Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | tyrosine protein kinase ABL1 | 0.0603 | 0.997 | 1 |
Echinococcus multilocularis | SH2 motif | 0.0354 | 0.2951 | 0.296 |
Schistosoma mansoni | adapter molecule crk | 0.0354 | 0.2951 | 0.296 |
Echinococcus granulosus | tyrosine protein phosphatase non receptor type | 0.0354 | 0.2951 | 0.2951 |
Brugia malayi | hypothetical protein | 0.0603 | 0.997 | 1 |
Echinococcus granulosus | tyrosine protein kinase Blk | 0.0603 | 0.997 | 0.997 |
Schistosoma mansoni | proto-oncogene tyrosine-protein kinase abl1 | 0.0354 | 0.2951 | 0.296 |
Brugia malayi | Protein kinase domain containing protein | 0.0603 | 0.997 | 1 |
Echinococcus multilocularis | tyrosine protein phosphatase non receptor type | 0.0354 | 0.2951 | 0.296 |
Brugia malayi | Protein kinase domain containing protein | 0.0603 | 0.997 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.0603 | 0.997 | 1 |
Schistosoma mansoni | tyrosine-protein kinase zap-70 | 0.0354 | 0.2951 | 0.296 |
Schistosoma mansoni | growth factor receptor-bound protein | 0.0354 | 0.2951 | 0.296 |
Entamoeba histolytica | protein kinase, putative | 0.0355 | 0.2981 | 0.299 |
Echinococcus granulosus | expressed conserved protein | 0.0354 | 0.2951 | 0.2951 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0603 | 0.997 | 1 |
Echinococcus multilocularis | NCK adaptor protein | 0.0354 | 0.2951 | 0.296 |
Entamoeba histolytica | SH2 domain containing protein | 0.0354 | 0.2951 | 0.296 |
Echinococcus multilocularis | suppressor of cytokine signaling 6 | 0.0354 | 0.2951 | 0.296 |
Schistosoma mansoni | suppressor of cytokine signaling | 0.0354 | 0.2951 | 0.296 |
Echinococcus granulosus | suppressor of cytokine signaling 7 | 0.0354 | 0.2951 | 0.2951 |
Brugia malayi | Protein kinase domain containing protein | 0.0603 | 0.997 | 1 |
Echinococcus granulosus | SH2 domain containing protein 7 | 0.0354 | 0.2951 | 0.2951 |
Echinococcus multilocularis | tyrosine protein kinase Src64B | 0.0603 | 0.997 | 1 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0603 | 0.997 | 1 |
Echinococcus granulosus | SHC transforming protein 3 | 0.0354 | 0.2951 | 0.2951 |
Echinococcus multilocularis | tyrosine protein kinase Src42A | 0.0354 | 0.2951 | 0.296 |
Onchocerca volvulus | 0.0603 | 0.997 | 1 | |
Loa Loa (eye worm) | SRC-1 | 0.0603 | 0.997 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0603 | 0.997 | 1 |
Trypanosoma cruzi | STE/STE11 serine/threonine-protein kinase, putative | 0.025 | 0 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0603 | 0.997 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0354 | 0.2951 | 0.296 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0603 | 0.997 | 0.997 |
Echinococcus granulosus | phosphatidylinositol 3 kinase regulatory subunit | 0.0354 | 0.2951 | 0.2951 |
Leishmania major | protein kinase, putative | 0.025 | 0 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase ABL1 | 0.0603 | 0.997 | 0.997 |
Echinococcus multilocularis | tyrosine protein kinase Blk | 0.0603 | 0.997 | 1 |
Onchocerca volvulus | 0.0603 | 0.997 | 1 | |
Echinococcus granulosus | tyrosine kinase | 0.0603 | 0.997 | 0.997 |
Schistosoma mansoni | tensin | 0.0354 | 0.2951 | 0.296 |
Echinococcus granulosus | guanine nucleotide exchange factor VAV2 | 0.0354 | 0.2951 | 0.2951 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0603 | 0.997 | 0.997 |
Echinococcus multilocularis | tyrosine protein kinase Abl | 0.0603 | 0.997 | 1 |
Echinococcus granulosus | SH2 domain containing adapter protein F | 0.0354 | 0.2951 | 0.2951 |
Brugia malayi | SRC-1 | 0.0603 | 0.997 | 1 |
Schistosoma mansoni | SH2A | 0.0354 | 0.2951 | 0.296 |
Echinococcus multilocularis | signal transduction protein lnk realted | 0.0354 | 0.2951 | 0.296 |
Schistosoma mansoni | GTPase activating protein | 0.0354 | 0.2951 | 0.296 |
Echinococcus granulosus | SH2 motif | 0.0354 | 0.2951 | 0.2951 |
Echinococcus granulosus | N chimaerin | 0.0354 | 0.2951 | 0.2951 |
Echinococcus multilocularis | tensin | 0.0354 | 0.2951 | 0.296 |
Schistosoma mansoni | protein tyrosine phosphatase n11 (shp2) | 0.0354 | 0.2951 | 0.296 |
