Detailed information for compound 1606344

Basic information

Technical information
  • TDR Targets ID: 1606344
  • Name: 2-[(2E)-2-[(E)-(4-diethylaminophenyl)methylid enehydrazinylidene]-4-oxo-3-prop-2-enyl-1,3-t hiazolidin-5-yl]acetic acid
  • MW: 388.484 | Formula: C19H24N4O3S
  • H donors: 1 H acceptors: 3 LogP: 3.2 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCN(c1ccc(cc1)/C=N/N=C\1/SC(C(=O)N1CC=C)CC(=O)O)CC
  • InChi: 1S/C19H24N4O3S/c1-4-11-23-18(26)16(12-17(24)25)27-19(23)21-20-13-14-7-9-15(10-8-14)22(5-2)6-3/h4,7-10,13,16H,1,5-6,11-12H2,2-3H3,(H,24,25)/b20-13+,21-19+
  • InChiKey: VMLINIPTNIGPLU-BSSBVLFISA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[(2E)-3-allyl-2-[(E)-(4-diethylaminophenyl)methylenehydrazono]-4-oxo-thiazolidin-5-yl]acetic acid
  • 2-[(2E)-3-allyl-2-[(E)-(4-diethylaminophenyl)methylenehydrazono]-4-oxo-5-thiazolidinyl]acetic acid
  • 2-[(2E)-3-allyl-2-[(E)-(4-diethylaminobenzylidene)hydrazono]-4-keto-thiazolidin-5-yl]acetic acid
  • 2-[(2E)-2-[(E)-(4-diethylaminophenyl)methylidenehydrazinylidene]-4-oxo-3-prop-2-enyl-1,3-thiazolidin-5-yl]ethanoic acid
  • ST044607

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens GNAS complex locus Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis fat cadherin tumor suppressor 0.0148 0.1547 0.1547
Plasmodium vivax SET domain protein, putative 0.0035 0.0282 0.8836
Schistosoma mansoni ankyrin 23/unc44 0.0016 0.0078 0.0078
Loa Loa (eye worm) hypothetical protein 0.0035 0.0282 0.0276
Onchocerca volvulus 0.0148 0.1547 0.1515
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0035 0.0282 0.0282
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0282 0.0282
Chlamydia trachomatis pyruvate kinase 0.0038 0.0319 0.5
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0705 1
Echinococcus multilocularis cathepsin L cysteine protease 0.0019 0.0108 0.0108
Onchocerca volvulus 0.0269 0.2909 0.2882
Brugia malayi notch-like transmembrane receptor 0.0148 0.1547 0.1542
Trypanosoma brucei cytochrome P450, putative 0.0018 0.0096 0.1308
Loa Loa (eye worm) hypothetical protein 0.0148 0.1547 0.1541
Loa Loa (eye worm) hypothetical protein 0.0148 0.1547 0.1541
Loa Loa (eye worm) hypothetical protein 0.0148 0.1547 0.1541
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0705 1
Echinococcus granulosus cathepsin l cysteine peptidase 0.0019 0.0108 0.0108
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.0022 0.0022
Schistosoma mansoni hypothetical protein 0.0148 0.1547 0.1547
Loa Loa (eye worm) hypothetical protein 0.0038 0.0319 0.0312
Schistosoma mansoni notch 0.0148 0.1548 0.1548
Echinococcus multilocularis fibropellin Ia 0.0148 0.1547 0.1547
Loa Loa (eye worm) hypothetical protein 0.0148 0.1547 0.1541
Brugia malayi Animal haem peroxidase family protein 0.0903 1 1
Trypanosoma cruzi cysteine peptidase, putative 0.0019 0.0108 0.1472
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0108 0.0355
Onchocerca volvulus 0.0903 1 1
Schistosoma mansoni notch 0.0148 0.1547 0.1547
Schistosoma mansoni notch 0.0148 0.1547 0.1547
Echinococcus multilocularis dnaJ subfamily B 0.0464 0.5083 0.5083
Echinococcus granulosus notch 0.0148 0.1547 0.1547
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0066 0.0634 0.8997
Brugia malayi Cadherin domain containing protein 0.0148 0.1547 0.1542
Onchocerca volvulus Peroxidase homolog 0.0903 1 1
Brugia malayi Cathepsin L-like precursor 0.0019 0.0108 0.0103
Echinococcus multilocularis neurogenic locus notch protein 4 0.0148 0.1547 0.1547
Onchocerca volvulus Cathepsin F homolog 0.0019 0.0108 0.007
Onchocerca volvulus Chorion peroxidase homolog 0.0903 1 1
