Detailed information for compound 1603992

Basic information

Technical information
  • TDR Targets ID: 1603992
  • Name: 3-amino-4-chloro-5-methyl-4-nitrocyclopent-2- ene-1,1,2-tricarbonitrile
  • MW: 251.629 | Formula: C9H6ClN5O2
  • H donors: 1 H acceptors: 5 LogP: 0.46 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#CC1=C(N)C(C(C1(C#N)C#N)C)(Cl)[N+](=O)[O-]
  • InChi: 1S/C9H6ClN5O2/c1-5-8(3-12,4-13)6(2-11)7(14)9(5,10)15(16)17/h5H,14H2,1H3
  • InChiKey: CWRGCDKIXIGGAV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-amino-1-chloro-3,4,4-tricyano-N-hydroxy-5-methylcyclopent-2-en-1-amine oxide
  • 3-amino-4-chloro-4-(hydroxy-oxidoamino)-5-methylcyclopent-2-ene-1,1,2-tricarbonitrile
  • 3-amino-4-chloro-5-methyl-4-nitro-cyclopent-2-ene-1,1,2-tricarbonitrile
  • 2-amino-1-chloro-3,4,4-tricyano-N-hydroxy-5-methyl-cyclopent-2-en-1-amine oxide
  • 3-amino-4-chloro-4-(hydroxy-oxido-amino)-5-methyl-cyclopent-2-ene-1,1,2-tricarbonitrile
  • 2-amino-1-chloro-3,4,4-tricyano-N-hydroxy-5-methyl-1-cyclopent-2-enamine oxide
  • 3-Amino-4-chloro-4-(hydroxy(oxido)amino)-5-methyl-2-cyclopentene-1,1,2-tricarbonitrile
  • AIDS-148791
  • AIDS148791
  • NSC681778
  • A2397/0101495
  • NCI60_029263
  • 2-Amino-3-nitro-3-chloro-4-methyl-1,5,5-tricyano-1-cyclopentene
  • 3-Amino-4-chloro-5-methyl-4-nitro-2-cyclopentene-1,1,2-tricarbonitrile

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0753 0.1881 0.5609
Entamoeba histolytica histone deacetylase, putative 0.0393 0.0962 0.2866
Echinococcus multilocularis tyrosine protein kinase csk 0.0035 0.0049 0.0146
Echinococcus granulosus peptide allatostatin:somatostatin 0.0753 0.1881 0.5609
Echinococcus multilocularis rhodopsin orphan GPCR 0.0753 0.1881 0.5609
Echinococcus granulosus tyrosine protein kinase Src42A 0.0053 0.0096 0.0286
Echinococcus granulosus tyrosine protein kinase Fyn 0.0053 0.0096 0.0286
Brugia malayi ORL1-like opioid receptor 0.0753 0.1881 0.1881
Schistosoma mansoni hypothetical protein 0.0033 0.0046 0.0137
Brugia malayi Histone deacetylase 1 0.0393 0.0962 0.0962
Echinococcus granulosus Tubulin beta 2C chain 0.133 0.3353 1
Loa Loa (eye worm) TYRA-2 protein 0.0753 0.1881 0.5609
Echinococcus granulosus neuropeptide FF receptor 2 0.0753 0.1881 0.5609
Echinococcus granulosus neuropeptide receptor 0.0753 0.1881 0.5609
Brugia malayi AKH receptor 0.0753 0.1881 0.1881
Echinococcus granulosus neuropeptide Y receptor 0.0753 0.1881 0.5609
Echinococcus multilocularis Tubulin beta 2C chain 0.133 0.3353 1
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0016 0.0002 0.0005
Echinococcus granulosus g protein coupled receptor 0.0753 0.1881 0.5609
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0068 0.0134 0.0172
Schistosoma mansoni histone deacetylase 1 2 3 0.0168 0.0388 0.1158
Toxoplasma gondii histone deacetylase HDAC3 0.0393 0.0962 0.1936
Loa Loa (eye worm) hypothetical protein 0.0753 0.1881 0.5609
Schistosoma mansoni furin-1 (S08 family) 0.0125 0.028 0.0834
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.0102 0.0076
Schistosoma mansoni hypothetical protein 0.0753 0.1881 0.5609
Brugia malayi RE15519p 0.0753 0.1881 0.1881
Loa Loa (eye worm) melatonin receptor type 1A 0.0753 0.1881 0.5609
Loa Loa (eye worm) hypothetical protein 0.0753 0.1881 0.5609
Echinococcus granulosus tyrosine protein kinase Blk 0.0043 0.007 0.0207
Loa Loa (eye worm) hypothetical protein 0.0753 0.1881 0.5609
Echinococcus multilocularis neuropeptide s receptor 0.0753 0.1881 0.5609
Echinococcus multilocularis beta tubulin 0.133 0.3353 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0046 0.0078 0.0226
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0753 0.1881 0.6329
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0753 0.1881 0.5609
Echinococcus multilocularis nuclear receptor co repressor related (ncor) 0.0544 0.1349 0.4022
Brugia malayi sulfakinin receptor protein 0.0753 0.1881 0.1881
Onchocerca volvulus 0.0753 0.1881 0.6329
Echinococcus multilocularis g-protein coupled receptor 0.0753 0.1881 0.5609
Echinococcus granulosus g protein coupled receptor 0.0753 0.1881 0.5609
Schistosoma mansoni adenoreceptor 0.0753 0.1881 0.5609
Loa Loa (eye worm) hypothetical protein 0.0753 0.1881 0.5609
Plasmodium vivax tubulin beta chain, putative 0.133 0.3353 1
Toxoplasma gondii beta-1 tubulin, putative 0.133 0.3353 1
Loa Loa (eye worm) hypothetical protein 0.0753 0.1881 0.5609
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0043 0.007 0.0207
Trichomonas vaginalis histone deacetylase, putative 0.0393 0.0962 0.2701
Trichomonas vaginalis tubulin gamma chain, putative 0.133 0.3353 1
Brugia malayi G protein-coupled receptor 0.0753 0.1881 0.1881
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0053 0.0096 0.0286
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0753 0.1881 0.5609
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0753 0.1881 0.5609
Schistosoma mansoni growth factor receptor-bound protein 0.0021 0.0014 0.0041
Trypanosoma brucei DNA polymerase kappa, putative 0.0046 0.0078 0.0226
