Detailed information for compound 16050

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 841.005 | Formula: C42H64N8O10
  • H donors: 9 H acceptors: 9 LogP: 2.64 Rotable bonds: 30
    Rule of 5 violations (Lipinski): 3
  • SMILES: COC(=O)CC(C(NC(=O)C(NC(=O)CC(C(NC(=O)C(NC(=O)C(Cc1c[nH]c2c1cccc2)NC(=O)OC(C)(C)C)Cc1nc[nH]c1)CC(C)C)O)C)CC(C)C)O
  • InChi: 1S/C42H64N8O10/c1-23(2)14-30(34(51)18-36(53)46-25(5)38(55)47-31(15-24(3)4)35(52)19-37(54)59-9)48-40(57)33(17-27-21-43-22-45-27)49-39(56)32(50-41(58)60-42(6,7)8)16-26-20-44-29-13-11-10-12-28(26)29/h10-13,20-25,30-35,44,51-52H,14-19H2,1-9H3,(H,43,45)(H,46,53)(H,47,55)(H,48,57)(H,49,56)(H,50,58)
  • InChiKey: QWBOCOHZLMYOIA-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium vivax plasmepsin IV, putative 0.0168 0.0781 0.1848
Echinococcus multilocularis g protein coupled receptor 0.0067 0.0149 0.0142
Brugia malayi EGF-like domain containing protein 0.0055 0.0072 0.0161
Loa Loa (eye worm) hypothetical protein 0.0084 0.0252 0.0693
Echinococcus multilocularis neuropeptide s receptor 0.1648 1 1
Onchocerca volvulus 0.0067 0.0149 0.0287
Echinococcus granulosus tachykinin peptides receptor 99D 0.0067 0.0149 0.0142
Loa Loa (eye worm) hypothetical protein 0.0091 0.0299 0.0822
Echinococcus granulosus tm gpcr rhodopsin 0.0067 0.0149 0.0142
Echinococcus granulosus peptide allatostatin:somatostatin 0.0067 0.0149 0.0142
Loa Loa (eye worm) hypothetical protein 0.005 0.0046 0.0128
Echinococcus multilocularis dro:myosuppressin receptor 0.0067 0.0149 0.0142
Echinococcus granulosus g protein coupled receptor 0.0067 0.0149 0.0142
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0084 0.0252 0.0318
Loa Loa (eye worm) hypothetical protein 0.0067 0.0149 0.0411
Onchocerca volvulus 0.0236 0.1204 0.3227
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0269 0.1408 0.1402
Toxoplasma gondii kringle domain-containing protein 0.0236 0.1204 0.2911
Echinococcus multilocularis chromobox protein 1 0.0068 0.0156 0.0149
Plasmodium vivax ataxin-2 like protein, putative 0.0111 0.0423 0.0948
Echinococcus multilocularis protein jagged 2 0.0055 0.0072 0.0065
Schistosoma mansoni neuropeptide receptor 0.0067 0.0149 0.0184
Loa Loa (eye worm) hypothetical protein 0.0084 0.0252 0.0693
Brugia malayi KE2 family protein 0.0064 0.0129 0.0304
Toxoplasma gondii hypothetical protein 0.0059 0.0097 0.0127
Echinococcus granulosus neurogenic locus notch protein 0.0055 0.0072 0.0065
Schistosoma mansoni growth hormone secretagogue receptor 0.0067 0.0149 0.0184
Onchocerca volvulus 0.0093 0.0309 0.0733
Loa Loa (eye worm) hypothetical protein 0.0054 0.007 0.0193
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.005 0.0046 0.0051
Onchocerca volvulus Neurogenic locus notch homolog 0.0055 0.0072 0.0071
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0168 0.0781 0.1848
Brugia malayi hypothetical protein 0.005 0.0046 0.0098
Brugia malayi Animal haem peroxidase family protein 0.0054 0.007 0.0157
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0067 0.0149 0.0184
Echinococcus multilocularis enteropeptidase 0.0084 0.0252 0.0245
Toxoplasma gondii dihydroorotate dehydrogenase reveal, putative 0.0689 0.4025 1
Loa Loa (eye worm) hypothetical protein 0.0054 0.007 0.0193
Schistosoma mansoni glutaminase 0.03 0.16 0.2066
Echinococcus granulosus Mastin 0.0084 0.0252 0.0245
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.005 0.0042 0.0035
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.005 0.0041 0.0113
Schistosoma mansoni hypothetical protein 0.0929 0.552 0.7148
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0265 0.1381 0.3336
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0067 0.0149 0.0184
Mycobacterium tuberculosis Probable dihydroorotate dehydrogenase PyrD 0.0689 0.4025 1
Echinococcus granulosus fmrfamide receptor 0.0067 0.0149 0.0142
Onchocerca volvulus 0.0093 0.0309 0.0733
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0067 0.0149 0.0184
Schistosoma mansoni notch 0.0055 0.0072 0.0084
Leishmania major dihydroorotate dehydrogenase 0.0689 0.4025 1
Brugia malayi Protein kinase domain containing protein 0.0236 0.1204 0.298
Onchocerca volvulus Dual oxidase homolog 0.0054 0.007 0.0067
Schistosoma mansoni lamin 0.0093 0.0309 0.0392
Loa Loa (eye worm) hypothetical protein 0.0067 0.0149 0.0411
Echinococcus granulosus neuropeptide receptor A26 0.1648 1 1
Onchocerca volvulus 0.0084 0.0252 0.0573
Brugia malayi hypothetical protein 0.0143 0.0625 0.1538
Schistosoma mansoni hypothetical protein 0.007 0.0171 0.0212
Toxoplasma gondii PAN domain-containing protein 0.0059 0.0097 0.0127
Onchocerca volvulus 0.0067 0.0149 0.0287
Echinococcus multilocularis sex peptide receptor 0.0067 0.0149 0.0142
Echinococcus multilocularis GPCR, family 2 0.007 0.0171 0.0164
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0052 0.0058 0.0051
Toxoplasma gondii 1,3(4)-beta-glucanase 0.0059 0.0097 0.0127
Loa Loa (eye worm) hypothetical protein 0.0054 0.007 0.0193
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0067 0.0149 0.0411
Schistosoma mansoni cercarial elastase (S01 family) 0.0084 0.0252 0.0318
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0053 0.0061 0.0006
Onchocerca volvulus 0.0067 0.0149 0.0287
Onchocerca volvulus 0.0054 0.007 0.0067
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.007 0.0171 0.0407
Loa Loa (eye worm) hypothetical protein 0.0067 0.0149 0.0411
Schistosoma mansoni 6-phosphofructokinase 0.0105 0.0386 0.0491
Schistosoma mansoni hypothetical protein 0.007 0.0171 0.0212
Loa Loa (eye worm) hypothetical protein 0.0055 0.0072 0.0197
Loa Loa (eye worm) neuropeptide F receptor 0.0067 0.0149 0.0411
Schistosoma mansoni biogenic amine receptor 0.0067 0.0149 0.0184
Schistosoma mansoni biogenic amine (5HT) receptor 0.0067 0.0149 0.0184
Schistosoma mansoni cathepsin D (A01 family) 0.0585 0.3373 0.4364
Brugia malayi EGF-like domain containing protein 0.0055 0.0072 0.0161
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.005 0.0046 0.0051
Loa Loa (eye worm) hypothetical protein 0.0152 0.068 0.1871
Plasmodium falciparum ataxin-2 like protein, putative 0.0111 0.0423 0.0948
Echinococcus granulosus neurogenic locus protein delta 0.0055 0.0072 0.0065
Echinococcus multilocularis g protein coupled receptor 0.0067 0.0149 0.0142
Loa Loa (eye worm) phosphofructokinase 0.0105 0.0386 0.1062
Schistosoma mansoni hypothetical protein 0.0055 0.0072 0.0084