Giardia lamblia Pyruvate kinase 0.0038 0.0319 0.1436
Trypanosoma cruzi cruzipain precursor, putative 0.0072 0.0705 1
Loa Loa (eye worm) pyruvate kinase 0.0038 0.0319 0.0312
Brugia malayi CXXC zinc finger family protein 0.0033 0.026 0.0255
Loa Loa (eye worm) hypothetical protein 0.0903 1 1
Echinococcus granulosus slit 2 protein 0.0148 0.1547 0.1547
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0705 1
Echinococcus granulosus pyruvate kinase 0.0038 0.0319 0.0319
Leishmania major cathepsin L-like protease 0.0019 0.0108 0.0189
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0705 1
Echinococcus granulosus delta-like protein 1 0.0148 0.1547 0.1547
Schistosoma mansoni hypothetical protein 0.0192 0.2045 0.2045
Brugia malayi Cytochrome P450 family protein 0.0018 0.0096 0.0092
Echinococcus granulosus nuclear factor of activated T cells 5 0.0084 0.0829 0.0829
Onchocerca volvulus 0.0019 0.0108 0.007
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0016 0.0078 0.0071
Echinococcus granulosus protein jagged 1 0.0148 0.1547 0.1547
Brugia malayi EGF-like domain containing protein 0.0148 0.1547 0.1542
Brugia malayi Animal haem peroxidase family protein 0.0903 1 1
Leishmania major cathepsin L-like protease 0.0072 0.0705 1
Brugia malayi Animal haem peroxidase family protein 0.0903 1 1
Mycobacterium ulcerans pyruvate kinase 0.0038 0.0319 1
Brugia malayi Cathepsin L-like precursor 0.0019 0.0108 0.0103
Schistosoma mansoni cell polarity protein 0.0148 0.1547 0.1547
Onchocerca volvulus 0.0903 1 1
Brugia malayi Muscle positioning protein 4 0.0148 0.1547 0.1542
Loa Loa (eye worm) hypothetical protein 0.0148 0.1547 0.1541
Brugia malayi EGF-like domain containing protein 0.0148 0.1547 0.1542
Echinococcus multilocularis neurogenic locus protein delta 0.0148 0.1547 0.1547
Echinococcus granulosus dnaJ subfamily B 0.0464 0.5083 0.5083
Echinococcus multilocularis geminin 0.0192 0.2045 0.2045
Onchocerca volvulus Cathepsin L homolog 0.0019 0.0108 0.007
Loa Loa (eye worm) hypothetical protein 0.0016 0.0078 0.0071
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0019 0.0108 0.0108
Echinococcus multilocularis pyruvate kinase 0.0019 0.0113 0.0113
Plasmodium vivax pyruvate kinase 2, putative 0.0019 0.0113 0.3435
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0108 0.0355
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0013 0.0038 0.0113
Brugia malayi EGF-like domain containing protein 0.0148 0.1547 0.1542
Echinococcus granulosus pyruvate kinase 0.0038 0.0319 0.0319
Schistosoma mansoni cathepsin F (C01 family) 0.0019 0.0108 0.0108
Schistosoma mansoni pyruvate kinase 0.0038 0.0319 0.0319
Onchocerca volvulus 0.0148 0.1547 0.1515
Brugia malayi Peroxidasin 0.0903 1 1
Loa Loa (eye worm) hypothetical protein 0.0148 0.1547 0.1541
Brugia malayi EGF-like domain containing protein 0.0148 0.1547 0.1542
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0513 0.0507
Echinococcus multilocularis neurogenic locus notch protein 0.0148 0.1547 0.1547
Loa Loa (eye worm) hypothetical protein 0.0148 0.1547 0.1541
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0016 0.0078 0.0078
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0019 0.0108 0.3282
Schistosoma mansoni notch 0.0148 0.1547 0.1547
Schistosoma mansoni hypothetical protein 0.0148 0.1547 0.1547
Echinococcus granulosus netrin receptor unc 5 0.0016 0.0078 0.0078
Brugia malayi Calcium binding EGF domain containing protein 0.0148 0.1547 0.1542
Brugia malayi Blistered cuticle protein 3 0.0903 1 1
Loa Loa (eye worm) animal heme peroxidase 0.0903 1 1
Toxoplasma gondii pyruvate kinase PyKII 0.0019 0.0113 0.0033
