Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | AGC/RSK/P70 protein kinase | 0.1293 | 0.9718 | 0.9718 |
Trypanosoma brucei | protein kinase, putative | 0.0046 | 0.0091 | 0.0074 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.0046 | 0.0091 | 0.0074 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0443 | 0.3156 | 0.4745 |
Echinococcus multilocularis | serine threonine protein kinase | 0.0443 | 0.3156 | 0.4731 |
Trichomonas vaginalis | AGC family protein kinase | 0.133 | 1 | 1 |
Entamoeba histolytica | p21-activated kinase | 0.0046 | 0.0091 | 0.0074 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0443 | 0.3156 | 0.4745 |
Brugia malayi | hypothetical protein | 0.0051 | 0.0129 | 0.0112 |
Echinococcus multilocularis | ribosomal protein s6 kinase beta 1 | 0.0443 | 0.3156 | 0.4731 |
Schistosoma mansoni | dynamin | 0.0036 | 0.0017 | 0.0025 |
Echinococcus granulosus | serine/threonine protein kinase | 0.0896 | 0.6653 | 1 |
Schistosoma mansoni | serine/threonine kinase | 0.0443 | 0.3156 | 0.4745 |
Leishmania major | rac serine-threonine kinase, putative,protein kinase, putative | 0.0046 | 0.0091 | 1 |
Trypanosoma cruzi | NIMA-related kinase, putative | 0.0046 | 0.0091 | 0.0111 |
Echinococcus granulosus | twitchin | 0.0074 | 0.0303 | 0.0432 |
Plasmodium vivax | rac-beta serine/threonine protein kinase, putative | 0.0859 | 0.6371 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0046 | 0.0091 | 0.0074 |
Trichomonas vaginalis | AGC family protein kinase | 0.0046 | 0.0091 | 0.0074 |
Echinococcus granulosus | Immunoglobulin | 0.0051 | 0.0129 | 0.0169 |
Schistosoma mansoni | Neurotrimin precursor (hNT) | 0.0051 | 0.0129 | 0.0194 |
Echinococcus multilocularis | roundabout 2 | 0.0081 | 0.0358 | 0.0514 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0829 | 0.6133 | 0.6126 |
Echinococcus granulosus | protein kinase c iota type | 0.0443 | 0.3156 | 0.4731 |
Trypanosoma cruzi | Protein kinase B | 0.0896 | 0.6653 | 1 |
Loa Loa (eye worm) | AGC/RSK/RSK protein kinase | 0.0443 | 0.3156 | 0.3145 |
Trypanosoma cruzi | Serine/threonine-protein kinase NEK21, putative | 0.0046 | 0.0091 | 0.0111 |
Trichomonas vaginalis | AGC family protein kinase | 0.0046 | 0.0091 | 0.0074 |
Echinococcus multilocularis | Ribosomal protein S6 kinase beta 2 | 0.0443 | 0.3156 | 0.4731 |
Echinococcus granulosus | ribosomal protein s6 kinase beta 1 | 0.0443 | 0.3156 | 0.4731 |
Trichomonas vaginalis | AGC family protein kinase | 0.0046 | 0.0091 | 0.0074 |
Loa Loa (eye worm) | AGC/AKT protein kinase | 0.133 | 1 | 1 |
Schistosoma mansoni | serine/threonine-protein kinase | 0.0896 | 0.6653 | 1 |
Echinococcus granulosus | serine threonine protein kinase nrc | 0.0859 | 0.6371 | 0.9576 |
Trichomonas vaginalis | AGC family protein kinase | 0.0046 | 0.0091 | 0.0074 |
Schistosoma mansoni | goodpasture antigen-binding protein | 0.0036 | 0.0017 | 0.0025 |
Trypanosoma cruzi | rac serine-threonine kinase, putative | 0.0896 | 0.6653 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.133 | 1 | 1 |
Echinococcus granulosus | sodium:potassium dependent atpase beta subunit | 0.085 | 0.6297 | 0.9465 |
Trichomonas vaginalis | AGC family protein kinase | 0.0046 | 0.0091 | 0.0074 |
Echinococcus granulosus | Protein kinase C brain isozyme | 0.0443 | 0.3156 | 0.4731 |
