Detailed information for compound 160601

Basic information

Technical information
  • TDR Targets ID: 160601
  • Name: methyl 3-[[4-[(3,4-dichlorophenyl)methoxy]-2H -indazol-3-yl]methylamino]cyclohexane-1-carbo xylate
  • MW: 462.369 | Formula: C23H25Cl2N3O3
  • H donors: 2 H acceptors: 2 LogP: 4.81 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: COC(=O)C1CCCC(C1)NCc1n[nH]c2c1c(ccc2)OCc1ccc(c(c1)Cl)Cl
  • InChi: 1S/C23H25Cl2N3O3/c1-30-23(29)15-4-2-5-16(11-15)26-12-20-22-19(27-28-20)6-3-7-21(22)31-13-14-8-9-17(24)18(25)10-14/h3,6-10,15-16,26H,2,4-5,11-13H2,1H3,(H,27,28)
  • InChiKey: OAYAVSHLOXDZCU-UHFFFAOYSA-N  

Network

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Synonyms

  • methyl 3-[[4-[(3,4-dichlorophenyl)methoxy]-2H-indazol-3-yl]methylamino]cyclohexanecarboxylate
  • 3-[[4-[(3,4-dichlorophenyl)methoxy]-2H-indazol-3-yl]methylamino]cyclohexanecarboxylic acid methyl ester
  • 3-[[4-(3,4-dichlorobenzyl)oxy-2H-indazol-3-yl]methylamino]cyclohexanecarboxylic acid methyl ester
  • 3-[[4-[(3,4-dichlorophenyl)methoxy]-2H-indazol-3-yl]methylamino]-1-cyclohexanecarboxylic acid methyl ester
  • 3-[[4-(3,4-dichlorobenzyl)oxy-2H-indazol-3-yl]methylamino]cyclohexane-1-carboxylic acid methyl ester

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Escherichia coli DNA gyrase, subunit B References
Escherichia coli DNA gyrase (type II topoisomerase), subunit A Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Theileria parva DNA gyrase subunit B, putative Get druggable targets OG5_128755 All targets in OG5_128755
Mycobacterium tuberculosis DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) Get druggable targets OG5_129568 All targets in OG5_129568
Mycobacterium leprae Probable DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) Get druggable targets OG5_129568 All targets in OG5_129568
Leishmania mexicana mitochondrial DNA topoisomerase II Get druggable targets OG5_128755 All targets in OG5_128755
Chlamydia trachomatis DNA gyrase subunit B Get druggable targets OG5_128755 All targets in OG5_128755
Trypanosoma congolense DNA topoisomerase II, putative Get druggable targets OG5_128755 All targets in OG5_128755
Plasmodium knowlesi DNA gyrase subunit A, putative Get druggable targets OG5_129568 All targets in OG5_129568
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative Get druggable targets OG5_128755 All targets in OG5_128755
Plasmodium knowlesi DNA gyrase subunit B, putative Get druggable targets OG5_128755 All targets in OG5_128755
Toxoplasma gondii DNA gyrase/topoisomerase IV, A subunit domain-containing protein Get druggable targets OG5_129568 All targets in OG5_129568
Babesia bovis DNA gyrase subunit B, putative Get druggable targets OG5_128755 All targets in OG5_128755
Mycobacterium ulcerans DNA gyrase subunit B Get druggable targets OG5_128755 All targets in OG5_128755
Leishmania braziliensis mitochondrial DNA topoisomerase II Get druggable targets OG5_128755 All targets in OG5_128755
Neospora caninum DNA gyrase subunit A, putative Get druggable targets OG5_129568 All targets in OG5_129568
Plasmodium vivax DNA gyrase subunit B, putative Get druggable targets OG5_128755 All targets in OG5_128755
Plasmodium falciparum DNA gyrase subunit B Get druggable targets OG5_128755 All targets in OG5_128755
Trypanosoma brucei gambiense DNA topoisomerase II, putative Get druggable targets OG5_128755 All targets in OG5_128755
Mycobacterium ulcerans DNA gyrase subunit A Get druggable targets OG5_129568 All targets in OG5_129568
Mycobacterium tuberculosis DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) Get druggable targets OG5_128755 All targets in OG5_128755
Treponema pallidum DNA gyrase, subunit B (gyrB) Get druggable targets OG5_128755 All targets in OG5_128755
Neospora caninum hypothetical protein Get druggable targets OG5_128755 All targets in OG5_128755
Leishmania infantum mitochondrial DNA topoisomerase II Get druggable targets OG5_128755 All targets in OG5_128755
Chlamydia trachomatis DNA gyrase subunit A Get druggable targets OG5_129568 All targets in OG5_129568
Leishmania major mitochondrial DNA topoisomerase II Get druggable targets OG5_128755 All targets in OG5_128755
Babesia bovis DNA gyrase A subunit, putative Get druggable targets OG5_129568 All targets in OG5_129568
Plasmodium yoelii DNA topoisomerase II, putative Get druggable targets OG5_128755 All targets in OG5_128755
Trypanosoma brucei DNA topoisomerase ii Get druggable targets OG5_128755 All targets in OG5_128755
Plasmodium berghei DNA gyrase subunit B, putative Get druggable targets OG5_128755 All targets in OG5_128755
