Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0224 | 0.5479 | 0.5479 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0224 | 0.5479 | 0.463 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0118 | 0.1998 | 0.0496 |
Loa Loa (eye worm) | hypothetical protein | 0.0118 | 0.1998 | 0.0496 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0118 | 0.1998 | 0.0496 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0118 | 0.1998 | 0.1998 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0224 | 0.5479 | 0.463 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0224 | 0.5479 | 0.463 |
Schistosoma mansoni | thyroid hormone receptor | 0.0224 | 0.5479 | 0.5479 |
Brugia malayi | nuclear receptor RXR | 0.0118 | 0.1998 | 0.0496 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0224 | 0.5479 | 0.5479 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0224 | 0.5479 | 0.463 |
Entamoeba histolytica | protein kinase , putative | 0.0361 | 1 | 1 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0224 | 0.5479 | 0.463 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0224 | 0.5479 | 0.5479 |
Echinococcus granulosus | aurora kinase A | 0.0361 | 1 | 1 |
Schistosoma mansoni | hepatocyte nuclear factor 4-alpha (hnf-4-alpha) | 0.0106 | 0.1581 | 0.1581 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0224 | 0.5479 | 0.463 |
Brugia malayi | serine/threonine kinase 12 | 0.0361 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0224 | 0.5479 | 0.463 |
Schistosoma mansoni | nuclear hormone receptor superfamily protein-related | 0.0106 | 0.1581 | 0.1581 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0224 | 0.5479 | 0.463 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0224 | 0.5479 | 0.463 |
Entamoeba histolytica | serine/threonine- protein kinase 6 , putative | 0.0361 | 1 | 1 |
Loa Loa (eye worm) | AUR protein kinase | 0.0361 | 1 | 1 |
Brugia malayi | steroid hormone receptor | 0.0224 | 0.5479 | 0.463 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0118 | 0.1998 | 0.0496 |
Entamoeba histolytica | serine/threonine- protein kinase 6, putative | 0.0361 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0224 | 0.5479 | 0.463 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0118 | 0.1998 | 0.0496 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0224 | 0.5479 | 0.463 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0224 | 0.5479 | 0.463 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0224 | 0.5479 | 0.463 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0224 | 0.5479 | 0.463 |
Plasmodium falciparum | serine/threonine protein kinase, putative | 0.0361 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0224 | 0.5479 | 0.463 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0224 | 0.5479 | 0.463 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0224 | 0.5479 | 0.463 |
Loa Loa (eye worm) | hypothetical protein | 0.0118 | 0.1998 | 0.0496 |
Loa Loa (eye worm) | hypothetical protein | 0.0118 | 0.1998 | 0.0496 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0224 | 0.5479 | 0.463 |
Brugia malayi | ecdysteroid receptor | 0.0224 | 0.5479 | 0.463 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0224 | 0.5479 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0224 | 0.5479 | 0.463 |
Brugia malayi | Ribonuclease 2-5A family protein | 0.011 | 0.1713 | 0.0157 |
Brugia malayi | serine/threonine-protein kinase 6 | 0.0361 | 1 | 1 |
Toxoplasma gondii | aurora kinase | 0.0361 | 1 | 0.5 |
Plasmodium vivax | serine/threonine protein kinase 6, putative | 0.0361 | 1 | 0.5 |
Trichomonas vaginalis | AGC family protein kinase | 0.0361 | 1 | 0.5 |
Loa Loa (eye worm) | AUR protein kinase | 0.0361 | 1 | 1 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0224 | 0.5479 | 0.463 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0224 | 0.5479 | 0.5479 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0224 | 0.5479 | 0.463 |
Loa Loa (eye worm) | hypothetical protein | 0.0118 | 0.1998 | 0.0496 |
Giardia lamblia | Aurora kinase | 0.0361 | 1 | 0.5 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0118 | 0.1998 | 0.1998 |
Schistosoma mansoni | nuclear hormone receptor | 0.0106 | 0.1581 | 0.1581 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0224 | 0.5479 | 0.463 |
Schistosoma mansoni | nuclear receptor nhr-48 | 0.0106 | 0.1581 | 0.1581 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0224 | 0.5479 | 1 |
Echinococcus multilocularis | serine:threonine protein kinase 12 B | 0.0361 | 1 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0224 | 0.5479 | 0.463 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0224 | 0.5479 | 0.463 |
Echinococcus granulosus | FTZ F1 alpha | 0.0224 | 0.5479 | 0.463 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0224 | 0.5479 | 0.463 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0224 | 0.5479 | 0.463 |
