035 0.022 0.1791
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0018 0.0061 0.0494
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0564 0.5224 0.6547
Echinococcus multilocularis polycomb protein SCMH1 0.0055 0.0413 0.0475
Onchocerca volvulus 0.0019 0.0073 0.0064
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0014 0.0021 0.0037
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0068 0.0535 0.064
Mycobacterium ulcerans NADP-dependent alcohol dehydrogenase AdhC 0.0035 0.022 0.0255
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0564 0.5224 0.6547
Brugia malayi Cathepsin L-like precursor 0.0019 0.0073 0.0061
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0218 0.1952 0.2604
Toxoplasma gondii histone lysine methyltransferase SET1 0.0064 0.0498 0.0897
Onchocerca volvulus 0.0033 0.0204 0.0202
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.0373 0.3417 0.4331
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0527 0.4873 0.6089
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.0454 0.4181 0.5183
Schistosoma mansoni sex comb on midleg homolog 0.0055 0.0413 0.0553
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0589 0.4795
Mycobacterium tuberculosis Polyketide synthetase MbtD (polyketide synthase) 0.0173 0.1529 0.1713
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0313 0.2543
Schistosoma mansoni [ACP] S-malonyltransferase 0.0036 0.0226 0.0303
Schistosoma mansoni microtubule-associated protein tau 0.0801 0.7462 1
Brugia malayi jmjC domain containing protein 0.0018 0.0061 0.0049
Onchocerca volvulus 0.0035 0.0224 0.0223
Mycobacterium ulcerans oxidoreductase 0.0035 0.022 0.0255
Loa Loa (eye worm) hypothetical protein 0.0055 0.0413 0.0453
Leishmania major cathepsin L-like protease 0.0019 0.0073 0.0483
Onchocerca volvulus 0.0019 0.0073 0.0064
Leishmania major zinc-binding dehydrogenase-like protein 0.0035 0.022 0.147
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0053 0.0391 0.0509
Entamoeba histolytica acyl-CoA synthetase, putative 0.0057 0.0428 0.1382
Brugia malayi jmjC domain containing protein 0.0018 0.0061 0.0049
Echinococcus multilocularis bloom syndrome protein 0.0023 0.0107 0.0061
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0564 0.5224 0.6635
Schistosoma mansoni hypothetical protein 0.0057 0.0428 0.0574
Schistosoma mansoni hypothetical protein 0.0096 0.0798 0.1069
Trypanosoma brucei DNA polymerase kappa, putative 0.0031 0.0181 0.1472
Trypanosoma brucei hypothetical protein, conserved 0.0014 0.0021 0.0163
Loa Loa (eye worm) hypothetical protein 0.0947 0.885 1
Leishmania major hypothetical protein, conserved 0.0036 0.0226 0.1506
Plasmodium vivax DNA repair protein REV1, putative 0.0014 0.0021 0.0168
Mycobacterium ulcerans Zn-dependent alcohol dehydrogenase, AdhX 0.0035 0.022 0.0255
Echinococcus multilocularis microtubule associated protein 2 0.0801 0.7462 1
Brugia malayi AMP-binding enzyme family protein 0.0173 0.1529 0.1519
Trypanosoma cruzi NADP-dependent alcohol hydrogenase, putative 0.0035 0.022 0.1791
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0564 0.5224 0.5218
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0053 0.0391 0.0509
Echinococcus granulosus polycomb protein SCMH1 0.0055 0.0413 0.0538
Trichomonas vaginalis CAMK family protein kinase 0.011 0.0926 0.2962
Leishmania major DNA damage repair protein, putative 0.0014 0.0021 0.0134
Trypanosoma brucei unspecified product 0.0031 0.0181 0.1472
Trichomonas vaginalis CAMK family protein kinase 0.011 0.0926 0.2962
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0073 0.0197
Echinococcus multilocularis expressed protein 0.0039 0.0256 0.0263
Toxoplasma gondii Zn-containing alcohol dehydrogenase 0.0035 0.022 0.0397
Schistosoma mansoni lozenge 0.0064 0.0499 0.0669
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0035 0.0224 0.0403
Schistosoma mansoni aldehyde dehydrogenase 0.007 0.0555 0.0744
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0021 0.0163
Loa Loa (eye worm) jmjC domain-containing protein 0.0018 0.0061 0.0056
Trypanosoma cruzi acyl transferase-like protein 0.0036 0.0226 0.1835
Brugia malayi acyl carrier protein, mitochondrial precursor, putative 0.0057 0.0428 0.0416
Loa Loa (eye worm) hypothetical protein 0.0514 0.475 0.536
Schistosoma mansoni cathepsin F (C01 family) 0.0013 0.0012 0.0016
Brugia malayi polk-prov protein 0.0014 0.0021 0.0008
Brugia malayi Cathepsin L-like precursor 0.0019 0.0073 0.0061
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.0096 0.0798 0.0995
Mycobacterium tuberculosis Conserved hypothetical protein 0.0057 0.0428 0.0271
Schistosoma mansoni myelin transcription factor 1 myt1 0.0063 0.0485 0.065
Mycobacterium ulcerans quinone oxidoreductase 0.0035 0.022 0.0255
Echinococcus granulosus AMP dependent ligase 0.0057 0.0428 0.0558
Entamoeba histolytica cysteine proteinase, putative 0.0019 0.0073 0.0235
Trichomonas vaginalis set domain proteins, putative 0.0276 0.2495 0.8051
Leishmania major nuclear receptor binding factor-like protein 0.0035 0.022 0.147
Brugia malayi mbt repeat family protein 0.0055 0.0413 0.0401
Trypanosoma brucei DNA polymerase IV, putative 0.0045 0.0313 0.2543