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0753 0.1881 0.1881
Loa Loa (eye worm) hypothetical protein 0.0753 0.1881 0.5609
Plasmodium vivax histone deacetylase 1, putative 0.0393 0.0962 0.1936
Echinococcus granulosus histone deacetylase 6 0.0307 0.0745 0.2221
Echinococcus multilocularis rhodopsin orphan GPCR 0.0753 0.1881 0.5609
Brugia malayi SH2 domain containing protein 0.0045 0.0076 0.0076
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0021 0.0014 0.0041
Trichomonas vaginalis proprotein convertase subtilisin/kexin type, putative 0.0056 0.0102 0.0076
Echinococcus multilocularis allatostatin A receptor 0.1163 0.2928 0.8732
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0024 0.0021 0.0056
Schistosoma mansoni neuropeptide F-like receptor 0.0753 0.1881 0.5609
Brugia malayi Melatonin receptor type 1A 0.0753 0.1881 0.1881
Brugia malayi Tachykinin-like peptides receptor 99D 0.0753 0.1881 0.1881
Loa Loa (eye worm) neuropeptide F receptor 0.0753 0.1881 0.5609
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0008 0.0018
Onchocerca volvulus 0.0753 0.1881 0.6329
Trypanosoma cruzi histone deacetylase, putative 0.0168 0.0388 0.1153
Echinococcus multilocularis fmrfamide receptor 0.0753 0.1881 0.5609
Loa Loa (eye worm) proprotein convertase 2 0.0068 0.0134 0.0399
Echinococcus granulosus tyrosine protein kinase HCK 0.0032 0.0043 0.0127
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0393 0.0962 0.2701
Trypanosoma cruzi histone deacetylase, putative 0.0307 0.0745 0.2217
Echinococcus granulosus hypothetical protein 0.0753 0.1881 0.5609
Leishmania major beta tubulin 0.133 0.3353 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0046 0.0078 0.0226
Toxoplasma gondii beta-tubulin, putative 0.133 0.3353 1
Brugia malayi celfurPC protein 0.0232 0.0552 0.0552
Schistosoma mansoni adapter molecule crk 0.0021 0.0014 0.0041
Loa Loa (eye worm) hypothetical protein 0.0753 0.1881 0.5609
Echinococcus granulosus rhodopsin orphan GPCR 0.0753 0.1881 0.5609
Echinococcus granulosus c src tyrosine kinase 0.0056 0.0102 0.0305
Loa Loa (eye worm) hypothetical protein 0.0753 0.1881 0.5609
Echinococcus granulosus rhodopsin orphan GPCR 0.0753 0.1881 0.5609
Toxoplasma gondii histone deacetylase HDAC2 0.0393 0.0962 0.1936
Loa Loa (eye worm) BEN-1 protein 0.133 0.3353 1
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0753 0.1881 0.5609
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0753 0.1881 0.5609
Brugia malayi G-protein coupled receptor 0.0753 0.1881 0.1881
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0753 0.1881 0.5609
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0175 0.0406 0.1004
Schistosoma mansoni hypothetical protein 0.0753 0.1881 0.5609
Trypanosoma brucei DNA polymerase kappa, putative 0.0035 0.0049 0.0141
Loa Loa (eye worm) histone deacetylase 11 0.0168 0.0388 0.1158
Brugia malayi polk-prov protein 0.0035 0.0049 0.0049
Giardia lamblia Beta tubulin 0.133 0.3353 1
Loa Loa (eye worm) hypothetical protein 0.0753 0.1881 0.5609
Leishmania major beta tubulin 0.133 0.3353 1
Schistosoma mansoni neuropeptide F-like receptor 0.0753 0.1881 0.5609
Brugia malayi neuropeptide F receptor 0.0753 0.1881 0.1881
Echinococcus granulosus tyrosine protein kinase csk 0.0035 0.0049 0.0146
Onchocerca volvulus 0.0753 0.1881 0.6329
Brugia malayi hypothetical protein 0.0753 0.1881 0.1881
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0008 0.0018
Echinococcus granulosus 7tm_1 domain containing protein 0.0753 0.1881 0.5609
Loa Loa (eye worm) histone deacetylase 7A 0.0307 0.0745 0.2221
Echinococcus multilocularis neuropeptides capa receptor 0.0753 0.1881 0.5609
Brugia malayi Tubulin beta-1 chain 0.133 0.3353 0.3353
Leishmania major beta tubulin 0.133 0.3353 1
Echinococcus multilocularis 0.0232 0.0552 0.1647
Loa Loa (eye worm) hypothetical protein 0.0753 0.1881 0.5609
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0753 0.1881 0.5609
Trypanosoma brucei beta tubulin 0.133 0.3353 1
Brugia malayi larval opioid receptor 0.0753 0.1881 0.1881
Echinococcus multilocularis tyrosine protein kinase csk 0.0035 0.0049 0.0146
Trypanosoma brucei DNA polymerase IV, putative 0.0039 0.0059 0.017
Echinococcus multilocularis c src tyrosine kinase 0.0056 0.0102 0.0305
Trichomonas vaginalis neuroendocrine convertase 2 precursor, putative 0.0056 0.0102 0.0076
Brugia malayi beta-tubulin, identical 0.133 0.3353 0.3353
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0393 0.0962 0.2701
Onchocerca volvulus 0.0753 0.1881 0.6329
Schistosoma mansoni hypothetical protein 0.1257 0.3168 0.9448
Brugia malayi neuroendocrine convertase 1 precursor 0.0181 0.0422 0.0422
Brugia malayi histone deacetylase 1 (HD1) 0.0393 0.0962 0.0962
Onchocerca volvulus 0.0753 0.1881 0.6329
Onchocerca volvulus 0.0753 0.1881 0.6329
Echinococcus granulosus histone deacetylase 3 0.0393 0.0962 0.287
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.0102 0.0076
Schistosoma mansoni biogenic amine receptor 0.0753 0.1881 0.5609