Schistosoma mansoni hypothetical protein 0.0016 0.0078 0.0078
Echinococcus multilocularis neurogenic locus notch protein 0.0148 0.1547 0.1547
Schistosoma mansoni peroxidasin 0.0903 1 1
Plasmodium falciparum pyruvate kinase 0.0038 0.0319 1
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0903 1 1
Echinococcus multilocularis pyruvate kinase 0.0038 0.0319 0.0319
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0035 0.0282 0.0282
Mycobacterium leprae Probable pyruvate kinase PykA 0.0038 0.0319 0.5
Echinococcus granulosus cathepsin L cysteine protease 0.001 0.0005 0.0005
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0084 0.0829 0.0829
Loa Loa (eye worm) hypothetical protein 0.0148 0.1547 0.1541
Brugia malayi Calcium binding EGF domain containing protein 0.0148 0.1547 0.1542
Echinococcus multilocularis cpg binding protein 0.0034 0.0281 0.0281
Echinococcus granulosus histone lysine methyltransferase setb 0.0035 0.0282 0.0282
Leishmania major pyruvate kinase 0.0038 0.0319 0.3653
Schistosoma mansoni septate junction protein 0.0148 0.1547 0.1547
Loa Loa (eye worm) animal heme peroxidase 0.0903 1 1
Echinococcus multilocularis pyruvate kinase 0.0019 0.0113 0.0113
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0513 0.0513
Loa Loa (eye worm) hypothetical protein 0.0013 0.0038 0.0031
Brugia malayi Animal haem peroxidase family protein 0.0903 1 1
Onchocerca volvulus Slit protein homolog 0.0148 0.1547 0.1515
Loa Loa (eye worm) hypothetical protein 0.0148 0.1547 0.1541
Brugia malayi Cathepsin L-like precursor 0.0013 0.0038 0.0033
Loa Loa (eye worm) hypothetical protein 0.0148 0.1547 0.1541
Loa Loa (eye worm) notch protein 0.0148 0.1547 0.1541
Brugia malayi Cytochrome P450 family protein 0.0018 0.0096 0.0092
Loa Loa (eye worm) pyruvate kinase-PB 0.0026 0.0191 0.0184
Schistosoma mansoni slit 0.0148 0.1547 0.1547
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0705 1
Echinococcus granulosus pyruvate kinase 0.0019 0.0113 0.0113
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0108 0.0355
Leishmania major cathepsin L-like protease 0.0072 0.0705 1
Echinococcus granulosus neural cadherin 0.0148 0.1547 0.1547
Trichomonas vaginalis pyruvate kinase, putative 0.0038 0.0319 0.1081
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0038 0.0319 0.5
Brugia malayi Protein kinase domain containing protein 0.0016 0.0078 0.0073
Loa Loa (eye worm) hypothetical protein 0.0903 1 1
Echinococcus granulosus peroxidasin 0.0903 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0108 0.0355
Brugia malayi Pyruvate kinase, alpha/beta domain containing protein 0.0011 0.0024 0.0019
Loa Loa (eye worm) fibroinase 0.0019 0.0108 0.0101
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0282 0.0282
Brugia malayi Pre-SET motif family protein 0.0035 0.0282 0.0277
Loa Loa (eye worm) pyruvate kinase 0.0038 0.0319 0.0312
Brugia malayi EGF-like domain containing protein 0.0148 0.1547 0.1542
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0705 1
Loa Loa (eye worm) hypothetical protein 0.0148 0.1547 0.1541
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0237 0.2543 0.2538
Leishmania major cathepsin L-like protease 0.0019 0.0108 0.0189
Trypanosoma cruzi cytochrome P450, putative 0.0018 0.0096 0.1308
Schistosoma mansoni cpg binding protein 0.0033 0.026 0.026
Trypanosoma cruzi cytochrome P450, putative 0.0018 0.0096 0.1308
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0108 0.0355
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0033 0.026 0.026
Echinococcus multilocularis protein jagged 2 0.0148 0.1547 0.1547
