Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | hypothetical protein | 0.0038 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0011 | 0.1372 | 0.1084 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0011 | 0.1372 | 0.1084 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.3909 | 0.6421 |
Trichomonas vaginalis | ap endonuclease, putative | 0.002 | 0.4273 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0011 | 0.1372 | 0.1084 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0011 | 0.1372 | 0.1084 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.002 | 0.4273 | 0.4082 |
Mycobacterium tuberculosis | Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) | 0.0007 | 0.0323 | 0.0546 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.002 | 0.4273 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0011 | 0.1372 | 0.1084 |
Schistosoma mansoni | thyroid hormone receptor | 0.0011 | 0.1372 | 0.1084 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0011 | 0.1372 | 0.1084 |
Brugia malayi | nuclear hormone receptor | 0.0011 | 0.1372 | 0.1084 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.1372 | 0.1878 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0025 | 0.5908 | 1 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0011 | 0.1372 | 0.1084 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0011 | 0.1372 | 0.1878 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.1372 | 0.1878 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 1 | 1 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.002 | 0.4273 | 0.7073 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0011 | 0.1372 | 0.1084 |
Mycobacterium tuberculosis | Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase | 0.0007 | 0.0323 | 0.0546 |
Trichomonas vaginalis | ap endonuclease, putative | 0.002 | 0.4273 | 1 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0018 | 0.3587 | 0.6071 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0025 | 0.5908 | 1 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0011 | 0.1372 | 0.1084 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0025 | 0.5908 | 1 |
Brugia malayi | steroid hormone receptor | 0.0011 | 0.1372 | 0.1084 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0011 | 0.1372 | 0.1084 |
Brugia malayi | nuclear receptor NHR-88 | 0.0011 | 0.1372 | 0.1084 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0011 | 0.1372 | 0.1084 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0011 | 0.1372 | 0.1878 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0011 | 0.1372 | 0.1878 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0011 | 0.1372 | 0.1878 |
Mycobacterium tuberculosis | P-hydroxybenzoyl-AMP ligase FadD22 | 0.0007 | 0.0323 | 0.0546 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0011 | 0.1372 | 0.1084 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 1 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0011 | 0.1372 | 0.1084 |
Schistosoma mansoni | nuclear hormone receptor | 0.0011 | 0.1372 | 0.1084 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.1372 | 0.1878 |
Schistosoma mansoni | ap endonuclease | 0.002 | 0.4273 | 0.4082 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.3909 | 0.6421 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0018 | 0.3587 | 0.6071 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0011 | 0.1372 | 0.1084 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0011 | 0.1372 | 0.1084 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0011 | 0.1372 | 0.1084 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.002 | 0.4273 | 0.7073 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.002 | 0.4273 | 0.4082 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0011 | 0.1372 | 0.1084 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0011 | 0.1372 | 0.1084 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0011 | 0.1372 | 0.1084 |
Schistosoma mansoni | thyroid hormone receptor | 0.0011 | 0.1372 | 0.1084 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0025 | 0.5908 | 1 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0025 | 0.5908 | 1 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0011 | 0.1372 | 0.1084 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0011 | 0.1372 | 0.1084 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0011 | 0.1372 | 0.1084 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0011 | 0.1372 | 0.1084 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0011 | 0.1372 | 0.1084 |
Plasmodium falciparum | acyl-CoA synthetase | 0.0019 | 0.3909 | 0.9078 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0019 | 0.3909 | 0.6617 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.002 | 0.4273 | 0.7073 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.002 | 0.4273 | 1 |
Echinococcus granulosus | FTZ F1 alpha | 0.0011 | 0.1372 | 0.1084 |
Brugia malayi | ecdysteroid receptor | 0.0011 | 0.1372 | 0.1084 |
Brugia malayi | AMP-binding enzyme family protein | 0.0025 | 0.5908 | 0.5772 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0011 | 0.1372 | 0.1084 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0007 | 0.0323 | 0.0546 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.5908 | 1 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.002 | 0.4273 | 1 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0025 | 0.5908 | 1 |
Mycobacterium tuberculosis | Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0007 | 0.0323 | 0.0546 |