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0269 0.1408 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0067 0.0149 0.0142
Loa Loa (eye worm) G-protein coupled receptor 0.0067 0.0149 0.0411
Toxoplasma gondii microneme protein MIC4 0.0059 0.0097 0.0127
Toxoplasma gondii aspartyl protease ASP3 0.0149 0.066 0.1542
Brugia malayi putative neuropeptide receptor NPR1 0.0067 0.0149 0.0354
Echinococcus multilocularis peroxidasin 0.0054 0.007 0.0063
Onchocerca volvulus Huntingtin homolog 0.0143 0.0625 0.1613
Toxoplasma gondii prefoldin subunit 6, putative 0.0064 0.0129 0.0209
Schistosoma mansoni hypothetical protein 0.0055 0.0072 0.0084
Schistosoma mansoni cercarial elastase (S01 family) 0.0084 0.0252 0.0318
Onchocerca volvulus 0.0503 0.2868 0.7862
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0067 0.0149 0.0184
Echinococcus multilocularis laminin 0.0069 0.0161 0.0154
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0081 0.0234 0.047
Echinococcus multilocularis G-protein coupled receptor, putative 0.0067 0.0149 0.0142
Loa Loa (eye worm) low-density lipoprotein receptor repeat class B containing protein 0.0069 0.0161 0.0442
Loa Loa (eye worm) hypothetical protein 0.0627 0.3635 1
Echinococcus granulosus hypothetical protein 0.0067 0.0149 0.0142
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0067 0.0149 0.0184
Schistosoma mansoni cercarial elastase (S01 family) 0.0084 0.0252 0.0318
Echinococcus multilocularis transmembrane protease serine 3 0.0084 0.0252 0.0245
Loa Loa (eye worm) PAN domain-containing protein 0.0059 0.0097 0.0266
Loa Loa (eye worm) hypothetical protein 0.0067 0.0149 0.0411
Echinococcus multilocularis tissue type plasminogen activator 0.0236 0.1204 0.1198
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0067 0.0149 0.0354
Loa Loa (eye worm) hypothetical protein 0.0064 0.0129 0.0356
Schistosoma mansoni cercarial elastase (S01 family) 0.0084 0.0252 0.0318
Loa Loa (eye worm) hypothetical protein 0.0067 0.0149 0.0411
Loa Loa (eye worm) hypothetical protein 0.0055 0.0072 0.0197
Loa Loa (eye worm) TK/ROR protein kinase 0.0236 0.1204 0.3313
Schistosoma mansoni intermediate filament proteins 0.0093 0.0309 0.0392
Onchocerca volvulus 0.0059 0.0097 0.0141
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0084 0.0252 0.0318
Brugia malayi PAN domain containing protein 0.0059 0.0097 0.0223
Schistosoma mansoni neuropeptide F-like receptor 0.0067 0.0149 0.0184
Loa Loa (eye worm) hypothetical protein 0.0084 0.0252 0.0693
Onchocerca volvulus Huntingtin homolog 0.0143 0.0625 0.1613
Echinococcus multilocularis muscleblind protein 1 0.0329 0.1779 0.1773
Brugia malayi Calcium binding EGF domain containing protein 0.0069 0.0161 0.0383
Echinococcus multilocularis notch 0.0055 0.0072 0.0065
Loa Loa (eye worm) hypothetical protein 0.0067 0.0149 0.0411
Schistosoma mansoni hypothetical protein 0.0055 0.0072 0.0084
Loa Loa (eye worm) notch protein 0.0055 0.0072 0.0197
Loa Loa (eye worm) hypothetical protein 0.0627 0.3635 1
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0084 0.0252 0.0318
Trichomonas vaginalis chromobox protein, putative 0.0068 0.0156 0.0182
Brugia malayi larval opioid receptor 0.0067 0.0149 0.0354
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0067 0.0149 0.0184
Loa Loa (eye worm) hypothetical protein 0.0223 0.1119 0.3078
Echinococcus granulosus tm gpcr rhodopsin 0.0067 0.0149 0.0142
Echinococcus multilocularis rhodopsin orphan GPCR 0.0067 0.0149 0.0142
Trichomonas vaginalis phosphofructokinase, putative 0.0105 0.0386 0.1744
Echinococcus granulosus protein jagged 1 0.0055 0.0072 0.0065
Echinococcus granulosus fibropellin Ia 0.0055 0.0072 0.0065
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0067 0.0149 0.0184
Plasmodium falciparum plasmepsin II 0.0168 0.0781 0.1848
Wolbachia endosymbiont of Brugia malayi dihydroorotate dehydrogenase 2 0.0689 0.4025 1
Echinococcus granulosus protein jagged 2 0.0055 0.0072 0.0065
Echinococcus granulosus transmembrane protease serine 3 0.0084 0.0252 0.0245
Loa Loa (eye worm) hypothetical protein 0.0067 0.0149 0.0411
Echinococcus granulosus lamin dm0 0.0093 0.0309 0.0302
Echinococcus multilocularis 6 phosphofructokinase 0.0105 0.0386 0.0379
Loa Loa (eye worm) hypothetical protein 0.0329 0.1779 0.4894
Brugia malayi Cadherin domain containing protein 0.0055 0.0072 0.0161
Loa Loa (eye worm) hypothetical protein 0.0055 0.0072 0.0197
Brugia malayi hypothetical protein 0.005 0.0046 0.0098
Brugia malayi Heterochromatin protein 1 0.0068 0.0156 0.0371
Echinococcus multilocularis geminin 0.0929 0.552 0.5517
Brugia malayi G protein-coupled receptor F59B2.13 0.0067 0.0149 0.0354
Leishmania major hypothetical protein, conserved 0.0236 0.1204 0.2889
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0105 0.0386 0.0826
Onchocerca volvulus 0.0084 0.0252 0.0573
Echinococcus multilocularis neurogenic locus notch protein 0.0055 0.0072 0.0065
Loa Loa (eye worm) hypothetical protein 0.0081 0.0234 0.0642
Brugia malayi Tachykinin-like peptides receptor 99D 0.0067 0.0149 0.0354
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0053 0.0061 0.0006
Echinococcus granulosus neuropeptide receptor 0.0067 0.0149 0.0142
Brugia malayi G-protein coupled receptor 0.0067 0.0149 0.0354
Loa Loa (eye worm) hypothetical protein 0.0067 0.0149 0.0411
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0168 0.0781 0.0775
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0067 0.0149 0.0142
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0067 0.0149 0.0142
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0269 0.1408 0.8693
Echinococcus multilocularis neuropeptide Y receptor 0.0067 0.0149 0.0142
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0236 0.1204 0.2911
Schistosoma mansoni cell polarity protein 0.0055 0.0072 0.0084
Echinococcus granulosus prefoldin subunit 6 0.0064 0.0129 0.0122
Echinococcus multilocularis G protein coupled receptor 139 0.0067 0.0149 0.0142
Loa Loa (eye worm) hypothetical protein 0.0069 0.0161 0.0442
Brugia malayi PAN domain containing protein 0.0059 0.0097 0.0223
Brugia malayi hypothetical protein 0.0067 0.0149 0.0354
Echinococcus granulosus neuropeptides capa receptor 0.0067 0.0149 0.0142
Loa Loa (eye worm) hypothetical protein 0.0055 0.0072 0.0197
Loa Loa (eye worm) hypothetical protein 0.0111 0.0423 0.1164
Brugia malayi Calcium binding EGF domain containing protein 0.0055 0.0072 0.0161
Echinococcus multilocularis neuropeptide receptor 0.0067 0.0149 0.0142
