Detailed information for compound 160475

Basic information

Technical information
  • TDR Targets ID: 160475
  • Name: N-acetyl-N-methylacetamide
  • MW: 115.13 | Formula: C5H9NO2
  • H donors: 0 H acceptors: 2 LogP: -0.5 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: CN(C(=O)C)C(=O)C
  • InChi: 1S/C5H9NO2/c1-4(7)6(3)5(2)8/h1-3H3
  • InChiKey: ZNQFZPCFVNOXJQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-acetyl-N-methyl-acetamide
  • N-ethanoyl-N-methyl-ethanamide
  • 1113-68-4
  • EINECS 214-207-0
  • Diacetamide, N-methyl-
  • FR-0481
  • SBB007865
  • InChI=1/C5H9NO2/c1-4(7)6(3)5(2)8/h1-3H
  • N-Methyldiacetamide
  • ZINC00409896
  • AI3-28901
  • Acetamide, N-acetyl-N-methyl-

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi hypothetical protein 0.014 0.0323 0.0323
Leishmania major beta tubulin 0.1329 0.382 1
Echinococcus multilocularis Tubulin beta 2C chain 0.1329 0.382 0.9698
Schistosoma mansoni hypothetical protein 0.1097 0.3139 0.6814
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.003 0.0078
Onchocerca volvulus 0.1097 0.3139 0.7968
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.1097 0.3139 0.7968
Schistosoma mansoni rhodopsin-like orphan GPCR 0.1097 0.3139 0.6814
Echinococcus multilocularis membrane associated guanylate kinase ww and pdz 0.005 0.0059 0.0151
Echinococcus multilocularis neuropeptides capa receptor 0.1097 0.3139 0.7968
Plasmodium falciparum plasmepsin V 0.0128 0.0288 0.0754
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.003 0.0078
Echinococcus granulosus rhodopsin orphan GPCR 0.1097 0.3139 0.7968
Loa Loa (eye worm) hypothetical protein 0.1097 0.3139 0.7968
Echinococcus granulosus tachykinin peptides receptor 99D 0.1097 0.3139 0.7968
Echinococcus multilocularis rhodopsin orphan GPCR 0.1097 0.3139 0.7968
Echinococcus granulosus orexin receptor type 2 0.1097 0.3139 0.7968
Schistosoma mansoni tubulin subunit beta 0.1329 0.382 0.8294
Giardia lamblia Beta tubulin 0.1329 0.382 0.5
Brugia malayi hypothetical protein 0.014 0.0323 0.0323
Echinococcus granulosus biogenic amine 5HT receptor 0.1097 0.3139 0.7968
Brugia malayi neuropeptide F receptor 0.1097 0.3139 0.3139
Brugia malayi G protein-coupled receptor 0.1097 0.3139 0.3139
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.1097 0.3139 0.7968
Loa Loa (eye worm) neuropeptide F receptor 0.1097 0.3139 0.7968
Echinococcus multilocularis rhodopsin orphan GPCR 0.1097 0.3139 0.7968
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0128 0.0288 0.0625
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0128 0.0288 0.0625
Schistosoma mansoni memapsin-2 (A01 family) 0.0128 0.0288 0.0625
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.1097 0.3139 0.6814
Schistosoma mansoni cd36 antigen 0.014 0.0323 0.0701
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.1097 0.3139 0.6814
Schistosoma mansoni amine GPCR 0.1097 0.3139 0.6814
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.003 0.0078
Echinococcus multilocularis neuropeptide FF receptor 2 0.1097 0.3139 0.7968
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0102 0.021 0.0457
Schistosoma mansoni tubulin subunit beta 0.1329 0.382 0.8294
Plasmodium vivax plasmepsin IV, putative 0.0541 0.1504 0.3751
Echinococcus granulosus neuropeptide receptor 0.1097 0.3139 0.7968
Echinococcus granulosus Tubulin beta 2C chain 0.1329 0.382 0.9698
Brugia malayi larval opioid receptor 0.1097 0.3139 0.3139
Echinococcus multilocularis Upstream activation factor subunit UAF30 0.0085 0.016 0.0407
Brugia malayi putative neuropeptide receptor NPR1 0.1097 0.3139 0.3139
Brugia malayi Dopamine receptor 0.1097 0.3139 0.3139
Loa Loa (eye worm) hypothetical protein 0.1097 0.3139 0.7968
Brugia malayi follicle stimulating hormone receptor 0.132 0.3794 0.3794
Plasmodium falciparum plasmepsin IV 0.0541 0.1504 0.3936
Echinococcus granulosus biogenic amine 5HT receptor 0.1097 0.3139 0.7968
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.0001 0.0003
Leishmania major beta tubulin 0.1329 0.382 1
Onchocerca volvulus 0.0128 0.0288 0.0731
Brugia malayi Melatonin receptor type 1A 0.1097 0.3139 0.3139
Echinococcus granulosus allatostatin A receptor 0.1369 0.3939 1
Echinococcus multilocularis Glycoside hydrolase, family 27 0.0102 0.021 0.0534
Brugia malayi G protein-coupled receptor F59B2.13 0.1097 0.3139 0.3139
Loa Loa (eye worm) hypothetical protein 0.1097 0.3139 0.7968
