Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable peptide synthetase Nrp (peptide synthase) | 0.0035 | 0.0486 | 0.1596 |
Trichomonas vaginalis | serine threonine-protein kinase, putative | 0.0157 | 0.4214 | 1 |
Leishmania major | acetyl-CoA synthetase, putative | 0.0035 | 0.0486 | 0.1596 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0035 | 0.05 | 0.05 |
Brugia malayi | hypothetical protein | 0.0035 | 0.05 | 0.0566 |
Echinococcus granulosus | ubiquitin carboxyl terminal hydrolase 8 | 0.0038 | 0.0579 | 0.0579 |
Echinococcus granulosus | Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 | 0.0038 | 0.0579 | 0.0579 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0118 | 0.3049 | 1 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.0089 | 0.2132 | 1 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0118 | 0.3049 | 1 |
Mycobacterium leprae | Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) | 0.0035 | 0.0486 | 0.0796 |
Loa Loa (eye worm) | hypothetical protein | 0.01 | 0.2492 | 0.2823 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0035 | 0.05 | 0.05 |
Plasmodium falciparum | acyl-CoA synthetase | 0.0089 | 0.2132 | 1 |
Treponema pallidum | ATP-dependent Clp protease proteolytic subunit | 0.008 | 0.187 | 1 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0035 | 0.0486 | 0.1596 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0118 | 0.3049 | 0.3454 |
Loa Loa (eye worm) | glutathione reductase | 0.0046 | 0.0839 | 0.095 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0118 | 0.3049 | 1 |
Schistosoma mansoni | peptidase Clp (S14 family) | 0.008 | 0.187 | 0.4154 |
Mycobacterium ulcerans | long-chain-acyl-CoA synthetase | 0.0035 | 0.0486 | 0.1596 |
Entamoeba histolytica | acyl-coA synthetase, putative | 0.0118 | 0.3049 | 0.3454 |
Plasmodium vivax | ATP-dependent Clp protease proteolytic subunit, putative | 0.008 | 0.187 | 0.8597 |
Echinococcus multilocularis | serine:threonine protein kinase:endoribonuclease | 0.0307 | 0.8827 | 0.8827 |
Schistosoma mansoni | hypothetical protein | 0.0166 | 0.4501 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0157 | 0.4214 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0158 | 0.4244 | 0.9428 |
Loa Loa (eye worm) | hypothetical protein | 0.0147 | 0.3913 | 0.4433 |
Echinococcus granulosus | GPCR family 2 | 0.0046 | 0.0843 | 0.0843 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.0089 | 0.2132 | 1 |
Echinococcus granulosus | acetyl coenzyme A synthetase cytoplasmic | 0.0035 | 0.0486 | 0.0486 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0118 | 0.3049 | 1 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0117 | 0.3015 | 0.9891 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0046 | 0.0843 | 0.0843 |
Entamoeba histolytica | protein kinase, putative | 0.0307 | 0.8827 | 1 |
Echinococcus granulosus | zinc finger protein | 0.0039 | 0.0609 | 0.0609 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0034 | 0.0456 | 0.0456 |
Brugia malayi | PHD-finger family protein | 0.0049 | 0.0933 | 0.1057 |
Mycobacterium tuberculosis | Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0035 | 0.0486 | 0.1596 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.1893 | 0.2144 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0119 | 0.3061 | 0.3468 |
Schistosoma mansoni | hypothetical protein | 0.0046 | 0.0843 | 0.1872 |
Echinococcus multilocularis | Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 | 0.0038 | 0.0579 | 0.0579 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0118 | 0.3049 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0089 | 0.2132 | 0.2415 |
Mycobacterium leprae | POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) | 0.0035 | 0.0486 | 0.0796 |
Schistosoma mansoni | bromodomain containing protein | 0.0125 | 0.326 | 0.7243 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0118 | 0.3049 | 1 |
Loa Loa (eye worm) | intermediate filament protein | 0.0028 | 0.0272 | 0.0308 |
Loa Loa (eye worm) | AMP-binding enzyme family protein | 0.0035 | 0.0486 | 0.0551 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.05 | 0.0566 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0045 | 0.0789 | 0.0789 |
Schistosoma mansoni | zinc finger protein | 0.003 | 0.035 | 0.0777 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0035 | 0.0486 | 0.1596 |
Schistosoma mansoni | hypothetical protein | 0.0166 | 0.4501 | 1 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0034 | 0.0456 | 0.1013 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0084 | 0.1984 | 0.6507 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) | 0.0052 | 0.1026 | 0.3366 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0084 | 0.1984 | 0.6507 |