Loa Loa (eye worm) hypothetical protein 0.0067 0.0149 0.0411
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0067 0.0149 0.0142
Loa Loa (eye worm) melatonin receptor type 1A 0.0067 0.0149 0.0411
Schistosoma mansoni opsin-like receptor 0.0067 0.0149 0.0184
Schistosoma mansoni hypothetical protein 0.0067 0.0149 0.0184
Brugia malayi Calcitonin receptor-like protein seb-1 0.0223 0.1119 0.2768
Echinococcus granulosus alpha 1A adrenergic receptor 0.0067 0.0149 0.0142
Echinococcus granulosus GPCR family 2 0.007 0.0171 0.0164
Schistosoma mansoni hypothetical protein 0.0055 0.0072 0.0084
Schistosoma mansoni hypothetical protein 0.0084 0.0252 0.0318
Schistosoma mansoni memapsin-2 (A01 family) 0.005 0.0046 0.0051
Schistosoma mansoni septate junction protein 0.0055 0.0072 0.0084
Schistosoma mansoni hypothetical protein 0.0236 0.1204 0.1552
Echinococcus granulosus peptidase Clp S14 family 0.0053 0.0061 0.0054
Echinococcus granulosus Tolloid protein 1 0.0069 0.0161 0.0154
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0269 0.1408 0.8693
Echinococcus multilocularis snurportin 1 0.0338 0.1836 0.183
Loa Loa (eye worm) hypothetical protein 0.0067 0.0149 0.0411
Loa Loa (eye worm) hypothetical protein 0.0069 0.0161 0.0442
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0168 0.0781 0.0775
Schistosoma mansoni hypothetical protein 0.0056 0.0084 0.0099
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0067 0.0149 0.0184
Plasmodium falciparum plasmepsin VI 0.0168 0.0781 0.1848
Echinococcus granulosus neurogenic locus notch protein 0.0055 0.0072 0.0065
Echinococcus granulosus neuropeptides capa receptor 0.0067 0.0149 0.0142
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0269 0.1408 0.8693
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.007 0.0171 0.0164
Loa Loa (eye worm) hypothetical protein 0.0055 0.0072 0.0197
Echinococcus multilocularis lamin 0.0093 0.0309 0.0302
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0338 0.1836 0.505
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0067 0.0149 0.0142
Toxoplasma gondii microneme protein MIC17B 0.0059 0.0097 0.0127
Onchocerca volvulus 0.0054 0.007 0.0067
Brugia malayi Intermediate filament tail domain containing protein 0.0093 0.0309 0.0752
Trypanosoma cruzi dihydroorotate dehydrogenase, putative 0.0689 0.4025 1
Onchocerca volvulus 0.0055 0.0072 0.0071
Onchocerca volvulus Peroxidasin homolog 0.0054 0.007 0.0067
Trichomonas vaginalis phosphofructokinase, putative 0.0105 0.0386 0.1744
Loa Loa (eye worm) hypothetical protein 0.0055 0.0072 0.0197
Brugia malayi Serotonin receptor 0.0067 0.0149 0.0354
Echinococcus granulosus enteropeptidase 0.0084 0.0252 0.0245
Brugia malayi Dihydroorotate dehydrogenase, mitochondrial precursor, putative 0.0689 0.4025 1
Trypanosoma cruzi prefoldin subunit, putative 0.0064 0.0129 0.0179
Brugia malayi Dihydroorotate dehydrogenase, mitochondrial precursor, putative 0.0689 0.4025 1
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0067 0.0149 0.0354
Loa Loa (eye worm) hypothetical protein 0.0067 0.0149 0.0411
Brugia malayi putative neuropeptide receptor 0.0067 0.0149 0.0354
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0067 0.0149 0.0411
Onchocerca volvulus 0.0059 0.0097 0.0141
Schistosoma mansoni notch 0.0055 0.0072 0.0084
Brugia malayi Low-density lipoprotein receptor repeat class B containing protein 0.0069 0.0161 0.0383
Onchocerca volvulus 0.0059 0.0097 0.0141
Loa Loa (eye worm) hypothetical protein 0.0069 0.0161 0.0442
Echinococcus granulosus peroxidasin 0.0054 0.007 0.0063
Onchocerca volvulus 0.0067 0.0149 0.0287
Onchocerca volvulus Peroxidase homolog 0.0054 0.007 0.0067
Echinococcus multilocularis serotonin receptor 0.0067 0.0149 0.0142
Schistosoma mansoni laminin gamma-3 chain 0.0055 0.0072 0.0084
Echinococcus granulosus delta-like protein 1 0.0055 0.0072 0.0065
Echinococcus granulosus tissue type plasminogen activator 0.0236 0.1204 0.1198
Brugia malayi Fibulin-1 precursor 0.0069 0.0161 0.0383
Loa Loa (eye worm) hypothetical protein 0.0067 0.0149 0.0411
Brugia malayi GCC2 and GCC3 family protein 0.0055 0.0072 0.0161
Loa Loa (eye worm) hypothetical protein 0.0055 0.0072 0.0197
Echinococcus multilocularis neuropeptide FF receptor 2 0.0067 0.0149 0.0142
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.007 0.0171 0.0164
Echinococcus granulosus rhodopsin orphan GPCR 0.0067 0.0149 0.0142
Loa Loa (eye worm) MH2 domain-containing protein 0.041 0.2288 0.6294
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0067 0.0149 0.0142
Loa Loa (eye worm) TYRA-2 protein 0.0067 0.0149 0.0411
Echinococcus granulosus biogenic amine 5HT receptor 0.0067 0.0149 0.0142
Loa Loa (eye worm) hypothetical protein 0.0143 0.0625 0.172
Schistosoma mansoni peroxidasin 0.0054 0.007 0.0082
Onchocerca volvulus 0.0059 0.0097 0.0141
Brugia malayi aspartic protease BmAsp-2, identical 0.005 0.0046 0.0098
Loa Loa (eye worm) hypothetical protein 0.0067 0.0149 0.0411
Onchocerca volvulus 0.0067 0.0149 0.0287
Onchocerca volvulus 0.0067 0.0149 0.0287
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.005 0.0046 0.0051
Schistosoma mansoni hypothetical protein 0.005 0.0042 0.0045
Echinococcus granulosus orexin receptor type 2 0.0067 0.0149 0.0142
Brugia malayi EGF-like domain containing protein 0.0055 0.0072 0.0161
Schistosoma mansoni neuropeptide receptor 0.0067 0.0149 0.0184
Onchocerca volvulus 0.0084 0.0252 0.0573
Brugia malayi MH2 domain containing protein 0.041 0.2288 0.5678
Toxoplasma gondii PAN domain-containing protein 0.0059 0.0097 0.0127
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0081 0.0234 0.0436
Schistosoma mansoni hypothetical protein 0.0067 0.0149 0.0184
Brugia malayi Eukaryotic aspartyl protease family protein 0.005 0.0046 0.0098
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.007 0.0171 0.0164
Echinococcus multilocularis g protein coupled receptor 0.0067 0.0149 0.0142
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0269 0.1408 0.8693
Trypanosoma cruzi prefoldin subunit, putative 0.0064 0.0129 0.0179
Loa Loa (eye worm) hypothetical protein 0.0055 0.0072 0.0197
Toxoplasma gondii PAN domain-containing protein 0.0059 0.0097 0.0127
Schistosoma mansoni cercarial elastase (S01 family) 0.0084 0.0252 0.0318
Echinococcus granulosus neuropeptide receptor 0.0067 0.0149 0.0142
Loa Loa (eye worm) hypothetical protein 0.0054 0.007 0.0193
Entamoeba histolytica phosphofructokinase, putative 0.0105 0.0386 0.2007