Echinococcus multilocularis tubulin subunit beta 0.1329 0.382 0.9698
Onchocerca volvulus 0.1097 0.3139 0.7968
Loa Loa (eye worm) hypothetical protein 0.1097 0.3139 0.7968
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.1097 0.3139 0.3139
Trichomonas vaginalis tubulin gamma chain, putative 0.1329 0.382 1
Loa Loa (eye worm) brahma associated protein 0.0085 0.016 0.0407
Echinococcus granulosus serotonin receptor 0.1097 0.3139 0.7968
Loa Loa (eye worm) hypothetical protein 0.1097 0.3139 0.7968
Schistosoma mansoni CD36-like class B scavenger receptor 0.014 0.0323 0.0701
Loa Loa (eye worm) thioredoxin reductase 0.0069 0.0113 0.0287
Loa Loa (eye worm) hypothetical protein 0.0086 0.0164 0.0416
Schistosoma mansoni hypothetical protein 0.1097 0.3139 0.6814
Schistosoma mansoni opsin-like receptor 0.1097 0.3139 0.6814
Brugia malayi Pepsin A precursor 0.0128 0.0288 0.0288
Onchocerca volvulus 0.1097 0.3139 0.7968
Echinococcus multilocularis neuropeptide Y receptor 0.1097 0.3139 0.7968
Echinococcus multilocularis rhodopsin orphan GPCR 0.1097 0.3139 0.7968
Echinococcus granulosus fmrfamide receptor 0.1097 0.3139 0.7968
Echinococcus granulosus integrin alpha ps 0.007 0.0117 0.0296
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0102 0.021 0.0457
Toxoplasma gondii beta-tubulin, putative 0.1329 0.382 1
Plasmodium falciparum plasmepsin I 0.0541 0.1504 0.3936
Brugia malayi RE15519p 0.1097 0.3139 0.3139
Loa Loa (eye worm) hypothetical protein 0.1097 0.3139 0.7968
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.1097 0.3139 0.7968
Schistosoma mansoni amine GPCR 0.1097 0.3139 0.6814
Echinococcus granulosus alpha 1A adrenergic receptor 0.1097 0.3139 0.7968
Schistosoma mansoni rhodopsin-like orphan GPCR 0.1097 0.3139 0.6814
Schistosoma mansoni rhodopsin-like orphan GPCR 0.1097 0.3139 0.6814
Brugia malayi neuropeptide F receptor 0.1097 0.3139 0.3139
Onchocerca volvulus 0.1097 0.3139 0.7968
Echinococcus granulosus 7TM GPCR rhodopsin 0.1097 0.3139 0.7968
Schistosoma mansoni cathepsin D (A01 family) 0.1596 0.4606 1
Echinococcus granulosus G protein coupled receptor 139 0.1097 0.3139 0.7968
Echinococcus multilocularis rhodopsin orphan GPCR 0.1097 0.3139 0.7968
Echinococcus multilocularis g protein coupled receptor 0.1097 0.3139 0.7968
Brugia malayi aspartic protease BmAsp-1, identical 0.0128 0.0288 0.0288
Echinococcus granulosus neuropeptide receptor 0.1097 0.3139 0.7968
Brugia malayi Dopamine receptor protein 2 0.1097 0.3139 0.3139
Schistosoma mansoni thyroid hormone receptor 0.0135 0.0308 0.0669
Echinococcus multilocularis Tubulin beta 2C chain 0.1329 0.382 0.9698
Trypanosoma cruzi trypanothione reductase, putative 0.0069 0.0113 0.0296
Plasmodium falciparum glutathione reductase 0.0069 0.0113 0.0296
Brugia malayi gonadotropin-releasing hormone receptor 2 0.1097 0.3139 0.3139
Echinococcus multilocularis rhodopsin orphan GPCR 0.1097 0.3139 0.7968
Echinococcus granulosus g protein coupled receptor 0.1097 0.3139 0.7968
Echinococcus multilocularis integrin alpha ps 0.007 0.0117 0.0296
Plasmodium vivax tubulin beta chain, putative 0.1329 0.382 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.1097 0.3139 0.6814
Toxoplasma gondii DNA topoisomerase domain-containing protein 0.0085 0.016 0.042
Echinococcus granulosus sex peptide receptor 0.1097 0.3139 0.7968
Schistosoma mansoni scavenger receptor class B type-2 (sr-B2) 0.014 0.0323 0.0701
Leishmania major beta tubulin 0.1329 0.382 1
Loa Loa (eye worm) aspartyl protease 6 0.0128 0.0288 0.0731
Loa Loa (eye worm) hypothetical protein 0.1097 0.3139 0.7968
Plasmodium falciparum plasmepsin IX 0.0128 0.0288 0.0754
Onchocerca volvulus 0.1097 0.3139 0.7968
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.1097 0.3139 0.7968
Loa Loa (eye worm) follicle stimulating hormone receptor 0.132 0.3794 0.9632
Trypanosoma brucei beta tubulin 0.1329 0.382 1
Leishmania major beta tubulin 0.1329 0.382 1
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.1097 0.3139 0.3139
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.0001 0.0003
Echinococcus granulosus neuropeptides capa receptor 0.1097 0.3139 0.7968
Schistosoma mansoni neuropeptide receptor 0.1097 0.3139 0.6814
Brugia malayi hypothetical protein 0.0128 0.0288 0.0288
Echinococcus granulosus neuropeptide Y receptor 0.1097 0.3139 0.7968
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0068 0.0111 0.0241