Trichomonas vaginalis | AGC family protein kinase | 0.0443 | 0.3156 | 0.3145 |
Echinococcus granulosus | neuroglian | 0.0064 | 0.023 | 0.0321 |
Trypanosoma cruzi | serine/threonine protein kinase, putative | 0.0046 | 0.0091 | 0.0111 |
Schistosoma mansoni | zinc finger protein | 0.0036 | 0.0017 | 0.0025 |
Echinococcus multilocularis | Immunoglobulin | 0.0051 | 0.0129 | 0.0169 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.0017 | 0.0025 |
Entamoeba histolytica | protein kinase, putative | 0.1293 | 0.9718 | 0.9718 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.0017 | 0.0025 |
Trichomonas vaginalis | AGC family protein kinase | 0.0046 | 0.0091 | 0.0074 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0443 | 0.3156 | 0.4745 |
Echinococcus multilocularis | serine:threonine protein kinase 38 | 0.0443 | 0.3156 | 0.4731 |
Leishmania major | protein kinase, putative,serine/threonine protein kinase, putative | 0.0046 | 0.0091 | 1 |
Schistosoma mansoni | phosphoinositol 4-phosphate adaptor protein | 0.0036 | 0.0017 | 0.0025 |
Echinococcus granulosus | protein kinase C gamma type | 0.0443 | 0.3156 | 0.4731 |
Trypanosoma brucei | NEK family Serine/threonine-protein kinase, putative | 0.0046 | 0.0091 | 0.0074 |
Trypanosoma cruzi | Serine/threonine-protein kinase NEK21, putative | 0.0046 | 0.0091 | 0.0111 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.0896 | 0.6653 | 0.6647 |
Echinococcus granulosus | nervana 2 | 0.085 | 0.6297 | 0.9465 |
Entamoeba histolytica | protein kinase, putative | 0.0046 | 0.0091 | 0.0074 |
Echinococcus multilocularis | protein kinase c iota type | 0.0443 | 0.3156 | 0.4731 |
Trichomonas vaginalis | AGC family protein kinase | 0.133 | 1 | 1 |
Schistosoma mansoni | nephrin | 0.0064 | 0.023 | 0.0345 |
Entamoeba histolytica | protein kinase, putative | 0.133 | 1 | 1 |
Schistosoma mansoni | vav2 | 0.0036 | 0.0017 | 0.0025 |
Toxoplasma gondii | protein kinase domain-containing protein | 0.0046 | 0.0091 | 0.0076 |
Schistosoma mansoni | zinc finger protein | 0.0036 | 0.0017 | 0.0025 |
Trichomonas vaginalis | AGC family protein kinase | 0.0046 | 0.0091 | 0.0074 |
Trichomonas vaginalis | AGC family protein kinase | 0.133 | 1 | 1 |
Echinococcus multilocularis | sodium:potassium dependent atpase beta subunit | 0.085 | 0.6297 | 0.9465 |
Loa Loa (eye worm) | CAMK/MLCK protein kinase | 0.0039 | 0.0038 | 0.0021 |
Echinococcus granulosus | calcium:calmodulin dependent protein kinase | 0.0859 | 0.6371 | 0.9576 |
Echinococcus multilocularis | protein kinase c epsilon type | 0.0443 | 0.3156 | 0.4731 |
Trichomonas vaginalis | AGC family protein kinase | 0.0046 | 0.0091 | 0.0074 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.0129 | 0.0112 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.0017 | 0.0025 |
Echinococcus granulosus | protein kinase c epsilon type | 0.0443 | 0.3156 | 0.4731 |
Schistosoma mansoni | serine/threonine-protein kinase | 0.0896 | 0.6653 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.048 | 0.3438 | 0.3427 |
Echinococcus granulosus | NDR protein kinase | 0.0443 | 0.3156 | 0.4731 |
Leishmania major | protein kinase, putative | 0.0046 | 0.0091 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0046 | 0.0091 | 0.0074 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.0129 | 0.0112 |
