Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | poly(ADP-ribose) polymerase, putative | 0.0463 | 0.117 | 1 |
Brugia malayi | Methyltransferase-like protein 4 | 0.0315 | 0.0309 | 0.0306 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.1111 | 0.4934 | 1 |
Mycobacterium ulcerans | multifunctional mycocerosic acid synthase membrane-associated Mas | 0.1111 | 0.4934 | 0.6522 |
Mycobacterium ulcerans | polyketide synthase MbtD | 0.0322 | 0.0347 | 0.0454 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.1046 | 0.4557 | 0.5856 |
Mycobacterium tuberculosis | Polyketide synthase Pks12 | 0.1111 | 0.4934 | 0.6376 |
Mycobacterium leprae | Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas | 0.1111 | 0.4934 | 0.6337 |
Wolbachia endosymbiont of Brugia malayi | 3-oxoacyl-ACP synthase | 0.0262 | 0.0003 | 0.5 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.1046 | 0.4557 | 0.6023 |
Loa Loa (eye worm) | hypothetical protein | 0.1757 | 0.869 | 1 |
Plasmodium falciparum | 3-oxoacyl-acyl-carrier protein synthase I/II | 0.0262 | 0.0003 | 0.5 |
Echinococcus granulosus | poly ADP ribose polymerase 1 | 0.0843 | 0.3379 | 1 |
Trypanosoma cruzi | poly(ADP-ribose) polymerase, putative | 0.0463 | 0.117 | 1 |
Schistosoma mansoni | poly [ADP-ribose] polymerase | 0.0843 | 0.3379 | 1 |
Loa Loa (eye worm) | AMP-binding enzyme family protein | 0.0977 | 0.4157 | 0.4782 |
Echinococcus granulosus | 3 oxoacyl acyl carrier protein synthase | 0.0262 | 0.0003 | 0.001 |
Mycobacterium leprae | Polyketide synthase Pks13 | 0.1563 | 0.7563 | 1 |
Echinococcus granulosus | poly adp ribose polymerase 2 | 0.0463 | 0.117 | 0.3464 |
Mycobacterium ulcerans | polyketide synthase Pks9 | 0.0692 | 0.2498 | 0.3299 |
Entamoeba histolytica | poly(ADP-ribose) polymerase, putative | 0.0843 | 0.3379 | 0.5 |
Mycobacterium tuberculosis | Probable thioesterase TesA | 0.0871 | 0.3543 | 0.4459 |
Loa Loa (eye worm) | hypothetical protein | 0.0642 | 0.2209 | 0.2539 |
Onchocerca volvulus | 0.182 | 0.9058 | 0.9285 | |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE | 0.0692 | 0.2498 | 0.2941 |
Brugia malayi | WGR domain containing protein | 0.0843 | 0.3379 | 0.3377 |
Schistosoma mansoni | poly [ADP-ribose] polymerase | 0.0463 | 0.117 | 0.3457 |
Mycobacterium tuberculosis | Polyketide synthetase MbtD (polyketide synthase) | 0.0322 | 0.0347 | 0.0052 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.0744 | 0.2805 | 0.5682 |
Echinococcus multilocularis | poly (ADP ribose) polymerase 1 | 0.0843 | 0.3379 | 1 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks5 | 0.1014 | 0.437 | 0.5599 |
Mycobacterium leprae | Probable polyketide synthase Pks1 | 0.1111 | 0.4934 | 0.6337 |
Brugia malayi | AMP-binding enzyme family protein | 0.0977 | 0.4157 | 0.4155 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks1 | 0.0751 | 0.2844 | 0.3495 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.1046 | 0.4557 | 0.6023 |
Loa Loa (eye worm) | fatty acid synthase | 0.1032 | 0.4476 | 0.5149 |
Toxoplasma gondii | AMP-binding enzyme domain-containing protein | 0.0529 | 0.155 | 0.3136 |
Toxoplasma gondii | poly(ADP-ribose) polymerase catalytic domain-containing protein | 0.0876 | 0.3571 | 0.7235 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsE | 0.0692 | 0.2498 | 0.3299 |
Giardia lamblia | Methyltransferase like 2 | 0.0315 | 0.0309 | 0.5 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.1046 | 0.4557 | 0.6023 |
Loa Loa (eye worm) | hypothetical protein | 0.0586 | 0.1883 | 0.2164 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.0841 | 0.3369 | 0.4452 |