Echinococcus multilocularis | methyl CpG binding domain protein 2 | 0.0034 | 0.0456 | 0.0456 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.008 | 0.187 | 0.6133 |
Mycobacterium tuberculosis | Peptide synthetase MbtF (peptide synthase) | 0.0035 | 0.0486 | 0.1596 |
Trypanosoma brucei | long-chain-fatty-acid-CoA ligase, putative | 0.0035 | 0.0486 | 0.5799 |
Echinococcus multilocularis | geminin | 0.0166 | 0.4501 | 0.4501 |
Entamoeba histolytica | protein kinase, putative | 0.0307 | 0.8827 | 1 |
Schistosoma mansoni | methyl-cpg binding protein mbd | 0.0034 | 0.0456 | 0.1013 |
Loa Loa (eye worm) | hypothetical protein | 0.014 | 0.3711 | 0.4205 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0035 | 0.0486 | 0.1596 |
Leishmania major | trypanothione reductase | 0.0046 | 0.0839 | 0.2752 |
Mycobacterium leprae | POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0035 | 0.0486 | 0.0796 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0089 | 0.2132 | 0.6992 |
Schistosoma mansoni | hypothetical protein | 0.0046 | 0.0843 | 0.1872 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0046 | 0.0843 | 0.0843 |
Trypanosoma cruzi | ubiquitin carboxyl-terminal hydrolase, putative | 0.0038 | 0.0579 | 0.6905 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0035 | 0.0486 | 0.1596 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0118 | 0.3049 | 1 |
Brugia malayi | Thioredoxin reductase | 0.0046 | 0.0839 | 0.095 |
Toxoplasma gondii | thioredoxin reductase | 0.0046 | 0.0839 | 0.3576 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0038 | 0.0579 | 0.1375 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0034 | 0.0456 | 0.0456 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0046 | 0.0843 | 0.0843 |
Loa Loa (eye worm) | hypothetical protein | 0.0118 | 0.3049 | 0.3454 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0028 | 0.0272 | 0.0308 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0118 | 0.3049 | 1 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) | 0.0052 | 0.1026 | 0.3366 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.2008 | 0.2275 |
Mycobacterium ulcerans | non-ribosomal peptide synthetase MbtF | 0.0035 | 0.0486 | 0.1596 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0084 | 0.1984 | 0.6507 |
Schistosoma mansoni | hypothetical protein | 0.0046 | 0.0843 | 0.1872 |
Echinococcus multilocularis | acetyl coenzyme A synthetase, cytoplasmic | 0.0035 | 0.0486 | 0.0486 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0118 | 0.3049 | 1 |
Loa Loa (eye worm) | IRE protein kinase | 0.0307 | 0.8827 | 1 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0035 | 0.0486 | 0.1596 |
Trypanosoma cruzi | long-chain-fatty-acid-CoA ligase, putative | 0.0035 | 0.0486 | 0.5799 |
Trichomonas vaginalis | Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase | 0.0038 | 0.0579 | 0.1375 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.097 | 0.1099 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.008 | 0.187 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0089 | 0.2132 | 0.2415 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0046 | 0.0823 | 0.0823 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.008 | 0.187 | 0.6133 |
Loa Loa (eye worm) | hypothetical protein | 0.008 | 0.187 | 0.2118 |
Echinococcus multilocularis | musashi | 0.0028 | 0.0272 | 0.0272 |
Echinococcus multilocularis | peptidase Clp (S14 family) | 0.0052 | 0.1026 | 0.1026 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0071 | 0.1601 | 0.1601 |
Schistosoma mansoni | zinc finger protein | 0.0039 | 0.0609 | 0.1353 |
Leishmania major | hypothetical protein, conserved | 0.003 | 0.035 | 0.1147 |
Echinococcus granulosus | ATP dependent Clp protease proteolytic subunit | 0.008 | 0.187 | 0.187 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0147 | 0.3913 | 0.4433 |
Trypanosoma brucei | ISWI complex protein | 0.003 | 0.035 | 0.4167 |
Trypanosoma cruzi | ubiquitin carboxyl-terminal hydrolase, putative | 0.0038 | 0.0579 | 0.6905 |
Schistosoma mansoni | intermediate filament proteins | 0.0028 | 0.0272 | 0.0605 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0147 | 0.3913 | 0.4433 |
Brugia malayi | AMP-binding enzyme family protein | 0.0035 | 0.0486 | 0.0551 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0046 | 0.0823 | 0.0933 |
Brugia malayi | AMP-binding enzyme family protein | 0.0035 | 0.0486 | 0.0551 |