Echinococcus granulosus | tyrosine protein kinase Fps85D | 0.0603 | 0.997 | 0.997 |
Echinococcus multilocularis | tyrosine protein kinase shark | 0.0603 | 0.997 | 1 |
Echinococcus granulosus | signal transduction protein lnk realted | 0.0354 | 0.2951 | 0.2951 |
Trypanosoma cruzi | STE/STE11 serine/threonine-protein kinase, putative | 0.025 | 0 | 0.5 |
Echinococcus granulosus | tyrosine kinase | 0.0603 | 0.997 | 0.997 |
Schistosoma mansoni | tyrosine kinase | 0.0603 | 0.997 | 1 |
Echinococcus granulosus | suppressor of cytokine signaling 6 | 0.0354 | 0.2951 | 0.2951 |
Echinococcus multilocularis | phosphatidylinositol 3 kinase regulatory subunit | 0.0354 | 0.2951 | 0.296 |
Echinococcus multilocularis | tyrosine protein kinase Fps85D | 0.0603 | 0.997 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0603 | 0.997 | 1 |
Echinococcus granulosus | tyrosine kinase|tyrosine protein kinase Fyn | 0.0603 | 0.997 | 0.997 |
Schistosoma mansoni | tyrosine kinase | 0.0603 | 0.997 | 1 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0603 | 0.997 | 0.997 |
Schistosoma mansoni | chimerin-related rho-gtpase-activating protein | 0.0354 | 0.2951 | 0.296 |
Schistosoma mansoni | tensin | 0.0354 | 0.2951 | 0.296 |
Echinococcus multilocularis | tensin | 0.0354 | 0.2951 | 0.296 |
Echinococcus multilocularis | suppressor of cytokine signaling 7 | 0.0354 | 0.2951 | 0.296 |
Echinococcus multilocularis | SH2 domain containing adapter protein F | 0.0354 | 0.2951 | 0.296 |
Schistosoma mansoni | vav2 | 0.0354 | 0.2951 | 0.296 |
Schistosoma mansoni | signal transduction protein lnk-related | 0.0354 | 0.2951 | 0.296 |
Trypanosoma brucei | protein kinase, putative | 0.025 | 0 | 0.5 |
Schistosoma mansoni | tensin-related | 0.0354 | 0.2951 | 0.296 |
Brugia malayi | SH2 domain containing protein | 0.0603 | 0.997 | 1 |
Echinococcus granulosus | c src tyrosine kinase | 0.0603 | 0.997 | 0.997 |
Onchocerca volvulus | 0.0603 | 0.997 | 1 | |
Echinococcus multilocularis | tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase | 0.0603 | 0.997 | 1 |
Schistosoma mansoni | shc transforming protein | 0.0354 | 0.2951 | 0.296 |
Loa Loa (eye worm) | hypothetical protein | 0.0603 | 0.997 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0603 | 0.997 | 1 |
Echinococcus multilocularis | 0.0354 | 0.2951 | 0.296 | |
Brugia malayi | protein-tyrosine kinase | 0.0603 | 0.997 | 1 |
Loa Loa (eye worm) | TK/ABL protein kinase | 0.0603 | 0.997 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Fgr | 0.0603 | 0.997 | 1 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0603 | 0.997 | 1 |
Echinococcus multilocularis | SH2 domain containing protein 7 | 0.0354 | 0.2951 | 0.296 |
Echinococcus granulosus | 3'partial|tyrosine protein kinase Fgr | 0.0603 | 0.997 | 0.997 |
Echinococcus multilocularis | tyrosine kinase | 0.0603 | 0.997 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0354 | 0.2951 | 0.296 |
Echinococcus granulosus | hypothetical protein | 0.0354 | 0.2951 | 0.2951 |
Echinococcus granulosus | tyrosine protein kinase Srms | 0.0603 | 0.997 | 0.997 |
Echinococcus granulosus | tyrosine protein kinase shark | 0.0603 | 0.997 | 0.997 |
Echinococcus granulosus | tensin | 0.0354 | 0.2951 | 0.2951 |
Echinococcus multilocularis | tyrosine protein kinase Srms | 0.0603 | 0.997 | 1 |
Toxoplasma gondii | calcium dependent protein kinase CDPK8 | 0.025 | 0 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0603 | 0.997 | 1 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0603 | 0.997 | 1 |
Brugia malayi | Tyrosine-protein kinase abl-1 | 0.0603 | 0.997 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0603 | 0.997 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0603 | 0.997 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0603 | 0.997 | 1 |
Echinococcus multilocularis | growth factor receptor bound protein 2 | 0.0354 | 0.2951 | 0.296 |
Loa Loa (eye worm) | TK protein kinase | 0.0603 | 0.997 | 1 |
Onchocerca volvulus | 0.0603 | 0.997 | 1 | |
Onchocerca volvulus | 0.0603 | 0.997 | 1 | |
Schistosoma mansoni | tensin | 0.0354 | 0.2951 | 0.296 |
