Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Treponema pallidum | methionine aminopeptidase (map) | 0.0294 | 0 | 0.5 |
Mycobacterium ulcerans | methionine aminopeptidase MapB | 0.0294 | 0 | 0.5 |
Loa Loa (eye worm) | methionine aminopeptidase type I | 0.0465 | 0.6709 | 0.5 |
Mycobacterium leprae | PROBABLE METHIONINE AMINOPEPTIDASE MAPB (MAP) (PEPTIDASE M) | 0.0294 | 0 | 0.5 |
Chlamydia trachomatis | methionine aminopeptidase | 0.0294 | 0 | 0.5 |
Mycobacterium ulcerans | methionine aminopeptidase | 0.0294 | 0 | 0.5 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0548 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | methionine aminopeptidase | 0.0294 | 0 | 0.5 |
Mycobacterium leprae | PROBABLE METHIONINE AMINOPEPTIDASE MAPA (MAP) (PEPTIDASE M) (MetAP) | 0.0294 | 0 | 0.5 |
Trypanosoma brucei | methionine aminopeptidase, type I, putative | 0.0465 | 0.6709 | 0.5 |
Toxoplasma gondii | methionine aminopeptidase | 0.0465 | 0.6709 | 1 |
Plasmodium vivax | methionine aminopeptidase 1b, putative | 0.0465 | 0.6709 | 1 |
Echinococcus multilocularis | methionyl aminopeptidase 1 (M24 family) | 0.0465 | 0.6709 | 0.6709 |
Brugia malayi | Methionine aminopeptidase protein type I | 0.0465 | 0.6709 | 0.5 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0548 | 1 | 1 |
Trypanosoma cruzi | metallo- peptidase, Clan MG, Family M24 | 0.0465 | 0.6709 | 0.5 |
Leishmania major | methionine aminopeptidase, putative,metallo-peptidase, Clan MG, Family M24 | 0.0465 | 0.6709 | 0.5 |
Trypanosoma brucei | methionine aminopeptidase, putative | 0.0465 | 0.6709 | 0.5 |
Mycobacterium tuberculosis | Methionine aminopeptidase MapB (map) (peptidase M) | 0.0294 | 0 | 0.5 |
Trypanosoma cruzi | metallo- peptidase, Clan MG, Family M24 | 0.0465 | 0.6709 | 0.5 |
Mycobacterium tuberculosis | Methionine aminopeptidase MapA (map) (peptidase M) (MetAP) | 0.0294 | 0 | 0.5 |
Trypanosoma brucei | metallo- peptidase, Clan MG, Family M24 | 0.0465 | 0.6709 | 0.5 |
Plasmodium falciparum | methionine aminopeptidase 1b, putative | 0.0465 | 0.6709 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IA (functional) | = 75.7 % | Intrinsic activity determined in rat aorta | ChEMBL. | No reference |
Log EC50 (functional) | = 7.61 | Negative logarithm of the molar concentration required to relax rat aorta precontracted with 30 mM KCL by 50% of intrinsic activity | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.