Loa Loa (eye worm) hypothetical protein 0.0148 0.1547 0.1541
Trypanosoma cruzi major cysteine proteinase, putative 0.0057 0.0531 0.7525
Toxoplasma gondii pyruvate kinase PyK1 0.0038 0.0319 0.1464
Loa Loa (eye worm) hypothetical protein 0.0903 1 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0513 0.0513
Onchocerca volvulus Pyruvate kinase homolog 0.0038 0.0319 0.0282
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0019 0.0108 0.0355
Echinococcus multilocularis pyruvate kinase 0.0019 0.0113 0.0113
Onchocerca volvulus Neurogenic locus notch protein homolog 0.0148 0.1547 0.1515
Loa Loa (eye worm) hypothetical protein 0.0903 1 1
Trypanosoma cruzi cysteine peptidase, putative 0.0072 0.0705 1
Entamoeba histolytica cysteine proteinase, putative 0.0019 0.0108 0.5546
Brugia malayi Immunoglobulin I-set domain containing protein 0.0016 0.0078 0.0073
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0108 0.0355
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0705 1
Echinococcus multilocularis cathepsin L cysteine protease 0.0019 0.0108 0.0108
Loa Loa (eye worm) pyruvate kinase 0.0038 0.0319 0.0312
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0705 1
Echinococcus granulosus death domain containing protein 0.0016 0.0078 0.0078
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0108 0.0355
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0108 0.0355
Echinococcus granulosus pyruvate kinase 0.0019 0.0113 0.0113
Echinococcus multilocularis cysteine protease 0.0019 0.0108 0.0108
Brugia malayi EGF-like domain containing protein 0.0148 0.1547 0.1542
Trypanosoma cruzi pyruvate kinase 2, putative 0.0038 0.0319 0.4483
Brugia malayi Death domain containing protein 0.0016 0.0078 0.0073
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0108 0.0355
Onchocerca volvulus 0.0019 0.0108 0.007
Loa Loa (eye worm) hypothetical protein 0.0903 1 1
Leishmania major pyruvate kinase 0.0038 0.0319 0.3653
Loa Loa (eye worm) hypothetical protein 0.0903 1 1
Brugia malayi Cathepsin L-like precursor 0.0019 0.0108 0.0103
Brugia malayi Delta serrate ligand family protein 0.0148 0.1547 0.1542
Onchocerca volvulus 0.0148 0.1547 0.1515
Schistosoma mansoni notch 0.0148 0.1547 0.1547
Onchocerca volvulus 0.0019 0.0108 0.007
Trichomonas vaginalis set domain proteins, putative 0.0269 0.2908 1
Brugia malayi Animal haem peroxidase family protein 0.0903 1 1
Onchocerca volvulus Dual oxidase homolog 0.0903 1 1
Echinococcus multilocularis cysteine protease 0.0019 0.0108 0.0108
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.001 0.0005 0.0005
Loa Loa (eye worm) CYP4Cod1 0.0018 0.0096 0.009
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0513 0.0509
Echinococcus multilocularis notch 0.0148 0.1547 0.1547
Loa Loa (eye worm) hypothetical protein 0.0013 0.0038 0.0031
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0513 0.0513
Schistosoma mansoni laminin gamma-3 chain 0.0148 0.1547 0.1547
Onchocerca volvulus 0.0019 0.0108 0.007
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0108 0.0355
Brugia malayi Cathepsin L-like precursor 0.0019 0.0108 0.0103
Entamoeba histolytica pyruvate kinase, putative 0.0026 0.0191 1
Echinococcus granulosus neurogenic locus notch protein 4 0.0148 0.1547 0.1547
Loa Loa (eye worm) hypothetical protein 0.0148 0.1547 0.1541
Echinococcus multilocularis neurogenic locus protein delta 0.0148 0.1547 0.1547
Loa Loa (eye worm) animal heme peroxidase 0.0903 1 1
Echinococcus granulosus cathepsin L cysteine proteinase 0.0019 0.0108 0.0108
Onchocerca volvulus Peroxidasin homolog 0.0903 1 1
Schistosoma mansoni pyruvate kinase 0.0019 0.0113 0.0113
