Detailed information for compound 1603906

Basic information

Technical information
  • TDR Targets ID: 1603906
  • Name: N-(2-Ethylphenyl)-3,4-bis(4-methoxyphenyl)-2, 4-dioxobutanamide
  • MW: 431.48 | Formula: C26H25NO5
  • H donors: 1 H acceptors: 3 LogP: 4.93 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)C(C(=O)c1ccc(cc1)OC)C(=O)C(=O)Nc1ccccc1CC
  • InChi: 1S/C26H25NO5/c1-4-17-7-5-6-8-22(17)27-26(30)25(29)23(18-9-13-20(31-2)14-10-18)24(28)19-11-15-21(32-3)16-12-19/h5-16,23H,4H2,1-3H3,(H,27,30)
  • InChiKey: KHSCGJATQXQZQI-UHFFFAOYSA-N  

Network

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Synonyms

  • N-(2-ethylphenyl)-3,4-bis(4-methoxyphenyl)-2,4-dioxo-butanamide
  • N-(2-ethylphenyl)-2,4-diketo-3,4-bis(4-methoxyphenyl)butyramide
  • NCI60_006613
  • AIDS-131208
  • AIDS131208
  • NSC622571

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0119 0.0299 0.0546
Brugia malayi Endoplasmin precursor 0.0034 0.0043 0.0062
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.1141 0.3374 0.7056
Schistosoma mansoni coup transcription factor 0.0042 0.0064 0.009
Trichomonas vaginalis ran, putative 0.0024 0.001 0.0108
Echinococcus granulosus heat shock protein 0.0034 0.0043 0.0057
Entamoeba histolytica hypothetical protein 0.0078 0.0174 0.3174
Leishmania major heat shock protein 83-1 0.0034 0.0043 0.0362
Trypanosoma brucei heat shock protein, putative 0.0034 0.0043 0.0442
Loa Loa (eye worm) acyl carrier protein 0.0494 0.1426 0.2645
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0022 0.0006 0.0001
Echinococcus granulosus acyl carrier protein mitochondrial 0.0108 0.0265 0.0398
Schistosoma mansoni hypothetical protein 0.0082 0.0185 0.0275
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0122 0.0308 0.0499
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.0082 0.0803
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.0035 0.0344
Echinococcus multilocularis heat shock protein 90 0.0034 0.0043 0.0038
Trypanosoma cruzi heat shock protein 85, putative 0.0034 0.0043 0.0567
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0122 0.0308 0.0602
Trypanosoma cruzi transcription factor btf3, putative 0.0078 0.0174 0.2312
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0697 0.2037 0.6019
Schistosoma mansoni 3-oxoacyl-[ACP] synthase 0.027 0.0751 0.1139
Mycobacterium tuberculosis Polyketide synthase Pks12 0.1141 0.3374 0.7056
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.0082 0.0803
Schistosoma mansoni hypothetical protein 0.0082 0.0185 0.0275
Leishmania major basic transcription factor 3a, putative 0.0078 0.0174 0.1813
Trypanosoma cruzi NADP-dependent alcohol hydrogenase, putative 0.0067 0.014 0.186
Schistosoma mansoni thyroid hormone receptor 0.0042 0.0064 0.009
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0042 0.0064 0.011
Echinococcus multilocularis AMP dependent ligase 0.011 0.0271 0.0266
Mycobacterium ulcerans polyketide synthase 0.1141 0.3374 0.7056
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.1141 0.3374 0.7056
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.004 0.004
Leishmania major heat shock protein 83-1 0.0034 0.0043 0.0362
Mycobacterium tuberculosis Conserved protein 0.0324 0.0913 0.1877
Echinococcus multilocularis muscleblind protein 1 0.0167 0.0442 0.0437
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0042 0.0064 0.011
Mycobacterium ulcerans polyketide synthase 0.1074 0.3173 0.6633
Brugia malayi F/Y-rich N-terminus family protein 0.0027 0.0021 0.0027
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0042 0.0064 0.0098
Loa Loa (eye worm) hypothetical protein 0.0042 0.0064 0.011
Toxoplasma gondii isocitrate dehydrogenase 0.0066 0.0138 0.039
Mycobacterium ulcerans NADP-dependent oxidoreductase 0.0067 0.014 0.0249
Leishmania major acyl carrier protein, putative 0.0108 0.0265 0.283
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0067 0.014 0.0222
Toxoplasma gondii type I fatty acid synthase, putative 0.0764 0.2241 0.6624
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.1017 0.3003 0.6275
Schistosoma mansoni hypothetical protein 0.0066 0.0138 0.0202
Brugia malayi glutathione reductase 0.0034 0.0041 0.0059
Mycobacterium tuberculosis Polyketide synthetase MbtD (polyketide synthase) 0.033 0.0933 0.1919
Loa Loa (eye worm) hypothetical protein 0.0197 0.0533 0.0983
Loa Loa (eye worm) phosphopantetheine attachment site family protein 0.0108 0.0265 0.0485
Trypanosoma brucei oxidoreductase, putative 0.0067 0.014 0.1753
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0024 0.001 0.0009
Loa Loa (eye worm) hypothetical protein 0.0036 0.0046 0.0076
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.0082 0.0128
Trypanosoma cruzi heat shock protein 85, putative 0.0027 0.0021 0.0285
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0066 0.0138 0.181
Mycobacterium tuberculosis Probable polyketide synthase Pks17 0.0262 0.0729 0.1489
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0086 0.0197 0.0369
Toxoplasma gondii histone lysine methyltransferase SET1 0.017 0.0451 0.1317
Trypanosoma cruzi NADP-dependent alcohol hydrogenase, putative 0.0067 0.014 0.186
Toxoplasma gondii type I fatty acid synthase, putative 0.1143 0.338 1
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0864 0.2541 0.5303
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0042 0.0064 0.009
Toxoplasma gondii quinone oxidoreductase, putative 0.0067 0.014 0.0395
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0066 0.0138 0.0133
Giardia lamblia Grp94/Hsp90 0.0027 0.0021 0.0128
Mycobacterium ulcerans Type I modular polyketide synthase 0.1074 0.3173 0.6633
Leishmania major heat shock protein 83-1 0.0034 0.0043 0.0362
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0042 0.0064 0.0098
Echinococcus granulosus heat shock protein 90 0.0034 0.0043 0.0057
