Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | mitogen-activated protein kinase kinase 2 | References | |
Homo sapiens | mitogen-activated protein kinase kinase 1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | dual specificity mitogen activated protein | 0.0179 | 0.0141 | 0.0141 |
Brugia malayi | Animal haem peroxidase family protein | 0.084 | 1 | 1 |
Onchocerca volvulus | Dual oxidase homolog | 0.084 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.084 | 1 | 1 |
Schistosoma mansoni | peroxidasin | 0.084 | 1 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.084 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.084 | 1 | 1 |
Trypanosoma brucei | mitogen-activated protein kinase kinase 5 | 0.0179 | 0.0141 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.084 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.084 | 1 | 1 |
Onchocerca volvulus | Peroxidase homolog | 0.084 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.084 | 1 | 1 |
Echinococcus granulosus | peroxidasin | 0.084 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.084 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.084 | 1 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.084 | 1 | 1 |
Onchocerca volvulus | 0.084 | 1 | 1 | |
Onchocerca volvulus | Peroxidasin homolog | 0.084 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.084 | 1 | 1 |
Onchocerca volvulus | 0.084 | 1 | 1 | |
Brugia malayi | Animal haem peroxidase family protein | 0.084 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.084 | 1 | 1 |
Trypanosoma cruzi | mitogen-activated protein kinase kinase 5 | 0.0179 | 0.0141 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.084 | 1 | 1 |
Brugia malayi | Dual specificity mitogen-activated protein kinase kinase mek-2 | 0.0179 | 0.0141 | 0.0141 |
Leishmania major | mitogen-activated protein kinase kinase 5, putative;with=GeneDB:LmxM36.0860 | 0.0179 | 0.0141 | 0.5 |
Schistosoma mansoni | peroxidasin | 0.084 | 1 | 1 |
Echinococcus granulosus | dual specificity mitogen activated protein | 0.0179 | 0.0141 | 0.0141 |
Loa Loa (eye worm) | animal heme peroxidase | 0.084 | 1 | 1 |
Giardia lamblia | Kinase, STE STE20 | 0.0179 | 0.0141 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.084 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.084 | 1 | 1 |
Loa Loa (eye worm) | STE/STE7/MEK1 protein kinase | 0.0179 | 0.0141 | 0.0141 |
Loa Loa (eye worm) | hypothetical protein | 0.084 | 1 | 1 |
Onchocerca volvulus | Peroxidase homolog | 0.084 | 1 | 1 |
Brugia malayi | Peroxidasin | 0.084 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.084 | 1 | 1 |
Trichomonas vaginalis | STE family protein kinase | 0.0179 | 0.0141 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.084 | 1 | 1 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.084 | 1 | 1 |
Echinococcus multilocularis | peroxidasin | 0.084 | 1 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.084 | 1 | 1 |
Trichomonas vaginalis | STE family protein kinase | 0.0179 | 0.0141 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.084 | 1 | 1 |
Brugia malayi | Blistered cuticle protein 3 | 0.084 | 1 | 1 |
Onchocerca volvulus | Peroxidasin homolog | 0.084 | 1 | 1 |
Schistosoma mansoni | protein kinase | 0.0179 | 0.0141 | 0.0141 |
Onchocerca volvulus | 0.084 | 1 | 1 | |
Onchocerca volvulus | Chorion peroxidase homolog | 0.084 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.084 | 1 | 1 |
Trichomonas vaginalis | STE family protein kinase | 0.0179 | 0.0141 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 3.2 uM | Non-competitive inhibition of the dual specificity kinase MEK | ChEMBL. | 9873633 |
IC50 (binding) | = 3.2 uM | Non-competitive inhibition of the dual specificity kinase MEK | ChEMBL. | 9873633 |
IC50 (functional) | = 18.7 uM | Ability to antagonise AP-1 transcriptional activity | ChEMBL. | 9873633 |
IC50 (functional) | = 18.7 uM | Ability to antagonise AP-1 transcriptional activity | ChEMBL. | 9873633 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.