Toxoplasma gondii | Acetyl-coenzyme A synthetase 2, putative | 0.0035 | 0.0486 | 0.138 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0118 | 0.3049 | 1 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.008 | 0.187 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0486 | 0.0551 |
Brugia malayi | glutathione reductase | 0.0046 | 0.0839 | 0.095 |
Onchocerca volvulus | 0.0051 | 0.097 | 0.2513 | |
Echinococcus granulosus | ubiquitin specific protease 41 | 0.0038 | 0.0579 | 0.0579 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0046 | 0.0843 | 0.0955 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0257 | 0.0291 |
Echinococcus granulosus | lamin dm0 | 0.0028 | 0.0272 | 0.0272 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0106 | 0.2655 | 0.8708 |
Entamoeba histolytica | ubiquitin carboxyl-terminal hydrolase domain containing protein | 0.0038 | 0.0579 | 0.0656 |
Echinococcus granulosus | geminin | 0.0166 | 0.4501 | 0.4501 |
Plasmodium falciparum | glutathione reductase | 0.0046 | 0.0839 | 0.3074 |
Mycobacterium tuberculosis | Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) | 0.0035 | 0.0486 | 0.1596 |
Echinococcus multilocularis | zinc finger protein | 0.0039 | 0.0609 | 0.0609 |
Loa Loa (eye worm) | hypothetical protein | 0.0118 | 0.3049 | 0.3454 |
Echinococcus granulosus | intermediate filament protein | 0.0028 | 0.0272 | 0.0272 |
Mycobacterium ulcerans | phenyloxazoline synthase MbtB | 0.0035 | 0.0486 | 0.1596 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0118 | 0.3043 | 0.3043 |
Brugia malayi | Ubiquitin carboxyl-terminal hydrolase family protein | 0.0038 | 0.0579 | 0.0656 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0035 | 0.0486 | 0.1596 |
Schistosoma mansoni | acetyl-CoA synthetase | 0.0035 | 0.0486 | 0.1081 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0034 | 0.0456 | 0.1013 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0035 | 0.05 | 0.1111 |
Trichomonas vaginalis | Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase | 0.0038 | 0.0579 | 0.1375 |
Plasmodium falciparum | ATP-dependent Clp protease proteolytic subunit | 0.008 | 0.187 | 0.8597 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0045 | 0.0789 | 0.0789 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0046 | 0.0839 | 0.3074 |
Mycobacterium ulcerans | hypothetical protein | 0.0118 | 0.3049 | 1 |
Schistosoma mansoni | ubiquitin-specific peptidase 2 (C19 family) | 0.0038 | 0.0579 | 0.1287 |
Leishmania major | ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative | 0.0038 | 0.0579 | 0.19 |
Entamoeba histolytica | long-chain-fatty-acid--CoA ligase, putative | 0.0035 | 0.0486 | 0.0551 |
Trypanosoma cruzi | long-chain-fatty-acid-CoA ligase, putative | 0.0035 | 0.0486 | 0.5799 |
Loa Loa (eye worm) | hypothetical protein | 0.0089 | 0.2132 | 0.2415 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0147 | 0.3913 | 0.4433 |
Mycobacterium ulcerans | bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase | 0.0035 | 0.0486 | 0.1596 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0084 | 0.1984 | 0.6507 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0106 | 0.2655 | 0.8708 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0106 | 0.2655 | 0.8708 |
Brugia malayi | AMP-binding enzyme family protein | 0.0118 | 0.3049 | 0.3454 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.0673 | 0.1496 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0046 | 0.0823 | 0.0823 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0046 | 0.0823 | 0.0933 |
Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0035 | 0.0486 | 0.0551 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0045 | 0.0789 | 0.1753 |
Trichomonas vaginalis | antibiotic synthetase, putative | 0.0035 | 0.0486 | 0.1154 |
Echinococcus multilocularis | ubiquitin specific protease 41 | 0.0038 | 0.0579 | 0.0579 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0117 | 0.3015 | 0.9891 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0117 | 0.3015 | 0.9891 |
Mycobacterium tuberculosis | PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.003 | 0.0338 | 0.111 |
Schistosoma mansoni | lamin | 0.0028 | 0.0272 | 0.0605 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0118 | 0.3049 | 1 |
Schistosoma mansoni | lamin | 0.0028 | 0.0272 | 0.0605 |
Echinococcus granulosus | lamin | 0.0028 | 0.0272 | 0.0272 |
Onchocerca volvulus | 0.0035 | 0.0486 | 0.0772 | |