Schistosoma mansoni hypothetical protein 0.0048 0.0084 0.012
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0086 0.0197 0.0369
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0066 0.0138 0.1728
Leishmania major heat shock protein 83-1 0.0034 0.0043 0.0362
Schistosoma mansoni endoplasmin 0.0034 0.0043 0.0057
Mycobacterium ulcerans polyketide synthase MbtD 0.033 0.0933 0.1919
Plasmodium falciparum basic transcription factor 3b, putative 0.0078 0.0174 0.2287
Mycobacterium ulcerans hypothetical protein 0.0108 0.0265 0.0514
Trichomonas vaginalis conserved hypothetical protein 0.0078 0.0174 0.1901
Echinococcus granulosus tar DNA binding protein 0.0067 0.0141 0.0208
Echinococcus granulosus cpg binding protein 0.0095 0.0224 0.0335
Loa Loa (eye worm) beta-ketoacyl synthase domain-containing protein 0.027 0.0751 0.1388
Trypanosoma cruzi NADP-dependent alcohol hydrogenase, putative 0.0067 0.014 0.186
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0165 0.0435 0.087
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0036 0.0046 0.0052
Brugia malayi Thioredoxin reductase 0.0034 0.0041 0.0059
Echinococcus multilocularis survival motor neuron protein 1 0.0236 0.0648 0.0644
Echinococcus granulosus Malonyl coenzyme A acyl carrier protein transacylase 0.0068 0.0143 0.0211
Mycobacterium ulcerans Zn-dependent alcohol dehydrogenase, AdhX 0.0067 0.014 0.0249
Leishmania major oxidoreductase, putative 0.0067 0.014 0.1437
Mycobacterium leprae conserved hypothetical protein 0.0108 0.0265 0.0514
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.2035 0.607 1
Echinococcus multilocularis protein patched 0.0085 0.0194 0.0189
Brugia malayi hypothetical protein 0.0479 0.1381 0.2269
Loa Loa (eye worm) hypothetical protein 0.0067 0.014 0.0251
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0048 0.0082 0.0128
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0122 0.0308 0.0602
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0048 0.0082 0.0128
Mycobacterium leprae Probable oxidireductase 0.0067 0.014 0.0249
Onchocerca volvulus Huntingtin homolog 0.0136 0.0349 0.0573
Leishmania major heat shock protein 83-1 0.0034 0.0043 0.0362
Brugia malayi Latrophilin receptor protein 2 0.0066 0.0138 0.0219
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.1074 0.3173 0.6633
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0042 0.0064 0.009
Mycobacterium tuberculosis Probable polyketide synthase Pks9 0.0611 0.1778 0.3696
Brugia malayi nuclear hormone receptor 0.0042 0.0064 0.0098
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0122 0.0308 0.0602
Mycobacterium ulcerans NADP-dependent alcohol dehydrogenase Adh 0.0067 0.014 0.0249
Schistosoma mansoni hypothetical protein 0.0823 0.2416 0.3685
Loa Loa (eye worm) latrophilin receptor protein 2 0.0066 0.0138 0.0247
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.0082 0.0128
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0122 0.0308 0.0602
Onchocerca volvulus 0.0479 0.1381 0.2367
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0042 0.0064 0.0059
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.1141 0.3374 0.7056
Wolbachia endosymbiont of Brugia malayi ACP S-malonyltransferase 0.0068 0.0143 0.1666
Echinococcus multilocularis transcription factor eb 0.012 0.03 0.0295
Leishmania major oxidoreductase-like protein 0.0067 0.014 0.1437
Plasmodium vivax acyl-CoA synthetase, putative 0.0036 0.0046 0.0535
Mycobacterium tuberculosis Probable oxidoreductase 0.0067 0.014 0.0249
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.027 0.0751 0.1229
Mycobacterium leprae PROBABLE NADP-DEPENDENT ALCOHOL DEHYDROGENASE ADHC 0.0067 0.014 0.0249
Mycobacterium ulcerans quinone reductase Qor 0.0067 0.014 0.0249
Mycobacterium ulcerans fatty acid synthase Fas 0.0337 0.0955 0.1964
Loa Loa (eye worm) hypothetical protein 0.0167 0.0442 0.0813
Onchocerca volvulus Putative alcohol dehydrogenase 0.0067 0.014 0.0209
Entamoeba histolytica Ran family GTPase 0.0024 0.001 0.0068
Loa Loa (eye worm) hypothetical protein 0.0036 0.0046 0.0076
Mycobacterium leprae PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) 0.0337 0.0955 0.1964
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0042 0.0064 0.011
Brugia malayi AMP-binding enzyme family protein 0.0048 0.0082 0.0128
Leishmania major quinone oxidoreductase, putative 0.0067 0.014 0.1437
Mycobacterium ulcerans acyl carrier protein 0.0108 0.0265 0.0514
Brugia malayi isocitrate dehydrogenase 0.0066 0.0138 0.0219
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0066 0.0138 0.0203
Plasmodium falciparum 26S proteasome regulatory subunit RPN11, putative 0.0022 0.0006 0.0051
Treponema pallidum acyl carrier protein 0.0108 0.0265 1
Trypanosoma cruzi oxidoreductase, putative 0.0067 0.014 0.186
Brugia malayi Muscleblind-like protein 0.0167 0.0442 0.072
Loa Loa (eye worm) MH2 domain-containing protein 0.026 0.0722 0.1335
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0067 0.014 0.153
Schistosoma mansoni hypothetical protein 0.0342 0.097 0.1474
Mycobacterium tuberculosis Possible quinone oxidoreductase (NADPH:quinone oxidoreductase) (zeta-crystallin) 0.0067 0.014 0.0249
Loa Loa (eye worm) hypothetical protein 0.0136 0.0349 0.064
Plasmodium vivax hypothetical protein, conserved 0.0154 0.0402 0.5321
Loa Loa (eye worm) hypothetical protein 0.0036 0.0046 0.0076
Toxoplasma gondii acyl carrier protein ACP 0.0108 0.0265 0.0768
Trichomonas vaginalis conserved hypothetical protein 0.0078 0.0174 0.1901
Leishmania major heat shock protein 83-1 0.0034 0.0043 0.0362
Trypanosoma cruzi beta-ketoacyl synthase family protein, putative 0.027 0.0751 1
Plasmodium vivax endoplasmin, putative 0.0034 0.0043 0.0488
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.1041 0.3074 0.6425
Mycobacterium ulcerans oxidoreductase FadB5 0.0067 0.014 0.0249
