Detailed information for compound 1605310

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 524.698 | Formula: C27H32N4O3S2
  • H donors: 2 H acceptors: 4 LogP: 6.79 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 2
  • SMILES: CCCCOc1ccc(cc1S(=O)(=O)Nc1ccc(cc1)c1csc2c1c(N)ncn2)C(CC)(C)C
  • InChi: 1S/C27H32N4O3S2/c1-5-7-14-34-22-13-10-19(27(3,4)6-2)15-23(22)36(32,33)31-20-11-8-18(9-12-20)21-16-35-26-24(21)25(28)29-17-30-26/h8-13,15-17,31H,5-7,14H2,1-4H3,(H2,28,29,30)
  • InChiKey: KNWWRJAPDGOPBT-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens TAO kinase 1 Starlite/ChEMBL No references
Homo sapiens calcium/calmodulin-dependent protein kinase II beta Starlite/ChEMBL No references
Homo sapiens calcium/calmodulin-dependent protein kinase II gamma Starlite/ChEMBL No references
Homo sapiens fms-related tyrosine kinase 3 Starlite/ChEMBL No references
Homo sapiens aurora kinase B Starlite/ChEMBL No references
Homo sapiens calcium/calmodulin-dependent protein kinase II delta Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi Serine/threonine-protein kinase SULU Get druggable targets OG5_129521 All targets in OG5_129521
Schistosoma mansoni protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Plasmodium knowlesi calcium-dependent protein kinase 3, putative Get druggable targets OG5_126600 All targets in OG5_126600
Leishmania donovani protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Candida albicans Serine-threonine protein kinase similar to S. cerevisiae CMK2 (YOL016C) calcium/calmodulin-dependent protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Theileria parva calmodulin-domain protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Toxoplasma gondii calcium-dependent protein kinase CDPK2A Get druggable targets OG5_126600 All targets in OG5_126600
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Loa Loa (eye worm) AUR protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium falciparum calcium-dependent protein kinase 3 Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium yoelii calcium-dependent protein kinase-3 Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus granulosus calcium:calmodulin dependent protein kinase type Get druggable targets OG5_126600 All targets in OG5_126600
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium berghei calcium-dependent protein kinase 4 Get druggable targets OG5_126600 All targets in OG5_126600
Leishmania mexicana protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Trypanosoma cruzi aurora B kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Plasmodium berghei calcium-dependent protein kinase 3 Get druggable targets OG5_126600 All targets in OG5_126600
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Plasmodium falciparum calcium-dependent protein kinase 5 Get druggable targets OG5_126600 All targets in OG5_126600
Schistosoma mansoni protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type Get druggable targets OG5_126600 All targets in OG5_126600
Neospora caninum hypothetical protein Get druggable targets OG5_126600 All targets in OG5_126600
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_129521 All targets in OG5_129521
Plasmodium yoelii Plasmodium falciparum CDPK2 protein Get druggable targets OG5_126600 All targets in OG5_126600
Entamoeba histolytica protein kinase , putative Get druggable targets OG5_127024 All targets in OG5_127024
Neospora caninum Calmodulin-like domain protein kinase isoenzyme gamma, related Get druggable targets OG5_126600 All targets in OG5_126600
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Candida albicans Serine-threonine protein kinase similar to S. cerevisiae CMK2 (YOL016C) calcium/calmodulin-dependent protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Neospora caninum hypothetical protein Get druggable targets OG5_126600 All targets in OG5_126600
Cryptosporidium hominis calcium-dependent protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Leishmania major protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Candida albicans likely protein kinase similar to S. cerevisiae IPL1 (YPL209C) Aurora protein kinase involved in regulating kinetochore-microtubu Get druggable targets OG5_127024 All targets in OG5_127024
Schistosoma japonicum Serine/threonine-protein kinase 12, putative Get druggable targets OG5_127024 All targets in OG5_127024
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus granulosus serine:threonine protein kinase TAO1 Get druggable targets OG5_129521 All targets in OG5_129521
Echinococcus granulosus calcium:calmodulin dependent protein kinase type Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium vivax calcium-dependent protein kinase 1, putative Get druggable targets OG5_126600 All targets in OG5_126600
Schistosoma japonicum ko:K04429 thousand and one amino acid protein kinase, putative Get druggable targets OG5_129521 All targets in OG5_129521
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID Get druggable targets OG5_126600 All targets in OG5_126600
Babesia bovis protein kinase domain containing protein Get druggable targets OG5_126600 All targets in OG5_126600