Echinococcus multilocularis tyrosine protein kinase csk 0.0035 0.0049 0.0146
Schistosoma mansoni opsin-like receptor 0.0753 0.1881 0.5609
Loa Loa (eye worm) BEN-1 protein 0.133 0.3353 1
Echinococcus granulosus tyrosine protein kinase Src64B 0.0053 0.0096 0.0286
Leishmania major histone deacetylase, putative 0.0307 0.0745 0.2217
Echinococcus multilocularis tyrosine protein kinase Blk 0.0043 0.007 0.0207
Loa Loa (eye worm) hypothetical protein 0.0753 0.1881 0.5609
Giardia lamblia High cysteine membrane protein Group 2 0.0107 0.0233 0.0638
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0024 0.0021 0.0063
Loa Loa (eye worm) hypothetical protein 0.0113 0.0248 0.0741
Loa Loa (eye worm) beta-tubulin 0.133 0.3353 1
Trypanosoma cruzi histone deacetylase 1, putative 0.0393 0.0962 0.2866
Echinococcus granulosus tyrosine protein kinase csk 0.0035 0.0049 0.0146
Echinococcus multilocularis sex peptide receptor 0.0753 0.1881 0.5609
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.0102 0.0076
Loa Loa (eye worm) hypothetical protein 0.0753 0.1881 0.5609
Leishmania major beta tubulin 0.133 0.3353 1
Brugia malayi neuropeptide F receptor 0.0753 0.1881 0.1881
Echinococcus granulosus MAP kinase activated protein kinase 2 0.0187 0.0438 0.1305
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0068 0.0134 0.0172
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0753 0.1881 0.5609
Brugia malayi Dopamine receptor 0.0753 0.1881 0.1881
Echinococcus granulosus nuclear receptor co repressor related ncor 0.0544 0.1349 0.4022
Brugia malayi endoprotease bli-4 precursor 0.0288 0.0694 0.0694
Brugia malayi Dopamine receptor protein 2 0.0753 0.1881 0.1881
Echinococcus granulosus proprotein convertase subtilisin:kexin type 5 0.0175 0.0406 0.1212
Onchocerca volvulus 0.0753 0.1881 0.6329
Echinococcus granulosus rhodopsin orphan GPCR 0.0753 0.1881 0.5609
Trichomonas vaginalis tubulin beta chain, putative 0.133 0.3353 1
Loa Loa (eye worm) hypothetical protein 0.0753 0.1881 0.5609
Echinococcus granulosus neuropeptide receptor 0.0753 0.1881 0.5609
Plasmodium vivax histone deacetylase, putative 0.0307 0.0745 0.1202
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.0102 0.0076
Trypanosoma brucei DNA polymerase kappa, putative 0.0046 0.0078 0.0226
Onchocerca volvulus 0.0753 0.1881 0.6329
Schistosoma mansoni tubulin subunit beta 0.133 0.3353 1
Trichomonas vaginalis leucine-rich repeat protein, BspA family 0.0056 0.0102 0.0076
Echinococcus multilocularis Tubulin beta 2C chain 0.133 0.3353 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0068 0.0134 0.0172
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0053 0.0096 0.0286
Plasmodium falciparum histone deacetylase 1 0.0393 0.0962 0.0834
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0016 0.0002 0.0005
Loa Loa (eye worm) hypothetical protein 0.0753 0.1881 0.5609
Entamoeba histolytica protein kinase, putative 0.0032 0.0043 0.0122
Loa Loa (eye worm) neuropeptide F receptor 0.0753 0.1881 0.5609
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0753 0.1881 0.5609
Loa Loa (eye worm) hypothetical protein 0.0753 0.1881 0.5609
Loa Loa (eye worm) G-protein coupled receptor 0.0753 0.1881 0.5609
Trypanosoma brucei DNA polymerase kappa, putative 0.0046 0.0078 0.0226
Loa Loa (eye worm) TK protein kinase 0.0032 0.0043 0.0127
Entamoeba histolytica tubulin family protein 0.133 0.3353 1
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0043 0.007 0.0207
Echinococcus multilocularis rhodopsin orphan GPCR 0.0753 0.1881 0.5609
Onchocerca volvulus Neuropeptide F receptor homolog 0.0753 0.1881 0.6329
Echinococcus granulosus rhodopsin orphan GPCR 0.0753 0.1881 0.5609
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.0102 0.0076
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0053 0.0096 0.0286
Loa Loa (eye worm) histone deacetylase 1 0.0393 0.0962 0.287
Leishmania major beta tubulin 0.133 0.3353 1
Loa Loa (eye worm) hypothetical protein 0.0753 0.1881 0.5609
Onchocerca volvulus 0.0753 0.1881 0.6329
Trypanosoma brucei histone deacetylase 2 0.0168 0.0388 0.1153
Loa Loa (eye worm) hypothetical protein 0.0168 0.0388 0.1158
Schistosoma mansoni myosin xvIII 0.0753 0.1881 0.5609
Echinococcus multilocularis histone deacetylase 3 0.0393 0.0962 0.287
Schistosoma mansoni biogenic amine (5HT) receptor 0.0753 0.1881 0.5609
Echinococcus multilocularis histone deacetylase 7 0.0307 0.0745 0.2221
Schistosoma mansoni alpha-1 adrenergic receptor 0.0753 0.1881 0.5609
Brugia malayi protein-tyrosine kinase 0.0043 0.007 0.007
Schistosoma mansoni neuropeptide receptor 0.0753 0.1881 0.5609
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0753 0.1881 0.5609
Echinococcus multilocularis rhodopsin orphan GPCR 0.0753 0.1881 0.5609
Brugia malayi hypothetical protein 0.0753 0.1881 0.1881
Echinococcus multilocularis G protein coupled receptor 139 0.0753 0.1881 0.5609
Leishmania major beta tubulin 0.133 0.3353 1
Trypanosoma cruzi histone deacetylase 1, putative 0.0393 0.0962 0.2866