Loa Loa (eye worm) glutathione reductase 0.0069 0.0113 0.0287
Echinococcus granulosus hypothetical protein 0.1097 0.3139 0.7968
Schistosoma mansoni peptide (allatostatin)-like receptor 0.1369 0.3939 0.8552
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0068 0.0111 0.0241
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.1097 0.3139 0.6814
Plasmodium vivax aspartyl protease, putative 0.0128 0.0288 0.0472
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.1097 0.3139 0.7968
Leishmania major beta tubulin 0.1329 0.382 1
Loa Loa (eye worm) hypothetical protein 0.1097 0.3139 0.7968
Schistosoma mansoni hypothetical protein 0.0085 0.016 0.0348
Trichomonas vaginalis tubulin epsilon chain, putative 0.1329 0.382 1
Loa Loa (eye worm) hypothetical protein 0.005 0.0059 0.0151
Loa Loa (eye worm) G-protein coupled receptor 0.1097 0.3139 0.7968
Schistosoma mansoni tubulin subunit beta 0.1329 0.382 0.8294
Plasmodium falciparum thioredoxin reductase 0.0069 0.0113 0.0296
Loa Loa (eye worm) hypothetical protein 0.1097 0.3139 0.7968
Leishmania major beta tubulin 0.1329 0.382 1
Echinococcus multilocularis allatostatin A receptor 0.1369 0.3939 1
Echinococcus granulosus beta tubulin 0.1329 0.382 0.9698
Trichomonas vaginalis tubulin, putative 0.1329 0.382 1
Loa Loa (eye worm) hypothetical protein 0.1097 0.3139 0.7968
Loa Loa (eye worm) hypothetical protein 0.0118 0.0258 0.0654
Schistosoma mansoni amine GPCR 0.1097 0.3139 0.6814
Loa Loa (eye worm) hypothetical protein 0.1097 0.3139 0.7968
Schistosoma mansoni brg-1 associated factor 0.0085 0.016 0.0348
Brugia malayi Tachykinin-like peptides receptor 99D 0.1097 0.3139 0.3139
Schistosoma mansoni opsin-like receptor 0.1097 0.3139 0.6814
Echinococcus multilocularis fmrfamide receptor 0.1097 0.3139 0.7968
Echinococcus multilocularis neuropeptide receptor 0.1097 0.3139 0.7968
Loa Loa (eye worm) hypothetical protein 0.0122 0.0271 0.0688
Schistosoma mansoni neuropeptide F-like receptor 0.1097 0.3139 0.6814
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.1097 0.3139 0.7968
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.1097 0.3139 0.7968
Schistosoma mansoni biogenic amine (5HT) receptor 0.1097 0.3139 0.6814
Echinococcus multilocularis dna polymerase kappa 0.004 0.003 0.0076
Echinococcus granulosus Alpha N acetylgalactosaminidase 0.0102 0.021 0.0534
Leishmania major beta tubulin 0.1329 0.382 1
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.003 0.0078
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.1097 0.3139 0.6814
Leishmania major beta tubulin 0.1329 0.382 1
Echinococcus granulosus rhodopsin orphan GPCR 0.1097 0.3139 0.7968
Echinococcus multilocularis CD36 class B scavenger receptor 0.014 0.0323 0.082
Onchocerca volvulus Lysosome membrane protein 2 homolog 0.014 0.0323 0.082
Trypanosoma brucei beta tubulin 0.1329 0.382 1
Leishmania major beta tubulin 0.1329 0.382 1
Plasmodium vivax aspartyl protease, putative 0.0128 0.0288 0.0472
Echinococcus granulosus neuropeptide Y receptor 0.1097 0.3139 0.7968
Trichomonas vaginalis conserved hypothetical protein 0.0085 0.016 0.0344
Echinococcus multilocularis dro:myosuppressin receptor 0.1097 0.3139 0.7968
Loa Loa (eye worm) hypothetical protein 0.1097 0.3139 0.7968
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0102 0.021 0.0457
Echinococcus multilocularis alpha 1A adrenergic receptor 0.1097 0.3139 0.7968
Leishmania major C-8 sterol isomerase-like protein 0.0401 0.1092 0.2859
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.003 0.0078
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0128 0.0288 0.0625
Schistosoma mansoni growth hormone secretagogue receptor 0.1097 0.3139 0.6814
Onchocerca volvulus 0.1097 0.3139 0.7968
Plasmodium falciparum plasmepsin X 0.0128 0.0288 0.0754
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0128 0.0288 0.0625
Echinococcus multilocularis integrin alpha ps 0.0033 0.001 0.0025
Loa Loa (eye worm) hypothetical protein 0.1097 0.3139 0.7968
Echinococcus granulosus g protein coupled receptor 0.1097 0.3139 0.7968
Echinococcus multilocularis tubulin, beta 4A class IVa 0.1329 0.382 0.9698
Trypanosoma brucei DNA polymerase IV, putative 0.0034 0.0011 0.0028
Schistosoma mansoni biogenic amine (5HT) receptor 0.1097 0.3139 0.6814
Plasmodium falciparum plasmepsin III 0.0128 0.0288 0.0754
Plasmodium falciparum tubulin beta chain 0.1329 0.382 1
Echinococcus granulosus integrin alpha 3 0.0119 0.0262 0.0666