Loa Loa (eye worm) hypothetical protein 0.0143 0.0625 0.172
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0084 0.0252 0.0245
Schistosoma mansoni amine GPCR 0.0067 0.0149 0.0184
Loa Loa (eye worm) hypothetical protein 0.0067 0.0149 0.0411
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0055 0.0072 0.0161
Echinococcus multilocularis rhodopsin orphan GPCR 0.0067 0.0149 0.0142
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0223 0.1119 0.2768
Brugia malayi Zinc finger, C2H2 type family protein 0.0269 0.1408 0.3487
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0067 0.0149 0.0354
Loa Loa (eye worm) hypothetical protein 0.0067 0.0149 0.0411
Echinococcus granulosus allatostatin A receptor 0.0067 0.0149 0.0142
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0269 0.1408 0.8693
Echinococcus multilocularis rhodopsin orphan GPCR 0.0067 0.0149 0.0142
Brugia malayi Dopamine receptor 0.0067 0.0149 0.0354
Brugia malayi hypothetical protein 0.0067 0.0149 0.0354
Loa Loa (eye worm) Notch2 0.0055 0.0072 0.0197
Brugia malayi hypothetical protein 0.0111 0.0423 0.1036
Schistosoma mansoni hypothetical protein 0.0055 0.0072 0.0084
Schistosoma mansoni dihydroorotate dehydrogenase 0.0689 0.4025 0.5209
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0045 0.0011 0.0003
Brugia malayi Trypsin family protein 0.0084 0.0252 0.061
Loa Loa (eye worm) hypothetical protein 0.0067 0.0149 0.0411
Schistosoma mansoni notch 0.0055 0.0072 0.0084
Brugia malayi hypothetical protein 0.0067 0.0149 0.0354
Loa Loa (eye worm) hypothetical protein 0.0054 0.007 0.0193
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0081 0.0234 0.047
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0067 0.0149 0.0142
Onchocerca volvulus 0.0067 0.0149 0.0287
Loa Loa (eye worm) PAN domain-containing protein 0.0059 0.0097 0.0266
Brugia malayi PAN domain containing protein 0.0059 0.0097 0.0223
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0052 0.0058 0.0051
Echinococcus granulosus sex peptide receptor 0.0067 0.0149 0.0142
Loa Loa (eye worm) hypothetical protein 0.0067 0.0149 0.0411
Brugia malayi PAN domain containing protein 0.0059 0.0097 0.0223
Loa Loa (eye worm) animal heme peroxidase 0.0054 0.007 0.0193
Loa Loa (eye worm) animal heme peroxidase 0.0054 0.007 0.0193
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0067 0.0149 0.0142
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0067 0.0149 0.0411
Trypanosoma cruzi dihydroorotate dehydrogenase (fumarate), putative 0.0689 0.4025 1
Loa Loa (eye worm) hypothetical protein 0.0236 0.1204 0.3313
Loa Loa (eye worm) hypothetical protein 0.0067 0.0149 0.0411
Onchocerca volvulus 0.0055 0.0072 0.0071
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0269 0.1408 0.8693
Loa Loa (eye worm) hypothetical protein 0.0067 0.0149 0.0411
Brugia malayi Muscleblind-like protein 0.0329 0.1779 0.4411
Brugia malayi EGF-like domain containing protein 0.0055 0.0072 0.0161
Onchocerca volvulus 0.0059 0.0097 0.0141
Echinococcus multilocularis neuropeptide receptor A26 0.1648 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0067 0.0149 0.0184
Echinococcus multilocularis glycoprotein Antigen 5 0.0084 0.0252 0.0245
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0223 0.1119 0.3078
Echinococcus multilocularis neuropeptides capa receptor 0.0067 0.0149 0.0142
Toxoplasma gondii PAN domain-containing protein 0.0059 0.0097 0.0127
Schistosoma mansoni histamine h1 receptor 0.0067 0.0149 0.0184
Echinococcus granulosus 7TM GPCR rhodopsin 0.0067 0.0149 0.0142
Loa Loa (eye worm) hypothetical protein 0.0067 0.0149 0.0411
Schistosoma mansoni amine GPCR 0.0067 0.0149 0.0184
Brugia malayi hypothetical protein 0.0054 0.007 0.0157
Brugia malayi hypothetical protein 0.0067 0.0149 0.0354
Schistosoma mansoni amine GPCR 0.0067 0.0149 0.0184
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0084 0.0252 0.0318
Trichomonas vaginalis glutaminase, putative 0.03 0.16 1
Loa Loa (eye worm) hypothetical protein 0.0055 0.0072 0.0197
Brugia malayi hypothetical protein 0.0067 0.0149 0.0354
Trypanosoma cruzi hypothetical protein, conserved 0.0236 0.1204 0.2889
Echinococcus multilocularis rhodopsin orphan GPCR 0.0067 0.0149 0.0142
Echinococcus granulosus biogenic amine 5HT receptor 0.0067 0.0149 0.0142
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0067 0.0149 0.0142
Leishmania major hypothetical protein, conserved 0.0111 0.0423 0.092
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.005 0.0046 0.0051
Echinococcus granulosus neural cadherin 0.0055 0.0072 0.0065
Plasmodium vivax aspartyl protease, putative 0.0149 0.066 0.1542
Loa Loa (eye worm) hypothetical protein 0.0054 0.007 0.0193
Schistosoma mansoni family A2 unassigned peptidase (A02 family) 0.0233 0.1184 0.1526
Echinococcus granulosus protein jagged 2 0.0055 0.0072 0.0065
Schistosoma mansoni opsin-like receptor 0.0067 0.0149 0.0184
Echinococcus granulosus chromobox protein 1 0.0068 0.0156 0.0149
Brugia malayi PAN domain containing protein 0.0059 0.0097 0.0223
Plasmodium falciparum plasmepsin I 0.0168 0.0781 0.1848
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0084 0.0252 0.0318
Loa Loa (eye worm) hypothetical protein 0.0055 0.0072 0.0197
Toxoplasma gondii LsmAD domain-containing protein 0.0111 0.0423 0.0948
Loa Loa (eye worm) hypothetical protein 0.0084 0.0252 0.0693
Onchocerca volvulus 0.0059 0.0097 0.0141
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0067 0.0149 0.0142
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0067 0.0149 0.0354
Onchocerca volvulus Peroxidase homolog 0.0054 0.007 0.0067
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.0055 0.0072 0.0084
Loa Loa (eye worm) hypothetical protein 0.0067 0.0149 0.0411
Brugia malayi hypothetical protein 0.0084 0.0252 0.061
Loa Loa (eye worm) blistered cuticle protein 3 0.0054 0.007 0.0193
Echinococcus granulosus slit 2 protein 0.0055 0.0072 0.0065
Schistosoma mansoni neuropeptide F-like receptor 0.0067 0.0149 0.0184
Brugia malayi Trypsin family protein 0.0084 0.0252 0.061
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.005 0.0042 0.0035
Brugia malayi Dopamine receptor protein 2 0.0067 0.0149 0.0354
Schistosoma mansoni hypothetical protein 0.0064 0.0129 0.0159
Mycobacterium leprae Probable dihydroorotate dehydrogenase PyrD 0.0689 0.4025 1
Loa Loa (eye worm) hypothetical protein 0.0067 0.0149 0.0411
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0269 0.1408 0.1402