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0288 0.0694 0.2071
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.0753 0.1881 0.5609
Schistosoma mansoni histone deacetylase hda2 0.0168 0.0388 0.1158
Trypanosoma brucei histone deacetylase 4 0.0307 0.0745 0.2217
Loa Loa (eye worm) camk/mapkapk/mapkapk protein kinase 0.0187 0.0438 0.1305
Echinococcus multilocularis neuropeptide FF receptor 2 0.0753 0.1881 0.5609
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0753 0.1881 0.5609
Echinococcus granulosus neuropeptides capa receptor 0.0753 0.1881 0.5609
Schistosoma mansoni opsin-like receptor 0.0753 0.1881 0.5609
Leishmania major histone deacetylase, putative 0.0307 0.0745 0.2217
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0753 0.1881 0.1881
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0085 0.0085
Echinococcus multilocularis g protein coupled receptor 0.0753 0.1881 0.5609
Loa Loa (eye worm) TK/ABL protein kinase 0.022 0.0522 0.1558
Echinococcus granulosus neuropeptides capa receptor 0.0753 0.1881 0.5609
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0053 0.0096 0.0286
Echinococcus granulosus tyrosine protein kinase Lyn 0.0054 0.0097 0.0289
Loa Loa (eye worm) hypothetical protein 0.0082 0.017 0.0506
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0016 0.0002 0.0005
Brugia malayi Serotonin receptor 0.0753 0.1881 0.1881
Echinococcus granulosus neuropeptide s receptor 0.0753 0.1881 0.5609
Echinococcus granulosus 7TM GPCR rhodopsin 0.0753 0.1881 0.5609
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0753 0.1881 0.5609
Echinococcus granulosus histone deacetylase 6 0.0307 0.0745 0.2221
Loa Loa (eye worm) hypothetical protein 0.0753 0.1881 0.5609
Loa Loa (eye worm) hypothetical protein 0.0033 0.0046 0.0137
Schistosoma mansoni tyrosine kinase 0.0056 0.0102 0.0305
Trypanosoma brucei DNA polymerase kappa, putative 0.0046 0.0078 0.0226
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0753 0.1881 0.5609
Echinococcus multilocularis neuropeptide receptor 0.0753 0.1881 0.5609
Mycobacterium ulcerans DNA polymerase IV 0.0046 0.0078 0.5
Echinococcus multilocularis neuroendocrine convertase 2 0.0181 0.0422 0.1257
Echinococcus multilocularis neuropeptide Y receptor 0.0753 0.1881 0.5609
Brugia malayi SRC-1 0.0053 0.0096 0.0096
Echinococcus multilocularis histone deacetylase 0.0307 0.0745 0.2221
Schistosoma mansoni serine-type protease inhibitor 0.043 0.1058 0.3154
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0753 0.1881 0.5609
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0053 0.0096 0.0286
Echinococcus granulosus tm gpcr rhodopsin 0.0753 0.1881 0.5609
Giardia lamblia Beta tubulin 0.133 0.3353 1
Echinococcus granulosus G protein coupled receptor 139 0.0753 0.1881 0.5609
Leishmania major beta tubulin 0.133 0.3353 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0046 0.0078 0.0226
Schistosoma mansoni neuropeptide f receptor 76f 0.0753 0.1881 0.5609
Schistosoma mansoni amine GPCR 0.0753 0.1881 0.5609
Brugia malayi ImpB/MucB/SamB family protein 0.0016 0.0002 0.0002
Brugia malayi Sex muscle abnormal protein 5 0.0021 0.0014 0.0014
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0053 0.0096 0.0286
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0753 0.1881 0.5609
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0753 0.1881 0.5609
Loa Loa (eye worm) hypothetical protein 0.0753 0.1881 0.5609
Echinococcus multilocularis growth factor receptor bound protein 2 0.0021 0.0014 0.0041
Schistosoma mansoni tubulin subunit beta 0.133 0.3353 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0753 0.1881 0.5609
Loa Loa (eye worm) endoprotease bli-4 0.0288 0.0694 0.2071
Schistosoma mansoni opsin-like receptor 0.0753 0.1881 0.5609
Echinococcus multilocularis rhodopsin orphan GPCR 0.0753 0.1881 0.5609
Echinococcus multilocularis beta tubulin 0.133 0.3353 1
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0753 0.1881 0.5609
Schistosoma mansoni histone deacetylase 4 5 0.0307 0.0745 0.2221
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0753 0.1881 0.5609
Echinococcus granulosus Furin 1 0.0068 0.0134 0.0399
Echinococcus multilocularis neuropeptide receptor A26 0.0753 0.1881 0.5609
Echinococcus granulosus histone deacetylase 7 0.0307 0.0745 0.2221
Echinococcus multilocularis tyrosine protein kinase Srms 0.0043 0.007 0.0207
Echinococcus granulosus neuropeptide receptor A26 0.0753 0.1881 0.5609
Brugia malayi histone deacetylase 11 0.0168 0.0388 0.0388
Trypanosoma brucei DNA polymerase kappa, putative 0.0046 0.0078 0.0226
Brugia malayi Histone deacetylase family protein 0.0307 0.0745 0.0745
Loa Loa (eye worm) tubulin beta-1 chain 0.133 0.3353 1
Brugia malayi Histone deacetylase family protein 0.0307 0.0745 0.0745
Schistosoma mansoni subfamily S8B non-peptidase homologue (S08 family) 0.0068 0.0134 0.0399
Brugia malayi hypothetical protein 0.0753 0.1881 0.1881
Brugia malayi putative neuropeptide receptor NPR1 0.0753 0.1881 0.1881