Echinococcus multilocularis 26S proteasome regulatory subunit N11 0.0022 0.0006 0.0001
Brugia malayi acyl carrier protein, mitochondrial precursor, putative 0.0108 0.0265 0.0429
Entamoeba histolytica NADP-dependent alcohol dehydrogenase, putative 0.0067 0.014 0.2531
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0066 0.0138 0.1768
Brugia malayi latrophilin 2 splice variant baaae 0.0143 0.0368 0.0599
Mycobacterium ulcerans zinc-containing alcohol dehydrogenase NAD-dependent AdhB 0.0067 0.014 0.0249
Schistosoma mansoni hypothetical protein 0.0082 0.0185 0.0275
Trypanosoma brucei heat shock protein 90, putative 0.0034 0.0043 0.0442
Loa Loa (eye worm) hypothetical protein 0.0143 0.0368 0.0676
Leishmania major heat shock protein 83-1 0.0034 0.0043 0.0362
Echinococcus granulosus NADH dehydrogenase 0.0108 0.0265 0.0398
Echinococcus granulosus importin subunit beta 1 0.0032 0.0035 0.0046
Trypanosoma cruzi heat shock protein 90, putative 0.0034 0.0043 0.0567
Wolbachia endosymbiont of Brugia malayi 3-oxoacyl-ACP synthase 0.027 0.0751 1
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.1605 0.4773 1
Echinococcus multilocularis ecdysone induced protein 78C 0.0042 0.0064 0.0059
Trypanosoma cruzi nuclear receptor binding factor, putative 0.0067 0.014 0.186
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0066 0.0138 0.0133
Schistosoma mansoni nuclear hormone receptor 0.0042 0.0064 0.009
Plasmodium falciparum acyl-CoA synthetase 0.0036 0.0046 0.0583
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0027 0.0021 0.0025
Echinococcus multilocularis isocitrate dehydrogenase 0.0066 0.0138 0.0133
Entamoeba histolytica transcription factor BTF3, putative 0.0078 0.0174 0.3174
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.004 0.004
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0042 0.0064 0.0098
Echinococcus multilocularis tar DNA binding protein 0.0067 0.0141 0.0136
Loa Loa (eye worm) intermediate filament protein 0.0027 0.002 0.0027
Loa Loa (eye worm) 26S proteasome regulatory subunit rpn11 0.0022 0.0006 0.0002
Mycobacterium tuberculosis Polyketide synthase Pks2 0.1041 0.3074 0.6425
Loa Loa (eye worm) hypothetical protein 0.0067 0.014 0.0251
Brugia malayi hypothetical protein 0.0136 0.0349 0.0567
Onchocerca volvulus 0.0067 0.014 0.0209
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0086 0.0197 0.0369
Brugia malayi ADP-specific Phosphofructokinase/Glucokinase conserved region family protein 0.0068 0.0143 0.0227
Echinococcus granulosus thioredoxin glutathione reductase 0.0034 0.0042 0.0056
Mycobacterium ulcerans non-ribosomal peptide synthetase 0.011 0.0271 0.0526
Plasmodium falciparum importin beta, putative 0.0032 0.0035 0.044
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.0082 0.0803
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0024 0.001 0.0008
Schistosoma mansoni hypothetical protein 0.0066 0.0138 0.0202
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0042 0.0064 0.009
Schistosoma mansoni steroid hormone receptor ad4bp 0.0042 0.0064 0.009
Loa Loa (eye worm) hypothetical protein 0.0026 0.0018 0.0025
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0042 0.0064 0.0098
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.0878 0.2584 0.5393
Trypanosoma brucei Heat shock protein 83, putative 0.0034 0.0043 0.0442
Loa Loa (eye worm) hypothetical protein 0.0067 0.014 0.0251
Trypanosoma cruzi Heat shock protein 83, putative 0.0034 0.0043 0.0567
Schistosoma mansoni cpg binding protein 0.0095 0.0224 0.0335
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0197 0.0533 1
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0042 0.0064 0.0098
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0042 0.0064 0.011
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0048 0.0082 0.0128
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0067 0.0141 0.0253
Entamoeba histolytica acyl-CoA synthetase, putative 0.011 0.0271 0.5029
Loa Loa (eye worm) TAR-binding protein 0.0067 0.0141 0.0253
Mycobacterium ulcerans Type I modular polyketide synthase 0.1074 0.3173 0.6633
Loa Loa (eye worm) hypothetical protein 0.0067 0.014 0.0251
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.1074 0.3173 0.6633
Brugia malayi heat shock protein 90 0.0034 0.0043 0.0062
Toxoplasma gondii Zn-containing alcohol dehydrogenase 0.0067 0.014 0.0395
Entamoeba histolytica NADP-dependent alcohol dehydrogenase 0.0067 0.014 0.2531
Schistosoma mansoni survival motor neuron protein 0.0048 0.0084 0.012
Brugia malayi nuclear receptor NHR-88 0.0042 0.0064 0.0098
Echinococcus granulosus expressed conserved protein 0.0185 0.0497 0.0752
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0048 0.0082 0.0128
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0067 0.014 0.0222
Toxoplasma gondii NAC domain-containing protein 0.0078 0.0174 0.0496
Plasmodium falciparum acyl carrier protein 0.0108 0.0265 0.3515
Mycobacterium ulcerans polyketide synthase MbtC 0.027 0.0751 0.1535
Loa Loa (eye worm) hypothetical protein 0.0048 0.0082 0.0144
Plasmodium vivax malonyl CoA-acyl carrier protein transacylase precursor, putative 0.0068 0.0143 0.1836
Echinococcus multilocularis Niemann Pick C1 protein 0.0197 0.0533 0.0529
Echinococcus multilocularis mitochondrial trans 2 enoyl coenzyme A reductase 0.0067 0.014 0.0135
Trypanosoma brucei heat shock protein, putative 0.0034 0.0043 0.0442
Brugia malayi ecdysteroid receptor 0.0042 0.0064 0.0098
Schistosoma mansoni hypothetical protein 0.0066 0.0138 0.0202
Loa Loa (eye worm) hypothetical protein 0.0165 0.0435 0.08
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0141 0.0208
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0022 0.0006 0.0001
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0042 0.0064 0.0098
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0042 0.0064 0.0059
Entamoeba histolytica hypothetical protein 0.0026 0.0017 0.0205