Echinococcus granulosus | roundabout 2 | 0.0081 | 0.0358 | 0.0514 |
Schistosoma mansoni | rho gtpase activating protein | 0.0036 | 0.0017 | 0.0025 |
Echinococcus multilocularis | Glutaredoxin protein 5 | 0.085 | 0.6297 | 0.9465 |
Loa Loa (eye worm) | AGC/PKN protein kinase | 0.0443 | 0.3156 | 0.3145 |
Trichomonas vaginalis | AGC family protein kinase | 0.133 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0046 | 0.0091 | 0.0074 |
Plasmodium falciparum | calcium-dependent protein kinase 7 | 0.0046 | 0.0091 | 0.0116 |
Trichomonas vaginalis | AGC family protein kinase | 0.0443 | 0.3156 | 0.3145 |
Schistosoma mansoni | cell adhesion molecule | 0.0068 | 0.0257 | 0.0387 |
Echinococcus multilocularis | serine:threonine protein kinase N2 | 0.0443 | 0.3156 | 0.4731 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.0046 | 0.0091 | 0.0074 |
Trypanosoma cruzi | Serine/threonine-protein kinase NEK17, putative | 0.0046 | 0.0091 | 0.0111 |
Schistosoma mansoni | dynamin | 0.0036 | 0.0017 | 0.0025 |
Loa Loa (eye worm) | AGC/DMPK/GEK protein kinase | 0.0443 | 0.3156 | 0.3145 |
Onchocerca volvulus | 0.0756 | 0.5575 | 0.9761 | |
Trichomonas vaginalis | AGC family protein kinase | 0.0046 | 0.0091 | 0.0074 |
Trichomonas vaginalis | AGC family protein kinase | 0.133 | 1 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0443 | 0.3156 | 0.3145 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.0129 | 0.0112 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.0017 | 0.0025 |
Schistosoma mansoni | syntrophin | 0.0036 | 0.0017 | 0.0025 |
Echinococcus multilocularis | rac serine:threonine kinase | 0.0896 | 0.6653 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0046 | 0.0091 | 0.0074 |
Trichomonas vaginalis | AGC family protein kinase | 0.0046 | 0.0091 | 0.0074 |
Plasmodium vivax | calcium-dependent protein kinase 7, putative | 0.0046 | 0.0091 | 0.0116 |
Entamoeba histolytica | protein kinase, putative | 0.0046 | 0.0091 | 0.0074 |
Plasmodium falciparum | RAC-beta serine/threonine protein kinase | 0.0859 | 0.6371 | 1 |
Echinococcus multilocularis | Immunoglobulin | 0.0051 | 0.0129 | 0.0169 |
Brugia malayi | Hr1 repeat family protein | 0.0443 | 0.3156 | 0.3145 |
Loa Loa (eye worm) | AGC/PKC/ETA protein kinase | 0.0443 | 0.3156 | 0.3145 |
Toxoplasma gondii | calcium dependent protein kinase CDPK7 | 0.0046 | 0.0091 | 0.0076 |
Echinococcus granulosus | neurotracting:lsamp:neurotrimin:obcam | 0.0068 | 0.0257 | 0.0362 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.0358 | 0.0342 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.0829 | 0.6133 | 0.6126 |
Echinococcus multilocularis | nervana 2 | 0.085 | 0.6297 | 0.9465 |
Trypanosoma cruzi | NEK family Serine/threonine-protein kinase, putative | 0.0046 | 0.0091 | 0.0111 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0051 | 0.0129 | 0.0112 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.0896 | 0.6653 | 0.6647 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.0129 | 0.0112 |
Trypanosoma cruzi | Serine/threonine-protein kinase NEK17, putative | 0.0046 | 0.0091 | 0.0111 |
Trichomonas vaginalis | 3-phosphoinositide dependent protein kinase-1, putative | 0.0046 | 0.0091 | 0.0074 |