Mycobacterium tuberculosis | Probable peptide synthetase Nrp (peptide synthase) | 0.0007 | 0.0323 | 0.0546 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.002 | 0.4273 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 1 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0038 | 1 | 1 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0025 | 0.5908 | 1 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0011 | 0.1372 | 0.1878 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0011 | 0.1372 | 0.1878 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0011 | 0.1372 | 0.1084 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0011 | 0.1372 | 0.1084 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0025 | 0.5908 | 1 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0011 | 0.1372 | 0.1878 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0011 | 0.1372 | 0.1084 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0011 | 0.1372 | 0.1084 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0011 | 0.1372 | 0.1084 |
Onchocerca volvulus | 0.0011 | 0.1372 | 0.1878 | |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.5908 | 1 |
Mycobacterium tuberculosis | Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) | 0.0007 | 0.0323 | 0.0546 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0019 | 0.3909 | 0.6421 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0011 | 0.1372 | 0.1878 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.1372 | 0.1878 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.002 | 0.4273 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0025 | 0.5908 | 1 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0011 | 0.1372 | 0.1084 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0011 | 0.1372 | 0.1084 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0025 | 0.5908 | 1 |
Mycobacterium tuberculosis | Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0007 | 0.0323 | 0.0546 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0011 | 0.1372 | 0.1084 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.0019 | 0.3909 | 0.9078 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.1372 | 0.1878 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0011 | 0.1372 | 0.1084 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0018 | 0.3587 | 0.6071 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0025 | 0.5908 | 1 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0011 | 0.1372 | 0.1084 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0025 | 0.5908 | 1 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.002 | 0.4273 | 0.4082 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.3909 | 0.6421 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.002 | 0.4273 | 0.7233 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0038 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.002 | 0.4273 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0011 | 0.1372 | 0.1084 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.002 | 0.4273 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.5908 | 1 |
Entamoeba histolytica | acyl-coA synthetase, putative | 0.0025 | 0.5908 | 0.5772 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0011 | 0.1372 | 0.1878 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0038 | 1 | 1 |
Mycobacterium tuberculosis | Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0007 | 0.0323 | 0.0546 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0011 | 0.1372 | 0.1084 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.0019 | 0.3909 | 0.5 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0025 | 0.5908 | 0.5772 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0011 | 0.1372 | 0.1084 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0018 | 0.3587 | 0.6071 |
Mycobacterium tuberculosis | Peptide synthetase MbtE (peptide synthase) | 0.0007 | 0.0323 | 0.0546 |
Brugia malayi | AMP-binding enzyme family protein | 0.0025 | 0.5908 | 0.5772 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0025 | 0.5908 | 1 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0011 | 0.1372 | 0.1084 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0011 | 0.1372 | 0.1084 |
Brugia malayi | AMP-binding enzyme family protein | 0.0025 | 0.5908 | 0.5772 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.3909 | 0.6421 |
Toxoplasma gondii | exonuclease III APE | 0.002 | 0.4273 | 1 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0025 | 0.5908 | 0.5772 |
Onchocerca volvulus | 0.0025 | 0.5908 | 1 | |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0011 | 0.1372 | 0.1084 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.1372 | 0.1878 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0025 | 0.5908 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.3909 | 0.6421 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.002 | 0.4273 | 0.4082 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0011 | 0.1372 | 0.1084 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0011 | 0.1372 | 0.1878 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.1372 | 0.1878 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.002 | 0.4273 | 1 |
Schistosoma mansoni | coup transcription factor | 0.0011 | 0.1372 | 0.1084 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0011 | 0.1372 | 0.1878 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.1372 | 0.1878 |
Schistosoma mansoni | ap endonuclease | 0.002 | 0.4273 | 0.4082 |
Mycobacterium tuberculosis | Peptide synthetase MbtF (peptide synthase) | 0.0007 | 0.0323 | 0.0546 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0025 | 0.5908 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -4.529 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.519 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.478 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.415 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.039 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.027 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.