Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.069 | 0.2868 | 0.2868 |
Brugia malayi | Tyrosine-protein kinase abl-1 | 0.0516 | 0.21 | 0.21 |
Echinococcus multilocularis | tyrosine protein kinase ABL1 | 0.1265 | 0.5413 | 0.5413 |
Brugia malayi | thymidylate synthase | 0.069 | 0.2868 | 0.2868 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.157 | 0.6761 | 0.5 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.157 | 0.6761 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Abl | 0.0516 | 0.21 | 0.21 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.2303 | 1 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.1247 | 0.5333 | 0.5333 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.069 | 0.2868 | 0.1831 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0328 | 0.127 | 0.5 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.157 | 0.6761 | 0.5 |
Echinococcus granulosus | thymidylate synthase | 0.069 | 0.2868 | 0.2868 |
Echinococcus multilocularis | thymidylate synthase | 0.069 | 0.2868 | 0.2868 |
Chlamydia trachomatis | dihydrofolate reductase | 0.2303 | 1 | 0.5 |
Brugia malayi | Dihydrofolate reductase | 0.2303 | 1 | 1 |
Onchocerca volvulus | 0.069 | 0.2868 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.048 | 0.1941 | 0.1941 |
Loa Loa (eye worm) | thymidylate synthase | 0.069 | 0.2868 | 0.2868 |
Echinococcus multilocularis | dihydrofolate reductase | 0.2303 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0328 | 0.127 | 0.127 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.2303 | 1 | 1 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.2303 | 1 | 1 |
Echinococcus granulosus | dihydrofolate reductase | 0.2303 | 1 | 1 |
Schistosoma mansoni | dihydrofolate reductase | 0.2303 | 1 | 1 |
Loa Loa (eye worm) | TK/ABL protein kinase | 0.1265 | 0.5413 | 0.5413 |
Echinococcus granulosus | tyrosine protein kinase ABL1 | 0.1265 | 0.5413 | 0.5413 |
Brugia malayi | Tyrosine-protein kinase abl-1 | 0.0767 | 0.3211 | 0.3211 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.157 | 0.6761 | 0.5 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.157 | 0.6761 | 0.5 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.2303 | 1 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.157 | 0.6761 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.