Toxoplasma gondii hypothetical protein 0.0059 0.0097 0.0127
Loa Loa (eye worm) hypothetical protein 0.0067 0.0149 0.0411
Toxoplasma gondii isocitrate dehydrogenase 0.0052 0.0058 0.003
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0045 0.0011 0.0003
Brugia malayi neuropeptide F receptor 0.0067 0.0149 0.0354
Echinococcus multilocularis neurogenic locus protein delta 0.0055 0.0072 0.0065
Schistosoma mansoni biogenic amine receptor 0.0067 0.0149 0.0184
Loa Loa (eye worm) 6-phosphofructokinase 0.0105 0.0386 0.1062
Loa Loa (eye worm) neuropeptide F receptor 0.0067 0.0149 0.0411
Mycobacterium ulcerans hypothetical protein 0.0084 0.0252 0.0049
Trypanosoma cruzi dihydroorotate dehydrogenase, putative 0.0269 0.1408 0.3403
Onchocerca volvulus Chorion peroxidase homolog 0.0054 0.007 0.0067
Onchocerca volvulus 0.0084 0.0252 0.0573
Schistosoma mansoni cercarial elastase (S01 family) 0.0084 0.0252 0.0318
Echinococcus multilocularis lamin dm0 0.0093 0.0309 0.0302
Echinococcus multilocularis chromobox protein 1 0.0068 0.0156 0.0149
Onchocerca volvulus Neurogenic locus notch protein homolog 0.0055 0.0072 0.0071
Trypanosoma brucei PAB1-binding protein , putative 0.0111 0.0423 0.092
Toxoplasma gondii PAN/Apple domain-containing protein 0.0059 0.0097 0.0127
Leishmania major ATP-dependent phosphofructokinase 0.0105 0.0386 0.0826
Onchocerca volvulus 0.0627 0.3635 1
Onchocerca volvulus 0.0067 0.0149 0.0287
Toxoplasma gondii isocitrate dehydrogenase 0.0052 0.0058 0.003
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0067 0.0149 0.0142
Schistosoma mansoni hypothetical protein 0.007 0.0171 0.0212
Plasmodium vivax aspartyl protease, putative 0.0149 0.066 0.1542
Onchocerca volvulus 0.0543 0.3115 0.8551
Plasmodium falciparum ataxin-2 like protein, putative 0.0111 0.0423 0.0948
Brugia malayi hypothetical protein 0.0503 0.2868 0.7121
Echinococcus multilocularis allatostatin A receptor 0.0067 0.0149 0.0142
Schistosoma mansoni chromobox protein 0.0068 0.0156 0.0193
Plasmodium falciparum cysteine repeat modular protein 1 0.0236 0.1204 0.2911
Loa Loa (eye worm) hypothetical protein 0.0067 0.0149 0.0411
Brugia malayi Animal haem peroxidase family protein 0.0054 0.007 0.0157
Loa Loa (eye worm) multiple epidermal growth factor-like domains 6 0.0069 0.0161 0.0442
Schistosoma mansoni 6-phosphofructokinase 0.0105 0.0386 0.0491
Brugia malayi cytoplasmic intermediate filament protein 0.005 0.0041 0.0085
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0067 0.0149 0.0142
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0052 0.0058 0.003
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0168 0.0781 0.2149
Plasmodium falciparum plasmepsin X 0.0149 0.066 0.1542
Loa Loa (eye worm) hypothetical protein 0.0067 0.0149 0.0411
Schistosoma mansoni adenoreceptor 0.0067 0.0149 0.0184
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0067 0.0149 0.0184
Loa Loa (eye worm) hypothetical protein 0.0055 0.0072 0.0197
Echinococcus multilocularis neuropeptide Y receptor 0.0067 0.0149 0.0142
Echinococcus granulosus neuropeptide Y receptor 0.0067 0.0149 0.0142
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0067 0.0149 0.0287
Loa Loa (eye worm) PAN domain-containing protein 0.0059 0.0097 0.0266
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0084 0.0252 0.061
Echinococcus multilocularis peptidase Clp (S14 family) 0.0053 0.0061 0.0054
Trichomonas vaginalis phosphofructokinase, putative 0.0105 0.0386 0.1744
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0081 0.0234 0.5
Echinococcus multilocularis neuropeptide receptor 0.0067 0.0149 0.0142
Loa Loa (eye worm) hypothetical protein 0.0054 0.007 0.0193
Brugia malayi aspartic protease BmAsp-1, identical 0.005 0.0046 0.0098
Brugia malayi Melatonin receptor type 1A 0.0067 0.0149 0.0354
Brugia malayi Probable ClpP-like protease 0.0081 0.0234 0.0563
Loa Loa (eye worm) hypothetical protein 0.0059 0.0097 0.0266
Brugia malayi EGF-like domain containing protein 0.0055 0.0072 0.0161
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0627 0.3635 0.4704
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0084 0.0252 0.0245
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0067 0.0149 0.0142
Loa Loa (eye worm) aspartic protease BmAsp-1 0.005 0.0046 0.0128
Loa Loa (eye worm) isocitrate dehydrogenase 0.0052 0.0058 0.016
Toxoplasma gondii calcium binding egf domain-containing protein 0.0069 0.0161 0.0288
Brugia malayi PAN domain containing protein 0.0059 0.0097 0.0223
Echinococcus granulosus neurogenic locus notch protein 4 0.0055 0.0072 0.0065
Plasmodium vivax dihydroorotate dehydrogenase, mitochondrial precursor, putative 0.0689 0.4025 1
Onchocerca volvulus 0.0055 0.0072 0.0071
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0067 0.0149 0.0184
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0105 0.0386 0.0821
Brugia malayi latrophilin 2 splice variant baaae 0.0152 0.068 0.1675
Schistosoma mansoni neuropeptide receptor 0.0067 0.0149 0.0184
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0067 0.0149 0.0142
Loa Loa (eye worm) animal heme peroxidase 0.0054 0.007 0.0193
Loa Loa (eye worm) hypothetical protein 0.0084 0.0252 0.0693
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.005 0.0046 0.0051
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0067 0.0149 0.0142
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0105 0.0386 1
Onchocerca volvulus 0.0059 0.0097 0.0141
Loa Loa (eye worm) hypothetical protein 0.0054 0.007 0.0193
Brugia malayi ORL1-like opioid receptor 0.0067 0.0149 0.0354
Leishmania major prefoldin subunit, putative 0.0064 0.0129 0.0179
Loa Loa (eye worm) hypothetical protein 0.0054 0.007 0.0193
Plasmodium falciparum dihydroorotate dehydrogenase 0.0689 0.4025 1
Echinococcus multilocularis Mastin 0.0084 0.0252 0.0245
Echinococcus multilocularis slit 2 protein 0.0055 0.0072 0.0065
Echinococcus multilocularis fat cadherin tumor suppressor 0.0055 0.0072 0.0065
Echinococcus multilocularis somatostatin receptor 0.0067 0.0149 0.0142
Loa Loa (eye worm) PAN domain-containing protein 0.0059 0.0097 0.0266
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0067 0.0149 0.0184
Brugia malayi hypothetical protein 0.0067 0.0149 0.0354
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0067 0.0149 0.0184
Onchocerca volvulus 0.0055 0.0072 0.0071
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0067 0.0149 0.0184
Echinococcus granulosus neuropeptide FF receptor 2 0.0067 0.0149 0.0142
