Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | non-ribosomal peptide synthetase | 0.0145 | 0.0225 | 0.0277 |
Echinococcus multilocularis | Acyl carrier protein, mitochondrial | 0.0144 | 0.0221 | 0.0465 |
Echinococcus granulosus | AMP dependent ligase | 0.0145 | 0.0225 | 0.0473 |
Mycobacterium ulcerans | fatty acid synthase Fas | 0.0447 | 0.1382 | 0.1759 |
Schistosoma mansoni | methyltransferase-related | 0.0429 | 0.1312 | 0.276 |
Loa Loa (eye worm) | acyl carrier protein | 0.0655 | 0.2176 | 0.2457 |
Plasmodium falciparum | conserved Plasmodium protein, unknown function | 0.0204 | 0.0452 | 0.4269 |
Trypanosoma brucei | Acyl carrier protein, mitochondrial | 0.0144 | 0.0221 | 0.2059 |
Echinococcus multilocularis | geminin | 0.0179 | 0.0356 | 0.075 |
Loa Loa (eye worm) | hypothetical protein | 0.009 | 0.0014 | 0.0006 |
Schistosoma mansoni | hypothetical protein | 0.0179 | 0.0356 | 0.075 |
Schistosoma mansoni | [ACP] S-malonyltransferase | 0.009 | 0.0014 | 0.003 |
Mycobacterium tuberculosis | Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) | 0.1337 | 0.479 | 0.6125 |
Plasmodium vivax | 3-oxoacyl-[acyl-carrier-protein] synthase i/ii, putative | 0.0357 | 0.1038 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0429 | 0.1312 | 1 |
Leishmania major | hypothetical protein, conserved | 0.009 | 0.0014 | 0.0042 |
Mycobacterium tuberculosis | Probable nicotinate-nucleotide adenylyltransferase NadD (deamido-NAD(+) pyrophosphorylase) (deamido-NAD(+) diphosphorylase) (nic | 0.0275 | 0.0722 | 0.0914 |
Mycobacterium ulcerans | polyketide synthase | 0.1423 | 0.512 | 0.6547 |
Echinococcus multilocularis | mitochondrial trans 2 enoyl coenzyme A reductase | 0.0088 | 0.0009 | 0.0019 |
Onchocerca volvulus | Fatty acid synthase homolog | 0.2566 | 0.9494 | 1 |
Mycobacterium ulcerans | non-ribosomal peptide synthetase MbtF | 0.0151 | 0.0249 | 0.0308 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0169 | 0.0317 | 1 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.1423 | 0.512 | 0.6547 |
Loa Loa (eye worm) | AMP-binding enzyme family protein | 0.1337 | 0.479 | 0.5421 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsB | 0.1145 | 0.4055 | 0.5183 |
Toxoplasma gondii | type I fatty acid synthase | 0.0218 | 0.0506 | 0.0912 |
Echinococcus multilocularis | AMP dependent ligase | 0.0145 | 0.0225 | 0.0473 |
Mycobacterium leprae | Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) | 0.0151 | 0.0249 | 0.0308 |
Onchocerca volvulus | Acyl carrier protein, mitochondrial homolog | 0.0144 | 0.0221 | 0.0223 |
Echinococcus granulosus | geminin | 0.0179 | 0.0356 | 0.075 |
Mycobacterium leprae | PROBABLE POLYKETIDE BETA-KETOACYL SYNTHASE PKS4 | 0.0218 | 0.0506 | 0.0637 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0151 | 0.0249 | 0.0308 |
Echinococcus granulosus | fibroblast growth factor receptor 4 | 0.1328 | 0.4754 | 1 |
Trypanosoma brucei | acyl transferase-like protein | 0.009 | 0.0014 | 0.0053 |
Mycobacterium leprae | Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0145 | 0.0225 | 0.0277 |
Echinococcus granulosus | acyl carrier protein mitochondrial | 0.0144 | 0.0221 | 0.0465 |