Trichomonas vaginalis | AGC family protein kinase | 0.0443 | 0.3156 | 0.3145 |
Trypanosoma cruzi | NIMA-related kinase, putative | 0.0046 | 0.0091 | 0.0111 |
Schistosoma mansoni | myotubularin-related protein | 0.0036 | 0.0017 | 0.0025 |
Leishmania major | serine/threonine-protein kinase a, putative | 0.0046 | 0.0091 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0046 | 0.0091 | 0.0074 |
Schistosoma mansoni | oxysterol-binding protein 1 | 0.0036 | 0.0017 | 0.0025 |
Entamoeba histolytica | protein kinase, putative | 0.0046 | 0.0091 | 0.0074 |
Echinococcus granulosus | Ribosomal protein S6 kinase beta 2 | 0.0443 | 0.3156 | 0.4731 |
Echinococcus multilocularis | ribosomal protein S6 kinase alpha 3 | 0.0443 | 0.3156 | 0.4731 |
Trypanosoma brucei | rac serine-threonine kinase, putative | 0.133 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0046 | 0.0091 | 0.0074 |
Schistosoma mansoni | defective proboscis extension response (dpr)-related | 0.0051 | 0.0129 | 0.0194 |
Echinococcus multilocularis | nervana 2 | 0.085 | 0.6297 | 0.9465 |
Schistosoma mansoni | oxysterol-binding protein 1 | 0.0036 | 0.0017 | 0.0025 |
Leishmania major | protein kinase, putative | 0.0046 | 0.0091 | 1 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.0046 | 0.0091 | 0.0074 |
Trypanosoma brucei | serine/threonine-protein kinase NRKB, putative | 0.0046 | 0.0091 | 0.0074 |
Onchocerca volvulus | Tyrosine kinase homolog | 0.0774 | 0.5711 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0046 | 0.0091 | 0.0074 |
Loa Loa (eye worm) | AGC/RSK/MSK protein kinase | 0.0443 | 0.3156 | 0.3145 |
Trichomonas vaginalis | AGC family protein kinase | 0.0046 | 0.0091 | 0.0074 |
Echinococcus multilocularis | serine threonine protein kinase nrc serine threonine protein kinase gad | 0.0859 | 0.6371 | 0.9576 |
Echinococcus multilocularis | serine:threonine protein kinase N2 | 0.0443 | 0.3156 | 0.4731 |
Echinococcus granulosus | defective proboscis extension response | 0.0051 | 0.0129 | 0.0169 |
Schistosoma mansoni | vesicular amine transporter | 0.0051 | 0.0129 | 0.0194 |
Schistosoma mansoni | atypical protein kinase C | 0.0443 | 0.3156 | 0.4745 |
Brugia malayi | p70 ribosomal S6 kinase beta | 0.1293 | 0.9718 | 0.9718 |
Echinococcus multilocularis | Protein kinase C, brain isozyme | 0.0443 | 0.3156 | 0.4731 |
Schistosoma mansoni | development and differentiation-enhancing factor ddef | 0.0036 | 0.0017 | 0.0025 |
Brugia malayi | protein kinase C II. | 0.0443 | 0.3156 | 0.3145 |
Brugia malayi | Protein kinase domain containing protein | 0.0443 | 0.3156 | 0.3145 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0443 | 0.3156 | 0.4745 |
Echinococcus multilocularis | neuroglian | 0.0064 | 0.023 | 0.0321 |
Echinococcus granulosus | serine:threonine protein kinase N2 | 0.0443 | 0.3156 | 0.4731 |
Trichomonas vaginalis | AGC family protein kinase | 0.0046 | 0.0091 | 0.0074 |
Loa Loa (eye worm) | hypothetical protein | 0.0443 | 0.3156 | 0.3145 |
Trypanosoma brucei | serine/threonine-protein kinase NrkA | 0.0046 | 0.0091 | 0.0074 |
Echinococcus multilocularis | basement membrane specific heparan sulfate | 0.0051 | 0.0129 | 0.0169 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.0129 | 0.0112 |