Cryptosporidium parvum calcium/calmodulin dependent protein kinase with a kinase domain and 4 calmodulin like EF hands Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium knowlesi serine/threonine protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Schistosoma japonicum ko:K08850 aurora kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Cryptosporidium parvum calcium/calmodulin dependent protein kinase with a kinase domain and 4 calmodulin like EF hands Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium yoelii calcium-dept. protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Toxoplasma gondii calcium-dependent protein kinase CDPK2B Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium yoelii putative protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Babesia bovis calcium-dependent protein kinase 4 Get druggable targets OG5_126600 All targets in OG5_126600
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium yoelii calmodulin-domain protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Leishmania infantum protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Toxoplasma gondii aurora kinase Get druggable targets OG5_127024 All targets in OG5_127024
Brugia malayi serine/threonine-protein kinase 6 Get druggable targets OG5_127024 All targets in OG5_127024
Cryptosporidium hominis calmodulin-domain protein kinase 1 Get druggable targets OG5_126600 All targets in OG5_126600
Brugia malayi hypothetical protein Get druggable targets OG5_129521 All targets in OG5_129521
Echinococcus multilocularis serine:threonine protein kinase 12 B Get druggable targets OG5_127024 All targets in OG5_127024
Plasmodium knowlesi calcium-dependent protein kinase 5, putative Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium knowlesi calcium-dependent protein kinase 4, putative Get druggable targets OG5_126600 All targets in OG5_126600
Loa Loa (eye worm) STE/STE20/TAO protein kinase Get druggable targets OG5_129521 All targets in OG5_129521
Trypanosoma brucei gambiense protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Leishmania mexicana protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Trypanosoma brucei aurora B kinase Get druggable targets OG5_127024 All targets in OG5_127024
Cryptosporidium parvum calmodulin-domain protein kinase 1, putative Get druggable targets OG5_126600 All targets in OG5_126600
Schistosoma japonicum Calcium/calmodulin-dependent protein kinase type 1, putative Get druggable targets OG5_126600 All targets in OG5_126600
Entamoeba histolytica serine/threonine- protein kinase 6, putative Get druggable targets OG5_127024 All targets in OG5_127024
Entamoeba histolytica serine/threonine- protein kinase 6 , putative Get druggable targets OG5_127024 All targets in OG5_127024
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Plasmodium falciparum calcium-dependent protein kinase 1 Get druggable targets OG5_126600 All targets in OG5_126600
Trypanosoma congolense protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium vivax calcium-dependent protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium falciparum serine/threonine protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 Get druggable targets OG5_126600 All targets in OG5_126600
Schistosoma japonicum Calcium/calmodulin-dependent protein kinase type II delta chain, putative Get druggable targets OG5_126600 All targets in OG5_126600
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Schistosoma japonicum ko:K08794 calcium/calmodulin-dependent protein kinase I, putative Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus granulosus calcium dependent protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium yoelii Protein kinase domain, putative Get druggable targets OG5_127024 All targets in OG5_127024
Leishmania donovani Aurora I-related kinase Get druggable targets OG5_127024 All targets in OG5_127024
Loa Loa (eye worm) AUR protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Leishmania braziliensis protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Schistosoma mansoni protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Cryptosporidium hominis CDPK2 Get druggable targets OG5_126600 All targets in OG5_126600
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium berghei calcium-dependent protein kinase 1 Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium berghei serine/threonine protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Brugia malayi Cam kinase protein 1 Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type Get druggable targets OG5_126600 All targets in OG5_126600
Neospora caninum hypothetical protein Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus multilocularis aurora kinase A Get druggable targets OG5_127024 All targets in OG5_127024
Plasmodium berghei calcium-dependent protein kinase 5 Get druggable targets OG5_126600 All targets in OG5_126600
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Cryptosporidium parvum protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Trypanosoma congolense protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Schistosoma japonicum Calcium/calmodulin-dependent protein kinase type II beta chain, putative Get druggable targets OG5_126600 All targets in OG5_126600