Echinococcus granulosus | serine:threonine protein kinase 12 B | 0.0361 | 1 | 1 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0224 | 0.5479 | 0.463 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0361 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0224 | 0.5479 | 0.463 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0224 | 0.5479 | 0.463 |
Echinococcus granulosus | serine:threonine protein kinase:endoribonuclease | 0.011 | 0.1713 | 0.0157 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0224 | 0.5479 | 0.463 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0224 | 0.5479 | 1 |
Trypanosoma cruzi | aurora B kinase, putative | 0.0361 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0224 | 0.5479 | 0.463 |
Leishmania major | protein kinase, putative | 0.0361 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0118 | 0.1998 | 0.0496 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0361 | 1 | 1 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0224 | 0.5479 | 0.463 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0224 | 0.5479 | 0.463 |
Loa Loa (eye worm) | hypothetical protein | 0.0224 | 0.5479 | 0.463 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0224 | 0.5479 | 0.463 |
Loa Loa (eye worm) | hypothetical protein | 0.0224 | 0.5479 | 0.463 |
Brugia malayi | nuclear receptor NHR-88 | 0.0224 | 0.5479 | 0.463 |
Echinococcus multilocularis | aurora kinase A | 0.0361 | 1 | 1 |
Schistosoma mansoni | nuclear receptor | 0.0106 | 0.1581 | 0.1581 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0224 | 0.5479 | 0.5479 |
Schistosoma mansoni | nuclear hormone receptor | 0.0224 | 0.5479 | 0.5479 |
Schistosoma mansoni | thyroid hormone receptor | 0.0224 | 0.5479 | 0.5479 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0224 | 0.5479 | 0.5479 |
Trichomonas vaginalis | AGC family protein kinase | 0.0361 | 1 | 0.5 |
Schistosoma mansoni | coup transcription factor | 0.0224 | 0.5479 | 0.5479 |
Loa Loa (eye worm) | AUR protein kinase | 0.0361 | 1 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0361 | 1 | 0.5 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0224 | 0.5479 | 0.5479 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0224 | 0.5479 | 0.463 |
Loa Loa (eye worm) | hypothetical protein | 0.0224 | 0.5479 | 0.463 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0224 | 0.5479 | 0.463 |
Loa Loa (eye worm) | hypothetical protein | 0.0224 | 0.5479 | 0.463 |
Brugia malayi | hypothetical protein | 0.0118 | 0.1998 | 0.0496 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0224 | 0.5479 | 0.5479 |
Schistosoma mansoni | nuclear receptor | 0.0106 | 0.1581 | 0.1581 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0224 | 0.5479 | 0.463 |
Entamoeba histolytica | protein kinase, putative | 0.0361 | 1 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0361 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0224 | 0.5479 | 0.463 |
Loa Loa (eye worm) | IRE protein kinase | 0.011 | 0.1713 | 0.0157 |
Schistosoma mansoni | zinc finger protein | 0.0106 | 0.1581 | 0.1581 |
Trypanosoma brucei | aurora B kinase | 0.0361 | 1 | 0.5 |
Entamoeba histolytica | serine/threonine protein kinase 6, putative | 0.0361 | 1 | 1 |
Onchocerca volvulus | 0.0224 | 0.5479 | 1 | |
Loa Loa (eye worm) | steroid hormone receptor | 0.0224 | 0.5479 | 0.463 |
Trichomonas vaginalis | AGC family protein kinase | 0.0361 | 1 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0224 | 0.5479 | 0.463 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0224 | 0.5479 | 0.463 |
Schistosoma mansoni | nuclear hormone receptor | 0.0106 | 0.1581 | 0.1581 |
Brugia malayi | hypothetical protein | 0.0118 | 0.1998 | 0.0496 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0224 | 0.5479 | 0.463 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0224 | 0.5479 | 0.463 |
Schistosoma mansoni | protein kinase | 0.0361 | 1 | 1 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0224 | 0.5479 | 0.5479 |
Brugia malayi | nuclear hormone receptor | 0.0224 | 0.5479 | 0.463 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0224 | 0.5479 | 0.463 |
Echinococcus multilocularis | serine:threonine protein kinase:endoribonuclease | 0.011 | 0.1713 | 0.0157 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0224 | 0.5479 | 0.463 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0118 | 0.1998 | 0.0496 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -5.849 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.843 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.628 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.627 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.458 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.451 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.449 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.388 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.339 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.976 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.