Echinococcus multilocularis NADH dehydrogenase 0.0108 0.0265 0.0261
Leishmania major heat shock protein 83-1 0.0034 0.0043 0.0362
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0024 0.001 0.0011
Plasmodium falciparum heat shock protein 90 0.0034 0.0043 0.0536
Mycobacterium ulcerans NADPH quinone oxidoreductase FadB4 0.0067 0.014 0.0249
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0042 0.0064 0.0098
Leishmania major heat shock protein 83-1 0.0034 0.0043 0.0362
Loa Loa (eye worm) hypothetical protein 0.0479 0.1381 0.2561
Mycobacterium tuberculosis Possible dehydrogenase 0.0067 0.014 0.0249
Schistosoma mansoni cpg binding protein 0.0095 0.0224 0.0335
Echinococcus granulosus dnaJ subfamily B 0.0823 0.2416 0.3685
Toxoplasma gondii heat shock protein 90, putative 0.0034 0.0043 0.0108
Mycobacterium tuberculosis Probable alcohol dehydrogenase AdhA 0.0067 0.014 0.0249
Brugia malayi beta-NAC-like protein 0.0078 0.0174 0.0278
Trypanosoma brucei heat shock protein, putative 0.0034 0.0043 0.0442
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0864 0.2541 0.5303
Schistosoma mansoni RAR-like nuclear receptor 0.0042 0.0064 0.009
Trypanosoma cruzi transcription factor btf3, putative 0.0078 0.0174 0.2312
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0017 0.0187
Schistosoma mansoni lamin 0.0027 0.002 0.0022
Loa Loa (eye worm) hypothetical protein 0.0027 0.002 0.0027
Echinococcus multilocularis muscleblind protein 0.0167 0.0442 0.0437
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE 0.071 0.2078 0.4327
Echinococcus granulosus Protein patched homolog 1 0.0085 0.0194 0.0289
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0036 0.0046 0.0052
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0122 0.0308 0.0602
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0042 0.0064 0.009
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0042 0.0064 0.0098
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.011 0.0271 0.0526
Schistosoma mansoni alcohol dehydrogenase 0.0067 0.014 0.0206
Wolbachia endosymbiont of Brugia malayi NADPH:quinone reductase 0.0067 0.014 0.1621
Chlamydia trachomatis malonyl CoA-ACP transacylase 0.0068 0.0143 0.1375
Mycobacterium ulcerans malonyl CoA-acyl carrier protein transacylase FabD 0.0068 0.0143 0.0256
Brugia malayi Helix-loop-helix DNA-binding domain containing protein 0.012 0.03 0.0487
Onchocerca volvulus Bile acid receptor homolog 0.0042 0.0064 0.0077
Echinococcus granulosus Niemann Pick C1 protein 0.0197 0.0533 0.0807
Schistosoma mansoni niemann-pick C1 (NPC1) 0.02 0.0543 0.0821
Trichomonas vaginalis conserved hypothetical protein 0.0085 0.0194 0.2124
Leishmania major nuclear receptor binding factor-like protein 0.0067 0.014 0.1437
Loa Loa (eye worm) hypothetical protein 0.1806 0.5378 1
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0024 0.001 0.0131
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0122 0.0308 0.0602
Echinococcus granulosus GPCR family 2 0.0066 0.0138 0.0202
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0066 0.0138 0.0133
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0042 0.0064 0.009
Plasmodium falciparum glutathione reductase 0.0034 0.0041 0.0509
Loa Loa (eye worm) alcohol dehydrogenase class III 0.0067 0.014 0.0251
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0042 0.0064 0.0098
Toxoplasma gondii HEAT repeat-containing protein 0.0032 0.0035 0.0086
Mycobacterium tuberculosis Possible dehydrogenase 0.0067 0.014 0.0249
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.002 0.0024
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0545 0.1579 0.4663
Entamoeba histolytica heat shock protein 90, putative 0.0034 0.0043 0.0689
Mycobacterium ulcerans Type I modular polyketide synthase 0.1074 0.3173 0.6633
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.1141 0.3374 0.7056
Echinococcus multilocularis Niemann Pick C1 protein 0.0282 0.0789 0.0784
Trypanosoma cruzi oxidoreductase, putative 0.0067 0.014 0.186
Trypanosoma cruzi heat shock protein 85, putative 0.0034 0.0043 0.0567
Mycobacterium ulcerans dehydrogenase 0.0067 0.014 0.0249
Schistosoma mansoni importin beta-1 0.0032 0.0035 0.0046
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0122 0.0308 0.0602
Toxoplasma gondii 3-oxoacyl-acyl-carrier protein synthase I/II, putative 0.027 0.0751 0.2206
Leishmania major heat shock protein 83-1 0.0034 0.0043 0.0362
Mycobacterium ulcerans 3-oxoacyl-(acyl carrier protein) synthase II 0.027 0.0751 0.1535
Mycobacterium ulcerans polyketide synthase Pks9 0.071 0.2078 0.4327
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.002 0.0027
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.004 0.004
Brugia malayi MH2 domain containing protein 0.026 0.0722 0.1182
Echinococcus granulosus AMP dependent ligase 0.011 0.0271 0.0407
Leishmania major heat shock protein 83-1 0.0034 0.0043 0.0362
Brugia malayi Niemann-Pick C1 protein precursor 0.0197 0.0533 0.0871
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.0082 0.0128
Entamoeba histolytica NADP-dependent alcohol dehydrogenase, putative 0.0067 0.014 0.2531
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.0864 0.2541 0.5303
Mycobacterium tuberculosis Hypothetical protein 0.0324 0.0913 0.1877
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0042 0.0064 0.011
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0048 0.0082 0.0128
Trichomonas vaginalis heat shock protein, putative 0.0027 0.0021 0.0235
Echinococcus granulosus mitochondrial trans 2 enoyl coenzyme A reductase 0.0067 0.014 0.0206
Trypanosoma cruzi acyl transferase-like protein, putative 0.0068 0.0143 0.1904
Leishmania major zinc-binding dehydrogenase-like protein 0.0067 0.014 0.1437
Echinococcus granulosus lamin 0.0027 0.002 0.0022
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0042 0.0064 0.009