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0753 0.1881 0.5609
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0053 0.0096 0.0286
Trichomonas vaginalis histone deacetylase, putative 0.0393 0.0962 0.2701
Schistosoma mansoni histone deacetylase 4 5 0.0307 0.0745 0.2221
Schistosoma mansoni neuropeptide receptor 0.0753 0.1881 0.5609
Brugia malayi proprotein convertase 2 0.0181 0.0422 0.0422
Echinococcus granulosus g protein coupled receptor 0.0753 0.1881 0.5609
Echinococcus granulosus alpha 1A adrenergic receptor 0.0753 0.1881 0.5609
Trypanosoma brucei DNA polymerase kappa, putative 0.0035 0.0049 0.0141
Schistosoma mansoni tyrosine kinase 0.0053 0.0096 0.0286
Loa Loa (eye worm) tubulin beta chain 0.133 0.3353 1
Entamoeba histolytica tubulin family protein 0.133 0.3353 1
Schistosoma mansoni tyrosine kinase 0.0053 0.0096 0.0286
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0753 0.1881 0.5609
Leishmania major beta tubulin 0.133 0.3353 1
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0753 0.1881 0.5609
Trypanosoma brucei DNA polymerase IV, putative 0.0046 0.0078 0.0226
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.0102 0.0076
Echinococcus granulosus neuroendocrine convertase 2 0.0181 0.0422 0.1257
Trypanosoma cruzi histone deacetylase, putative 0.0168 0.0388 0.1153
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0753 0.1881 0.5609
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0753 0.1881 0.5609
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0753 0.1881 0.5609
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0068 0.0134 0.0172
Loa Loa (eye worm) TK protein kinase 0.0043 0.007 0.0207
Brugia malayi Serotonin receptor 0.0753 0.1881 0.1881
Echinococcus multilocularis dna polymerase eta 0.0016 0.0002 0.0005
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0753 0.1881 0.5609
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0068 0.0134 0.0172
Brugia malayi hypothetical protein 0.0753 0.1881 0.1881
Echinococcus multilocularis rhodopsin orphan GPCR 0.0753 0.1881 0.5609
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0016 0.0002 0.0005
Loa Loa (eye worm) tubulin beta-2A chain 0.133 0.3353 1
Brugia malayi hypothetical protein 0.0753 0.1881 0.1881
Brugia malayi Dopamine receptor protein 1 0.0753 0.1881 0.1881
Echinococcus granulosus orexin receptor type 2 0.0753 0.1881 0.5609
Onchocerca volvulus Histone deacetylase 10 homolog 0.0168 0.0388 0.1095
Trypanosoma brucei DNA polymerase kappa, putative 0.0046 0.0078 0.0226
Leishmania major beta tubulin 0.133 0.3353 1
Schistosoma mansoni serine/threonine protein kinase 0.0187 0.0438 0.1305
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0175 0.0406 0.1004
Schistosoma mansoni growth hormone secretagogue receptor 0.0753 0.1881 0.5609
Trypanosoma cruzi DNA polymerase kappa, putative 0.0046 0.0078 0.0226
Onchocerca volvulus 0.0753 0.1881 0.6329
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.0102 0.0076
Trypanosoma cruzi DNA polymerase kappa, putative 0.0046 0.0078 0.0226
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0085 0.0085
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0753 0.1881 0.5609
Loa Loa (eye worm) hypothetical protein 0.0753 0.1881 0.5609
Loa Loa (eye worm) hypothetical protein 0.0152 0.0348 0.1038
Echinococcus granulosus sex peptide receptor 0.0753 0.1881 0.5609
Echinococcus multilocularis proprotein convertase subtilisin:kexin type 5 0.0175 0.0406 0.1212
Schistosoma mansoni amine GPCR 0.0753 0.1881 0.5609
Loa Loa (eye worm) histone deacetylase 3 0.0393 0.0962 0.287
Loa Loa (eye worm) hypothetical protein 0.0753 0.1881 0.5609
Echinococcus granulosus tubulin beta 1 chain 0.133 0.3353 1
Echinococcus multilocularis Tubulin beta 2C chain 0.133 0.3353 1
Echinococcus multilocularis histone deacetylase 6 0.0307 0.0745 0.2221
Echinococcus granulosus beta tubulin 0.133 0.3353 1
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.0102 0.0076
Echinococcus multilocularis tyrosine protein kinase Abl 0.0103 0.0223 0.0665
Leishmania major beta tubulin 0.133 0.3353 1
Giardia lamblia Histone deacetylase 0.0393 0.0962 0.2826
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0753 0.1881 0.5609
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0021 0.0014 0.0041
Loa Loa (eye worm) hypothetical protein 0.0753 0.1881 0.5609
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.0102 0.0076
Echinococcus multilocularis tubulin subunit beta 0.133 0.3353 1
Echinococcus granulosus dnaJ subfamily B 0.1257 0.3168 0.9448
Echinococcus multilocularis MAP kinase activated protein kinase 2 0.0187 0.0438 0.1305
Echinococcus multilocularis histone deacetylase 1 0.0393 0.0962 0.287
Echinococcus multilocularis dnaJ subfamily B 0.1257 0.3168 0.9448
Echinococcus multilocularis orexin receptor type 2 0.0753 0.1881 0.5609
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.1253 0.3157 0.9414
Loa Loa (eye worm) hypothetical protein 0.0753 0.1881 0.5609
Echinococcus granulosus histone deacetylase 6 0.032 0.0776 0.2314