Brugia malayi EGF-like domain containing protein 0.0055 0.0072 0.0161
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0052 0.0058 0.0051
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0269 0.1408 0.1402
Echinococcus multilocularis rhodopsin orphan GPCR 0.0067 0.0149 0.0142
Brugia malayi Serotonin receptor 0.0067 0.0149 0.0354
Toxoplasma gondii calcium binding egf domain-containing protein 0.0069 0.0161 0.0288
Onchocerca volvulus 0.0054 0.007 0.0067
Onchocerca volvulus 0.0067 0.0149 0.0287
Brugia malayi RNA, U transporter 1 0.009 0.0292 0.071
Echinococcus granulosus g-protein coupled receptor 0.0067 0.0149 0.0142
Loa Loa (eye worm) hypothetical protein 0.0045 0.0011 0.0029
Schistosoma mansoni hypothetical protein 0.0067 0.0149 0.0184
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0052 0.0058 0.0051
Echinococcus granulosus tm gpcr rhodopsin 0.0067 0.0149 0.0142
Echinococcus granulosus rhodopsin orphan GPCR 0.0067 0.0149 0.0142
Schistosoma mansoni cercarial elastase (S01 family) 0.0084 0.0252 0.0318
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0067 0.0149 0.0184
Brugia malayi G protein-coupled receptor 0.0067 0.0149 0.0354
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0269 0.1408 0.1402
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0905 0.5368 0.5365
Toxoplasma gondii EGF family domain-containing protein 0.0055 0.0072 0.0064
Loa Loa (eye worm) hypothetical protein 0.007 0.0171 0.047
Brugia malayi Animal haem peroxidase family protein 0.0054 0.007 0.0157
Echinococcus multilocularis neural cadherin 0.0055 0.0072 0.0065
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0067 0.0149 0.0354
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0067 0.0149 0.0142
Brugia malayi Peroxidasin 0.0054 0.007 0.0157
Loa Loa (eye worm) hypothetical protein 0.0067 0.0149 0.0411
Loa Loa (eye worm) hypothetical protein 0.0059 0.0097 0.0266
Loa Loa (eye worm) glutaminase 2 0.03 0.16 0.4402
Echinococcus multilocularis fibropellin Ia 0.0055 0.0072 0.0065
Toxoplasma gondii PAN domain-containing protein 0.0059 0.0097 0.0127
Loa Loa (eye worm) hypothetical protein 0.0067 0.0149 0.0411
Schistosoma mansoni lamin 0.0093 0.0309 0.0392
Brugia malayi hypothetical protein 0.0067 0.0149 0.0354
Echinococcus granulosus 7tm_1 domain containing protein 0.0067 0.0149 0.0142
Loa Loa (eye worm) hypothetical protein 0.0055 0.0072 0.0197
Loa Loa (eye worm) hypothetical protein 0.0067 0.0149 0.0411
Schistosoma mansoni chromobox protein 0.0068 0.0156 0.0193
Echinococcus granulosus lamin 0.0093 0.0309 0.0302
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0067 0.0149 0.0411
Brugia malayi PAN domain containing protein 0.0059 0.0097 0.0223
Echinococcus granulosus rhodopsin orphan GPCR 0.0067 0.0149 0.0142
Plasmodium vivax prefoldin subunit 6, putative 0.0064 0.0129 0.0209
Loa Loa (eye worm) hypothetical protein 0.0067 0.0149 0.0411
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.007 0.0171 0.0164
Loa Loa (eye worm) 6-phosphofructokinase 0.0105 0.0386 0.1062
Schistosoma mansoni notch 0.0055 0.0072 0.0084
Echinococcus multilocularis neurogenic locus notch protein 0.0055 0.0072 0.0065
Onchocerca volvulus Putative cubilin 0.0055 0.0072 0.0071
Schistosoma mansoni cercarial elastase (S01 family) 0.0084 0.0252 0.0318
Brugia malayi EGF-like domain containing protein 0.0055 0.0072 0.0161
Brugia malayi Isocitrate dehydrogenase 0.0052 0.0058 0.0127
Loa Loa (eye worm) hypothetical protein 0.0067 0.0149 0.0411
Echinococcus granulosus somatostatin receptor 0.0067 0.0149 0.0142
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0067 0.0149 0.0184
Echinococcus granulosus serotonin receptor 0.0067 0.0149 0.0142
Brugia malayi PAN domain containing protein 0.0059 0.0097 0.0223
Loa Loa (eye worm) glutaminase 0.03 0.16 0.4402
Loa Loa (eye worm) hypothetical protein 0.0067 0.0149 0.0411
Echinococcus granulosus rhodopsin orphan GPCR 0.0067 0.0149 0.0142
Schistosoma mansoni neuropeptide f receptor 76f 0.0067 0.0149 0.0184
Trypanosoma cruzi dihydroorotate dehydrogenase, putative 0.0689 0.4025 1
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0168 0.0781 0.4432
Schistosoma mansoni hypothetical protein 0.0055 0.0072 0.0084
Echinococcus granulosus g protein coupled receptor 0.0067 0.0149 0.0142
Onchocerca volvulus 0.0067 0.0149 0.0287
Brugia malayi Dopamine receptor protein 1 0.0067 0.0149 0.0354
Echinococcus granulosus rhodopsin orphan GPCR 0.0067 0.0149 0.0142
Echinococcus multilocularis isocitrate dehydrogenase 0.0052 0.0058 0.0051
Echinococcus multilocularis fibrillin 1 0.0069 0.0161 0.0154
Brugia malayi follicle stimulating hormone receptor 0.0067 0.0149 0.0354
Echinococcus multilocularis fmrfamide receptor 0.0067 0.0149 0.0142
Schistosoma mansoni hypothetical protein 0.0338 0.1836 0.2371
Brugia malayi 6-phosphofructokinase 0.0105 0.0386 0.0943
Loa Loa (eye worm) hypothetical protein 0.0069 0.0161 0.0442
Loa Loa (eye worm) hypothetical protein 0.0503 0.2868 0.789
Onchocerca volvulus Arrow homolog 0.0069 0.0161 0.0319
Loa Loa (eye worm) hypothetical protein 0.0067 0.0149 0.0411
Brugia malayi Delta serrate ligand family protein 0.0055 0.0072 0.0161
Schistosoma mansoni neuropeptide receptor 0.0067 0.0149 0.0184
Loa Loa (eye worm) hypothetical protein 0.0055 0.0072 0.0197
Echinococcus multilocularis musashi 0.0093 0.0309 0.0302
Schistosoma mansoni cercarial elastase (S01 family) 0.0084 0.0252 0.0318
Schistosoma mansoni biogenic amine (5HT) receptor 0.0067 0.0149 0.0184
Onchocerca volvulus Peroxidasin homolog 0.0054 0.007 0.0067
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0067 0.0149 0.0184
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0084 0.0252 0.0318
Brugia malayi notch-like transmembrane receptor 0.0055 0.0072 0.0161
Brugia malayi Animal haem peroxidase family protein 0.0054 0.007 0.0157
Echinococcus granulosus rhodopsin orphan GPCR 0.0067 0.0149 0.0142
Trichomonas vaginalis phosphofructokinase, putative 0.0105 0.0386 0.1744
Brugia malayi Cadherin domain containing protein 0.0055 0.0072 0.0161
Loa Loa (eye worm) hypothetical protein 0.0055 0.0072 0.0197
Brugia malayi neuropeptide F receptor 0.0067 0.0149 0.0354
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0627 0.3635 0.4704
Loa Loa (eye worm) hypothetical protein 0.0054 0.007 0.0193
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0067 0.0149 0.0142
Brugia malayi glutaminase DH11.1 0.03 0.16 0.3966
Echinococcus multilocularis protein jagged 1 0.0055 0.0072 0.0065