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0017 0.0187
Trypanosoma brucei heat shock protein, putative 0.0034 0.0043 0.0442
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0042 0.0064 0.009
Loa Loa (eye worm) fatty acid synthase 0.106 0.313 0.5816
Brugia malayi CXXC zinc finger family protein 0.009 0.0209 0.0336
Schistosoma mansoni acyl carrier protein 0.0108 0.0265 0.0398
Toxoplasma gondii isocitrate dehydrogenase 0.0066 0.0138 0.039
Brugia malayi Calcitonin receptor-like protein seb-1 0.0209 0.0567 0.0927
Trypanosoma cruzi acyl transferase-like protein 0.0068 0.0143 0.1904
Schistosoma mansoni patched 1 0.0085 0.0194 0.0289
Mycobacterium tuberculosis Probable NADPH quinone oxidoreductase FadB4 (NADPH:quinone reductase) (zeta-crystallin) 0.0067 0.014 0.0249
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0042 0.0064 0.009
Brugia malayi 26S proteasome regulatory subunit rpn11 0.0022 0.0006 0.0002
Onchocerca volvulus 0.0042 0.0064 0.0077
Mycobacterium tuberculosis S-nitrosomycothiol reductase MscR 0.0067 0.014 0.0249
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0042 0.0064 0.0059
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.004 0.004
Loa Loa (eye worm) hypothetical protein 0.0036 0.0046 0.0076
Leishmania major beta-ketoacyl synthase family protein, putative,3-oxoacyl-acyl carrier protein synthase ii, putative 0.027 0.0751 0.8201
Loa Loa (eye worm) AMP-binding enzyme family protein 0.1017 0.3003 0.5579
Brugia malayi RNA binding protein 0.0067 0.0141 0.0224
Trypanosoma cruzi NADP-dependent alcohol hydrogenase, putative 0.0067 0.014 0.186
Onchocerca volvulus 0.0048 0.0082 0.0109
Echinococcus multilocularis microtubule associated protein 2 0.2195 0.655 0.6548
Brugia malayi steroid hormone receptor 0.0042 0.0064 0.0098
Onchocerca volvulus 0.1883 0.5611 0.9724
Plasmodium vivax importin-beta 2, putative 0.0032 0.0035 0.039
Loa Loa (eye worm) isocitrate dehydrogenase 0.0066 0.0138 0.0247
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0209 0.0567 0.0927
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0077 0.0171 0.0315
Trichomonas vaginalis heat shock protein, putative 0.0021 0.0002 0.0027
Loa Loa (eye worm) steroid hormone receptor 0.0042 0.0064 0.011
Brugia malayi photoreceptor-specific nuclear receptor 0.0042 0.0064 0.0098
Mycobacterium ulcerans acyl carrier protein 0.0108 0.0265 0.0514
Loa Loa (eye worm) acyl carrier protein 0.0108 0.0265 0.0485
Trypanosoma brucei oxidoreductase, putative 0.0067 0.014 0.1753
Brugia malayi hypothetical protein 0.0236 0.0648 0.1061
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0042 0.0064 0.0098
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0042 0.0064 0.0098
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0122 0.0308 0.0602
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0022 0.0006 0.0001
Loa Loa (eye worm) ICD-1 protein 0.0078 0.0174 0.0314
Schistosoma mansoni retinoic acid receptor RXR 0.0042 0.0064 0.009
Leishmania major heat shock protein 83-1 0.0034 0.0043 0.0362
Entamoeba histolytica acyl-CoA synthetase, putative 0.0156 0.0409 0.7642
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0066 0.0138 0.0202
Leishmania major NADP-dependent alcohol dehydrogenase, putative 0.0067 0.014 0.1437
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0141 0.0208
Mycobacterium tuberculosis Probable fatty acid synthase Fas (fatty acid synthetase) 0.0337 0.0955 0.1964
Giardia lamblia Methyltransferase like 2 0.0324 0.0913 1
Trypanosoma brucei Trans-2-enoyl-ACP reductase 2, putative 0.0067 0.014 0.1753
Trichomonas vaginalis importin beta-1, putative 0.0026 0.0017 0.0187
Schistosoma mansoni methyltransferase-related 0.0324 0.0913 0.1388
Mycobacterium tuberculosis Probable quinone reductase Qor (NADPH:quinone reductase) (zeta-crystallin homolog protein) 0.0067 0.014 0.0249
Mycobacterium tuberculosis Probable dehydrogenase 0.0077 0.0171 0.0315
Schistosoma mansoni heat shock protein 0.0034 0.0043 0.0057
Toxoplasma gondii type I fatty acid synthase 0.0165 0.0435 0.127
Loa Loa (eye worm) hypothetical protein 0.0048 0.0082 0.0144
Loa Loa (eye worm) hypothetical protein 0.0085 0.0194 0.0352
Trypanosoma cruzi Acyl carrier protein, mitochondrial, putative 0.0108 0.0265 0.3536
Schistosoma mansoni thyroid hormone receptor 0.0042 0.0064 0.009
Schistosoma mansoni hypothetical protein 0.0709 0.2074 0.3161
Mycobacterium ulcerans quinone oxidoreductase 0.0067 0.014 0.0249
Echinococcus multilocularis transcription factor btf3 0.0078 0.0174 0.0169
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0048 0.0082 0.0128
Schistosoma mansoni mixed-lineage leukemia protein mll 0.019 0.0512 0.0774
Echinococcus multilocularis Acyl carrier protein, mitochondrial 0.0108 0.0265 0.0261
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.1074 0.3173 0.6633
Onchocerca volvulus 0.0122 0.0308 0.0501
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0042 0.0064 0.009
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0122 0.0308 0.0602
Echinococcus multilocularis sterol regulatory element binding protein 0.0085 0.0194 0.0189
Trypanosoma cruzi heat shock protein 90, putative 0.0027 0.0021 0.0285
Giardia lamblia Heat shock protein HSP 90-alpha 0.0034 0.0043 0.0362
Wolbachia endosymbiont of Brugia malayi acyl carrier protein 0.0108 0.0265 0.3347
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.071 0.2078 0.4327
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0077 0.0171 0.0315
Echinococcus multilocularis 3 oxoacyl (acyl carrier protein) synthase 0.027 0.0751 0.0746
Mycobacterium leprae Probable S-nitrosomycothiol reductase MscR 0.0067 0.014 0.0249
Echinococcus multilocularis cpg binding protein 0.0095 0.0224 0.0219
Brugia malayi AMP-binding enzyme family protein 0.0332 0.0939 0.154
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0027 0.0021 0.0128