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative Get druggable targets OG5_128755 All targets in OG5_128755
Mycobacterium leprae Probable DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) Get druggable targets OG5_128755 All targets in OG5_128755
Theileria parva DNA gyrase subunit A, putative Get druggable targets OG5_129568 All targets in OG5_129568
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein Get druggable targets OG5_128755 All targets in OG5_128755
Wolbachia endosymbiont of Brugia malayi DNA gyrase subunit A Get druggable targets OG5_129568 All targets in OG5_129568
Plasmodium falciparum DNA gyrase subunit A Get druggable targets OG5_129568 All targets in OG5_129568
Plasmodium berghei DNA gyrase subunit A, putative Get druggable targets OG5_129568 All targets in OG5_129568
Plasmodium vivax DNA gyrase subunit A, putative Get druggable targets OG5_129568 All targets in OG5_129568
Treponema pallidum DNA gyrase, subunit A (gyrA) Get druggable targets OG5_129568 All targets in OG5_129568
Leishmania donovani mitochondrial DNA topoisomerase II Get druggable targets OG5_128755 All targets in OG5_128755
Wolbachia endosymbiont of Brugia malayi DNA gyrase, topoisomerase II, B subunit, GyrB Get druggable targets OG5_128755 All targets in OG5_128755
Plasmodium yoelii DNA gyrase subunit a-related Get druggable targets OG5_129568 All targets in OG5_129568

By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0121 0.0488 0.0488
Mycobacterium leprae Probable DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) 0.0152 0.0627 0.2154
Toxoplasma gondii phosphorylase family protein 0.0034 0.009 0.009
Onchocerca volvulus Huntingtin homolog 0.0072 0.0262 0.1647
Echinococcus multilocularis geminin 0.0189 0.0797 0.0797
Schistosoma mansoni nuclear receptor 0.0053 0.0178 0.0178
Brugia malayi Steroid receptor seven-up type 2 0.0113 0.0451 0.0451
Chlamydia trachomatis DNA gyrase subunit B 0.01 0.0393 0.1089
Toxoplasma gondii sedoheptulose-1,7-bisphosphatase 0.0817 0.3677 0.3677
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0113 0.0451 0.0451
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0704 0.3158 0.3158
Brugia malayi Pre-SET motif family protein 0.0063 0.022 0.022
Loa Loa (eye worm) hypothetical protein 0.1387 0.6285 0.6285
Brugia malayi ecdysone receptor 0.0053 0.0178 0.0178
Echinococcus granulosus purine nucleoside phosphorylase 0.0165 0.0688 0.0688
Onchocerca volvulus Huntingtin homolog 0.0072 0.0262 0.1647
Brugia malayi hypothetical protein 0.006 0.0207 0.0207
Loa Loa (eye worm) hypothetical protein 0.006 0.0207 0.0207
Trypanosoma cruzi cytochrome P450, putative 0.005 0.0164 0.0164
Brugia malayi Inositol-1 0.0092 0.0354 0.0354
Onchocerca volvulus Protein ultraspiracle homolog 0.0113 0.0451 0.5361
Trypanosoma cruzi DNA topoisomerase II, putative 0.0058 0.0198 0.0198
Giardia lamblia UPL-1 0.0034 0.009 0.1214
Echinococcus granulosus purine nucleoside phosphorylase 0.0165 0.0688 0.0688
Brugia malayi orphan nuclear receptor NR2E1 0.0053 0.0178 0.0178
Loa Loa (eye worm) hypothetical protein 0.0053 0.0178 0.0178
Brugia malayi jmjC domain containing protein 0.0045 0.0139 0.0139
Brugia malayi nuclear receptor NHR-88 0.0113 0.0451 0.0451
Echinococcus granulosus inosine guanosine and xanthosine phosphorylase 0.0131 0.0532 0.0532
Toxoplasma gondii fructose-bisphospatase I 0.0817 0.3677 0.3677
Schistosoma mansoni steroid hormone receptor ad4bp 0.0113 0.0451 0.0451
Leishmania major cathepsin L-like protease 0.0019 0.0022 0.0022
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0113 0.0451 0.0451
Echinococcus multilocularis purine nucleoside phosphorylase 0.0165 0.0688 0.0688
Chlamydia trachomatis AMP nucleosidase 0.0034 0.009 0.0018
Echinococcus multilocularis nuclear receptor nhr 48 0.0053 0.0178 0.0178
Trypanosoma brucei methylthioadenosine phosphorylase, putative 0.0034 0.009 0.009
Treponema pallidum DNA gyrase, subunit B (gyrB) 0.0153 0.0634 0.3269
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.006 0.0207 0.0207
Brugia malayi nuclear hormone receptor 0.0113 0.0451 0.0451
Trypanosoma brucei DNA polymerase kappa, putative 0.0024 0.0042 0.0042
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0113 0.0451 0.0451
Echinococcus granulosus purine nucleoside phosphorylase 0.0165 0.0688 0.0688
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0113 0.0451 0.0451
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0113 0.0451 0.0451
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0092 0.0354 0.0354
Trypanosoma brucei uridine phosphorylase 0.0034 0.009 0.009