Toxoplasma gondii peptidylprolyl isomerase 0.0038 0.0247 0.0445
Trypanosoma cruzi NADP-dependent alcohol hydrogenase, putative 0.0035 0.022 0.1791
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0313 0.2543
Schistosoma mansoni jumonji domain containing protein 0.0068 0.0535 0.0716
Mycobacterium ulcerans polyketide synthase MbtD 0.0173 0.1529 0.1924
Loa Loa (eye worm) cysteine protease 0.0019 0.0073 0.0069
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0599 0.5555 0.6981
Brugia malayi MH2 domain containing protein 0.0139 0.1199 0.1189
Echinococcus multilocularis NADH dehydrogenase 0.0057 0.0428 0.0496
Trypanosoma brucei oxidoreductase, putative 0.0035 0.022 0.1791
Trypanosoma cruzi cysteine peptidase, putative 0.0019 0.0073 0.0589
Mycobacterium tuberculosis Conserved hypothetical protein 0.0045 0.0313 0.0121
Echinococcus multilocularis dnaJ subfamily B 0.0475 0.4378 0.5833
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0073 0.0197
Schistosoma mansoni protein phosphatase 2C 0.0018 0.0061 0.0082
Trypanosoma brucei unspecified product 0.0045 0.0313 0.2543
Mycobacterium ulcerans zinc-containing alcohol dehydrogenase NAD-dependent AdhB 0.0035 0.022 0.0255
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0072 0.057 0.0763
Toxoplasma gondii type I fatty acid synthase, putative 0.0401 0.3686 0.6636
Trichomonas vaginalis conserved hypothetical protein 0.017 0.1496 0.4811
Onchocerca volvulus 0.0057 0.0428 0.0438
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0033 0.0205 0.0258
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0313 0.2543
Loa Loa (eye worm) fibroinase 0.0019 0.0073 0.0069
Mycobacterium ulcerans oxidoreductase 0.0035 0.022 0.0255
Mycobacterium ulcerans short-chain dehydrogenase 0.0035 0.022 0.0255
Plasmodium falciparum mannose-6-phosphate isomerase, putative 0.0113 0.0956 0.7748
Brugia malayi mbt repeat family protein 0.0055 0.0413 0.0401
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0313 0.2543
Entamoeba histolytica deoxycytidyl transferase, putative 0.0045 0.0313 0.101
Mycobacterium ulcerans zinc-type alcohol dehydrogenase AdhD 0.0035 0.022 0.0255
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0073 0.0197
Schistosoma mansoni DNA polymerase IV / kappa 0.0014 0.0021 0.0028
Echinococcus granulosus cpg binding protein 0.0035 0.0222 0.0282
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0018 0.0061 0.011
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0589 0.4795
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0073 0.0197
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0035 0.022 0.0676
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0023 0.0107 0.0061
Toxoplasma gondii phosphomannose isomerase type I protein 0.0113 0.0956 0.1721
Trypanosoma cruzi major cysteine proteinase, putative 0.0058 0.0439 0.3575
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.007 0.0555 0.0729
Trypanosoma cruzi cruzipain precursor, putative 0.0074 0.0589 0.4795
Echinococcus granulosus 3 oxoacyl acyl carrier protein synthase 0.0142 0.1228 0.1632
Schistosoma mansoni cpg binding protein 0.0035 0.0222 0.0298
Trypanosoma cruzi cysteine peptidase, putative 0.0074 0.0589 0.4795
Loa Loa (eye worm) MBCTL1 0.0063 0.0485 0.0535
Toxoplasma gondii aldehyde dehydrogenase 0.007 0.0555 0.1
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0038 0.0247 0.2008
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0023 0.0107 0.0107
Loa Loa (eye worm) hypothetical protein 0.0087 0.0707 0.0787
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0018 0.0061 0.0494
Toxoplasma gondii type I fatty acid synthase 0.0087 0.0707 0.1273
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0073 0.0197
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0843 0.7862 1
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0023 0.0107 0.0864
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.0391 0.0524
Mycobacterium tuberculosis Conserved protein 0.017 0.1496 0.1669
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0053 0.0391 0.0379
Schistosoma mansoni kinase 0.0056 0.0416 0.0557
Mycobacterium tuberculosis Probable polyketide synthase Pks17 0.0138 0.1193 0.1272
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0589 0.4795
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0023 0.0107 0.0712
Toxoplasma gondii cathepsin CPL 0.0019 0.0073 0.0131
Loa Loa (eye worm) beta-ketoacyl synthase domain-containing protein 0.0142 0.1228 0.1376
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0589 0.4795

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -5.128 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.928 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.8 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.771 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.741 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.705 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.668 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.537 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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