Mycobacterium tuberculosis | Polyketide synthase Pks2 | 0.138 | 0.4953 | 0.6333 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.1423 | 0.512 | 0.6547 |
Brugia malayi | acyl carrier protein, mitochondrial precursor, putative | 0.0144 | 0.0221 | 0.0212 |
Plasmodium vivax | acyl carrier protein, putative | 0.0144 | 0.0221 | 0.2016 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.1367 | 0.4905 | 0.49 |
Echinococcus multilocularis | 3 oxoacyl (acyl carrier protein) synthase | 0.0357 | 0.1038 | 0.2184 |
Plasmodium vivax | hypothetical protein, conserved | 0.0204 | 0.0452 | 0.4269 |
Treponema pallidum | hypothetical protein | 0.0275 | 0.0722 | 1 |
Trypanosoma cruzi | acyl transferase-like protein, putative | 0.009 | 0.0014 | 0.0053 |
Mycobacterium tuberculosis | Probable multifunctional mycocerosic acid synthase membrane-associated Mas | 0.1512 | 0.5459 | 0.6981 |
Toxoplasma gondii | acyl carrier protein ACP | 0.0144 | 0.0221 | 0.0389 |
Trypanosoma cruzi | Acyl carrier protein, mitochondrial, putative | 0.0144 | 0.0221 | 0.2059 |
Brugia malayi | Methyltransferase-like protein 4 | 0.0429 | 0.1312 | 0.1304 |
Mycobacterium leprae | Polyketide synthase Pks13 | 0.2128 | 0.7816 | 1 |
Trypanosoma cruzi | beta-ketoacyl synthase family protein, putative | 0.0357 | 0.1038 | 1 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsE | 0.0941 | 0.3274 | 0.4183 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks1 | 0.1023 | 0.3585 | 0.4581 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA | 0.1423 | 0.512 | 0.6547 |
Chlamydia trachomatis | acyl carrier protein | 0.0144 | 0.0221 | 0.2016 |
Brugia malayi | Beta-ketoacyl synthase, N-terminal domain containing protein | 0.1423 | 0.512 | 0.5116 |
Giardia lamblia | Methyltransferase like 2 | 0.0429 | 0.1312 | 0.5 |
Brugia malayi | Phosphopantetheine attachment site family protein | 0.0144 | 0.0221 | 0.0212 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsE | 0.0218 | 0.0506 | 0.0637 |
Mycobacterium leprae | Probable polyketide synthase Pks1 | 0.1512 | 0.5459 | 0.6981 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.1423 | 0.512 | 0.6547 |
Toxoplasma gondii | beta-ketoacyl synthase, N-terminal domain-containing protein | 0.0923 | 0.3206 | 0.5862 |
Mycobacterium tuberculosis | Probable polyketide beta-ketoacyl synthase Pks4 | 0.0218 | 0.0506 | 0.0637 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks17 | 0.0348 | 0.1002 | 0.1272 |
Echinococcus multilocularis | Malonyl coenzyme A acyl carrier protein transacylase | 0.009 | 0.0014 | 0.003 |
Loa Loa (eye worm) | phosphopantetheine attachment site family protein | 0.0144 | 0.0221 | 0.024 |
Schistosoma mansoni | [ACP] S-malonyltransferase | 0.009 | 0.0014 | 0.003 |
Mycobacterium ulcerans | polyketide synthase MbtD | 0.0438 | 0.1346 | 0.1713 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0145 | 0.0225 | 0.0277 |
Echinococcus granulosus | Malonyl coenzyme A acyl carrier protein transacylase | 0.009 | 0.0014 | 0.003 |
Loa Loa (eye worm) | hypothetical protein | 0.2392 | 0.8829 | 1 |
Mycobacterium tuberculosis | Polyketide synthetase MbtD (polyketide synthase) | 0.0438 | 0.1346 | 0.1713 |
Schistosoma mansoni | tyrosine kinase | 0.1328 | 0.4754 | 1 |