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0092 0.0354 0.0354
Loa Loa (eye worm) hypothetical protein 0.0072 0.0262 0.0262
Trypanosoma cruzi DNA topoisomerase II, putative 0.0058 0.0198 0.0198
Trypanosoma brucei DNA polymerase kappa, putative 0.0031 0.0077 0.0077
Echinococcus multilocularis thyroid hormone receptor alpha 0.0817 0.3676 0.3676
Trypanosoma brucei fructose-1,6-bisphosphatase 0.2198 1 1
Loa Loa (eye worm) hypothetical protein 0.0104 0.0409 0.0409
Trypanosoma brucei DNA topoisomerase II alpha, putative 0.0058 0.0198 0.0198
Loa Loa (eye worm) hypothetical protein 0.0053 0.0178 0.0178
Brugia malayi ecdysteroid receptor 0.0113 0.0451 0.0451
Echinococcus granulosus inositol monophosphatase 1 0.0092 0.0354 0.0354
Schistosoma mansoni thyroid hormone receptor 0.0817 0.3676 0.3676
Trypanosoma brucei DNA topoisomerase II beta, putative 0.0058 0.0198 0.0198
Loa Loa (eye worm) hypothetical protein 0.0033 0.0085 0.0085
Trypanosoma brucei DNA polymerase kappa, putative 0.0031 0.0077 0.0077
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0113 0.0451 0.0451
Trypanosoma cruzi DNA polymerase kappa, putative 0.0031 0.0077 0.0077
Chlamydia trachomatis dehyroquinate synthase 0.0253 0.1093 0.3566
Loa Loa (eye worm) nuclear hormone receptor 0.0053 0.0178 0.0178
Toxoplasma gondii fructose-bisphospatase II 0.2198 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.009 0.0211
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0113 0.0451 0.0451
Toxoplasma gondii DNA topoisomerase 2, putative 0.0069 0.0248 0.0248
Loa Loa (eye worm) hypothetical protein 0.0113 0.0451 0.0451
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.1393 0.6315 0.6315
Loa Loa (eye worm) CYP4Cod1 0.005 0.0164 0.0164
Loa Loa (eye worm) inositol-1 0.0092 0.0354 0.0354
Brugia malayi steroid hormone receptor 0.0113 0.0451 0.0451
Trypanosoma brucei DNA polymerase IV, putative 0.0026 0.0054 0.0054
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0092 0.0354 0.4537
Mycobacterium tuberculosis 3-dehydroquinate synthase AroB 0.0253 0.1093 0.7871
Echinococcus granulosus ecdysone induced protein 78C 0.0113 0.0451 0.0451
Mycobacterium ulcerans bifunctional Mta/Sah nucleosidase Mtn 0.0034 0.009 0.0308
Schistosoma mansoni DNA topoisomerase II 0.0069 0.0248 0.0248
Plasmodium falciparum DNA gyrase subunit B 0.0153 0.0634 0.4186
Mycobacterium ulcerans DNA polymerase IV 0.0031 0.0077 0.0264
Plasmodium vivax DNA gyrase subunit A, putative 0.0318 0.1389 1
Chlamydia trachomatis DNA gyrase subunit B 0.0153 0.0634 0.1941
Echinococcus granulosus geminin 0.0189 0.0797 0.0797
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0082 0.031 0.2232
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0053 0.0178 0.0178
Trypanosoma brucei DNA polymerase kappa, putative 0.0024 0.0042 0.0042
Loa Loa (eye worm) DR-78 0.0053 0.0178 0.0178
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0113 0.0451 0.0451
Plasmodium vivax DNA topoisomerase II, putative 0.0069 0.0248 0.122
Chlamydia trachomatis UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.0397 0.1753 0.59
Trypanosoma brucei DNA polymerase IV, putative 0.0031 0.0077 0.0077
Mycobacterium tuberculosis DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.0153 0.0634 0.4561
Echinococcus multilocularis dna polymerase kappa 0.0031 0.0077 0.0077
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0019 0.0022 0.0022
Brugia malayi photoreceptor-specific nuclear receptor 0.0113 0.0451 0.0451
Schistosoma mansoni methylthioadenosine phosphorylase 0.0034 0.009 0.009
Schistosoma mansoni 3-dehydroquinate synthase 0.0253 0.1093 0.1093
Loa Loa (eye worm) hypothetical protein 0.0113 0.0451 0.0451
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0121 0.0488 0.0488
Brugia malayi Nuclear hormone receptor-like 1 0.1393 0.6315 0.6315
Echinococcus granulosus purine nucleoside phosphorylase 0.0165 0.0688 0.0688
Trichomonas vaginalis set domain proteins, putative 0.0071 0.026 0.2998
Trypanosoma cruzi cysteine peptidase, putative 0.0019 0.0022 0.0022
Trypanosoma cruzi cytochrome P450, putative 0.005 0.0164 0.0164
Schistosoma mansoni sodium-bile acid cotransporter 0.0056 0.0188 0.0188
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0113 0.0451 0.0451
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0034 0.009 0.0211
Onchocerca volvulus Purine nucleoside phosphorylase homolog 0.0165 0.0688 1
Chlamydia trachomatis phosphoshikimate 1-carboxyl vinyltransferase 0.0651 0.2913 1
Loa Loa (eye worm) hypothetical protein 0.0053 0.0178 0.0178
Loa Loa (eye worm) cytochrome P450 family protein 0.005 0.0164 0.0164