Loa Loa (eye worm) hypothetical protein 0.0036 0.0046 0.0076
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0066 0.0138 0.0133
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0042 0.0064 0.0059
Onchocerca volvulus 0.009 0.0209 0.0329
Brugia malayi Methyltransferase-like protein 4 0.0324 0.0913 0.1497
Toxoplasma gondii heat shock protein HSP90 0.0034 0.0043 0.0108
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0895 0.2634 0.5499
Echinococcus granulosus endoplasmin 0.0027 0.0021 0.0025
Leishmania major heat shock protein 83-1 0.0034 0.0043 0.0362
Mycobacterium tuberculosis Acyl carrier protein (ACP) MbtL 0.0108 0.0265 0.0514
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0042 0.0064 0.011
Schistosoma mansoni endoplasmin 0.0034 0.0043 0.0057
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0154 0.0402 0.5345
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0066 0.0138 0.1728
Mycobacterium ulcerans hypothetical protein 0.0048 0.0082 0.0128
Schistosoma mansoni microtubule-associated protein tau 0.2195 0.655 1
Mycobacterium leprae Probable alcohol dehydrogenase AdhA 0.0067 0.014 0.0249
Leishmania major hypothetical protein, conserved 0.0068 0.0143 0.1473
Trichomonas vaginalis heat shock protein, putative 0.0034 0.0043 0.0467
Trichomonas vaginalis conserved hypothetical protein 0.0078 0.0174 0.1901
Plasmodium vivax acyl carrier protein, putative 0.0108 0.0265 0.3482
Echinococcus granulosus muscleblind protein 0.0167 0.0442 0.0667
Trypanosoma brucei heat shock protein 90, putative 0.0034 0.0043 0.0442
Echinococcus multilocularis snurportin 1 0.0342 0.097 0.0965
Plasmodium falciparum 3-oxoacyl-acyl-carrier protein synthase I/II 0.027 0.0751 1
Echinococcus granulosus intermediate filament protein 0.0027 0.002 0.0022
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0022 0.0006 0.0001
Schistosoma mansoni transcription factor btf3 0.0078 0.0174 0.0258
Schistosoma mansoni hypothetical protein 0.0709 0.2074 0.3161
Brugia malayi Isocitrate dehydrogenase 0.0066 0.0138 0.0219
Loa Loa (eye worm) glutathione reductase 0.0034 0.0041 0.0066
Schistosoma mansoni hypothetical protein 0.0082 0.0185 0.0275
Brugia malayi Nuclear hormone receptor-like 1 0.0042 0.0064 0.0098
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.1074 0.3173 0.6633
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.1074 0.3173 0.5224
Schistosoma mansoni hypothetical protein 0.0066 0.0138 0.0202
Echinococcus multilocularis musashi 0.0027 0.002 0.0015
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0066 0.0138 0.0133
Loa Loa (eye worm) hypothetical protein 0.0136 0.0349 0.064
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0066 0.0138 0.0133
Loa Loa (eye worm) RNA binding protein 0.0067 0.0141 0.0253
Mycobacterium ulcerans thioesterase TesA 0.0895 0.2634 0.5499
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0066 0.0138 0.0203
Mycobacterium tuberculosis Conserved hypothetical protein 0.0108 0.0265 0.0514
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0028 0.0022 0.0017
Mycobacterium ulcerans polyketide synthase Pks13 0.1605 0.4773 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.0064 0.011
Echinococcus granulosus 3 oxoacyl acyl carrier protein synthase 0.027 0.0751 0.1139
Trypanosoma cruzi oxidoreductase, putative 0.0067 0.014 0.186
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0042 0.0064 0.011
Trypanosoma cruzi nuclear receptor binding factor, putative 0.0067 0.014 0.186
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0077 0.0171 0.0315
Plasmodium vivax basic transcription factor 3b, putative 0.0078 0.0174 0.2248
Echinococcus multilocularis thioredoxin glutathione reductase 0.0034 0.0042 0.0037
Mycobacterium ulcerans zinc-containing alcohol dehydrogenase NAD dependent AdhB 0.0067 0.014 0.0249
Brugia malayi intermediate filament protein 0.0027 0.002 0.0024
Echinococcus multilocularis protein dispatched 1 0.0097 0.023 0.0225
Mycobacterium tuberculosis Probable reductase 0.0077 0.0171 0.0315
Echinococcus multilocularis thyroid hormone receptor alpha 0.0042 0.0064 0.0059
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.0035 0.0344
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0042 0.0064 0.0077
Trypanosoma cruzi beta-ketoacyl synthase family protein, putative 0.027 0.0751 1
Trichomonas vaginalis heat shock protein, putative 0.0027 0.0021 0.0235
Schistosoma mansoni heat shock protein 0.0034 0.0043 0.0057
Brugia malayi Importin beta-1 subunit 0.0032 0.0035 0.005
Mycobacterium ulcerans thioesterase 0.0895 0.2634 0.5499
Mycobacterium tuberculosis Probable polyketide beta-ketoacyl synthase Pks3 0.0165 0.0435 0.087
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.0165 0.0435 0.087
Trypanosoma brucei acyl transferase-like protein 0.0068 0.0143 0.1797
Mycobacterium tuberculosis Meromycolate extension acyl carrier protein AcpM 0.0108 0.0265 0.0514
Trypanosoma brucei heat shock protein, putative 0.0034 0.0043 0.0442
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0024 0.001 0.0005
Loa Loa (eye worm) heat shock protein 90 0.0034 0.0043 0.007
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0066 0.0138 0.1417
Trichomonas vaginalis endoplasmin, putative 0.0021 0.0002 0.0027
Schistosoma mansoni intermediate filament proteins 0.0027 0.002 0.0022
Loa Loa (eye worm) hypothetical protein 0.0165 0.0435 0.08
Loa Loa (eye worm) hypothetical protein 0.0042 0.0064 0.011
Plasmodium vivax heat shock protein 86, putative 0.0034 0.0043 0.0488
Leishmania major trypanothione reductase 0.0034 0.0041 0.034
Leishmania major importin beta-1 subunit, putative 0.0026 0.0017 0.008
Plasmodium vivax thioredoxin reductase, putative 0.0034 0.0041 0.046
Echinococcus multilocularis Malonyl coenzyme A acyl carrier protein transacylase 0.0068 0.0143 0.0138
Echinococcus granulosus survival motor neuron protein 1 0.0236 0.0648 0.0983