Schistosoma mansoni myosin xvIII 0.0067 0.0149 0.0184
Loa Loa (eye worm) hypothetical protein 0.0054 0.007 0.0193
Echinococcus multilocularis g-protein coupled receptor 0.0067 0.0149 0.0142
Brugia malayi Blistered cuticle protein 3 0.0054 0.007 0.0157
Echinococcus multilocularis neurogenic locus protein delta 0.0055 0.0072 0.0065
Loa Loa (eye worm) hypothetical protein 0.0067 0.0149 0.0411
Schistosoma mansoni hypothetical protein 0.0067 0.0149 0.0184
Schistosoma mansoni intracisternal A-particle retropepsin (A02 family) 0.1282 0.772 1
Loa Loa (eye worm) hypothetical protein 0.0059 0.0097 0.0266
Brugia malayi hypothetical protein 0.0067 0.0149 0.0354
Loa Loa (eye worm) hypothetical protein 0.0067 0.0149 0.0411
Brugia malayi hypothetical protein 0.0277 0.1456 0.3607
Loa Loa (eye worm) hypothetical protein 0.0054 0.007 0.0193
Loa Loa (eye worm) hypothetical protein 0.0055 0.0072 0.0197
Loa Loa (eye worm) hypothetical protein 0.0054 0.007 0.0193
Echinococcus granulosus notch 0.0055 0.0072 0.0065
Echinococcus multilocularis neuropeptides capa receptor 0.0067 0.0149 0.0142
Loa Loa (eye worm) hypothetical protein 0.0055 0.0072 0.0197
Toxoplasma gondii subtilisin SUB12 0.0059 0.0097 0.0127
Echinococcus granulosus chromobox protein 1 0.0068 0.0156 0.0149
Schistosoma mansoni slit 0.0055 0.0072 0.0084
Toxoplasma gondii microneme protein, putative 0.0059 0.0097 0.0127
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0067 0.0149 0.0411
Plasmodium falciparum prefoldin subunit 6, putative 0.0064 0.0129 0.0209
Toxoplasma gondii microneme protein MIC17A 0.0059 0.0097 0.0127
Schistosoma mansoni peroxidasin 0.0054 0.007 0.0082
Loa Loa (eye worm) hypothetical protein 0.0277 0.1456 0.4005
Echinococcus multilocularis Tolloid protein 1 0.0069 0.0161 0.0154
Trypanosoma cruzi PAB1-binding protein , putative 0.0111 0.0423 0.092
Loa Loa (eye worm) hypothetical protein 0.0059 0.0097 0.0266
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0067 0.0149 0.0142
Echinococcus granulosus rhodopsin orphan GPCR 0.0067 0.0149 0.0142
Echinococcus granulosus snurportin 1 0.0338 0.1836 0.183
Brugia malayi Trypsin family protein 0.0084 0.0252 0.061
Loa Loa (eye worm) intermediate filament protein 0.0093 0.0309 0.0851
Schistosoma mansoni notch 0.0055 0.0072 0.0084
Echinococcus granulosus geminin 0.0929 0.552 0.5517
Schistosoma mansoni cercarial elastase (S01 family) 0.0084 0.0252 0.0318
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0067 0.0149 0.0142
Onchocerca volvulus 0.0059 0.0097 0.0141
Onchocerca volvulus 0.0067 0.0149 0.0287
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0084 0.0252 0.0245
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.005 0.0046 0.0051
Brugia malayi Trypsin-like protease protein 5 0.0084 0.0252 0.061
Onchocerca volvulus 0.0055 0.0072 0.0071
Schistosoma mansoni cathepsin D (A01 family) 0.0585 0.3373 0.4364
Schistosoma mansoni survival motor neuron protein 0.0056 0.0084 0.0099
Echinococcus multilocularis rhodopsin orphan GPCR 0.0067 0.0149 0.0142
Schistosoma mansoni egf-like domain protein 0.0069 0.0161 0.0199
Schistosoma mansoni opsin-like receptor 0.0067 0.0149 0.0184
Loa Loa (eye worm) hypothetical protein 0.0093 0.0309 0.0851
Schistosoma mansoni hypothetical protein 0.0055 0.0072 0.0084
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0105 0.0386 0.0826
Mycobacterium ulcerans glutaminase 0.03 0.16 0.3605
Loa Loa (eye worm) hypothetical protein 0.0055 0.0072 0.0197
Loa Loa (eye worm) hypothetical protein 0.0059 0.0097 0.0266
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0084 0.0252 0.0245
Trypanosoma brucei prefoldin subunit, putative 0.0064 0.0129 0.0179
Loa Loa (eye worm) hypothetical protein 0.0067 0.0149 0.0411
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0067 0.0149 0.0184
Echinococcus granulosus glycoprotein Antigen 5 0.0084 0.0252 0.0245
Brugia malayi Trypsin family protein 0.0627 0.3635 0.9031
Onchocerca volvulus 0.0059 0.0097 0.0141
Loa Loa (eye worm) hypothetical protein 0.0067 0.0149 0.0411
Plasmodium falciparum plasmepsin IV 0.0168 0.0781 0.1848
Trypanosoma cruzi PAB1-binding protein , putative 0.0111 0.0423 0.092
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.005 0.0046 0.0051
Loa Loa (eye worm) aspartyl protease 6 0.005 0.0046 0.0128
Schistosoma mansoni peptidase Clp (S14 family) 0.0081 0.0234 0.0293
Onchocerca volvulus 0.0056 0.0084 0.0104
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0081 0.0234 0.0227
Echinococcus multilocularis muscleblind protein 0.0329 0.1779 0.1773
Plasmodium falciparum plasmepsin IX 0.0149 0.066 0.1542
Brugia malayi GnHR receptor homolog 0.0067 0.0149 0.0354
Loa Loa (eye worm) bone morphogenetic protein 1b 0.0069 0.0161 0.0442
Giardia lamblia Hypothetical protein 0.0064 0.0129 1
Loa Loa (eye worm) hypothetical protein 0.0055 0.0072 0.0197
Brugia malayi Animal haem peroxidase family protein 0.0054 0.007 0.0157
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0056 0.0084 0.019
Brugia malayi intermediate filament protein 0.0093 0.0309 0.0752
Loa Loa (eye worm) hypothetical protein 0.0067 0.0149 0.0411
Brugia malayi PAN domain containing protein 0.0059 0.0097 0.0223
Loa Loa (eye worm) hypothetical protein 0.0054 0.007 0.0193
Toxoplasma gondii microneme protein MIC17C 0.0059 0.0097 0.0127
Brugia malayi Calcium binding EGF domain containing protein 0.0055 0.0072 0.0161
Brugia malayi sulfakinin receptor protein 0.0067 0.0149 0.0354
Mycobacterium ulcerans 6-phosphofructokinase 0.0105 0.0386 0.0402
Entamoeba histolytica phosphofructokinase, putative 0.0105 0.0386 0.2007
Brugia malayi hypothetical protein 0.0072 0.0178 0.0426
Echinococcus multilocularis rhodopsin orphan GPCR 0.0067 0.0149 0.0142
Loa Loa (eye worm) hypothetical protein 0.0067 0.0149 0.0411
Brugia malayi PAN domain containing protein 0.0059 0.0097 0.0223
Onchocerca volvulus 0.0067 0.0149 0.0287
Loa Loa (eye worm) hypothetical protein 0.005 0.0046 0.0128
Brugia malayi Calcium binding EGF domain containing protein 0.0055 0.0072 0.0161
Echinococcus multilocularis fmrfamide receptor 0.0067 0.0149 0.0142
Onchocerca volvulus 0.0067 0.0149 0.0287
Brugia malayi Muscle positioning protein 4 0.0055 0.0072 0.0161
Loa Loa (eye worm) animal heme peroxidase 0.0054 0.007 0.0193
Loa Loa (eye worm) hypothetical protein 0.0067 0.0149 0.0411
Loa Loa (eye worm) latrophilin receptor protein 2 0.007 0.0171 0.047
Loa Loa (eye worm) hypothetical protein 0.0168 0.0781 0.2149