Echinococcus granulosus Nuclear hormone receptor HR96 0.0053 0.0178 0.0178
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0121 0.0489 0.0489
Leishmania major nucleoside phosphorylase-like protein 0.0034 0.009 0.009
Leishmania major cathepsin L-like protease 0.0019 0.0022 0.0022
Echinococcus multilocularis purine nucleoside phosphorylase 0.0165 0.0688 0.0688
Brugia malayi nuclear receptor NHR-88 0.0053 0.0178 0.0178
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0113 0.0451 0.0451
Loa Loa (eye worm) hypothetical protein 0.0113 0.0451 0.0451
Trypanosoma cruzi nucleoside phosphorylase, putative 0.0034 0.009 0.009
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0053 0.0178 0.0178
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0063 0.022 0.022
Echinococcus multilocularis fructose 1,6 bisphosphatase 1 0.2198 1 1
Loa Loa (eye worm) fructose-1,6-bisphosphatase 0.2198 1 1
Loa Loa (eye worm) hypothetical protein 0.0072 0.0262 0.0262
Trypanosoma cruzi nucleoside phosphorylase, putative 0.0034 0.009 0.009
Mycobacterium tuberculosis DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.0318 0.1389 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0113 0.0451 0.0451
Leishmania major methylthioadenosine phosphorylase, putative 0.0034 0.009 0.009
Onchocerca volvulus Putative DNA topoisomerase 2, mitochondrial 0.0069 0.0248 0.1382
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0019 0.0022 0.0022
Brugia malayi nuclear hormone receptor family member odr-7 0.0053 0.0178 0.0178
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0113 0.0451 0.0451
Schistosoma mansoni inositol monophosphatase 0.0092 0.0354 0.0354
Loa Loa (eye worm) hypothetical protein 0.0024 0.0042 0.0042
Loa Loa (eye worm) hypothetical protein 0.0113 0.0451 0.0451
Echinococcus granulosus nuclear receptor nhr 48 0.0053 0.0178 0.0178
Trypanosoma brucei unspecified product 0.0026 0.0054 0.0054
Wolbachia endosymbiont of Brugia malayi DNA gyrase, topoisomerase II, B subunit, GyrB 0.0153 0.0634 0.1997
Mycobacterium ulcerans 3-phosphoshikimate 1-carboxyvinyltransferase 0.0651 0.2913 1
Brugia malayi hypothetical protein 0.006 0.0207 0.0207
Trypanosoma cruzi DNA polymerase kappa, putative 0.0031 0.0077 0.0077
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0092 0.0354 0.0354
Brugia malayi conserved hypotetical protein 0.0053 0.0178 0.0178
Brugia malayi DNA topoisomerase II, alpha isozyme 0.0069 0.0248 0.0248
Mycobacterium ulcerans DNA polymerase IV 0.0031 0.0077 0.0264
Loa Loa (eye worm) hypothetical protein 0.006 0.0207 0.0207
Mycobacterium ulcerans purine nucleoside phosphorylase 0.0165 0.0688 0.2361
Trypanosoma brucei DNA polymerase kappa, putative 0.0031 0.0077 0.0077
Wolbachia endosymbiont of Brugia malayi UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.0397 0.1753 1
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0121 0.0489 0.0489
Giardia lamblia Purine nucleoside phosphorylase lateral transfer candidate 0.0165 0.0688 1
Brugia malayi nuclear receptor RXR 0.006 0.0207 0.0207
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0019 0.0022 0.0022
Brugia malayi hypothetical protein 0.0072 0.0262 0.0262
Schistosoma mansoni inositol monophosphatase 0.0092 0.0354 0.0354
Trypanosoma brucei DNA polymerase kappa, putative 0.0031 0.0077 0.0077
Brugia malayi Nuclear hormone receptor-like 1 0.1393 0.6315 0.6315
Trypanosoma cruzi fructose-1,6-bisphosphatase, cytosolic, putative 0.2198 1 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0047 0.0047
Mycobacterium leprae probable 3-phosphoshikimate 1-carboxyvinyl transferase AroA (5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE SYNTHASE) (EPSP SYNTHASE) (EPSPS 0.0651 0.2913 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0113 0.0451 0.0451
Brugia malayi uridine phosphorylase family protein 0.0034 0.009 0.009
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.006 0.0207 0.0207
Trypanosoma cruzi nucleoside phosphorylase, putative 0.0034 0.009 0.009
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0113 0.0451 0.0451
Trypanosoma brucei DNA polymerase kappa, putative 0.0031 0.0077 0.0077
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.005 0.0164 0.0564
Echinococcus granulosus sodium bile acid cotransporter 0.0094 0.0362 0.0362
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0113 0.0451 0.0451
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0113 0.0451 0.0451
Echinococcus multilocularis ecdysone induced protein 78C 0.0113 0.0451 0.0451
Treponema pallidum DNA gyrase, subunit A (gyrA) 0.0318 0.1389 0.781