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0282 0.0282
Echinococcus granulosus protein jagged 1 0.0148 0.1547 0.1547
Onchocerca volvulus Peroxidasin homolog 0.0903 1 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0513 0.0513
Echinococcus granulosus Ankyrin 0.0016 0.0079 0.0079
Loa Loa (eye worm) hypothetical protein 0.0903 1 1
Schistosoma mansoni cathepsin F (C01 family) 0.0019 0.0108 0.0108
Brugia malayi cathepsin L-like precursor 0.0013 0.0038 0.0033
Echinococcus granulosus neurogenic locus notch protein 0.0148 0.1547 0.1547
Trichomonas vaginalis pyruvate kinase, putative 0.0038 0.0319 0.1081
Brugia malayi Pyruvate kinase, muscle isozyme 0.0038 0.0319 0.0314
Echinococcus multilocularis cathepsin L 0.001 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0903 1 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0018 0.0096 0.009
Trypanosoma cruzi cysteine peptidase, putative 0.0072 0.0705 1
Echinococcus granulosus protein jagged 2 0.0148 0.1547 0.1547
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0108 0.0355
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.001 0.0005 0.0005
Brugia malayi Pre-SET motif family protein 0.0237 0.2543 0.2539
Onchocerca volvulus 0.0019 0.0108 0.007
Entamoeba histolytica cysteine protease, putative 0.0019 0.0108 0.5546
Echinococcus granulosus neurogenic locus protein delta 0.0148 0.1547 0.1547
Echinococcus granulosus cpg binding protein 0.0034 0.0281 0.0281
Loa Loa (eye worm) Notch2 0.0148 0.1547 0.1541
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0705 1
Brugia malayi Cathepsin L-like precursor 0.0019 0.0108 0.0103
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0513 0.0513
Loa Loa (eye worm) hypothetical protein 0.0148 0.1547 0.1541
Schistosoma mansoni hypothetical protein 0.0148 0.1547 0.1547
Loa Loa (eye worm) hypothetical protein 0.0148 0.1547 0.1541
Echinococcus granulosus pyruvate kinase 0.0019 0.0113 0.0113
Trypanosoma brucei pyruvate kinase 1, putative 0.0038 0.0319 0.4483
Echinococcus granulosus cathepsin l1 0.0019 0.0108 0.0108
Onchocerca volvulus 0.0148 0.1547 0.1515
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0019 0.0108 0.0355
Loa Loa (eye worm) blistered cuticle protein 3 0.0903 1 1
Echinococcus multilocularis protein jagged 1 0.0148 0.1547 0.1547
Leishmania major cysteine peptidase A (CPA) 0.0019 0.0108 0.0189
Echinococcus granulosus fibropellin Ia 0.0148 0.1547 0.1547
Leishmania major cathepsin L-like protease 0.0072 0.0705 1
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0035 0.0282 0.1211
Brugia malayi Cathepsin L-like precursor 0.0013 0.0038 0.0033
Brugia malayi F/Y-rich N-terminus family protein 0.0011 0.0021 0.0016
Schistosoma mansoni notch 0.0148 0.1547 0.1547
Loa Loa (eye worm) hypothetical protein 0.0013 0.0038 0.0031
Loa Loa (eye worm) hypothetical protein 0.0903 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0108 0.0355
Onchocerca volvulus 0.0035 0.0282 0.0245
Plasmodium vivax vivapain-2 0.0019 0.0108 0.3282
Onchocerca volvulus Putative cubilin 0.0148 0.1547 0.1515
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0019 0.0108 0.0108
Schistosoma mansoni hypothetical protein 0.0192 0.2045 0.2045
Brugia malayi Cadherin domain containing protein 0.0148 0.1547 0.1542
Loa Loa (eye worm) cysteine protease 0.0019 0.0108 0.0101
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0016 0.0078 0.0078
Loa Loa (eye worm) hypothetical protein 0.0148 0.1547 0.1541
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0016 0.0079 0.0079
Brugia malayi EGF-like domain containing protein 0.0148 0.1547 0.1542
Onchocerca volvulus 0.0019 0.0108 0.007