Mycobacterium ulcerans | malonyl CoA-acyl carrier protein transacylase FabD | 0.009 | 0.0014 | 0.0007 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.0058 | 0.0056 |
Toxoplasma gondii | acyl transferase domain-containing protein | 0.009 | 0.0014 | 0.001 |
Trypanosoma cruzi | acyl transferase-like protein | 0.009 | 0.0014 | 0.0053 |
Mycobacterium ulcerans | polyketide synthase | 0.1512 | 0.5459 | 0.6981 |
Mycobacterium tuberculosis | P-hydroxybenzoyl-AMP ligase FadD22 | 0.0151 | 0.0249 | 0.0308 |
Loa Loa (eye worm) | hypothetical protein | 0.0798 | 0.2724 | 0.3078 |
Echinococcus granulosus | 3 oxoacyl acyl carrier protein synthase | 0.0357 | 0.1038 | 0.2184 |
Mycobacterium ulcerans | polyketide synthase MbtC | 0.0357 | 0.1038 | 0.1319 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks15 | 0.0576 | 0.1874 | 0.2389 |
Loa Loa (eye worm) | fatty acid synthase | 0.1405 | 0.5048 | 0.5712 |
Mycobacterium tuberculosis | Peptide synthetase MbtE (peptide synthase) | 0.0151 | 0.0249 | 0.0308 |
Mycobacterium ulcerans | phenyloxazoline synthase MbtB | 0.0151 | 0.0249 | 0.0308 |
Mycobacterium tuberculosis | Acyl carrier protein (ACP) MbtL | 0.0144 | 0.0221 | 0.0271 |
Mycobacterium ulcerans | fatty-acid-CoA ligase FadD9 | 0.0145 | 0.0225 | 0.0277 |
Loa Loa (eye worm) | TK protein kinase | 0.1367 | 0.4905 | 0.5551 |
Echinococcus granulosus | basic fibroblast growth factor receptor 1 A | 0.1328 | 0.4754 | 1 |
Onchocerca volvulus | 0.0151 | 0.0249 | 0.0253 | |
Schistosoma mansoni | acyl carrier protein | 0.0144 | 0.0221 | 0.0465 |
Mycobacterium tuberculosis | Polyketide synthase Pks12 | 0.1512 | 0.5459 | 0.6981 |
Mycobacterium tuberculosis | Probable membrane bound polyketide synthase Pks6 | 0.2128 | 0.7816 | 1 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.1423 | 0.512 | 0.6547 |
Onchocerca volvulus | 0.1337 | 0.479 | 0.5041 | |
Loa Loa (eye worm) | hypothetical protein | 0.0218 | 0.0506 | 0.0564 |
Chlamydia trachomatis | 3-oxoacyl-ACP synthase | 0.0357 | 0.1038 | 1 |
Schistosoma mansoni | zinc binding dehydrogenase | 0.0088 | 0.0009 | 0.0019 |
Wolbachia endosymbiont of Brugia malayi | acyl carrier protein | 0.0144 | 0.0221 | 0.2059 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.1513 | 0.5463 | 1 |
Brugia malayi | Beta-ketoacyl synthase, N-terminal domain containing protein | 0.0357 | 0.1038 | 0.103 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks5 | 0.138 | 0.4953 | 0.6333 |
Schistosoma mansoni | hypothetical protein | 0.0144 | 0.0221 | 0.0465 |
Mycobacterium tuberculosis | Peptide synthetase MbtF (peptide synthase) | 0.0151 | 0.0249 | 0.0308 |
Mycobacterium ulcerans | hypothetical protein | 0.0144 | 0.0221 | 0.0271 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB | 0.1145 | 0.4055 | 0.5183 |
Mycobacterium tuberculosis | Polyketide synthase Pks13 | 0.2128 | 0.7816 | 1 |
Mycobacterium leprae | PROBABLE THIOESTERASE TESA | 0.1186 | 0.4212 | 0.5384 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks7 | 0.1512 | 0.5459 | 0.6981 |
Trypanosoma brucei | beta-ketoacyl-ACP synthase | 0.0357 | 0.1038 | 1 |
Mycobacterium ulcerans | 3-oxoacyl-(acyl carrier protein) synthase II | 0.0357 | 0.1038 | 0.1319 |