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0082 0.031 0.1064
Echinococcus multilocularis lysine specific demethylase 5A 0.0045 0.0139 0.0139
Brugia malayi Probable DNA topoisomerase II 0.0069 0.0248 0.0248
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0113 0.0451 0.0451
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0113 0.0451 0.0451
Echinococcus granulosus lysine specific demethylase 5A 0.0045 0.0139 0.0139
Loa Loa (eye worm) hypothetical protein 0.0113 0.0451 0.0451
Mycobacterium leprae Probable DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) 0.0053 0.0175 0.0599
Echinococcus multilocularis purine nucleoside phosphorylase 0.0165 0.0688 0.0688
Leishmania major DNA topoisomerase ii 0.0058 0.0198 0.0198
Echinococcus multilocularis sodium bile acid cotransporter 0.0094 0.0362 0.0362
Schistosoma mansoni family A2 unassigned peptidase (A02 family) 0.0215 0.092 0.092
Brugia malayi nuclear hormone receptor family member nhr-6 0.0053 0.0178 0.0178
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0092 0.0354 0.0354
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0113 0.0451 0.0451
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0053 0.0178 0.0178
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0113 0.0451 0.0451
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0113 0.0451 0.0451
Trypanosoma brucei DNA polymerase kappa, putative 0.0031 0.0077 0.0077
Loa Loa (eye worm) hypothetical protein 0.0025 0.0047 0.0047
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0088 0.0338 0.0338
Echinococcus multilocularis purine nucleoside phosphorylase 0.0165 0.0688 0.0688
Giardia lamblia 5-methylthioadenosine nucleosidase, S-adenosylhomocysteine nucleosidase 0.0034 0.009 0.1214
Trypanosoma brucei DNA polymerase kappa, putative 0.0031 0.0077 0.0077
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0019 0.0022 0.0022
Trypanosoma brucei DNA topoisomerase ii 0.0121 0.0489 0.0489
Loa Loa (eye worm) hypothetical protein 0.0053 0.0178 0.0178
Toxoplasma gondii Purine nucleoside phosphorylase 0.0034 0.009 0.009
Chlamydia trachomatis DNA gyrase subunit A 0.0318 0.1389 0.4612
Mycobacterium tuberculosis Conserved hypothetical protein 0.0034 0.009 0.0646
Brugia malayi nuclear receptor RXR 0.0053 0.0178 0.0178
Brugia malayi Phospholipase A2 family protein 0.0104 0.0409 0.0409
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0092 0.0354 0.0354
Schistosoma mansoni retinoic acid receptor RXR 0.0113 0.0451 0.0451
Mycobacterium tuberculosis Probable bifunctional MTA/SAH nucleosidase Mtn: 5'-methylthioadenosine nucleosidase (methylthioadenosine methylthioribohydrolase 0.0034 0.009 0.0646
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0053 0.0178 0.0178
Schistosoma mansoni coup transcription factor 0.0113 0.0451 0.0451
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0113 0.0451 0.0451
Trypanosoma cruzi methylthioadenosine phosphorylase, putative 0.0034 0.009 0.009
Echinococcus multilocularis purine nucleoside phosphorylase 0.0165 0.0688 0.0688
Mycobacterium ulcerans DNA gyrase subunit A 0.0318 0.1389 0.4768
Loa Loa (eye worm) hypothetical protein 0.0131 0.0532 0.0532
Loa Loa (eye worm) hypothetical protein 0.006 0.0207 0.0207
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0069 0.0248 0.1382
Onchocerca volvulus 0.0113 0.0451 0.5361
Schistosoma mansoni methylthioadenosine phosphorylase 0.0034 0.009 0.009
Echinococcus granulosus sodium bile acid cotransporter 0.0094 0.0362 0.0362
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0018 0.0014 0.0014
Schistosoma mansoni jumonji/arid domain-containing protein 0.0045 0.0139 0.0139
Mycobacterium leprae 3-dehydroquinate synthase AroB 0.0253 0.1093 0.3753
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.009 0.0211
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0113 0.0451 0.0451
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0069 0.0248 0.1382
Onchocerca volvulus Phospholipase A2 homolog 0.0104 0.0409 0.4529
Trypanosoma brucei DNA polymerase kappa, putative 0.0031 0.0077 0.0077
Echinococcus granulosus uridine phosphorylase 1 0.0034 0.009 0.009
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0113 0.0451 0.0451
Brugia malayi Sodium Bile acid symporter family protein 0.0094 0.0362 0.0362
Schistosoma mansoni retinoid-x-receptor (RXR) 0.006 0.0207 0.0207
Trichomonas vaginalis DNA topoisomerase II, putative 0.0069 0.0248 0.2805
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0019 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0104 0.0409 0.0409
Loa Loa (eye worm) hypothetical protein 0.0053 0.0178 0.0178
