Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.000000015 M | Inhibition of hog man plasma renin activity | ChEMBL. | 3543358 |
IC50 (binding) | = 0.000000022 M | Inhibition of rat plasma renin activity | ChEMBL. | 3543358 |
IC50 (binding) | = 0.000000025 M | Inhibition of monkey plasma renin activity | ChEMBL. | 3543358 |
IC50 (binding) | = 0.000000042 M | Inhibition of dog plasma renin activity | ChEMBL. | 3543358 |
IC50 (binding) | = 0.00000015 M | In vitro inhibitory activity against human plasma renin | ChEMBL. | 3543358 |
IC50 (binding) | = 0.00000015 M | Inhibition of man plasma renin activity | ChEMBL. | 3543358 |
Log IC50 (binding) | = 6.82 | Inhibition of human plasma renin | ChEMBL. | 3316655 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.