Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.189 | 1 | 1 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0025 | 0.0093 | 0.0093 |
Plasmodium falciparum | acyl-CoA synthetase | 0.0018 | 0.006 | 0.006 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.189 | 1 | 1 |
Trypanosoma brucei | unspecified product | 0.002 | 0.0068 | 0.0068 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.0018 | 0.006 | 0.006 |
Brugia malayi | Isocitrate dehydrogenase | 0.189 | 1 | 1 |
Trypanosoma brucei | isocitrate dehydrogenase, putative | 0.189 | 1 | 1 |
Entamoeba histolytica | tartrate dehydrogenase, putative | 0.023 | 0.1181 | 1 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.002 | 0.0068 | 0.0068 |
Trypanosoma cruzi | isocitrate dehydrogenase, putative | 0.189 | 1 | 1 |
Trichomonas vaginalis | isocitrate dehydrogenase, putative | 0.023 | 0.1181 | 1 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0025 | 0.0093 | 0.0785 |
Leishmania major | DNA polymerase kappa, putative | 0.002 | 0.0068 | 0.0068 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.189 | 1 | 1 |
Loa Loa (eye worm) | isocitrate dehydrogenase gamma subunit | 0.023 | 0.1181 | 0.1181 |
Loa Loa (eye worm) | ImpB/MucB/SamB family protein | 0.002 | 0.0068 | 0.0068 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0025 | 0.0093 | 0.0785 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0025 | 0.0093 | 0.0785 |
Echinococcus multilocularis | isocitrate dehydrogenase (NAD+) | 0.023 | 0.1181 | 0.1181 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0025 | 0.0093 | 0.0785 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0048 | 0.0215 | 0.0215 |
Echinococcus multilocularis | dna polymerase eta | 0.002 | 0.0068 | 0.0068 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0025 | 0.0093 | 0.0785 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0017 | 0.0054 | 0.0054 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.189 | 1 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0048 | 0.0215 | 0.0215 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0025 | 0.0093 | 0.0785 |
Trypanosoma brucei | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.189 | 1 | 1 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.002 | 0.0068 | 0.0068 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0.0068 | 0.0068 |
Brugia malayi | Isocitrate dehydrogenase subunit gamma, mitochondrial precursor | 0.023 | 0.1181 | 0.1181 |
Echinococcus multilocularis | terminal deoxycytidyl transferase rev1 | 0.002 | 0.0068 | 0.0068 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0025 | 0.0093 | 0.0093 |
Brugia malayi | AMP-binding enzyme family protein | 0.0025 | 0.0093 | 0.0093 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0048 | 0.0215 | 0.0215 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0093 | 0.0093 |
Schistosoma mansoni | Isocitrate dehydrogenase [NAD] subunit gamma mitochondrial | 0.023 | 0.1181 | 0.1181 |
Mycobacterium leprae | PROBABLE 3-ISOPROPYLMALATE DEHYDROGENASE LEUB (BETA-IPM DEHYDROGENASE) (IMDH) (3-IPM-DH) | 0.023 | 0.1181 | 1 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.002 | 0.0068 | 0.0068 |
Leishmania major | DNA polymerase kappa, putative,DNA polymerase IV, putative | 0.002 | 0.0068 | 0.0068 |
Brugia malayi | AMP-binding enzyme family protein | 0.0025 | 0.0093 | 0.0093 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0.0068 | 0.0068 |
Schistosoma mansoni | DNA polymerase eta | 0.002 | 0.0068 | 0.0068 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0093 | 0.0093 |
Trypanosoma cruzi | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.189 | 1 | 1 |
Schistosoma mansoni | rab geranylgeranyl transferase alpha subunit | 0.002 | 0.0068 | 0.0068 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0025 | 0.0093 | 0.0093 |
Echinococcus multilocularis | dna polymerase kappa | 0.002 | 0.0068 | 0.0068 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0017 | 0.0054 | 0.0054 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.006 | 0.006 |
Entamoeba histolytica | deoxycytidyl transferase, putative | 0.002 | 0.0068 | 0.0578 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.0845 | 0.4449 | 0.4449 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.189 | 1 | 1 |
Plasmodium vivax | isocitrate dehydrogenase [NADP], mitochondrial, putative | 0.189 | 1 | 1 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.189 | 1 | 1 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.189 | 1 | 1 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0025 | 0.0093 | 0.0093 |
Wolbachia endosymbiont of Brugia malayi | isocitrate dehydrogenase | 0.023 | 0.1181 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0014 | 0.0035 | 0.0035 |
Echinococcus multilocularis | isocitrate dehydrogenase (NAD) subunit | 0.023 | 0.1181 | 0.1181 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0068 | 0.0068 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.002 | 0.0068 | 0.0068 |
Echinococcus granulosus | isocitrate dehydrogenase NAD subunit | 0.023 | 0.1181 | 0.1181 |
Onchocerca volvulus | 0.0025 | 0.0093 | 1 | |
Echinococcus granulosus | dna polymerase eta | 0.002 | 0.0068 | 0.0068 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0018 | 0.006 | 0.006 |
Echinococcus granulosus | isocitrate dehydrogenase NAD | 0.023 | 0.1181 | 0.1181 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.006 | 0.006 |