Trypanosoma brucei trypanothione reductase 0.0034 0.0041 0.0414
Brugia malayi Steroid receptor seven-up type 2 0.0042 0.0064 0.0098
Schistosoma mansoni lamin 0.0027 0.002 0.0022
Echinococcus multilocularis heat shock protein 0.0034 0.0043 0.0038
Loa Loa (eye worm) endoplasmin 0.0034 0.0043 0.007
Echinococcus multilocularis dnaJ subfamily B 0.0823 0.2416 0.2413
Leishmania major heat shock protein 83-1 0.0034 0.0043 0.0362
Echinococcus multilocularis endoplasmin 0.0027 0.0021 0.0016
Leishmania major heat shock protein 83-1 0.0034 0.0043 0.0362
Entamoeba histolytica acyl-CoA synthetase, putative 0.0048 0.0082 0.1444
Echinococcus granulosus sterol regulatory element binding protein 0.0085 0.0194 0.0289
Chlamydia trachomatis 3-oxoacyl-ACP synthase 0.027 0.0751 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.011 0.0271 0.0526
Echinococcus granulosus lamin dm0 0.0027 0.002 0.0022
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0042 0.0064 0.0098
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0066 0.0138 0.0245
Brugia malayi Phosphopantetheine attachment site family protein 0.0108 0.0265 0.0429
Echinococcus granulosus ecdysone induced protein 78C 0.0042 0.0064 0.009
Brugia malayi TAR-binding protein 0.0067 0.0141 0.0224
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.1074 0.3173 0.6633
Echinococcus multilocularis GPCR, family 2 0.0066 0.0138 0.0133
Mycobacterium leprae Polyketide synthase Pks13 0.1605 0.4773 1
Echinococcus granulosus heat shock protein 90 0.0027 0.0021 0.0025
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0771 0.2262 0.4716
Toxoplasma gondii acyl transferase domain-containing protein 0.0068 0.0143 0.0405
Plasmodium vivax 3-oxoacyl-[acyl-carrier-protein] synthase i/ii, putative 0.027 0.0751 1
Onchocerca volvulus Acyl carrier protein, mitochondrial homolog 0.0108 0.0265 0.0427
Leishmania major zinc binding dehydrogenase-like protein 0.0067 0.014 0.1437
Trichomonas vaginalis conserved hypothetical protein 0.0324 0.0913 1
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.1141 0.3374 0.7056
Loa Loa (eye worm) histone methyltransferase 0.0028 0.0022 0.0032
Mycobacterium ulcerans oxidoreductase 0.0067 0.014 0.0249
Schistosoma mansoni [ACP] S-malonyltransferase 0.0068 0.0143 0.0211
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0141 0.0208
Echinococcus granulosus snurportin 1 0.0342 0.097 0.1474
Brugia malayi AMP-binding enzyme family protein 0.0048 0.0082 0.0128
Echinococcus granulosus mixed lineage leukemia protein mll 0.0022 0.0006 0.0001
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0042 0.0064 0.009
Loa Loa (eye worm) hypothetical protein 0.0042 0.0064 0.011
Mycobacterium leprae PROBABLE POLYKETIDE BETA-KETOACYL SYNTHASE PKS4 0.0165 0.0435 0.087
Leishmania major d-xylulose reductase, putative 0.0067 0.014 0.1437
Echinococcus multilocularis importin subunit beta 1 0.0032 0.0035 0.003
Leishmania major heat shock protein 83-1 0.0034 0.0043 0.0362
Loa Loa (eye worm) hypothetical protein 0.0042 0.0064 0.011
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0066 0.0138 0.1836
Loa Loa (eye worm) hypothetical protein 0.0066 0.0138 0.0247
Schistosoma mansoni cpg binding protein 0.009 0.0209 0.0312
Echinococcus granulosus transcription factor btf3 0.0078 0.0174 0.0258
Schistosoma mansoni hypothetical protein 0.0143 0.0368 0.0555
Schistosoma mansoni [ACP] S-malonyltransferase 0.0068 0.0143 0.0211
Echinococcus granulosus transcription factor eb 0.012 0.03 0.0451
Mycobacterium tuberculosis Probable alcohol dehydrogenase Adh 0.0067 0.014 0.0249
Schistosoma mansoni ran 0.0024 0.001 0.0007
Trichomonas vaginalis heat shock protein, putative 0.0027 0.0021 0.0235
Loa Loa (eye worm) helix-loop-helix DNA-binding domain-containing protein 0.0119 0.0299 0.0546
Mycobacterium ulcerans acyl-CoA synthetase 0.0122 0.0308 0.0602
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0067 0.014 0.0222
Trypanosoma brucei heat shock protein, putative 0.0034 0.0043 0.0442
Brugia malayi RNA, U transporter 1 0.0091 0.0213 0.0344
Echinococcus granulosus Niemann Pick C1 protein 0.0282 0.0789 0.1197
Brugia malayi CHE-14 protein 0.0085 0.0194 0.0312
Brugia malayi AMP-binding enzyme family protein 0.1017 0.3003 0.4943
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0034 0.0041 0.004
Echinococcus multilocularis FTZ F1 alpha 0.0042 0.0064 0.0059
Entamoeba histolytica heat shock protein 90, putative 0.0034 0.0043 0.0689
Mycobacterium ulcerans short-chain dehydrogenase 0.0067 0.014 0.0249
Loa Loa (eye worm) hypothetical protein 0.0042 0.0064 0.011
Trypanosoma brucei Acyl carrier protein, mitochondrial 0.0108 0.0265 0.3451
Mycobacterium tuberculosis Probable acyl carrier protein AcpA (ACP) 0.0108 0.0265 0.0514
Mycobacterium ulcerans zinc-dependent alcohol dehydrogenase 0.0067 0.014 0.0249
Mycobacterium tuberculosis Polyketide synthase Pks13 0.1605 0.4773 1
Mycobacterium leprae Probable polyketide synthase Pks1 0.1141 0.3374 0.7056
Loa Loa (eye worm) hypothetical protein 0.0032 0.0035 0.0056
Loa Loa (eye worm) hypothetical protein 0.0236 0.0648 0.1197
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0209 0.0567 0.1046
Onchocerca volvulus 0.0067 0.014 0.0209
Mycobacterium tuberculosis Probable NADP-dependent alcohol dehydrogenase AdhC 0.0067 0.014 0.0249
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 0.011 0.0271 0.0526
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0077 0.0171 0.0315
Mycobacterium tuberculosis Probable thioesterase TesA 0.0895 0.2634 0.5499
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0141 0.0208
Onchocerca volvulus 0.0048 0.0084 0.0111
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0067 0.014 0.153
Mycobacterium ulcerans NADP-dependent alcohol dehydrogenase AdhC 0.0067 0.014 0.0249
Brugia malayi Alcohol dehydrogenase class III 0.0067 0.014 0.0222