Echinococcus multilocularis | suppressor of cytokine signaling 7 | 0.0354 | 0.2951 | 0.296 |
Echinococcus multilocularis | tyrosine protein kinase lyn tyrosine protein kinase blk | 0.0603 | 0.997 | 1 |
Echinococcus multilocularis | proto oncogene tyrosine protein kinase LCK | 0.0603 | 0.997 | 1 |
Echinococcus multilocularis | SH2 motif | 0.0354 | 0.2951 | 0.296 |
Onchocerca volvulus | 0.0603 | 0.997 | 1 | |
Echinococcus multilocularis | SHC transforming protein 3 | 0.0354 | 0.2951 | 0.296 |
Schistosoma mansoni | tyrosine kinase | 0.0603 | 0.997 | 1 |
Plasmodium falciparum | protein kinase, putative | 0.025 | 0 | 0.5 |
Echinococcus multilocularis | c src tyrosine kinase | 0.0603 | 0.997 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Src42A | 0.0603 | 0.997 | 1 |
Echinococcus granulosus | tyrosine protein kinase Src64B | 0.0603 | 0.997 | 0.997 |
Echinococcus granulosus | proto oncogene tyrosine protein kinase LCK | 0.0603 | 0.997 | 0.997 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0603 | 0.997 | 1 |
Schistosoma mansoni | nck2/grb4 | 0.0354 | 0.2951 | 0.296 |
Echinococcus granulosus | tyrosine protein kinase Src42A | 0.0354 | 0.2951 | 0.2951 |
Echinococcus granulosus | NCK adaptor protein | 0.0354 | 0.2951 | 0.2951 |
Echinococcus multilocularis | SH2 motif | 0.0354 | 0.2951 | 0.296 |
Echinococcus multilocularis | tyrosine protein kinase Btk29A | 0.0603 | 0.997 | 1 |
Schistosoma mansoni | suppressor of cytokine signaling | 0.0354 | 0.2951 | 0.296 |
Echinococcus granulosus | tyrosine protein kinase Src42A | 0.0603 | 0.997 | 0.997 |
Trypanosoma brucei | STE/STE11 serine/threonine-protein kinase, putative | 0.025 | 0 | 0.5 |
Brugia malayi | Protein kinase domain containing protein | 0.0603 | 0.997 | 1 |
Schistosoma mansoni | chimerin-related rho-gtpase-activating protein | 0.0354 | 0.2951 | 0.296 |
Entamoeba histolytica | SH2-protein kinase domain containing protein | 0.0355 | 0.2981 | 0.299 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0603 | 0.997 | 1 |
Echinococcus multilocularis | N chimaerin | 0.0354 | 0.2951 | 0.296 |
Echinococcus multilocularis | guanine nucleotide exchange factor VAV2 | 0.0354 | 0.2951 | 0.296 |
Echinococcus granulosus | tyrosine protein kinase Btk29A | 0.0603 | 0.997 | 0.997 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0603 | 0.997 | 1 |
Echinococcus granulosus | growth factor receptor bound protein 2 | 0.0354 | 0.2951 | 0.2951 |
Echinococcus granulosus | SH2 motif | 0.0354 | 0.2951 | 0.2951 |
Echinococcus granulosus | tensin C1 domain containing phosphatase | 0.0354 | 0.2951 | 0.2951 |
Schistosoma mansoni | growth factor receptor-bound protein | 0.0354 | 0.2951 | 0.296 |
Brugia malayi | SH2 domain containing protein | 0.0603 | 0.997 | 1 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0603 | 0.997 | 1 |
Schistosoma mansoni | tensin-related | 0.0354 | 0.2951 | 0.296 |
Echinococcus multilocularis | tyrosine protein phosphatase non receptor type | 0.0354 | 0.2951 | 0.296 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0603 | 0.997 | 1 |
Echinococcus granulosus | tyrosine protein phosphatase non receptor type | 0.0354 | 0.2951 | 0.2951 |
Entamoeba histolytica | SH2-protein kinase domain containing protein | 0.0603 | 0.997 | 1 |
Schistosoma mansoni | proto-oncogene tyrosine-protein kinase src | 0.0603 | 0.997 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -5.393 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the K-562 Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.255 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.151 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.118 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.107 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.085 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.083 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.066 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.968 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.905 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.789 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.789 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.