Mycobacterium ulcerans | non-ribosomal peptide synthetase MbtE | 0.0035 | 0.0486 | 0.1596 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0035 | 0.0486 | 0.1596 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.05 | 0.1111 |
Mycobacterium tuberculosis | Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0035 | 0.0486 | 0.1596 |
Schistosoma mansoni | ubiquitin-specific peptidase 8 (C19 family) | 0.0038 | 0.0579 | 0.1287 |
Trypanosoma brucei | acetyl-CoA synthetase, putative | 0.0035 | 0.0486 | 0.5799 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0046 | 0.0839 | 0.0839 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0272 | 0.0308 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0046 | 0.0823 | 0.0823 |
Schistosoma mansoni | methyl-cpg binding protein mbd | 0.0034 | 0.0456 | 0.1013 |
Echinococcus multilocularis | GPCR, family 2 | 0.0046 | 0.0843 | 0.0843 |
Schistosoma mansoni | hypothetical protein | 0.01 | 0.2492 | 0.5536 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0041 | 0.0673 | 0.0763 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0046 | 0.0843 | 0.0955 |
Trypanosoma cruzi | ISWI complex protein | 0.003 | 0.035 | 0.4167 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0028 | 0.0272 | 0.0308 |
Brugia malayi | MH2 domain containing protein | 0.0119 | 0.3061 | 0.3468 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0106 | 0.2655 | 0.8708 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0456 | 0.0517 |
Mycobacterium tuberculosis | Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase | 0.0035 | 0.0486 | 0.1596 |
Loa Loa (eye worm) | hypothetical protein | 0.0089 | 0.2132 | 0.2415 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0035 | 0.0486 | 0.1596 |
Echinococcus multilocularis | lamin | 0.0028 | 0.0272 | 0.0272 |
Trypanosoma cruzi | acetyl-CoA synthetase, putative | 0.0035 | 0.0486 | 0.5799 |
Echinococcus multilocularis | ubiquitin carboxyl terminal hydrolase 8 | 0.0038 | 0.0579 | 0.0579 |
Trichomonas vaginalis | antibiotic synthetase, putative | 0.0035 | 0.0486 | 0.1154 |
Brugia malayi | Ribonuclease 2-5A family protein | 0.0307 | 0.8827 | 1 |
Echinococcus granulosus | serine:threonine protein kinase:endoribonuclease | 0.0307 | 0.8827 | 0.8827 |
Mycobacterium tuberculosis | P-hydroxybenzoyl-AMP ligase FadD22 | 0.0035 | 0.0486 | 0.1596 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0046 | 0.0843 | 0.0843 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0046 | 0.0823 | 0.0823 |
Brugia malayi | intermediate filament protein | 0.0028 | 0.0272 | 0.0308 |
Schistosoma mansoni | hypothetical protein | 0.003 | 0.035 | 0.0777 |
Brugia malayi | Probable ClpP-like protease | 0.008 | 0.187 | 0.2118 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0119 | 0.3061 | 0.3468 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0046 | 0.0839 | 1 |
Loa Loa (eye worm) | bromodomain containing protein | 0.0035 | 0.0493 | 0.0559 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.05 | 0.0566 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.0823 | 0.1829 |
Loa Loa (eye worm) | hypothetical protein | 0.0118 | 0.3049 | 0.3454 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0486 | 0.0551 |
Echinococcus granulosus | methyl CpG binding domain protein 2 | 0.0034 | 0.0456 | 0.0456 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0118 | 0.3049 | 1 |
Trypanosoma brucei | ubiquitin carboxyl-terminal hydrolase, putative | 0.0038 | 0.0579 | 0.6905 |
Mycobacterium tuberculosis | Probable reductase | 0.0106 | 0.2655 | 0.8708 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) | 0.008 | 0.187 | 0.5765 |
Schistosoma mansoni | hypothetical protein | 0.0046 | 0.0843 | 0.1872 |
Mycobacterium tuberculosis | Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0035 | 0.0486 | 0.1596 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0843 | 0.0955 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0046 | 0.0839 | 0.2752 |
Brugia malayi | acetyl-Coenzyme A synthetase 2 | 0.0035 | 0.0486 | 0.0551 |
Leishmania major | acetyl-CoA synthetase, putative | 0.0035 | 0.0486 | 0.1596 |
Brugia malayi | Bromodomain containing protein | 0.0149 | 0.3971 | 0.4499 |
Trypanosoma cruzi | acetyl-CoA synthetase, putative | 0.0035 | 0.0486 | 0.5799 |
Mycobacterium tuberculosis | Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) | 0.0035 | 0.0486 | 0.1596 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0118 | 0.3049 | 1 |
Brugia malayi | Bromodomain containing protein | 0.0076 | 0.1745 | 0.1977 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.05 | 0.0566 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0118 | 0.3049 | 0.3454 |