Mycobacterium tuberculosis | Hypothetical protein | 0.0429 | 0.1312 | 0.1669 |
Plasmodium vivax | nicotinate-nucleotide adenylyltransferase, putative | 0.0275 | 0.0722 | 0.6913 |
Mycobacterium ulcerans | thioesterase | 0.1186 | 0.4212 | 0.5384 |
Brugia malayi | AMP-binding enzyme family protein | 0.0439 | 0.135 | 0.1342 |
Plasmodium falciparum | nicotinamide/nicotinic acid mononucleotide adenylyltransferase | 0.0275 | 0.0722 | 0.6913 |
Mycobacterium leprae | PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) | 0.0447 | 0.1382 | 0.1759 |
Mycobacterium tuberculosis | Probable thioesterase TesA | 0.1186 | 0.4212 | 0.5384 |
Loa Loa (eye worm) | acyl carrier protein | 0.0144 | 0.0221 | 0.024 |
Trypanosoma cruzi | beta-ketoacyl synthase family protein, putative | 0.0357 | 0.1038 | 1 |
Mycobacterium tuberculosis | Probable polyketide beta-ketoacyl synthase Pks3 | 0.0218 | 0.0506 | 0.0637 |
Mycobacterium ulcerans | polyketide synthase Pks9 | 0.0941 | 0.3274 | 0.4183 |
Schistosoma mansoni | [ACP] S-malonyltransferase | 0.009 | 0.0014 | 0.003 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.0858 | 0.2953 | 0.6213 |
Mycobacterium tuberculosis | Probable peptide synthetase Nrp (peptide synthase) | 0.0151 | 0.0249 | 0.0308 |
Mycobacterium tuberculosis | Probable acyl carrier protein AcpA (ACP) | 0.0144 | 0.0221 | 0.0271 |
Echinococcus multilocularis | basic fibroblast growth factor receptor 1 A | 0.1328 | 0.4754 | 1 |
Loa Loa (eye worm) | beta-ketoacyl synthase domain-containing protein | 0.0357 | 0.1038 | 0.1167 |
Mycobacterium leprae | PROBABLE NICOTINATE-NUCLEOTIDE ADENYLYLTRANSFERASE NADD (DEAMIDO-NAD(+) PYROPHOSPHORYLASE) (DEAMIDO-NAD(+) DIPHOSPHORYLASE) (NIC | 0.0275 | 0.0722 | 0.0914 |
Brugia malayi | AMP-binding enzyme family protein | 0.1337 | 0.479 | 0.4786 |
Schistosoma mansoni | hypothetical protein | 0.0179 | 0.0356 | 0.075 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.0058 | 0.0056 |
Mycobacterium tuberculosis | Polyketide synthetase MbtC (polyketide synthase) | 0.0489 | 0.1544 | 0.1966 |
Brugia malayi | ADP-specific Phosphofructokinase/Glucokinase conserved region family protein | 0.009 | 0.0014 | 0.0005 |
Toxoplasma gondii | 3-oxoacyl-acyl-carrier protein synthase I/II, putative | 0.0357 | 0.1038 | 0.1887 |
Wolbachia endosymbiont of Brugia malayi | ACP S-malonyltransferase | 0.009 | 0.0014 | 0.0053 |
Mycobacterium ulcerans | non-ribosomal peptide synthetase MbtE | 0.0151 | 0.0249 | 0.0308 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsB | 0.0218 | 0.0506 | 0.0637 |
Mycobacterium tuberculosis | Meromycolate extension acyl carrier protein AcpM | 0.0144 | 0.0221 | 0.0271 |
Echinococcus multilocularis | NADH dehydrogenase | 0.0144 | 0.0221 | 0.0465 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0243 | 0.0602 | 0.0759 |
Mycobacterium ulcerans | 3-oxoacyl-(acyl carrier protein) synthase II | 0.0357 | 0.1038 | 0.1319 |
Echinococcus granulosus | roundabout 2 | 0.0101 | 0.0058 | 0.0122 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC | 0.1512 | 0.5459 | 0.6981 |
Leishmania major | beta-ketoacyl synthase family protein, putative,3-oxoacyl-acyl carrier protein synthase ii, putative | 0.0357 | 0.1038 | 0.7899 |