Schistosoma mansoni hypothetical protein 0.0125 0.0279 0.0605
Echinococcus granulosus integrin alpha ps 0.0033 0.001 0.0025
Echinococcus multilocularis CD36 class B scavenger receptor 0.014 0.0323 0.082
Echinococcus multilocularis SWI:SNF matrix associated 0.0085 0.016 0.0407
Plasmodium falciparum plasmepsin VII 0.0128 0.0288 0.0754
Loa Loa (eye worm) hypothetical protein 0.003 0.0001 0.0003
Brugia malayi glutathione reductase 0.0069 0.0113 0.0113
Onchocerca volvulus 0.1097 0.3139 0.7968
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.1097 0.3139 0.6814
Schistosoma mansoni cathepsin D (A01 family) 0.1596 0.4606 1
Trypanosoma brucei beta tubulin 0.1329 0.382 1
Loa Loa (eye worm) hypothetical protein 0.014 0.0323 0.082
Brugia malayi beta-tubulin, identical 0.1329 0.382 0.382
Leishmania major beta tubulin 0.1329 0.382 1
Trypanosoma brucei C-8 sterol isomerase, putative 0.0401 0.1092 0.2859
Echinococcus granulosus tubulin subunit beta 0.1329 0.382 0.9698
Echinococcus multilocularis CD36 class B scavenger receptor 0.014 0.0323 0.082
Onchocerca volvulus 0.1097 0.3139 0.7968
Echinococcus granulosus neuropeptide FF receptor 2 0.1097 0.3139 0.7968
Echinococcus multilocularis Tubulin beta 2C chain 0.1329 0.382 0.9698
Trypanosoma brucei trypanothione reductase 0.0069 0.0113 0.0296
Schistosoma mansoni membrane associated guanylate kinase inverted related 0.005 0.0059 0.0129
Echinococcus multilocularis g protein coupled receptor 0.1097 0.3139 0.7968
Schistosoma mansoni hypothetical protein 0.0653 0.1833 0.398
Loa Loa (eye worm) hypothetical protein 0.014 0.0323 0.082
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.1097 0.3139 0.6814
Echinococcus multilocularis membrane associated guanylate kinase, WW and PDZ 0.005 0.0059 0.0151
Loa Loa (eye worm) hypothetical protein 0.014 0.0323 0.082
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0541 0.1504 0.3265
Echinococcus multilocularis Tubulin beta 2C chain 0.1329 0.382 0.9698
Schistosoma mansoni neuropeptide F-like receptor 0.1097 0.3139 0.6814
Trypanosoma brucei DNA polymerase IV, putative 0.004 0.003 0.0078
Plasmodium falciparum plasmepsin VI 0.0541 0.1504 0.3936
Echinococcus granulosus rhodopsin orphan GPCR 0.1097 0.3139 0.7968
Leishmania major beta tubulin 0.1329 0.382 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.003 0.0078
Onchocerca volvulus Neuropeptide F receptor homolog 0.1097 0.3139 0.7968
Schistosoma mansoni hypothetical protein 0.0085 0.016 0.0348
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0401 0.1092 0.1092
Loa Loa (eye worm) G-protein coupled receptor 0.1097 0.3139 0.7968
Loa Loa (eye worm) hypothetical protein 0.1097 0.3139 0.7968
Echinococcus granulosus neuropeptide s receptor 0.1097 0.3139 0.7968
Mycobacterium ulcerans DNA polymerase IV 0.004 0.003 0.5
Brugia malayi hypothetical protein 0.1097 0.3139 0.3139
Leishmania major beta tubulin 0.1329 0.382 1
Echinococcus granulosus lysosome membrane protein 2 0.014 0.0323 0.082
Brugia malayi putative neuropeptide receptor 0.1097 0.3139 0.3139
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.0085 0.016 0.042
Toxoplasma gondii aspartyl protease ASP1 0.0541 0.1504 0.3936
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0102 0.021 0.0457
Trichomonas vaginalis tubulin beta chain, putative 0.1329 0.382 1
Schistosoma mansoni tubulin subunit beta 0.1329 0.382 0.8294
Echinococcus multilocularis G protein coupled receptor 139 0.1097 0.3139 0.7968
Echinococcus multilocularis SWI:SNF matrix associated 0.0085 0.016 0.0407
Loa Loa (eye worm) hypothetical protein 0.1097 0.3139 0.7968
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.1097 0.3139 0.7968
Schistosoma mansoni tubulin subunit beta 0.1329 0.382 0.8294
Plasmodium vivax plasmepsin V, putative 0.0128 0.0288 0.0472
Loa Loa (eye worm) BEN-1 protein 0.1329 0.382 0.9698
Echinococcus multilocularis sex peptide receptor 0.1097 0.3139 0.7968
Loa Loa (eye worm) hypothetical protein 0.1097 0.3139 0.7968
Schistosoma mansoni tubulin subunit beta 0.1329 0.382 0.8294
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.003 0.0078
Brugia malayi hypothetical protein 0.0128 0.0288 0.0288
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.1097 0.3139 0.7968
Schistosoma mansoni myosin xvIII 0.1097 0.3139 0.6814
Brugia malayi Serotonin receptor 0.1097 0.3139 0.3139
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0128 0.0288 0.0625