Candida albicans likely protein kinase similar to S. cerevisiae IPL1 (YPL209C) Aurora protein kinase involved in regulating kinetochore-microtubu Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus multilocularis calcium dependent protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Loa Loa (eye worm) AUR protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Leishmania major protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Giardia lamblia Aurora kinase Get druggable targets OG5_127024 All targets in OG5_127024
Neospora caninum Calcium-dependent protein kinase 2, related Get druggable targets OG5_126600 All targets in OG5_126600
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Schistosoma japonicum Calcium/calmodulin-dependent protein kinase type II alpha chain, putative Get druggable targets OG5_126600 All targets in OG5_126600
Cryptosporidium parvum calcium/calmodulin dependent protein kinase with a kinas domain and 4 calmodulin-like EF hands Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium falciparum calcium-dependent protein kinase 2 Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium falciparum calcium-dependent protein kinase 4 Get druggable targets OG5_126600 All targets in OG5_126600
Leishmania infantum protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Cryptosporidium hominis protein kinase (EC 2.7.1.-) p46XlEg22 Get druggable targets OG5_127024 All targets in OG5_127024
Theileria parva calcium-dependent protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus multilocularis serine:threonine protein kinase TAO1 Get druggable targets OG5_129521 All targets in OG5_129521
Echinococcus granulosus serine:threonine protein kinase 12 B Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus granulosus aurora kinase A Get druggable targets OG5_127024 All targets in OG5_127024
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Neospora caninum hypothetical protein Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium vivax calcium-dependent protein kinase 3, putative Get druggable targets OG5_126600 All targets in OG5_126600
Trypanosoma brucei gambiense protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Brugia malayi serine/threonine kinase 12 Get druggable targets OG5_127024 All targets in OG5_127024
Entamoeba histolytica serine/threonine protein kinase 6, putative Get druggable targets OG5_127024 All targets in OG5_127024
Leishmania braziliensis protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus granulosus calcium:calmodulin dependent protein kinase type Get druggable targets OG5_126600 All targets in OG5_126600
Schistosoma japonicum ko:K04515 calcium/calmodulin-dependent protein kinase (CaM kinase) II, putative Get druggable targets OG5_126600 All targets in OG5_126600
Loa Loa (eye worm) CAMK/CAMK2 protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Brugia malayi serine/threonine protein kinase 6 Get druggable targets OG5_127024 All targets in OG5_127024
Plasmodium knowlesi calcium-dependent protein kinase 1, putative Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium vivax serine/threonine protein kinase 6, putative Get druggable targets OG5_127024 All targets in OG5_127024
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Trypanosoma congolense aurora B kinase Get druggable targets OG5_127024 All targets in OG5_127024
Schistosoma mansoni protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type Get druggable targets OG5_126600 All targets in OG5_126600
Toxoplasma gondii calcium-dependent protein kinase CDPK3 Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium vivax calcium-dependent protein kinase 4, putative Get druggable targets OG5_126600 All targets in OG5_126600
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei mitogen-activated protein kinase 5 aurora kinase B 303 aa 299 aa 22.1 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0057 0.0344 0.0022
Brugia malayi Isocitrate dehydrogenase 0.1056 1 1
Loa Loa (eye worm) AUR protein kinase 0.007 0.0472 0.0132
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.1056 1 1
Toxoplasma gondii isocitrate dehydrogenase 0.1056 1 1
Schistosoma mansoni protein kinase 0.0457 0.421 0.4004
Brugia malayi serine/threonine kinase 12 0.007 0.0472 0.0132
Loa Loa (eye worm) hypothetical protein 0.0128 0.1037 0.0717
Brugia malayi Probable isocitrate dehydrogenase 0.0128 0.1037 0.0717
Leishmania major protein kinase, putative 0.007 0.0472 0.0132
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0057 0.0344 0.0344
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.1056 1 1
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.1056 1 1
Trichomonas vaginalis isocitrate dehydrogenase, putative 0.0128 0.1037 1
Echinococcus granulosus calcium dependent protein kinase 0.0054 0.0323 0.0323
Brugia malayi isocitrate dehydrogenase [NAD] subunit beta, mitochondrial 0.0128 0.1037 0.0717
Trypanosoma brucei isocitrate dehydrogenase, putative 0.1056 1 1
Loa Loa (eye worm) isocitrate dehydrogenase gamma subunit 0.0128 0.1037 0.0717
Brugia malayi hypothetical protein 0.0229 0.2016 0.1731
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase subunit type II alpha 0.04 0.3663 0.3438
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.1056 1 1
Brugia malayi Probable isocitrate dehydrogenase 0.0128 0.1037 0.0717
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0057 0.0344 0.0344