Loa Loa (eye worm) | poly(ADP-ribose) polymerase | 0.0332 | 0.0409 | 0.0467 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.1046 | 0.4557 | 0.5856 |
Mycobacterium tuberculosis | Polyketide synthetase MbtC (polyketide synthase) | 0.036 | 0.0567 | 0.0356 |
Chlamydia trachomatis | 3-oxoacyl-ACP synthase | 0.0262 | 0.0003 | 0.5 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.1111 | 0.4934 | 0.6522 |
Trypanosoma brucei | poly(adp-ribose) polymerase | 0.0463 | 0.117 | 1 |
Loa Loa (eye worm) | acyl carrier protein | 0.0481 | 0.1273 | 0.1462 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks8 | 0.0855 | 0.3449 | 0.4329 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.1046 | 0.4557 | 0.6023 |
Mycobacterium tuberculosis | Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) | 0.0977 | 0.4157 | 0.5305 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0315 | 0.0309 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0315 | 0.0309 | 1 |
Mycobacterium ulcerans | fatty acid synthase Fas | 0.0328 | 0.0387 | 0.0508 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB | 0.0841 | 0.3369 | 0.4155 |
Mycobacterium tuberculosis | Probable multifunctional mycocerosic acid synthase membrane-associated Mas | 0.1111 | 0.4934 | 0.6376 |
Brugia malayi | WGR domain containing protein | 0.0463 | 0.117 | 0.1167 |
Toxoplasma gondii | beta-ketoacyl synthase, N-terminal domain-containing protein | 0.0678 | 0.2421 | 0.4903 |
Mycobacterium tuberculosis | Probable fatty acid synthase Fas (fatty acid synthetase) | 0.0328 | 0.0387 | 0.0108 |
Mycobacterium ulcerans | polyketide synthase | 0.1046 | 0.4557 | 0.6023 |
Mycobacterium ulcerans | thioesterase | 0.0871 | 0.3543 | 0.4682 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks7 | 0.1111 | 0.4934 | 0.6376 |
Mycobacterium tuberculosis | Polyketide synthase Pks13 | 0.1563 | 0.7563 | 1 |
Mycobacterium tuberculosis | Probable membrane bound polyketide synthase Pks6 | 0.1563 | 0.7563 | 1 |
Mycobacterium ulcerans | polyketide synthase Pks13 | 0.1563 | 0.7563 | 1 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC | 0.1111 | 0.4934 | 0.6337 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks9 | 0.0595 | 0.1934 | 0.224 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks15 | 0.0423 | 0.0936 | 0.0864 |
Mycobacterium tuberculosis | Polyketide synthase Pks2 | 0.1014 | 0.437 | 0.5599 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.1046 | 0.4557 | 0.5856 |
Schistosoma mansoni | methyltransferase-related | 0.0315 | 0.0309 | 0.0905 |
Loa Loa (eye worm) | hypothetical protein | 0.0463 | 0.117 | 0.1343 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA | 0.1046 | 0.4557 | 0.581 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD | 0.1046 | 0.4557 | 0.581 |
Schistosoma mansoni | poly [ADP-ribose] polymerase | 0.0401 | 0.0807 | 0.238 |
Mycobacterium ulcerans | polyketide synthase | 0.1111 | 0.4934 | 0.6522 |
Echinococcus multilocularis | poly (adp ribose) polymerase 2 | 0.0463 | 0.117 | 0.3457 |
Brugia malayi | AMP-binding enzyme family protein | 0.0322 | 0.0347 | 0.0343 |
Plasmodium vivax | 3-oxoacyl-[acyl-carrier-protein] synthase i/ii, putative | 0.0262 | 0.0003 | 0.5 |
Onchocerca volvulus | Fatty acid synthase homolog | 0.1885 | 0.9436 | 1 |
Mycobacterium leprae | PROBABLE THIOESTERASE TESA | 0.0871 | 0.3543 | 0.4398 |
Brugia malayi | Beta-ketoacyl synthase, N-terminal domain containing protein | 0.1046 | 0.4557 | 0.4555 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsB | 0.0841 | 0.3369 | 0.4452 |
Mycobacterium ulcerans | thioesterase TesA | 0.0871 | 0.3543 | 0.4682 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the K-562 Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.