Loa Loa (eye worm) | hypothetical protein | 0.023 | 0.1181 | 0.1181 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.002 | 0.0068 | 0.0068 |
Brugia malayi | Probable isocitrate dehydrogenase | 0.023 | 0.1181 | 0.1181 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0.0068 | 0.0068 |
Trypanosoma brucei | unspecified product | 0.0014 | 0.0035 | 0.0035 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.002 | 0.0068 | 0.0068 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.002 | 0.0068 | 0.0578 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0048 | 0.0215 | 0.0215 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0048 | 0.0215 | 0.0215 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.002 | 0.0068 | 0.0068 |
Brugia malayi | AMP-binding enzyme family protein | 0.0025 | 0.0093 | 0.0093 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.002 | 0.0068 | 0.0068 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0048 | 0.0215 | 0.0215 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0025 | 0.0093 | 0.0785 |
Giardia lamblia | DINP protein human, muc B family | 0.002 | 0.0068 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.006 | 0.006 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0.0068 | 0.0068 |
Leishmania major | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.189 | 1 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0048 | 0.0215 | 0.0215 |
Schistosoma mansoni | isocitrate dehydrogenase | 0.023 | 0.1181 | 0.1181 |
Brugia malayi | Probable isocitrate dehydrogenase | 0.023 | 0.1181 | 0.1181 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.006 | 0.006 |
Mycobacterium tuberculosis | Probable 3-isopropylmalate dehydrogenase LeuB (beta-IPM dehydrogenase) (IMDH) (3-IPM-DH) | 0.023 | 0.1181 | 0.1181 |
Entamoeba histolytica | acyl-coA synthetase, putative | 0.0025 | 0.0093 | 0.0785 |
Mycobacterium ulcerans | 3-isopropylmalate dehydrogenase | 0.023 | 0.1181 | 1 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0025 | 0.0093 | 0.0785 |
Brugia malayi | isocitrate dehydrogenase [NAD] subunit beta, mitochondrial | 0.023 | 0.1181 | 0.1181 |
Echinococcus granulosus | dna polymerase kappa | 0.002 | 0.0068 | 0.0068 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.006 | 0.006 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.189 | 1 | 1 |
Trypanosoma brucei | unspecified product | 0.0014 | 0.0035 | 0.0035 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0025 | 0.0093 | 0.0785 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.002 | 0.0068 | 0.0068 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0014 | 0.0035 | 0.0035 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0017 | 0.0054 | 0.0054 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0.0068 | 0.0068 |
Brugia malayi | isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial | 0.023 | 0.1181 | 0.1181 |
Schistosoma mansoni | terminal deoxycytidyl transferase | 0.002 | 0.0068 | 0.0068 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0.0068 | 0.0068 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0014 | 0.0035 | 0.0035 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.002 | 0.0068 | 0.0068 |
Mycobacterium ulcerans | DNA polymerase IV | 0.002 | 0.0068 | 0.0578 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0.0068 | 0.0068 |
Mycobacterium ulcerans | hypothetical protein | 0.0025 | 0.0093 | 0.0785 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0048 | 0.0215 | 0.0215 |
Schistosoma mansoni | unc-13 (munc13) | 0.023 | 0.1181 | 0.1181 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.0018 | 0.006 | 0.5 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.189 | 1 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0.0068 | 0.0068 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0025 | 0.0093 | 0.0785 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.002 | 0.0068 | 0.0068 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.002 | 0.0068 | 0.0578 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.002 | 0.0068 | 0.0068 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0.0068 | 0.0068 |
Echinococcus granulosus | terminal deoxycytidyl transferase rev1 | 0.002 | 0.0068 | 0.0068 |
Mycobacterium ulcerans | DNA polymerase IV | 0.002 | 0.0068 | 0.0578 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.002 | 0.0068 | 0.0068 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0.0068 | 0.0068 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.189 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0093 | 0.0093 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.189 | 1 | 1 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0025 | 0.0093 | 0.0093 |
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.189 | 1 | 1 |
Leishmania major | DNA polymerase eta, putative | 0.002 | 0.0068 | 0.0068 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0018 | 0.006 | 0.0504 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0025 | 0.0093 | 0.0785 |
Leishmania major | isocitrate dehydrogenase, putative | 0.023 | 0.1181 | 0.1181 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0017 | 0.0054 | 0.0054 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0048 | 0.0215 | 0.0215 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 29 % | Inhibition of bovine plasma thrombin using Boc-Val-Pro-Arg-AMC as substrate at 25 uM preincubated for 15 mins measured after 10 mins by fluorimetric assay | ChEMBL. | 22077389 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.