Brugia malayi serine/threonine-protein kinase 6 0.007 0.0472 0.0132
Trichomonas vaginalis AGC family protein kinase 0.007 0.0472 0.1845
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.1056 1 1
Loa Loa (eye worm) AUR protein kinase 0.007 0.0472 0.0132
Echinococcus multilocularis aurora kinase A 0.007 0.0472 0.0154
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.04 0.3663 0.3438
Schistosoma mansoni protein kinase 0.0457 0.421 0.4004
Echinococcus granulosus isocitrate dehydrogenase NAD 0.0128 0.1037 0.1037
Schistosoma mansoni protein kinase 0.0457 0.421 0.4004
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.1056 1 1
Echinococcus granulosus isocitrate dehydrogenase NAD subunit 0.0128 0.1037 0.1037
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0057 0.0344 0.0344
Brugia malayi Serine/threonine-protein kinase SULU 0.0229 0.2016 0.1731
Loa Loa (eye worm) isocitrate dehydrogenase 0.1056 1 1
Trypanosoma brucei aurora B kinase 0.007 0.0472 0.0132
Entamoeba histolytica protein kinase domain containing protein 0.007 0.0472 0.1845
Schistosoma mansoni serine/threonine protein kinase 0.0229 0.2016 0.1731
Echinococcus granulosus aurora kinase A 0.007 0.0472 0.0472
Echinococcus granulosus serine:threonine protein kinase TAO1 0.0229 0.2016 0.2016
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0457 0.421 0.4017
Trichomonas vaginalis AGC family protein kinase 0.007 0.0472 0.1845
Plasmodium vivax serine/threonine protein kinase 6, putative 0.007 0.0472 0.0132
Mycobacterium ulcerans 3-isopropylmalate dehydrogenase 0.0128 0.1037 0.5
Entamoeba histolytica protein kinase, putative 0.007 0.0472 0.1845
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.1056 1 1
Plasmodium falciparum serine/threonine protein kinase, putative 0.007 0.0472 0.0132
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.007 0.0472 0.1845
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.1056 1 1
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.1056 1 1
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.007 0.0472 0.1845
Entamoeba histolytica protein kinase, putative 0.007 0.0472 0.1845
Schistosoma mansoni serine/threonine protein kinase 0.007 0.0472 0.0132
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.007 0.0472 0.1845
Wolbachia endosymbiont of Brugia malayi isocitrate dehydrogenase 0.0128 0.1037 0.5
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.1056 1 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.1056 1 1
Brugia malayi Isocitrate dehydrogenase subunit gamma, mitochondrial precursor 0.0128 0.1037 0.0717
Echinococcus granulosus serine:threonine protein kinase 12 B 0.007 0.0472 0.0472
Leishmania major isocitrate dehydrogenase, putative 0.0128 0.1037 0.0717
Loa Loa (eye worm) AUR protein kinase 0.007 0.0472 0.0132
Toxoplasma gondii aurora kinase 0.007 0.0472 0.0132
Echinococcus multilocularis isocitrate dehydrogenase (NAD+) 0.0128 0.1037 0.0738
Entamoeba histolytica tartrate dehydrogenase, putative 0.0128 0.1037 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.1056 1 1
Entamoeba histolytica protein kinase , putative 0.007 0.0472 0.1845
Brugia malayi isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial 0.0128 0.1037 0.0717
Giardia lamblia Aurora kinase 0.007 0.0472 0.5
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.007 0.0472 0.0154
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0457 0.421 0.421
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.1056 1 1
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0057 0.0344 0.0022
Schistosoma mansoni isocitrate dehydrogenase 0.0128 0.1037 0.0717
Loa Loa (eye worm) STE/STE20/TAO protein kinase 0.0229 0.2016 0.1731
Trichomonas vaginalis AGC family protein kinase 0.007 0.0472 0.1845
Schistosoma mansoni protein kinase 0.007 0.0472 0.0132
Schistosoma mansoni Isocitrate dehydrogenase [NAD] subunit gamma mitochondrial 0.0128 0.1037 0.0717
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0057 0.0344 0.0022
Schistosoma mansoni unc-13 (munc13) 0.0128 0.1037 0.0717
Toxoplasma gondii isocitrate dehydrogenase 0.1056 1 1
Echinococcus multilocularis serine:threonine protein kinase TAO1 0.0229 0.2016 0.1749
Echinococcus multilocularis isocitrate dehydrogenase 0.1056 1 1
Echinococcus multilocularis isocitrate dehydrogenase (NAD) subunit 0.0128 0.1037 0.0738
Brugia malayi serine/threonine protein kinase 6 0.007 0.0472 0.0132
Trichomonas vaginalis AGC family protein kinase 0.007 0.0472 0.1845
Mycobacterium leprae PROBABLE 3-ISOPROPYLMALATE DEHYDROGENASE LEUB (BETA-IPM DEHYDROGENASE) (IMDH) (3-IPM-DH) 0.0128 0.1037 0.5

Activities

Activity type Activity value Assay description Source Reference
Ki (functional) = 5.1 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: TAO1 ChEMBL. No reference
Ki (functional) = 5.2 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: CAMK2G ChEMBL. No reference
Ki (functional) = 5.2 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: STK12 ChEMBL. No reference
Ki (functional) = 5.2 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: CAMK2D ChEMBL. No reference
Ki (functional) = 5.4 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: CAMK2B ChEMBL. No reference
Ki (functional) = 5.7 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: FLT3 ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.