Schistosoma mansoni tubulin subunit beta 0.133 0.3353 1
Trichomonas vaginalis tubulin, putative 0.133 0.3353 1
Loa Loa (eye worm) histone deacetylase 0.0307 0.0745 0.2221
Echinococcus granulosus g-protein coupled receptor 0.0753 0.1881 0.5609
Brugia malayi hypothetical protein 0.0753 0.1881 0.1881
Loa Loa (eye worm) hypothetical protein 0.0288 0.0694 0.2071
Echinococcus multilocularis tyrosine protein kinase csk 0.0035 0.0049 0.0146
Schistosoma mansoni histone deacetylase 0.0393 0.0962 0.287
Schistosoma mansoni amine GPCR 0.0753 0.1881 0.5609
Trypanosoma brucei unspecified product 0.0039 0.0059 0.017
Echinococcus multilocularis histone deacetylase 6 0.0307 0.0745 0.2221
Brugia malayi hypothetical protein 0.0753 0.1881 0.1881
Schistosoma mansoni amine GPCR 0.0753 0.1881 0.5609
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0393 0.0962 0.2701
Echinococcus granulosus biogenic amine 5HT receptor 0.0753 0.1881 0.5609
Echinococcus multilocularis neuropeptide receptor 0.0753 0.1881 0.5609
Echinococcus granulosus Tubulin beta 2C chain 0.133 0.3353 1
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0053 0.0096 0.0286
Echinococcus multilocularis dna polymerase kappa 0.0046 0.0078 0.0231
Echinococcus granulosus histone deacetylase 1 0.0393 0.0962 0.287
Leishmania major DNA polymerase kappa, putative 0.0024 0.0021 0.0056
Brugia malayi G protein-coupled receptor F59B2.13 0.0753 0.1881 0.1881
Echinococcus granulosus dro:myosuppressin receptor 0.0753 0.1881 0.5609
Echinococcus granulosus serotonin receptor 0.0753 0.1881 0.5609
Plasmodium falciparum tubulin beta chain 0.133 0.3353 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0753 0.1881 0.5609
Schistosoma mansoni biogenic amine (5HT) receptor 0.0753 0.1881 0.5609
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0753 0.1881 0.5609
Trypanosoma brucei DNA polymerase kappa, putative 0.0046 0.0078 0.0226
Loa Loa (eye worm) hypothetical protein 0.0393 0.0962 0.287
Schistosoma mansoni hypothetical protein 0.0753 0.1881 0.5609
Loa Loa (eye worm) hypothetical protein 0.0753 0.1881 0.5609
Echinococcus multilocularis tubulin, beta 4A class IVa 0.133 0.3353 1
Trypanosoma brucei histone deacetylase, putative 0.0307 0.0745 0.2217
Loa Loa (eye worm) hypothetical protein 0.0753 0.1881 0.5609
Schistosoma mansoni histamine h1 receptor 0.0753 0.1881 0.5609
Brugia malayi Variant SH3 domain containing protein 0.0021 0.0014 0.0014
Giardia lamblia Furin precursor putative serine protease 0.0056 0.0102 0.0246
Trichomonas vaginalis histone deacetylase, putative 0.0393 0.0962 0.2701
Schistosoma mansoni tubulin subunit beta 0.133 0.3353 1
Onchocerca volvulus 0.0753 0.1881 0.6329
Loa Loa (eye worm) hypothetical protein 0.1163 0.2928 0.8732
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0753 0.1881 0.1881
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.0102 0.0076
Loa Loa (eye worm) tubulin beta-4 chain 0.133 0.3353 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0753 0.1881 0.5609
Brugia malayi map kinase activated protein kinase protein 2 0.0187 0.0438 0.0438
Echinococcus granulosus dna polymerase kappa 0.0046 0.0078 0.0231
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0024 0.0021 0.0063
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0753 0.1881 0.1881
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0753 0.1881 0.5609
Brugia malayi hypothetical protein 0.0753 0.1881 0.1881
Echinococcus granulosus furin 0.0288 0.0694 0.2071
Schistosoma mansoni histone deacetylase hda2 0.032 0.0776 0.2314
Echinococcus multilocularis rhodopsin orphan GPCR 0.0753 0.1881 0.5609
Schistosoma mansoni amine GPCR 0.0753 0.1881 0.5609
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0053 0.0096 0.0286
Loa Loa (eye worm) TK/CSK protein kinase 0.0035 0.0049 0.0146
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0068 0.0134 0.0172
Echinococcus granulosus Tubulin beta 2C chain 0.133 0.3353 1
Trichomonas vaginalis tubulin alpha chain, putative 0.133 0.3353 1
Leishmania major beta tubulin 0.133 0.3353 1
Leishmania major beta tubulin 0.133 0.3353 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0753 0.1881 0.5609
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0753 0.1881 0.5609
Echinococcus multilocularis serotonin receptor 0.0753 0.1881 0.5609
Schistosoma mansoni neuropeptide receptor 0.0753 0.1881 0.5609
Loa Loa (eye worm) SRC-1 0.0053 0.0096 0.0286
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0753 0.1881 0.5609
Echinococcus granulosus allatostatin A receptor 0.1163 0.2928 0.8732
Leishmania major beta tubulin 0.133 0.3353 1
Echinococcus multilocularis Tubulin beta 2C chain 0.133 0.3353 1
Echinococcus granulosus tachykinin peptides receptor 99D 0.0753 0.1881 0.5609
Brugia malayi G-protein coupled receptor 0.0753 0.1881 0.1881
Leishmania major histone deacetylase, putative 0.0393 0.0962 0.2866
Echinococcus multilocularis dro:myosuppressin receptor 0.0753 0.1881 0.5609
Trichomonas vaginalis histone deacetylase, putative 0.0393 0.0962 0.2701