Plasmodium falciparum | 3-oxoacyl-acyl-carrier protein synthase I/II | 0.0357 | 0.1038 | 1 |
Mycobacterium tuberculosis | Probable fatty acid synthase Fas (fatty acid synthetase) | 0.0447 | 0.1382 | 0.1759 |
Leishmania major | acyl carrier protein, putative | 0.0144 | 0.0221 | 0.1626 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks8 | 0.1164 | 0.4127 | 0.5275 |
Mycobacterium leprae | conserved hypothetical protein | 0.0144 | 0.0221 | 0.0271 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.1512 | 0.5459 | 0.6981 |
Schistosoma mansoni | alcohol dehydrogenase | 0.0088 | 0.0009 | 0.0019 |
Mycobacterium ulcerans | bifunctional nicotinate-nucleotide adenylyltransferase NadD/hypothetical protein | 0.0275 | 0.0722 | 0.0914 |
Plasmodium falciparum | acyl carrier protein | 0.0144 | 0.0221 | 0.2016 |
Onchocerca volvulus | 0.2485 | 0.9184 | 0.9673 | |
Mycobacterium tuberculosis | Probable polyketide synthase Pks9 | 0.0809 | 0.2769 | 0.3535 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0144 | 0.0221 | 0.0271 |
Wolbachia endosymbiont of Brugia malayi | 3-oxoacyl-ACP synthase | 0.0357 | 0.1038 | 1 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.1145 | 0.4055 | 0.5183 |
Mycobacterium ulcerans | acyl carrier protein | 0.0144 | 0.0221 | 0.0271 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE | 0.0941 | 0.3274 | 0.4183 |
Mycobacterium ulcerans | polyketide synthase Pks13 | 0.2128 | 0.7816 | 1 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD | 0.1423 | 0.512 | 0.6547 |
Toxoplasma gondii | AMP-binding enzyme domain-containing protein | 0.072 | 0.2429 | 0.4437 |
Echinococcus multilocularis | fibroblast growth factor receptor 4 | 0.1328 | 0.4754 | 1 |
Mycobacterium tuberculosis | Conserved protein | 0.0429 | 0.1312 | 0.1669 |
Echinococcus granulosus | mitochondrial trans 2 enoyl coenzyme A reductase | 0.0088 | 0.0009 | 0.0019 |
Mycobacterium leprae | Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas | 0.1512 | 0.5459 | 0.6981 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0429 | 0.1312 | 1 |
Schistosoma mansoni | 3-oxoacyl-[ACP] synthase | 0.0357 | 0.1038 | 0.2184 |
Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0151 | 0.0249 | 0.024 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.1423 | 0.512 | 0.6547 |
Loa Loa (eye worm) | hypothetical protein | 0.0218 | 0.0506 | 0.0564 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0145 | 0.0225 | 0.701 |
Mycobacterium ulcerans | multifunctional mycocerosic acid synthase membrane-associated Mas | 0.1512 | 0.5459 | 0.6981 |
Mycobacterium ulcerans | acyl carrier protein | 0.0144 | 0.0221 | 0.0271 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.1013 | 0.355 | 0.6493 |
Echinococcus granulosus | NADH dehydrogenase | 0.0144 | 0.0221 | 0.0465 |
Mycobacterium ulcerans | peptide synthetase Nrp (peptide synthase) | 0.0151 | 0.0249 | 0.0308 |
Mycobacterium ulcerans | thioesterase TesA | 0.1186 | 0.4212 | 0.5384 |
Echinococcus multilocularis | roundabout 2 | 0.0101 | 0.0058 | 0.0122 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.1423 | 0.512 | 0.6547 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.1423 | 0.512 | 0.6547 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.