Loa Loa (eye worm) CXXC zinc finger family protein 0.0033 0.026 0.0253
Plasmodium falciparum pyruvate kinase 2 0.0019 0.0113 0.3435
Loa Loa (eye worm) hypothetical protein 0.0903 1 1
Loa Loa (eye worm) hypothetical protein 0.0148 0.1547 0.1541
Loa Loa (eye worm) cytochrome P450 family protein 0.003 0.0227 0.0221
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0108 0.0355
Loa Loa (eye worm) ctsf protein 0.0019 0.0108 0.0101
Loa Loa (eye worm) animal heme peroxidase 0.0903 1 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0018 0.0096 0.009
Loa Loa (eye worm) hypothetical protein 0.0016 0.0079 0.0073
Entamoeba histolytica cysteine proteinase, putative 0.0019 0.0108 0.5546
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0108 0.0355
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.0148 0.1547 0.1547
Brugia malayi GCC2 and GCC3 family protein 0.0148 0.1547 0.1542
Onchocerca volvulus Pyruvate kinase homolog 0.0038 0.0319 0.0282
Brugia malayi Papain family cysteine protease containing protein 0.0019 0.0108 0.0103
Echinococcus multilocularis pyruvate kinase 0.0038 0.0319 0.0319
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0705 1
Echinococcus multilocularis slit 2 protein 0.0148 0.1547 0.1547
Loa Loa (eye worm) histone methyltransferase 0.0011 0.0022 0.0016
Schistosoma mansoni cpg binding protein 0.0034 0.0281 0.0281
Trypanosoma brucei pyruvate kinase 1 0.0038 0.0319 0.4483
Leishmania major cathepsin L-like protease 0.0019 0.0108 0.0189
Brugia malayi Cathepsin L-like precursor 0.0019 0.0108 0.0103
Onchocerca volvulus Peroxidase homolog 0.0903 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0108 0.0355
Schistosoma mansoni netrin receptor unc5 0.0016 0.0078 0.0078
Loa Loa (eye worm) hypothetical protein 0.0903 1 1
Schistosoma mansoni pyruvate kinase 0.0038 0.0319 0.0319
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0108 0.0355
Loa Loa (eye worm) hypothetical protein 0.0148 0.1547 0.1541
Trypanosoma cruzi cysteine peptidase, putative 0.0072 0.0705 1
Schistosoma mansoni hypothetical protein 0.0464 0.5083 0.5083
Trypanosoma cruzi pyruvate kinase 2, putative 0.0038 0.0319 0.4483
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0108 0.0355
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0035 0.0282 0.0282
Toxoplasma gondii histone lysine methyltransferase SET1 0.0063 0.06 0.3417
Schistosoma mansoni hypothetical protein 0.0148 0.1547 0.1547
Onchocerca volvulus 0.0033 0.026 0.0223
Echinococcus multilocularis Ankyrin 0.0016 0.0079 0.0079
Loa Loa (eye worm) hypothetical protein 0.0026 0.0191 0.0184
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0705 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0513 0.0513
Loa Loa (eye worm) hypothetical protein 0.0019 0.0108 0.0101
Loa Loa (eye worm) hypothetical protein 0.0148 0.1547 0.1541
Echinococcus multilocularis peroxidasin 0.0903 1 1
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0148 0.1547 0.1542
Echinococcus multilocularis protein jagged 1 0.0148 0.1547 0.1547
Leishmania major cathepsin L-like protease 0.0019 0.0108 0.0189
Onchocerca volvulus 0.0019 0.0108 0.007
Schistosoma mansoni hypothetical protein 0.0148 0.1547 0.1547
Plasmodium vivax pyruvate kinase, putative 0.0038 0.0319 1
Echinococcus multilocularis neural cadherin 0.0148 0.1547 0.1547
Loa Loa (eye worm) hypothetical protein 0.0148 0.1547 0.1541
Plasmodium vivax vivapain-2 0.0019 0.0108 0.3282
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0013 0.0038 0.0113
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0019 0.0108 0.0101
Onchocerca volvulus Pyruvate kinase homolog 0.0038 0.0319 0.0282