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.1097 0.3139 0.7968
Brugia malayi hypothetical protein 0.1097 0.3139 0.3139
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0541 0.1504 0.3817
Onchocerca volvulus 0.1097 0.3139 0.7968
Brugia malayi hypothetical protein 0.1097 0.3139 0.3139
Echinococcus multilocularis orexin receptor type 2 0.1097 0.3139 0.7968
Loa Loa (eye worm) hypothetical protein 0.0205 0.0515 0.1307
Loa Loa (eye worm) hypothetical protein 0.0033 0.001 0.0025
Loa Loa (eye worm) melatonin receptor type 1A 0.1097 0.3139 0.7968
Echinococcus granulosus 3'partial|membrane associated guanylate kinase ww and pdz 0.005 0.0059 0.0151
Loa Loa (eye worm) hypothetical protein 0.1097 0.3139 0.7968
Echinococcus granulosus thyrotropin releasing hormone receptor 0.1097 0.3139 0.7968
Schistosoma mansoni integrin alpha-ps 0.007 0.0117 0.0253
Echinococcus granulosus Upstream activation factor subunit UAF30 0.0085 0.016 0.0407
Loa Loa (eye worm) hypothetical protein 0.1097 0.3139 0.7968
Echinococcus granulosus membrane associated guanylate kinase ww and pdz 0.007 0.0118 0.0298
Loa Loa (eye worm) hypothetical protein 0.014 0.0323 0.082
Echinococcus multilocularis neuropeptide Y receptor 0.1097 0.3139 0.7968
Toxoplasma gondii beta-1 tubulin, putative 0.1329 0.382 1
Loa Loa (eye worm) hypothetical protein 0.1097 0.3139 0.7968
Brugia malayi hypothetical protein 0.1097 0.3139 0.3139
Echinococcus granulosus Tubulin beta 2C chain 0.1329 0.382 0.9698
Loa Loa (eye worm) hypothetical protein 0.014 0.0323 0.082
Brugia malayi hypothetical protein 0.1097 0.3139 0.3139
Echinococcus multilocularis integrin alpha 3 0.0119 0.0262 0.0666
Echinococcus multilocularis thioredoxin glutathione reductase 0.0069 0.0113 0.0287
Brugia malayi aspartic protease BmAsp-2, identical 0.0128 0.0288 0.0288
Echinococcus granulosus membrane associated guanylate kinase ww and pdz 0.005 0.0059 0.0151
Schistosoma mansoni adenoreceptor 0.1097 0.3139 0.6814
Schistosoma mansoni biogenic amine (dopamine) receptor 0.1097 0.3139 0.6814
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.003 0.0078
Loa Loa (eye worm) hypothetical protein 0.1369 0.3939 1
Echinococcus granulosus CD36 class B scavenger receptor 0.014 0.0323 0.082
Schistosoma mansoni hypothetical protein 0.0033 0.001 0.0021
Echinococcus multilocularis neuropeptide receptor 0.1097 0.3139 0.7968
Echinococcus granulosus Tubulin beta 2C chain 0.1329 0.382 0.9698
Brugia malayi brahma associated protein 60 kDa 0.0085 0.016 0.016
Giardia lamblia Beta tubulin 0.1329 0.382 0.5
Onchocerca volvulus 0.0128 0.0288 0.0731
Schistosoma mansoni integrin alpha-ps 0.0036 0.0018 0.004
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0401 0.1092 0.2859
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.1097 0.3139 0.6814
Loa Loa (eye worm) hypothetical protein 0.1097 0.3139 0.7968
Loa Loa (eye worm) hypothetical protein 0.0036 0.0018 0.0047
Trypanosoma brucei unspecified product 0.0034 0.0011 0.0028
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0541 0.1504 0.3936
Leishmania major beta tubulin 0.1329 0.382 1
Brugia malayi Integrin alpha pat-2 precursor 0.0156 0.0369 0.0369
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0128 0.0288 0.0625
Brugia malayi PDZ domain containing protein 0.0051 0.0063 0.0063
Brugia malayi ORL1-like opioid receptor 0.1097 0.3139 0.3139
Loa Loa (eye worm) beta-tubulin 0.1329 0.382 0.9698
Loa Loa (eye worm) tubulin beta-2A chain 0.1329 0.382 0.9698
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0128 0.0288 0.0625
Leishmania major trypanothione reductase 0.0069 0.0113 0.0296
Echinococcus multilocularis beta tubulin 0.1329 0.382 0.9698
Echinococcus multilocularis thyroid hormone receptor alpha 0.0135 0.0308 0.0783
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.003 0.0078
Echinococcus multilocularis integrin alpha ps 0.007 0.0117 0.0296
Echinococcus granulosus thioredoxin glutathione reductase 0.0069 0.0113 0.0287
Leishmania major beta tubulin 0.1329 0.382 1
Trypanosoma brucei RNA helicase, putative 0.0653 0.1833 0.4799
Echinococcus granulosus somatostatin receptor 0.1097 0.3139 0.7968
Loa Loa (eye worm) hypothetical protein 0.1097 0.3139 0.7968
Onchocerca volvulus 0.1097 0.3139 0.7968
Brugia malayi CD36 family protein 0.014 0.0323 0.0323
Mycobacterium ulcerans DNA polymerase IV 0.004 0.003 0.5
Loa Loa (eye worm) hypothetical protein 0.1097 0.3139 0.7968