Echinococcus multilocularis tyrosine protein kinase ABL1 0.022 0.0522 0.1558
Loa Loa (eye worm) hypothetical protein 0.0753 0.1881 0.5609
Loa Loa (eye worm) hypothetical protein 0.0049 0.0085 0.0255
Onchocerca volvulus 0.0753 0.1881 0.6329
Onchocerca volvulus 0.0753 0.1881 0.6329
Schistosoma mansoni biogenic amine receptor 0.0753 0.1881 0.5609
Echinococcus granulosus rhodopsin orphan GPCR 0.0753 0.1881 0.5609
Echinococcus granulosus somatostatin receptor 0.0753 0.1881 0.5609
Leishmania major beta tubulin 0.133 0.3353 1
Trichomonas vaginalis histone deacetylase, putative 0.0393 0.0962 0.2701
Loa Loa (eye worm) hypothetical protein 0.014 0.0317 0.0945
Echinococcus granulosus beta tubulin 0.133 0.3353 1
Leishmania major beta tubulin 0.133 0.3353 1
Schistosoma mansoni serine-type protease inhibitor 0.043 0.1058 0.3154
Loa Loa (eye worm) hypothetical protein 0.0753 0.1881 0.5609
Loa Loa (eye worm) SH2 domain-containing protein 0.0042 0.0068 0.0204
Echinococcus granulosus Tubulin beta 2C chain 0.133 0.3353 1
Schistosoma mansoni hypothetical protein 0.0056 0.0102 0.0305
Trypanosoma cruzi histone deacetylase, putative 0.0307 0.0745 0.2217
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0753 0.1881 0.5609
Mycobacterium ulcerans DNA polymerase IV 0.0046 0.0078 0.5
Echinococcus granulosus rhodopsin orphan GPCR 0.0753 0.1881 0.5609
Echinococcus granulosus NCK adaptor protein 0.0021 0.0014 0.0041
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.0102 0.0076
Schistosoma mansoni biogenic amine receptor 0.0753 0.1881 0.5609
Loa Loa (eye worm) hypothetical protein 0.0753 0.1881 0.5609
Echinococcus granulosus rhodopsin orphan GPCR 0.0753 0.1881 0.5609
Brugia malayi Tyrosine-protein kinase abl-1 0.0128 0.0286 0.0286
Loa Loa (eye worm) hypothetical protein 0.0753 0.1881 0.5609
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0753 0.1881 0.5609
Onchocerca volvulus 0.0753 0.1881 0.6329
Loa Loa (eye worm) hypothetical protein 0.0753 0.1881 0.5609
Echinococcus multilocularis neuropeptides capa receptor 0.0753 0.1881 0.5609
Echinococcus multilocularis histone deacetylase 6 0.032 0.0776 0.2314
Schistosoma mansoni DNA polymerase eta 0.0016 0.0002 0.0005
Brugia malayi ImpB/MucB/SamB family protein 0.0016 0.0002 0.0002
Leishmania major beta tubulin 0.133 0.3353 1
Trypanosoma brucei histone deacetylase 1 0.0393 0.0962 0.2866
Loa Loa (eye worm) hypothetical protein 0.0753 0.1881 0.5609
Echinococcus granulosus histone deacetylase 8 0.0168 0.0388 0.1158
Schistosoma mansoni growth factor receptor-bound protein 0.0021 0.0014 0.0041
Loa Loa (eye worm) hypothetical protein 0.0753 0.1881 0.5609
Leishmania major beta tubulin 0.133 0.3353 1
Echinococcus granulosus histone deacetylase 0.0307 0.0745 0.2221
Echinococcus multilocularis somatostatin receptor 0.0753 0.1881 0.5609
Loa Loa (eye worm) hypothetical protein 0.0753 0.1881 0.5609
Echinococcus multilocularis tubulin beta 1 chain 0.133 0.3353 1
Toxoplasma gondii histone deacetylase HDAC1 0.0307 0.0745 0.1202
Plasmodium vivax histone deacetylase 2, putative 0.0307 0.0745 0.1202
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0053 0.0096 0.0286
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0753 0.1881 0.5609
Trypanosoma brucei DNA polymerase kappa, putative 0.0024 0.0021 0.0056
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0753 0.1881 0.5609
Brugia malayi histone deacetylase 3 (HD3) 0.0393 0.0962 0.0962
Schistosoma mansoni nck2/grb4 0.0021 0.0014 0.0041
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0753 0.1881 0.5609
Echinococcus multilocularis histone deacetylase 8 0.0168 0.0388 0.1158
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0024 0.0021 1
Loa Loa (eye worm) hypothetical protein 0.0753 0.1881 0.5609
Echinococcus multilocularis Tubulin beta 2C chain 0.133 0.3353 1
Loa Loa (eye worm) hypothetical protein 0.0753 0.1881 0.5609
Loa Loa (eye worm) G-protein coupled receptor 0.0753 0.1881 0.5609
Onchocerca volvulus 0.0753 0.1881 0.6329
Onchocerca volvulus 0.0753 0.1881 0.6329
Trypanosoma brucei DNA polymerase IV, putative 0.0046 0.0078 0.0226
Trypanosoma cruzi beta tubulin, putative 0.133 0.3353 1
Echinococcus granulosus growth factor receptor bound protein 2 0.0021 0.0014 0.0041
Echinococcus multilocularis Furin 1 0.0068 0.0134 0.0399
Schistosoma mansoni tyrosine kinase 0.0024 0.0021 0.0063
Echinococcus granulosus tubulin beta 4A class IVa 0.133 0.3353 1
Loa Loa (eye worm) hypothetical protein 0.0753 0.1881 0.5609
Brugia malayi hypothetical protein 0.0753 0.1881 0.1881
Schistosoma mansoni peptide (allatostatin)-like receptor 0.1163 0.2928 0.8732
Loa Loa (eye worm) hypothetical protein 0.0016 0.0002 0.0005
Echinococcus granulosus fmrfamide receptor 0.0753 0.1881 0.5609
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0753 0.1881 0.5609
Loa Loa (eye worm) hypothetical protein 0.0753 0.1881 0.5609
Trypanosoma cruzi DNA polymerase kappa, putative 0.0046 0.0078 0.0226
Echinococcus multilocularis fmrfamide receptor 0.0753 0.1881 0.5609