Giardia lamblia High cysteine protein 0.0148 0.1547 1
Brugia malayi Pyruvate kinase, M2 isozyme 0.0038 0.0319 0.0314
Schistosoma mansoni peroxidasin 0.0903 1 1
Onchocerca volvulus Netrin receptor homolog 0.0016 0.0078 0.004
Toxoplasma gondii EGF family domain-containing protein 0.0148 0.1547 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0108 0.0355
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0019 0.0108 0.0101
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0108 0.0355
Leishmania major cathepsin L-like protease 0.0019 0.0108 0.0189
Echinococcus granulosus protein jagged 2 0.0148 0.1547 0.1547
Echinococcus granulosus geminin 0.0192 0.2045 0.2045
Loa Loa (eye worm) hypothetical protein 0.0903 1 1
Echinococcus granulosus cathepsin l1 0.0013 0.0038 0.0038
Schistosoma mansoni cathepsin F (C01 family) 0.0013 0.0038 0.0038
Onchocerca volvulus Neurogenic locus notch homolog 0.0148 0.1548 0.1516
Echinococcus granulosus neurogenic locus notch protein 0.0148 0.1547 0.1547
Schistosoma mansoni hypothetical protein 0.0148 0.1547 0.1547
Schistosoma mansoni cpg binding protein 0.0034 0.0281 0.0281
Loa Loa (eye worm) hypothetical protein 0.0148 0.1547 0.1541
Echinococcus granulosus cysteine protease 0.001 0.0005 0.0005
Brugia malayi Cathepsin L-like cysteine proteinase 0.0013 0.0038 0.0033
Brugia malayi Uncoordinated protein 44 0.0016 0.0078 0.0073
Loa Loa (eye worm) hypothetical protein 0.0903 1 1
Schistosoma mansoni hypothetical protein 0.0148 0.1547 0.1547
Brugia malayi Cytochrome P450 family protein 0.003 0.0227 0.0222
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.001 0.0005 0.0005
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0108 0.0355
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0108 0.0355
Echinococcus multilocularis netrin receptor unc 5 0.0016 0.0078 0.0078
Plasmodium falciparum cysteine proteinase falcipain 3 0.0019 0.0108 0.3282
Onchocerca volvulus Cathepsin L homolog 0.0019 0.0108 0.007
Echinococcus multilocularis pyruvate kinase 0.003 0.023 0.023
Entamoeba histolytica cysteine proteinase, putative 0.0013 0.0038 0.1765
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0513 0.0513
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0108 0.0355
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0108 0.0355
Onchocerca volvulus 0.0903 1 1
Loa Loa (eye worm) hypothetical protein 0.0148 0.1547 0.1541
Echinococcus granulosus cathepsin L 0.001 0.0005 0.0005
Brugia malayi Calcium binding EGF domain containing protein 0.0148 0.1547 0.1542
Schistosoma mansoni mixed-lineage leukemia protein mll 0.007 0.0682 0.0682
Onchocerca volvulus 0.0148 0.1547 0.1515
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0019 0.0108 0.3282

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 21.3313 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) 22.3872 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] ChEMBL. No reference
Potency (functional) 28.1838 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Vif-A3F Interactions: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 2 (EPAC2): primary screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 31.6228 uM PubChem BioAssay. Inhibitors of Secretory Acid Sphingomyelinase (S-ASM): qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 31.6228 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 56.2341 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: qHTS Assay for Substrates of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) 112.2018 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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