Echinococcus multilocularis rhodopsin orphan GPCR 0.0067 0.0149 0.0142
Loa Loa (eye worm) hypothetical protein 0.0055 0.0072 0.0197
Loa Loa (eye worm) transcription factor SMAD2 0.041 0.2288 0.6294
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0067 0.0149 0.0184
Loa Loa (eye worm) hypothetical protein 0.0055 0.0072 0.0197
Onchocerca volvulus 0.0067 0.0149 0.0287
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0052 0.0058 0.003
Toxoplasma gondii PAN domain-containing protein 0.0059 0.0097 0.0127
Schistosoma mansoni hypothetical protein 0.0152 0.068 0.0873
Loa Loa (eye worm) PAN domain-containing protein 0.0059 0.0097 0.0266
Echinococcus multilocularis serotonin receptor 0.0067 0.0149 0.0142
Echinococcus multilocularis neurogenic locus notch protein 4 0.0055 0.0072 0.0065
Schistosoma mansoni biogenic amine receptor 0.0067 0.0149 0.0184
Schistosoma mansoni amine GPCR 0.0067 0.0149 0.0184
Loa Loa (eye worm) hypothetical protein 0.0055 0.0072 0.0197
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0105 0.0386 0.0826
Brugia malayi hypothetical protein 0.0067 0.0149 0.0354
Mycobacterium ulcerans dihydroorotate dehydrogenase 2 0.0689 0.4025 1
Onchocerca volvulus 0.0067 0.0149 0.0287
Echinococcus granulosus laminin 0.0069 0.0161 0.0154
Trichomonas vaginalis chromobox protein, putative 0.0068 0.0156 0.0182
Echinococcus granulosus intermediate filament protein 0.0093 0.0309 0.0302
Schistosoma mansoni cercarial elastase (S01 family) 0.0084 0.0252 0.0318
Loa Loa (eye worm) G-protein coupled receptor 0.0067 0.0149 0.0411
Loa Loa (eye worm) hypothetical protein 0.0067 0.0149 0.0411
Echinococcus granulosus dro:myosuppressin receptor 0.0067 0.0149 0.0142
Trypanosoma brucei dihydroorotate dehydrogenase (fumarate) 0.0689 0.4025 1
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0081 0.0234 0.5
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0052 0.0058 0.0066
Schistosoma mansoni hypothetical protein 0.007 0.0171 0.0212
Brugia malayi isocitrate dehydrogenase 0.0052 0.0058 0.0127
Onchocerca volvulus 0.0067 0.0149 0.0287
Onchocerca volvulus 0.0084 0.0252 0.0573
Brugia malayi 6-phosphofructokinase 0.0105 0.0386 0.0943
Brugia malayi G-protein coupled receptor 0.0067 0.0149 0.0354
Echinococcus multilocularis protein jagged 1 0.0055 0.0072 0.0065
Onchocerca volvulus 0.0059 0.0097 0.0141
Loa Loa (eye worm) trypsin family protein 0.0084 0.0252 0.0693
Brugia malayi RE15519p 0.0067 0.0149 0.0354
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0081 0.0234 0.047
Echinococcus granulosus survival motor neuron protein 1 0.0277 0.1456 0.145
Onchocerca volvulus 0.0059 0.0097 0.0141
Loa Loa (eye worm) hypothetical protein 0.0067 0.0149 0.0411
Schistosoma mansoni alpha-1 adrenergic receptor 0.0067 0.0149 0.0184
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0067 0.0149 0.0184
Echinococcus granulosus g protein coupled receptor 0.0067 0.0149 0.0142
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0067 0.0149 0.0142
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0067 0.0149 0.0184
Echinococcus multilocularis survival motor neuron protein 1 0.0277 0.1456 0.145
Brugia malayi hypothetical protein 0.0067 0.0149 0.0354
Schistosoma mansoni notch 0.0055 0.0072 0.0084
Schistosoma mansoni amine GPCR 0.0067 0.0149 0.0184
Loa Loa (eye worm) hypothetical protein 0.0069 0.0161 0.0442
Loa Loa (eye worm) hypothetical protein 0.0067 0.0149 0.0411
Loa Loa (eye worm) hypothetical protein 0.0059 0.0097 0.0266
Loa Loa (eye worm) hypothetical protein 0.0067 0.0149 0.0411
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.005 0.0046 0.0051
Loa Loa (eye worm) hypothetical protein 0.0059 0.0097 0.0266
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0168 0.0781 0.1004
Echinococcus multilocularis orexin receptor type 2 0.0067 0.0149 0.0142
Loa Loa (eye worm) hypothetical protein 0.0055 0.0072 0.0197
Brugia malayi phosphofructokinase 0.0105 0.0386 0.0943
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0052 0.0058 0.0051
Brugia malayi AKH receptor 0.0067 0.0149 0.0354
Schistosoma mansoni hypothetical protein 0.0084 0.0252 0.0318
Echinococcus granulosus G protein coupled receptor 139 0.0067 0.0149 0.0142
Echinococcus granulosus 6 phosphofructokinase 0.0105 0.0386 0.0379
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0044 0.0007 0.002
Onchocerca volvulus 0.0067 0.0149 0.0287
Entamoeba histolytica phosphofructokinase, putative 0.0105 0.0386 0.2007
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0093 0.0309 0.0851
Schistosoma mansoni hypothetical protein 0.0929 0.552 0.7148
Loa Loa (eye worm) hypothetical protein 0.0067 0.0149 0.0411
Echinococcus multilocularis prefoldin subunit 6 0.0064 0.0129 0.0122
Onchocerca volvulus Slit protein homolog 0.0055 0.0072 0.0071
Plasmodium vivax aspartyl proteinase, putative 0.0168 0.0781 0.1848
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0067 0.0149 0.0184
Brugia malayi Pepsin A precursor 0.005 0.0046 0.0098
Onchocerca volvulus Neuropeptide F receptor homolog 0.0067 0.0149 0.0287
Echinococcus granulosus neuropeptide Y receptor 0.0067 0.0149 0.0142
Loa Loa (eye worm) heterochromatin protein 1 0.0068 0.0156 0.043
Schistosoma mansoni subfamily M12A unassigned peptidase (M12 family) 0.0069 0.0161 0.0199
Loa Loa (eye worm) hypothetical protein 0.0329 0.1779 0.4894
Echinococcus granulosus protein jagged 1 0.0055 0.0072 0.0065
Loa Loa (eye worm) hypothetical protein 0.0067 0.0149 0.0411
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0081 0.0234 0.047
Echinococcus granulosus muscleblind protein 0.0329 0.1779 0.1773
Brugia malayi Kringle domain containing protein 0.0236 0.1204 0.298
Toxoplasma gondii aspartyl protease ASP1 0.0168 0.0781 0.1848
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0081 0.0234 0.0227
Brugia malayi Latrophilin receptor protein 2 0.007 0.0171 0.0407

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.00000011 M Inhibition of monkey plasma renin activity ChEMBL. 3543358
IC50 (binding) = 0.00000014 M In vitro inhibitory activity against human plasma renin ChEMBL. 3543358
IC50 (binding) = 0.00000014 M Inhibition of man plasma renin activity ChEMBL. 3543358
IC50 (binding) = 0.0000013 M Inhibition of rat plasma renin activity ChEMBL. 3543358
Log IC50 (binding) = 6.85 Inhibition of human plasma renin ChEMBL. 3316655

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

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