Mycobacterium leprae | PROBABLE NADH DEHYDROGENASE NDH | 0.0106 | 0.2655 | 0.8585 |
Onchocerca volvulus | 0.0118 | 0.3049 | 1 | |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) | 0.0052 | 0.1026 | 0.2735 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.0823 | 0.1829 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0118 | 0.3049 | 1 |
Trypanosoma cruzi | ISWI complex protein | 0.003 | 0.035 | 0.4167 |
Toxoplasma gondii | AMP-binding enzyme domain-containing protein | 0.0035 | 0.0486 | 0.138 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0051 | 0.097 | 0.2155 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0106 | 0.2655 | 0.8708 |
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.1749 | 0.1981 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.05 | 0.0566 |
Mycobacterium ulcerans | O-succinylbenzoic acid--CoA ligase | 0.0035 | 0.0486 | 0.1596 |
Echinococcus multilocularis | lamin dm0 | 0.0028 | 0.0272 | 0.0272 |
Onchocerca volvulus | 0.0035 | 0.0486 | 0.0772 | |
Mycobacterium ulcerans | acetyl-CoA synthetase | 0.0035 | 0.0486 | 0.1596 |
Loa Loa (eye worm) | oxidoreductase | 0.0035 | 0.0486 | 0.0551 |
Wolbachia endosymbiont of Brugia malayi | ATP-dependent Clp protease proteolytic subunit | 0.008 | 0.187 | 0.5 |
Loa Loa (eye worm) | AMP-binding enzyme family protein | 0.0035 | 0.0486 | 0.0551 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0046 | 0.0843 | 0.0955 |
Plasmodium falciparum | acetyl-CoA synthetase, putative | 0.0035 | 0.0486 | 0.1186 |
Plasmodium falciparum | thioredoxin reductase | 0.0046 | 0.0839 | 0.3074 |
Plasmodium vivax | acetyl-CoA synthetase, putative | 0.0035 | 0.0486 | 0.1186 |
Echinococcus granulosus | peptidase Clp S14 family | 0.0052 | 0.1026 | 0.1026 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.0823 | 0.1829 |
Brugia malayi | AMP-binding enzyme family protein | 0.0118 | 0.3049 | 0.3454 |
Mycobacterium ulcerans | peptide synthetase Nrp (peptide synthase) | 0.0035 | 0.0486 | 0.1596 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0118 | 0.3043 | 0.3043 |
Trypanosoma brucei | trypanothione reductase | 0.0046 | 0.0839 | 1 |
Echinococcus multilocularis | tumor protein p63 | 0.0346 | 1 | 1 |
Plasmodium vivax | glutathione reductase, putative | 0.0046 | 0.0839 | 0.3074 |
Loa Loa (eye worm) | hypothetical protein | 0.0089 | 0.2132 | 0.2415 |
Onchocerca volvulus | 0.0035 | 0.0486 | 0.0772 | |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0035 | 0.0486 | 0.1596 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0089 | 0.2132 | 0.6992 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.01 | 0.2492 | 0.2823 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0117 | 0.3015 | 0.9881 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0071 | 0.1601 | 0.1601 |
Brugia malayi | AMP-binding enzyme family protein | 0.0035 | 0.0486 | 0.0551 |
Mycobacterium tuberculosis | Peptide synthetase MbtE (peptide synthase) | 0.0035 | 0.0486 | 0.1596 |
Brugia malayi | AMP-binding enzyme family protein | 0.0035 | 0.0486 | 0.0551 |
Echinococcus multilocularis | ATP dependent Clp protease proteolytic subunit | 0.008 | 0.187 | 0.187 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0046 | 0.0839 | 0.0839 |
Brugia malayi | AMP-binding enzyme family protein | 0.0118 | 0.3049 | 0.3454 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0046 | 0.0839 | 0.095 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0579 | 0.0656 |
Toxoplasma gondii | propionate-CoA ligase | 0.0035 | 0.0486 | 0.138 |
Onchocerca volvulus | 0.0035 | 0.0486 | 0.0772 | |
Giardia lamblia | Ubiquitin carboxyl-terminal hydrolase 4 | 0.0038 | 0.0579 | 1 |
Leishmania major | long-chain-fatty-acid-CoA ligase, putative | 0.0035 | 0.0486 | 0.1596 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0035 | 0.0486 | 0.1596 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -7.557 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -6.925 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -6.732 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -6.647 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -6.405 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -6.254 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -6.247 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.984 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.939 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.831 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.715 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.