Echinococcus multilocularis serotonin receptor 0.0753 0.1881 0.5609
Echinococcus granulosus tyrosine kinase 0.0043 0.007 0.0207
Loa Loa (eye worm) hypothetical protein 0.0753 0.1881 0.5609
Trypanosoma brucei beta tubulin 0.133 0.3353 1
Schistosoma mansoni neuropeptide receptor 0.0753 0.1881 0.5609
Echinococcus granulosus tyrosine protein kinase csk 0.0035 0.0049 0.0146
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0085 0.0255
Trypanosoma brucei beta tubulin 0.133 0.3353 1
Echinococcus granulosus tyrosine protein kinase Fyn 0.0053 0.0096 0.0286
Echinococcus granulosus tm gpcr rhodopsin 0.0753 0.1881 0.5609
Echinococcus granulosus tubulin subunit beta 0.133 0.3353 1
Echinococcus multilocularis neuropeptide Y receptor 0.0753 0.1881 0.5609
Loa Loa (eye worm) hypothetical protein 0.0021 0.0014 0.0041
Giardia lamblia Beta tubulin 0.133 0.3353 1
Echinococcus granulosus tm gpcr rhodopsin 0.1253 0.3157 0.9414
Echinococcus granulosus biogenic amine 5HT receptor 0.0753 0.1881 0.5609
Echinococcus granulosus tyrosine protein kinase Fyn 0.0053 0.0096 0.0286
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0053 0.0096 0.0286
Trichomonas vaginalis tubulin epsilon chain, putative 0.133 0.3353 1
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0753 0.1881 0.5609
Leishmania major histone deacetylase, putative 0.0393 0.0962 0.2866
Echinococcus multilocularis G-protein coupled receptor, putative 0.0753 0.1881 0.5609
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0021 0.0014 0.0041
Echinococcus multilocularis NCK adaptor protein 0.0021 0.0014 0.0041
Echinococcus multilocularis rhodopsin orphan GPCR 0.0753 0.1881 0.5609
Echinococcus granulosus tyrosine protein kinase Src42A 0.004 0.0062 0.0185
Trypanosoma brucei histone deacetylase 3 0.0307 0.0745 0.2217
Schistosoma mansoni histone deacetylase 0.0393 0.0962 0.287
Echinococcus multilocularis tyrosine protein kinase HCK 0.0032 0.0043 0.0127
Echinococcus multilocularis tyrosine protein kinase Src42A 0.004 0.0062 0.0185
Loa Loa (eye worm) hypothetical protein 0.0753 0.1881 0.5609
Trichomonas vaginalis tubulin epsilon chain, putative 0.133 0.3353 1
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0753 0.1881 0.5609
Loa Loa (eye worm) hypothetical protein 0.0035 0.0049 0.0146
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0753 0.1881 0.5609
Leishmania major beta tubulin 0.133 0.3353 1
Brugia malayi putative neuropeptide receptor 0.0753 0.1881 0.1881
Loa Loa (eye worm) hypothetical protein 0.0753 0.1881 0.5609
Schistosoma mansoni tubulin subunit beta 0.133 0.3353 1
Echinococcus multilocularis g protein coupled receptor 0.0753 0.1881 0.5609
Loa Loa (eye worm) hypothetical protein 0.0753 0.1881 0.5609
Echinococcus multilocularis g protein coupled receptor 0.0753 0.1881 0.5609
Toxoplasma gondii beta tubulin 0.133 0.3353 1
Schistosoma mansoni tubulin subunit beta 0.133 0.3353 1
Trichomonas vaginalis hypothetical protein 0.0056 0.0102 0.0076
Echinococcus granulosus dna polymerase eta 0.0016 0.0002 0.0005
Brugia malayi hypothetical protein 0.0753 0.1881 0.1881
Brugia malayi Variant SH3 domain containing protein 0.0021 0.0014 0.0014
Brugia malayi Tyrosine-protein kinase abl-1 0.0103 0.0223 0.0223
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0753 0.1881 0.1881
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0008 0.0018
Echinococcus granulosus neuropeptide Y receptor 0.0753 0.1881 0.5609
Loa Loa (eye worm) hypothetical protein 0.0753 0.1881 0.5609
Trichomonas vaginalis histone deacetylase, putative 0.0393 0.0962 0.2701
Schistosoma mansoni terminal deoxycytidyl transferase 0.0016 0.0002 0.0005
Trypanosoma cruzi histone deacetylase, putative 0.0307 0.0745 0.2217
Brugia malayi follicle stimulating hormone receptor 0.0753 0.1881 0.1881
Echinococcus granulosus tyrosine protein kinase ABL1 0.022 0.0522 0.1558
Schistosoma mansoni tyrosine kinase 0.021 0.0495 0.1478
Loa Loa (eye worm) hypothetical protein 0.0753 0.1881 0.5609
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0753 0.1881 0.5609
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0024 0.0021 0.0063
Onchocerca volvulus 0.1163 0.2928 1
Trypanosoma brucei beta tubulin 0.133 0.3353 1
Echinococcus granulosus Tubulin beta 2C chain 0.133 0.3353 1
Schistosoma mansoni hypothetical protein 0.0753 0.1881 0.5609

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -5.682 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.626 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.243 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.087 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.044 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.947 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.94 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.919 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.81 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.777 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.728 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.