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0024 0.001 0.0131
Toxoplasma gondii thioredoxin reductase 0.0034 0.0041 0.0102
Loa Loa (eye worm) thioredoxin reductase 0.0034 0.0041 0.0066
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0024 0.001 0.0099
Mycobacterium tuberculosis Probable polyketide beta-ketoacyl synthase Pks4 0.0165 0.0435 0.087
Brugia malayi RNA recognition motif domain containing protein 0.0067 0.0141 0.0224
Mycobacterium tuberculosis Probable polyketide synthase Pks15 0.0434 0.1247 0.2579
Mycobacterium tuberculosis Probable oxidoreductase 0.0086 0.0197 0.0369
Echinococcus multilocularis heat shock protein 90 0.0027 0.0021 0.0016
Mycobacterium ulcerans quinone oxidoreductase 0.0067 0.014 0.0249
Echinococcus multilocularis expressed conserved protein 0.0185 0.0497 0.0493
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0024 0.001 0.0048
Loa Loa (eye worm) hypothetical protein 0.0209 0.0567 0.1046
Echinococcus granulosus FTZ F1 alpha 0.0042 0.0064 0.009
Loa Loa (eye worm) hypothetical protein 0.0068 0.0143 0.0257
Trypanosoma brucei transcription factor BTF3, putative 0.0078 0.0174 0.221
Loa Loa (eye worm) CXXC zinc finger family protein 0.009 0.0209 0.0379
Schistosoma mansoni zinc binding dehydrogenase 0.0067 0.014 0.0206
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0067 0.014 0.153
Leishmania major heat shock protein 83-1 0.0034 0.0043 0.0362
Mycobacterium tuberculosis Possible oxidoreductase FadB5 0.0067 0.014 0.0249
Trypanosoma cruzi importin beta-1 subunit, putative 0.0026 0.0017 0.0227
Echinococcus granulosus geminin 0.0709 0.2074 0.3161
Loa Loa (eye worm) hypothetical protein 0.0104 0.0251 0.0458
Schistosoma mansoni hypothetical protein 0.0108 0.0265 0.0398
Mycobacterium ulcerans zinc-dependent alcohol dehydrogenase AdhE2 0.0067 0.014 0.0249
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.1074 0.3173 0.6633
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0042 0.0064 0.0059
Mycobacterium tuberculosis Polyketide synthetase MbtC (polyketide synthase) 0.0369 0.1051 0.2166
Giardia lamblia Heat shock protein HSP 90-alpha 0.0027 0.0021 0.0128
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0066 0.0138 0.1836
Mycobacterium ulcerans 3-oxoacyl-(acyl carrier protein) synthase II 0.027 0.0751 0.1535
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0085 0.0194 0.0352
Onchocerca volvulus Protein ultraspiracle homolog 0.0042 0.0064 0.0077
Echinococcus granulosus 26S proteasome regulatory subunit N11 0.0022 0.0006 0.0002
Plasmodium vivax glutathione reductase, putative 0.0034 0.0041 0.046
Trypanosoma cruzi heat shock protein 85, putative 0.0034 0.0043 0.0567
Mycobacterium ulcerans oxidoreductase 0.0067 0.014 0.0249
Schistosoma mansoni [ACP] S-malonyltransferase 0.0068 0.0143 0.0211
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0066 0.0138 0.0219
Onchocerca volvulus Fatty acid synthase homolog 0.1936 0.577 1
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0048 0.0082 0.0128
Trypanosoma cruzi trypanothione reductase, putative 0.0034 0.0041 0.0539
Loa Loa (eye worm) transcription factor SMAD2 0.026 0.0722 0.1335
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0342 0.097 0.1795
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0048 0.0082 0.0128
Mycobacterium tuberculosis Probable zinc-type alcohol dehydrogenase AdhD (aldehyde reductase) 0.0067 0.014 0.0249
Mycobacterium ulcerans zinc-type alcohol dehydrogenase AdhD 0.0067 0.014 0.0249
Chlamydia trachomatis acyl carrier protein 0.0108 0.0265 0.3114
Echinococcus multilocularis geminin 0.0709 0.2074 0.207
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0028 0.0022 0.0026
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0042 0.0064 0.009
Loa Loa (eye worm) hypothetical protein 0.0042 0.0064 0.011
Onchocerca volvulus 0.1017 0.3003 0.5188
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0066 0.0138 0.0202
Plasmodium falciparum thioredoxin reductase 0.0034 0.0041 0.0509
Loa Loa (eye worm) hypothetical protein 0.0167 0.0442 0.0813
Trypanosoma brucei beta-ketoacyl-ACP synthase 0.027 0.0751 1
Loa Loa (eye worm) hypothetical protein 0.0602 0.1751 0.3249
Brugia malayi Hypothetical 35.8 kDa protein F37A4.5 in chromosome III 0.0022 0.0006 0.0002
Onchocerca volvulus Huntingtin homolog 0.0136 0.0349 0.0573
Echinococcus granulosus GTP binding nuclear protein Ran 0.0024 0.001 0.0007
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.0084 0.0129
Plasmodium falciparum malonyl CoA-acyl carrier protein transacylase 0.0068 0.0143 0.1878
Echinococcus granulosus microtubule associated protein 2 0.2195 0.655 1
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0042 0.0064 0.009
Leishmania major hypothetical protein, conserved 0.0324 0.0913 1
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0141 0.0208
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0042 0.0064 0.0059
Trypanosoma brucei heat shock protein, putative 0.0034 0.0043 0.0442
Echinococcus multilocularis lamin dm0 0.0027 0.002 0.0015
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0077 0.0171 0.0315
Schistosoma mansoni ran 0.0024 0.001 0.0007
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.1141 0.3374 0.7056
Brugia malayi AMP-binding enzyme family protein 0.0048 0.0082 0.0128
Trypanosoma brucei heat shock protein, putative 0.0034 0.0043 0.0442
Loa Loa (eye worm) hypothetical protein 0.0048 0.0082 0.0144
Loa Loa (eye worm) hypothetical protein 0.0042 0.0064 0.011
Entamoeba histolytica acyl-coA synthetase, putative 0.0048 0.0082 0.1444
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0042 0.0064 0.009
Echinococcus multilocularis lamin 0.0027 0.002 0.0015
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0042 0.0064 0.0098

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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