Schistosoma mansoni uridine phosphorylase 0.0034 0.009 0.009
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0053 0.0178 0.0178
Treponema pallidum UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.0397 0.1753 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0031 0.0077 0.0077
Brugia malayi hypothetical protein 0.0053 0.0178 0.0178
Echinococcus granulosus DNA topoisomerase 2 alpha 0.0069 0.0248 0.0248
Schistosoma mansoni lipoxygenase 0.0025 0.0047 0.0047
Brugia malayi jmjC domain containing protein 0.0045 0.0139 0.0139
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0113 0.0451 0.0451
Brugia malayi MTAP 0.0034 0.009 0.009
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0113 0.0451 0.0451
Loa Loa (eye worm) hypothetical protein 0.0053 0.0178 0.0178
Mycobacterium tuberculosis Probable purine nucleoside phosphorylase DeoD (inosine phosphorylase) (PNP) 0.0165 0.0688 0.4953
Schistosoma mansoni methylthioadenosine phosphorylase 0.0034 0.009 0.009
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.006 0.0207 0.0207
Trypanosoma brucei DNA polymerase IV, putative 0.0031 0.0077 0.0077
Brugia malayi tailless protein 0.0053 0.0178 0.0178
Echinococcus granulosus Nuclear hormone receptor HR96 0.0053 0.0178 0.0178
Echinococcus multilocularis sodium bile acid cotransporter 0.0094 0.0362 0.0362
Leishmania major mitochondrial DNA topoisomerase II 0.0121 0.0489 0.0489
Trypanosoma cruzi cysteine peptidase, putative 0.0019 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0053 0.0178 0.0178
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0053 0.0178 0.0178
Schistosoma mansoni hypothetical protein 0.0189 0.0797 0.0797
Trypanosoma brucei sedoheptulose-1,7-bisphosphatase 0.0817 0.3677 0.3677
Echinococcus multilocularis purine nucleoside phosphorylase 0.0131 0.0532 0.0532
Loa Loa (eye worm) TOPoisomerase family member 0.0069 0.0248 0.0248
Schistosoma mansoni hypothetical protein 0.0189 0.0797 0.0797
Mycobacterium leprae probable uridine phosphorylase 0.0034 0.009 0.0308
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0045 0.0139 0.0139
Trichomonas vaginalis purine nucleoside phosphorylase I, putative 0.0165 0.0688 1
Schistosoma mansoni nuclear receptor nhr-48 0.0053 0.0178 0.0178
Giardia lamblia 5-methylthioadenosine nucleosidase, S-adenosylhomocysteine nucleosidase 0.0034 0.009 0.1214
Mycobacterium tuberculosis Hypothetical protein 0.0034 0.009 0.0646
Echinococcus multilocularis purine nucleoside phosphorylase 0.0165 0.0688 0.0688
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0113 0.0451 0.0451
Schistosoma mansoni nuclear hormone receptor 0.0053 0.0178 0.0178
Schistosoma mansoni nuclear receptor 0.0053 0.0178 0.0178
Loa Loa (eye worm) hypothetical protein 0.0094 0.0362 0.0362
Trypanosoma cruzi cruzipain precursor, putative 0.0019 0.0022 0.0022
Wolbachia endosymbiont of Brugia malayi DNA gyrase subunit A 0.0318 0.1389 0.7396
Loa Loa (eye worm) S-methyl-5'-thioadenosine phosphorylase MTAP 0.0034 0.009 0.009
Schistosoma mansoni zinc finger protein 0.0053 0.0178 0.0178
Toxoplasma gondii phosphorylase family protein 0.0034 0.009 0.009
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0034 0.009 0.0211
Trypanosoma brucei DNA polymerase kappa, putative 0.0031 0.0077 0.0077
Echinococcus multilocularis FTZ F1 alpha 0.0113 0.0451 0.0451
Schistosoma mansoni nuclear hormone receptor 0.0053 0.0178 0.0178
Leishmania major cathepsin L-like protease 0.0019 0.0022 0.0022
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0034 0.009 0.0211
Echinococcus granulosus sodium bile acid cotransporter 0.0094 0.0362 0.0362
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0113 0.0451 0.0451
Brugia malayi nuclear receptor NHR-67 0.0053 0.0178 0.0178
Loa Loa (eye worm) hypothetical protein 0.0053 0.0178 0.0178
Schistosoma mansoni sodium-bile acid cotransporter related 0.0094 0.0362 0.0362
Brugia malayi Nuclear hormone receptor-like 1 0.1447 0.6559 0.6559
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0113 0.0451 0.0451
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0036 0.0096 0.0096
Loa Loa (eye worm) hypothetical protein 0.0113 0.0451 0.0451
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0121 0.0488 0.0488
Schistosoma mansoni thyroid hormone receptor 0.0817 0.3676 0.3676
Onchocerca volvulus Bile acid receptor homolog 0.0113 0.0451 0.5361
Loa Loa (eye worm) hypothetical protein 0.0033 0.0085 0.0085
Loa Loa (eye worm) cytochrome P450 family protein 0.005 0.0164 0.0164
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0007 0.0007