Entamoeba histolytica | protein kinase, putative | 0.0046 | 0.0091 | 0.0074 |
Trichomonas vaginalis | ribosomal protein S6 kinase, 90kD, polypeptide, putative | 0.0046 | 0.0091 | 0.0074 |
Schistosoma mansoni | goodpasture antigen-binding protein | 0.0036 | 0.0017 | 0.0025 |
Echinococcus granulosus | ribosomal protein S6 kinase alpha 3 | 0.0443 | 0.3156 | 0.4731 |
Leishmania major | folate/biopterin transporter, putative | 0.0046 | 0.0091 | 1 |
Echinococcus granulosus | nervana 2 | 0.085 | 0.6297 | 0.9465 |
Trypanosoma cruzi | rac serine-threonine kinase, putative | 0.0046 | 0.0091 | 0.0111 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.0129 | 0.0112 |
Entamoeba histolytica | protein kinase, putative | 0.0046 | 0.0091 | 0.0074 |
Trichomonas vaginalis | AGC family protein kinase | 0.0046 | 0.0091 | 0.0074 |
Trichomonas vaginalis | serine/threonine-protein kinase sgk, putative | 0.0434 | 0.3083 | 0.3071 |
Brugia malayi | Fibronectin type III domain containing protein | 0.0051 | 0.0129 | 0.0112 |
Loa Loa (eye worm) | hypothetical protein | 0.0068 | 0.0257 | 0.0241 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0443 | 0.3156 | 0.4745 |
Echinococcus granulosus | Glutaredoxin protein 5 | 0.085 | 0.6297 | 0.9465 |
Toxoplasma gondii | AGC kinase | 0.1293 | 0.9718 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.133 | 1 | 1 |
Giardia lamblia | Kinase, AGC PKA | 0.0859 | 0.6371 | 0.5 |
Loa Loa (eye worm) | AGC/NDR protein kinase | 0.0443 | 0.3156 | 0.3145 |
Schistosoma mansoni | guanyl-nucleotide exchange factor | 0.0036 | 0.0017 | 0.0025 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.0358 | 0.0342 |
Entamoeba histolytica | protein kinase 2, putative | 0.0859 | 0.6371 | 0.6365 |
Trichomonas vaginalis | AGC family protein kinase | 0.133 | 1 | 1 |
Schistosoma mansoni | rhogef and pleckstrin domain protein | 0.0036 | 0.0017 | 0.0025 |
Brugia malayi | Protein kinase domain containing protein | 0.0443 | 0.3156 | 0.3145 |
Trichomonas vaginalis | AGC family protein kinase | 0.0046 | 0.0091 | 0.0074 |
Trypanosoma brucei | Serine/threonine-protein kinase NEK21, putative | 0.0046 | 0.0091 | 0.0074 |
Trypanosoma cruzi | rac serine-threonine kinase, putative | 0.0859 | 0.6371 | 0.9576 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0443 | 0.3156 | 0.4745 |
Trypanosoma cruzi | serine/threonine-protein kinase NRKB, putative | 0.0046 | 0.0091 | 0.0111 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0443 | 0.3156 | 0.4745 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.0046 | 0.0091 | 0.0074 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.0017 | 0.0025 |
Trichomonas vaginalis | AGC family protein kinase | 0.0046 | 0.0091 | 0.0074 |
Schistosoma mansoni | centaurin alpha | 0.0036 | 0.0017 | 0.0025 |
Schistosoma mansoni | growth factor receptor-bound protein | 0.0036 | 0.0017 | 0.0025 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -5.344 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.121 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.874 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.763 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.735 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.656 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.