Loa Loa (eye worm) hypothetical protein 0.0128 0.0288 0.0731
Plasmodium vivax hypothetical protein, conserved 0.0085 0.016 0.0128
Loa Loa (eye worm) hypothetical protein 0.0128 0.0288 0.0731
Schistosoma mansoni membrane associated guanylate kinase inverted related 0.007 0.0118 0.0255
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0128 0.0288 0.0625
Echinococcus multilocularis tubulin beta 1 chain 0.1329 0.382 0.9698
Loa Loa (eye worm) hypothetical protein 0.1097 0.3139 0.7968
Loa Loa (eye worm) hypothetical protein 0.0051 0.0063 0.0159
Loa Loa (eye worm) hypothetical protein 0.1097 0.3139 0.7968
Onchocerca volvulus 0.1097 0.3139 0.7968
Brugia malayi hypothetical protein 0.1097 0.3139 0.3139
Loa Loa (eye worm) hypothetical protein 0.0068 0.0111 0.0281
Chlamydia trachomatis SWIB complex protein 0.0085 0.016 0.5
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.1097 0.3139 0.7968
Chlamydia trachomatis DNA topoisomerase I 0.0085 0.016 0.5
Loa Loa (eye worm) hypothetical protein 0.1097 0.3139 0.7968
Trypanosoma cruzi beta tubulin, putative 0.1329 0.382 1
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.1097 0.3139 0.3139
Echinococcus granulosus CD36 class B scavenger receptor 0.014 0.0323 0.082
Echinococcus multilocularis SWI:SNF matrix associated 0.0085 0.016 0.0407
Echinococcus granulosus rhodopsin orphan GPCR 0.1097 0.3139 0.7968
Schistosoma mansoni rhodopsin-like orphan GPCR 0.1097 0.3139 0.6814
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.003 0.0078
Schistosoma mansoni hypothetical protein 0.0085 0.016 0.0348
Schistosoma mansoni biogenic amine receptor 0.1097 0.3139 0.6814
Echinococcus granulosus neuropeptide receptor A26 0.1097 0.3139 0.7968
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.003 0.0078
Brugia malayi G-protein coupled receptor 0.1097 0.3139 0.3139
Plasmodium vivax SWIB/MDM2 domain-containing protein, putative 0.0085 0.016 0.0128
Trypanosoma brucei beta tubulin 0.1329 0.382 1
Schistosoma mansoni neuropeptide receptor 0.1097 0.3139 0.6814
Brugia malayi polk-prov protein 0.003 0.0001 0.0001
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.003 0.0078
Mycobacterium tuberculosis Possible exported protein 0.0544 0.1513 1
Leishmania major beta tubulin 0.1329 0.382 1
Loa Loa (eye worm) hypothetical protein 0.0541 0.1504 0.3817
Schistosoma mansoni rhodopsin-like orphan GPCR 0.1097 0.3139 0.6814
Echinococcus multilocularis beta tubulin 0.1329 0.382 0.9698
Echinococcus multilocularis serotonin receptor 0.1097 0.3139 0.7968
Toxoplasma gondii beta tubulin 0.1329 0.382 1
Echinococcus multilocularis g-protein coupled receptor 0.1097 0.3139 0.7968
Echinococcus granulosus 7tm_1 domain containing protein 0.1097 0.3139 0.7968
Brugia malayi Tubulin beta-1 chain 0.1329 0.382 0.382
Schistosoma mansoni neuropeptide receptor 0.1097 0.3139 0.6814
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0541 0.1504 0.3888
Schistosoma mansoni rhodopsin-like orphan GPCR 0.1097 0.3139 0.6814
Schistosoma mansoni hypothetical protein 0.1097 0.3139 0.6814
Onchocerca volvulus 0.1097 0.3139 0.7968
Loa Loa (eye worm) hypothetical protein 0.1097 0.3139 0.7968
Echinococcus granulosus tm gpcr rhodopsin 0.1097 0.3139 0.7968
Loa Loa (eye worm) hypothetical protein 0.1097 0.3139 0.7968
Echinococcus granulosus CD36 class B scavenger receptor 0.014 0.0323 0.082
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.1097 0.3139 0.7968
Loa Loa (eye worm) tubulin beta-4 chain 0.1329 0.382 0.9698
Echinococcus granulosus dro:myosuppressin receptor 0.1097 0.3139 0.7968
Brugia malayi SWIB/MDM2 domain containing protein 0.0085 0.016 0.016
Toxoplasma gondii SWIB/MDM2 domain-containing protein 0.0085 0.016 0.042
Loa Loa (eye worm) hypothetical protein 0.1097 0.3139 0.7968
Trichomonas vaginalis tubulin alpha chain, putative 0.1329 0.382 1
Toxoplasma gondii aspartyl protease ASP3 0.0128 0.0288 0.0754
Onchocerca volvulus 0.1097 0.3139 0.7968
Plasmodium vivax aspartyl protease, putative 0.0128 0.0288 0.0472
Loa Loa (eye worm) hypothetical protein 0.1097 0.3139 0.7968
Brugia malayi hypothetical protein 0.1097 0.3139 0.3139
Loa Loa (eye worm) hypothetical protein 0.1097 0.3139 0.7968
Schistosoma mansoni amine GPCR 0.1097 0.3139 0.6814
Brugia malayi Eukaryotic aspartyl protease family protein 0.0128 0.0288 0.0288
Echinococcus multilocularis rhodopsin orphan GPCR 0.1097 0.3139 0.7968
Brugia malayi brahma associated protein 60 kDa 0.0085 0.016 0.016