Brugia malayi Nuclear hormone receptor E75 0.0053 0.0178 0.0178
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0045 0.0139 0.0139
Trichomonas vaginalis inositol monophosphatase, putative 0.0092 0.0354 0.4537
Toxoplasma gondii shikimate dehydrogenase substrate binding domain-containing protein 0.0651 0.2913 0.2913
Echinococcus multilocularis uridine phosphorylase 1 0.0034 0.009 0.009
Mycobacterium ulcerans 5'-methylthioadenosine phosphorylase 0.0034 0.009 0.0308
Schistosoma mansoni hypothetical protein 0.0704 0.3158 0.3158
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0092 0.0354 0.4537
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0036 0.0096 0.0096
Schistosoma mansoni uridine phosphorylase 0.0034 0.009 0.009
Leishmania major DNA polymerase kappa, putative 0.0016 0.0007 0.0007
Leishmania major cytochrome p450-like protein 0.005 0.0164 0.0164
Schistosoma mansoni purine nucleoside phosphorylase 0.0165 0.0688 0.0688
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0113 0.0451 0.0451
Loa Loa (eye worm) hypothetical protein 0.0113 0.0451 0.0451
Loa Loa (eye worm) jmjC domain-containing protein 0.0045 0.0139 0.0139
Trypanosoma cruzi sedoheptulose-1,7-bisphosphatase, putative 0.0817 0.3677 0.3677
Echinococcus multilocularis purine nucleoside phosphorylase 0.0131 0.0532 0.0532
Trypanosoma cruzi sedoheptulose-1,7-bisphosphatase, putative 0.0817 0.3677 0.3677
Echinococcus granulosus purine nucleoside phosphorylase 0.0165 0.0688 0.0688
Leishmania major 0.2198 1 1
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0113 0.0451 0.0451
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0034 0.009 0.0211
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0019 0.0022 0.0022
Echinococcus granulosus dna polymerase kappa 0.0031 0.0077 0.0077
Loa Loa (eye worm) hypothetical protein 0.0053 0.0178 0.0178
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0019 0.0022 0.0022
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0053 0.0178 0.0178
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0113 0.0451 0.0451
Onchocerca volvulus Phospholipase A2 homolog 0.0104 0.0409 0.4529
Schistosoma mansoni fructose-16-bisphosphatase-related 0.2198 1 1
Echinococcus granulosus methylthioadenosine phosphorylase 0.0034 0.009 0.009
Loa Loa (eye worm) hypothetical protein 0.006 0.0207 0.0207
Echinococcus granulosus FTZ F1 alpha 0.0113 0.0451 0.0451
Schistosoma mansoni purine nucleoside phosphorylase 0.0165 0.0688 0.0688
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0704 0.3158 0.3158
Schistosoma mansoni jumonji/arid domain-containing protein 0.0045 0.0139 0.0139
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0092 0.0354 0.1216
Trypanosoma cruzi methylthioadenosine phosphorylase, putative 0.0034 0.009 0.009
Brugia malayi Nuclear hormone receptor E75 0.0053 0.0178 0.0178
Loa Loa (eye worm) hypothetical protein 0.006 0.0207 0.0207
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0113 0.0451 0.0451
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0019 0.0022 0.0022
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0053 0.0178 0.0178
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0053 0.0178 0.0178
Schistosoma mansoni sodium-bile acid cotransporter related 0.0038 0.0107 0.0107
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0053 0.0178 0.0178
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0034 0.009 0.0211
Onchocerca volvulus 0.0094 0.0362 0.3606
Onchocerca volvulus 0.0071 0.026 0.1613
Echinococcus granulosus purine nucleoside phosphorylase 0.0165 0.0688 0.0688
Loa Loa (eye worm) steroid hormone receptor 0.0113 0.0451 0.0451
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0113 0.0451 0.0451
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0113 0.0451 0.0451
Plasmodium falciparum DNA topoisomerase 2 0.0069 0.0248 0.122
Brugia malayi hypothetical protein 0.0053 0.0178 0.0178
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein 0.0069 0.0248 0.0248
Mycobacterium leprae Probable purine nucleoside phosphorylase DeoD (INOSINE PHOSPHORYLASE) (PNP) 0.0165 0.0688 0.2361
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0053 0.0178 0.0178
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0113 0.0451 0.0451
Entamoeba histolytica DNA topoisomerase II, putative 0.0069 0.0248 0.5997
Loa Loa (eye worm) hypothetical protein 0.0053 0.0178 0.0178
Trypanosoma brucei cytochrome P450, putative 0.005 0.0164 0.0164
Mycobacterium tuberculosis 3-phosphoshikimate 1-carboxyvinyltransferase AroA (5-enolpyruvylshikimate-3-phosphate synthase) (EPSP synthase) (EPSPS) 0.0253 0.1093 0.7871
