Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | anaplastic lymphoma receptor tyrosine kinase | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_132231 | All targets in OG5_132231 |
Brugia malayi | Protein kinase domain containing protein | Get druggable targets OG5_132231 | All targets in OG5_132231 |
Loa Loa (eye worm) | TK/ALK protein kinase | Get druggable targets OG5_132231 | All targets in OG5_132231 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | mitogen activated protein kinase | 0.0201 | 0.6913 | 1 |
Trichomonas vaginalis | cyclin B, putative | 0.0031 | 0.0671 | 0.0971 |
Entamoeba histolytica | cell division protein kinase 2, putative | 0.0044 | 0.1142 | 1 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.0201 | 0.6913 | 1 |
Giardia lamblia | G2/mitotic-specific cyclin B | 0.0031 | 0.0671 | 0.0971 |
Trichomonas vaginalis | cyclins, putative | 0.0031 | 0.0671 | 0.0971 |
Trypanosoma brucei | protein kinase, putative | 0.0201 | 0.6913 | 1 |
Trichomonas vaginalis | cyclins, putative | 0.0021 | 0.0307 | 0.0444 |
Trypanosoma cruzi | cdc2-related kinase 3 | 0.0044 | 0.1142 | 0.0754 |
Echinococcus granulosus | MAM | 0.0034 | 0.0769 | 0.1113 |
Trypanosoma cruzi | cdc2-related kinase 1 | 0.0044 | 0.1142 | 0.0754 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0044 | 0.1142 | 0.1652 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0201 | 0.6913 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0191 | 0.0191 |
Giardia lamblia | Kinase, CMGC CDK | 0.0044 | 0.1142 | 0.1652 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.0201 | 0.6913 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0044 | 0.1142 | 0.1652 |
Trypanosoma cruzi | cdc2-related kinase 1 | 0.0044 | 0.1142 | 0.0754 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0201 | 0.6913 | 0.6916 |
Echinococcus multilocularis | MAM | 0.0034 | 0.0769 | 0.1113 |
Trichomonas vaginalis | cyclin B, putative | 0.0031 | 0.0671 | 0.0971 |
Loa Loa (eye worm) | hypothetical protein | 0.025 | 0.87 | 0.8703 |
Echinococcus granulosus | cyclin dependent kinase | 0.0044 | 0.1142 | 0.1652 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.0769 | 0.1113 |
Leishmania major | cell division protein kinase 2,cdc2-related kinase | 0.0044 | 0.1142 | 0.0754 |
Plasmodium falciparum | protein kinase 5 | 0.0044 | 0.1142 | 1 |
Echinococcus granulosus | cyclin dependent kinase 1 | 0.0044 | 0.1142 | 0.1652 |
Echinococcus multilocularis | cyclin dependent kinase 1 | 0.0044 | 0.1142 | 0.1652 |
Giardia lamblia | Kinase, CMGC MAPK | 0.0201 | 0.6913 | 1 |
Loa Loa (eye worm) | CMGC/CDK/CDC2 protein kinase | 0.0044 | 0.1142 | 0.1143 |
Trichomonas vaginalis | cyclins, putative | 0.0031 | 0.0671 | 0.0971 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0044 | 0.1142 | 0.1652 |
Trypanosoma cruzi | cdc2-related kinase 3 | 0.0044 | 0.1142 | 0.0754 |
Echinococcus granulosus | 5'partial|cyclin dependent kinase 1 | 0.0044 | 0.1142 | 0.1652 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.0201 | 0.6913 | 1 |
Plasmodium vivax | protein kinase Crk2 | 0.0044 | 0.1142 | 0.5 |
Brugia malayi | Cyclin, N-terminal domain containing protein | 0.0031 | 0.0671 | 0.0671 |
Entamoeba histolytica | cell division protein kinase 2, putative | 0.0044 | 0.1142 | 1 |
Echinococcus multilocularis | cyclin B | 0.0031 | 0.0671 | 0.0971 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0671 | 0.0671 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0769 | 0.077 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0044 | 0.1142 | 0.1652 |
Echinococcus multilocularis | cyclin dependent kinase | 0.0044 | 0.1142 | 0.1652 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0769 | 0.077 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.0201 | 0.6913 | 1 |
Trichomonas vaginalis | cyclins, putative | 0.0031 | 0.0671 | 0.0971 |
Echinococcus granulosus | cyclin dependent kinase 5 | 0.0044 | 0.1142 | 0.1652 |
Onchocerca volvulus | 0.0034 | 0.0769 | 1 | |
Echinococcus multilocularis | cyclin dependent kinase 1 | 0.0044 | 0.1142 | 0.1652 |
Brugia malayi | cell division control protein 2 homolog | 0.0044 | 0.1142 | 0.1142 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.0201 | 0.6913 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0769 | 0.077 |
Trichomonas vaginalis | cyclin B, putative | 0.0031 | 0.0671 | 0.0971 |
Echinococcus multilocularis | cyclin dependent kinase 5 | 0.0044 | 0.1142 | 0.1652 |
Trypanosoma brucei | cdc2-related kinase 3 | 0.0044 | 0.1142 | 0.0754 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0201 | 0.6913 | 1 |
Trypanosoma brucei | cdc2-related kinase 1 | 0.0044 | 0.1142 | 0.0754 |
Onchocerca volvulus | 0.0034 | 0.0769 | 1 | |
Schistosoma mansoni | cyclin B | 0.0031 | 0.0671 | 0.0971 |
Trichomonas vaginalis | cyclin B, putative | 0.0031 | 0.0671 | 0.0971 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0201 | 0.6913 | 1 |
Loa Loa (eye worm) | CMGC/CDK/CDK5 protein kinase | 0.0044 | 0.1142 | 0.1143 |
Trichomonas vaginalis | cyclins, putative | 0.0031 | 0.0671 | 0.0971 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.1059 | 0.1059 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0201 | 0.6913 | 1 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.0201 | 0.6913 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0201 | 0.6913 | 1 |
Brugia malayi | MAP kinase sur-1 | 0.0201 | 0.6913 | 0.6913 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0201 | 0.6913 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0044 | 0.1142 | 0.1652 |
Giardia lamblia | Kinase, CMGC CDK | 0.0044 | 0.1142 | 0.1652 |
Echinococcus granulosus | cyclin B | 0.0031 | 0.0671 | 0.0971 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0671 | 0.0671 |
Entamoeba histolytica | cyclin, putative | 0.0031 | 0.0671 | 0.5877 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.0201 | 0.6913 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.0769 | 0.1113 |
Brugia malayi | hypothetical protein | 0.0034 | 0.0769 | 0.0769 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0201 | 0.6913 | 1 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.0201 | 0.6913 | 1 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.0201 | 0.6913 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.0044 | 0.1142 | 0.1142 |
Leishmania major | cell division related protein kinase 2,cdc2-related kinase | 0.0044 | 0.1142 | 0.0754 |
Loa Loa (eye worm) | CMGC/CDK/CDC2 protein kinase | 0.0044 | 0.1142 | 0.1143 |
Trichomonas vaginalis | cyclin A, putative | 0.0031 | 0.0671 | 0.0971 |
Brugia malayi | Cyclin, N-terminal domain containing protein | 0.0031 | 0.0671 | 0.0671 |
Loa Loa (eye worm) | TK/ALK protein kinase | 0.0285 | 0.9996 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (functional) | > 4 | PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: CDC2L6 | ChEMBL. | No reference |
Ki (functional) | = 6.8 | PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: ALK | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.