Echinococcus multilocularis neuropeptides capa receptor 0.1097 0.3139 0.7968
Echinococcus multilocularis Alpha N acetylgalactosaminidase 0.0102 0.021 0.0534
Echinococcus multilocularis fmrfamide receptor 0.1097 0.3139 0.7968
Echinococcus granulosus g-protein coupled receptor 0.1097 0.3139 0.7968
Schistosoma mansoni neuropeptide f receptor 76f 0.1097 0.3139 0.6814
Brugia malayi hypothetical protein 0.1097 0.3139 0.3139
Loa Loa (eye worm) hypothetical protein 0.1097 0.3139 0.7968
Loa Loa (eye worm) TYRA-2 protein 0.1097 0.3139 0.7968
Echinococcus granulosus tm gpcr rhodopsin 0.1097 0.3139 0.7968
Schistosoma mansoni alpha-1 adrenergic receptor 0.1097 0.3139 0.6814
Echinococcus granulosus CD36 class B scavenger receptor 0.014 0.0323 0.082
Echinococcus multilocularis lysosome membrane protein 2 0.014 0.0323 0.082
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0125 0.0279 0.0708
Brugia malayi G-protein coupled receptor 0.1097 0.3139 0.3139
Plasmodium vivax aspartyl proteinase, putative 0.0128 0.0288 0.0472
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0125 0.0279 0.0708
Leishmania major beta tubulin 0.1329 0.382 1
Echinococcus granulosus dna polymerase kappa 0.004 0.003 0.0076
Brugia malayi Thioredoxin reductase 0.0069 0.0113 0.0113
Echinococcus multilocularis tachykinin peptides receptor 99D 0.1097 0.3139 0.7968
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.1097 0.3139 0.7968
Leishmania major beta tubulin 0.1329 0.382 1
Echinococcus granulosus tm gpcr rhodopsin 0.1097 0.3139 0.7968
Echinococcus multilocularis CD36 class B scavenger receptor 0.014 0.0323 0.082
Entamoeba histolytica tubulin family protein 0.1329 0.382 0.5
Echinococcus multilocularis neuropeptide s receptor 0.1097 0.3139 0.7968
Entamoeba histolytica tubulin family protein 0.1329 0.382 0.5
Brugia malayi Serotonin/octopamine receptor family protein 7 0.1097 0.3139 0.3139
Onchocerca volvulus 0.1097 0.3139 0.7968
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.003 0.0078
Echinococcus multilocularis 0.007 0.0118 0.0298
Onchocerca volvulus 0.1097 0.3139 0.7968
Loa Loa (eye worm) tubulin beta-1 chain 0.1329 0.382 0.9698
Plasmodium vivax aspartyl proteinase, putative 0.0541 0.1504 0.3751
Echinococcus granulosus peptide allatostatin:somatostatin 0.1097 0.3139 0.7968
Schistosoma mansoni neuropeptide receptor 0.1097 0.3139 0.6814
Loa Loa (eye worm) neuropeptide F receptor 0.1097 0.3139 0.7968
Loa Loa (eye worm) hypothetical protein 0.1097 0.3139 0.7968
Loa Loa (eye worm) hypothetical protein 0.1097 0.3139 0.7968
Plasmodium falciparum plasmepsin VIII, putative 0.0128 0.0288 0.0754
Schistosoma mansoni opsin-like receptor 0.1097 0.3139 0.6814
Echinococcus granulosus rhodopsin orphan GPCR 0.1097 0.3139 0.7968
Echinococcus multilocularis g protein coupled receptor 0.1097 0.3139 0.7968
Echinococcus granulosus membrane associated guanylate kinase, WW and PDZ 0.005 0.0059 0.0151
Echinococcus granulosus beta tubulin 0.1329 0.382 0.9698
Loa Loa (eye worm) hypothetical protein 0.014 0.0323 0.082
Plasmodium falciparum plasmepsin II 0.0541 0.1504 0.3936
Brugia malayi AKH receptor 0.1097 0.3139 0.3139
Echinococcus multilocularis biogenic amine (5HT) receptor 0.1097 0.3139 0.7968
Brugia malayi hypothetical protein 0.1097 0.3139 0.3139
Loa Loa (eye worm) hypothetical protein 0.1097 0.3139 0.7968
Schistosoma mansoni hypothetical protein 0.1097 0.3139 0.6814
Loa Loa (eye worm) hypothetical protein 0.1097 0.3139 0.7968
Loa Loa (eye worm) aspartic protease BmAsp-1 0.0128 0.0288 0.0731
Trichomonas vaginalis tubulin epsilon chain, putative 0.1329 0.382 1
Echinococcus multilocularis somatostatin receptor 0.1097 0.3139 0.7968
Onchocerca volvulus 0.0085 0.016 0.0407
Toxoplasma gondii thioredoxin reductase 0.0069 0.0113 0.0296
Echinococcus granulosus g protein coupled receptor 0.1097 0.3139 0.7968
Schistosoma mansoni biogenic amine receptor 0.1097 0.3139 0.6814
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.0085 0.016 0.042
Echinococcus granulosus Tubulin beta 2C chain 0.1329 0.382 0.9698
Schistosoma mansoni amine GPCR 0.1097 0.3139 0.6814
Echinococcus granulosus SWI:SNF matrix associated 0.0085 0.016 0.0407
Schistosoma mansoni CD36-like class B scavenger receptor 0.014 0.0323 0.0701
Echinococcus multilocularis Tubulin beta 2C chain 0.1329 0.382 0.9698
Brugia malayi Serotonin receptor 0.1097 0.3139 0.3139