Echinococcus granulosus thyroid hormone receptor alpha 0.0053 0.0178 0.0178
Brugia malayi Cytochrome P450 family protein 0.005 0.0164 0.0164
Plasmodium falciparum DNA gyrase subunit A 0.0318 0.1389 1
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0113 0.0451 0.0451
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0016 0.0007 0.0051
Schistosoma mansoni jumonji domain containing protein 0.0045 0.0139 0.0139
Echinococcus granulosus fructose 16 bisphosphatase 1 0.2198 1 1
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0016 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0036 0.0098 0.0098
Giardia lamblia DNA topoisomerase II 0.0064 0.0226 0.322
Brugia malayi nuclear hormone receptor 0.0053 0.0178 0.0178
Echinococcus multilocularis DNA topoisomerase 2 alpha 0.0069 0.0248 0.0248
Mycobacterium ulcerans UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.0397 0.1753 0.6019
Loa Loa (eye worm) hypothetical protein 0.0053 0.0178 0.0178
Trypanosoma cruzi DNA polymerase kappa, putative 0.0031 0.0077 0.0077
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0092 0.0354 1
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0113 0.0451 0.0451
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0019 0.0022 0.0022
Schistosoma mansoni intracisternal A-particle retropepsin (A02 family) 0.1184 0.5357 0.5357
Loa Loa (eye worm) uridine phosphorylase 0.0034 0.009 0.009
Plasmodium vivax DNA gyrase subunit B, putative 0.0153 0.0634 0.4186
Echinococcus multilocularis methylthioadenosine phosphorylase 0.0034 0.009 0.009
Loa Loa (eye worm) hypothetical protein 0.0053 0.0178 0.0178
Trypanosoma cruzi fructose-1,6-bisphosphatase, cytosolic, putative 0.2198 1 1
Echinococcus granulosus purine nucleoside phosphorylase 0.0165 0.0688 0.0688
Trypanosoma cruzi cysteine peptidase, putative 0.0019 0.0022 0.0022
Trypanosoma cruzi major cysteine proteinase, putative 0.0015 0.0003 0.0003
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0034 0.009 0.0211
Loa Loa (eye worm) nuclear receptor NHR-67 0.0053 0.0178 0.0178
Mycobacterium ulcerans DNA gyrase subunit B 0.0153 0.0634 0.2175
Mycobacterium ulcerans 3-dehydroquinate synthase 0.0253 0.1093 0.3753
Loa Loa (eye worm) hypothetical protein 0.0113 0.0451 0.0451
Brugia malayi polk-prov protein 0.0024 0.0042 0.0042
Brugia malayi Cytochrome P450 family protein 0.005 0.0164 0.0164
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0019 0.0022 0.0022
Schistosoma mansoni RAR-like nuclear receptor 0.0113 0.0451 0.0451
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0113 0.0451 0.0451
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0113 0.0451 0.5361
Echinococcus multilocularis sodium bile acid cotransporter 0.0094 0.0362 0.0362
Schistosoma mansoni nuclear hormone receptor 0.0113 0.0451 0.0451
Toxoplasma gondii DNA gyrase/topoisomerase IV, A subunit domain-containing protein 0.0318 0.1389 0.1389
Schistosoma mansoni protein tyrosine phosphatase non-receptor type nt1 0.0121 0.0488 0.0488
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0019 0.0022 0.0022
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0034 0.009 0.0211
Echinococcus multilocularis inositol monophosphatase 1 0.0092 0.0354 0.0354
Brugia malayi purine nucleoside phosphorylase I, inosine and guanosine-specific family protein 0.0165 0.0688 0.0688
Echinococcus granulosus purine nucleoside phosphorylase 0.0165 0.0688 0.0688
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0121 0.0488 0.0488
Schistosoma mansoni lipoxygenase 0.0036 0.0096 0.0096

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 1 ug ml-1 Inhibitory activity against E. coli DNA gyrase ChEMBL. 15125947
IC50 (binding) = 1 ug ml-1 Inhibitory activity against E. coli DNA gyrase ChEMBL. 15125947
IC50 (binding) > 128 ug ml-1 E. coli DNA topoisomerase IV decatenation activity was determined ChEMBL. 15125947
IC50 (binding) > 400 ug ml-1 Human DNA topoisomerase II relaxation activity was determined ChEMBL. 15125947
IC50 (binding) > 400 ug ml-1 Human DNA topoisomerase II relaxation activity was determined ChEMBL. 15125947
MIC (functional) = 4 ug ml-1 Inhibitory activity against Staphylococcus aureus FDA 209P ChEMBL. 15125947
MIC (functional) = 4 ug ml-1 Inhibitory activity against Staphylococcus aureus KMP9 ChEMBL. 15125947
MIC (functional) = 4 ug ml-1 Inhibitory activity against Enterococcus faecalis ATCC 29212 ChEMBL. 15125947
MIC (functional) = 4 ug ml-1 Inhibitory activity against Enterococcus faecalis KU 1777 ChEMBL. 15125947

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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