Toxoplasma gondii aspartyl protease 0.0128 0.0288 0.0754
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.1097 0.3139 0.7968
Trichomonas vaginalis alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative 0.0068 0.0111 0.0214
Loa Loa (eye worm) hypothetical protein 0.1097 0.3139 0.7968
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.1097 0.3139 0.7968
Onchocerca volvulus 0.1097 0.3139 0.7968
Echinococcus multilocularis neuropeptide receptor A26 0.1097 0.3139 0.7968
Schistosoma mansoni rhodopsin-like orphan GPCR 0.1097 0.3139 0.6814
Loa Loa (eye worm) hypothetical protein 0.1097 0.3139 0.7968
Brugia malayi hypothetical protein 0.1097 0.3139 0.3139
Toxoplasma gondii eukaryotic aspartyl protease superfamily protein 0.0128 0.0288 0.0754
Echinococcus granulosus neuropeptides capa receptor 0.1097 0.3139 0.7968
Echinococcus multilocularis G-protein coupled receptor, putative 0.1097 0.3139 0.7968
Echinococcus granulosus Tubulin beta 2C chain 0.1329 0.382 0.9698
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.1097 0.3139 0.7968
Echinococcus granulosus rhodopsin orphan GPCR 0.1097 0.3139 0.7968
Echinococcus multilocularis serotonin receptor 0.1097 0.3139 0.7968
Schistosoma mansoni biogenic amine (dopamine) receptor 0.1097 0.3139 0.6814
Schistosoma mansoni rhodopsin-like orphan GPCR 0.1097 0.3139 0.6814
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.1097 0.3139 0.7968
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0541 0.1504 0.3817
Echinococcus multilocularis rhodopsin orphan GPCR 0.1097 0.3139 0.7968
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.1097 0.3139 0.7968
Echinococcus granulosus CD36 class B scavenger receptor 0.014 0.0323 0.082
Schistosoma mansoni integrin alpha 0.0156 0.0369 0.0802
Loa Loa (eye worm) hypothetical protein 0.1097 0.3139 0.7968
Toxoplasma gondii melibiase subfamily protein 0.0102 0.021 0.0551
Loa Loa (eye worm) hypothetical protein 0.1097 0.3139 0.7968
Schistosoma mansoni rhodopsin-like orphan GPCR 0.1097 0.3139 0.6814
Brugia malayi Dopamine receptor protein 1 0.1097 0.3139 0.3139
Schistosoma mansoni thyroid hormone receptor 0.0135 0.0308 0.0669
Giardia lamblia Beta tubulin 0.1329 0.382 0.5
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.1097 0.3139 0.7968
Loa Loa (eye worm) hypothetical protein 0.1097 0.3139 0.7968
Onchocerca volvulus 0.1369 0.3939 1
Trypanosoma brucei DNA polymerase IV, putative 0.004 0.003 0.0078
Brugia malayi Melibiase family protein 0.0068 0.0111 0.0111
Echinococcus granulosus rhodopsin orphan GPCR 0.1097 0.3139 0.7968
Echinococcus multilocularis rhodopsin orphan GPCR 0.1097 0.3139 0.7968
Leishmania major beta tubulin 0.1329 0.382 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.1097 0.3139 0.6814
Schistosoma mansoni biogenic amine receptor 0.1097 0.3139 0.6814
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.1097 0.3139 0.6814
Loa Loa (eye worm) tubulin beta chain 0.1329 0.382 0.9698
Echinococcus multilocularis CD36 class B scavenger receptor 0.014 0.0323 0.082
Schistosoma mansoni histamine h1 receptor 0.1097 0.3139 0.6814
Loa Loa (eye worm) hypothetical protein 0.0401 0.1092 0.2773
Brugia malayi Integrin alpha cytoplasmic region family protein 0.0118 0.0258 0.0258
Echinococcus granulosus tubulin beta 4A class IVa 0.1329 0.382 0.9698
Loa Loa (eye worm) hypothetical protein 0.1097 0.3139 0.7968
Loa Loa (eye worm) integrin alpha pat-2 0.024 0.0617 0.1567
Loa Loa (eye worm) BEN-1 protein 0.1329 0.382 0.9698
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.1097 0.3139 0.7968
Loa Loa (eye worm) hypothetical protein 0.1097 0.3139 0.7968
Loa Loa (eye worm) SWIB/MDM2 domain-containing protein 0.0085 0.016 0.0407
Loa Loa (eye worm) hypothetical protein 0.1097 0.3139 0.7968
Brugia malayi sulfakinin receptor protein 0.1097 0.3139 0.3139
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0541 0.1504 0.3817
Echinococcus granulosus tubulin beta 1 chain 0.1329 0.382 0.9698
Loa Loa (eye worm) hypothetical protein 0.1097 0.3139 0.7968
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.1097 0.3139 0.7968

Activities

Activity type Activity value Assay description Source Reference
kOH (ADMET) = 1.54 M-1 s-1 Second-order rate constant (M-1 s-1) for the alkaline hydrolysis of the compound in water at 30 degrees C ChEMBL. 12061887

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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