Detailed information for compound 1607706

Basic information

Technical information
  • TDR Targets ID: 1607706
  • Name: 2-(2,6-dimethylmorpholin-4-yl)ethanol
  • MW: 159.226 | Formula: C8H17NO2
  • H donors: 1 H acceptors: 1 LogP: 0.07 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: OCCN1CC(C)OC(C1)C
  • InChi: 1S/C8H17NO2/c1-7-5-9(3-4-10)6-8(2)11-7/h7-8,10H,3-6H2,1-2H3
  • InChiKey: VAFPVCCEXLHAGE-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-(2,6-Dimethyl-4-morpholinyl)ethanol
  • 73813-49-7
  • NSC 371727
  • AIDS-129908
  • AIDS129908
  • NSC371727
  • NCI60_003430

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0017 0.0012 0.0009
Echinococcus granulosus protein kinase c epsilon type 0.0044 0.0097 0.0097
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0144 0.0426 0.0426
Brugia malayi RhoGAP domain containing protein 0.0016 0.0007 0.0004
Brugia malayi protein kinase C3,putative 0.002 0.0021 0.0018
Brugia malayi Protein kinase c protein 2 0.0068 0.0176 0.0173
Entamoeba histolytica protein kinase, putative 0.0026 0.0041 0.0327
Brugia malayi Protein kinase domain containing protein 0.0017 0.001 0.0007
Echinococcus granulosus protein kinase C gamma type 0.0074 0.0196 0.0196
Trichomonas vaginalis AGC family protein kinase 0.0026 0.0041 0.0116
Echinococcus multilocularis MAP kinase activated protein kinase 2 0.0215 0.0656 0.0656
Echinococcus granulosus raf serine:threonine protein kinase 0.0022 0.0028 0.0028
Schistosoma mansoni tyrosine kinase 0.0265 0.0822 0.0822
Schistosoma mansoni serine/threonine protein kinase 0.0144 0.0426 0.0426
Loa Loa (eye worm) hypothetical protein 0.0016 0.0007 0.0005
Entamoeba histolytica protein kinase, putative 0.0026 0.0041 0.0327
Entamoeba histolytica hypothetical protein 0.0016 0.0007 0.0043
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0017 0.001 0.001
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.3076 1 1
Echinococcus multilocularis mitogen activated protein kinase 11 0.0298 0.0929 0.0929
Echinococcus multilocularis mitogen activated protein kinase 11 0.0298 0.0929 0.0929
Loa Loa (eye worm) hypothetical protein 0.0162 0.0483 0.0481
Schistosoma mansoni protein kinase C 0.0017 0.0012 0.0012
Echinococcus multilocularis Protein kinase C, brain isozyme 0.009 0.0248 0.0248
Loa Loa (eye worm) AGC/PKA protein kinase 0.0144 0.0426 0.0423
Schistosoma mansoni tyrosine kinase 0.0017 0.001 0.001
Onchocerca volvulus 0.0017 0.001 0.0046
Loa Loa (eye worm) hypothetical protein 0.0016 0.0007 0.0005
Loa Loa (eye worm) RasGEF domain-containing protein 0.0016 0.0007 0.0005
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0021 0.0024 0.0024
Loa Loa (eye worm) AGC/PKN protein kinase 0.0026 0.0041 0.0038
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0021 0.0024 0.0024
Brugia malayi diacylglycerol kinase 0.0016 0.0007 0.0004
Echinococcus multilocularis serine:threonine protein kinase N2 0.0026 0.0041 0.0041
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0026 0.0041 0.0041
Brugia malayi cAMP-dependent protein kinase catalytic subunit, putative 0.0144 0.0426 0.0423
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.3076 1 1
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0015 0.0003 0.0003
Echinococcus granulosus tyrosine protein kinase Fyn 0.0021 0.0024 0.0024
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0026 0.0041 0.0041
Echinococcus granulosus tyrosine protein kinase ABL1 0.0017 0.001 0.001
Loa Loa (eye worm) TK/FER protein kinase 0.0017 0.001 0.0007
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0017 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0016 0.0007 0.0005
Brugia malayi C1-like domain containing protein 0.002 0.0021 0.0018
Brugia malayi Probable isocitrate dehydrogenase 0.0374 0.1175 0.1173
Brugia malayi Protein kinase domain containing protein 0.0017 0.001 0.0007
Loa Loa (eye worm) hypothetical protein 0.0162 0.0483 0.0481
Loa Loa (eye worm) isocitrate dehydrogenase gamma subunit 0.0374 0.1175 0.1173
Schistosoma mansoni hypothetical protein 0.0016 0.0007 0.0007
Loa Loa (eye worm) raf kinase 0.0016 0.0007 0.0005
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.0046 0.0106 0.0106
Echinococcus multilocularis isocitrate dehydrogenase (NAD+) 0.0374 0.1175 0.1175
Entamoeba histolytica protein kinase, putative 0.0026 0.0041 0.0327
Schistosoma mansoni rac gtpase activating protein 0.0016 0.0007 0.0007
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.3076 1 1
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0021 0.0024 0.0024
Entamoeba histolytica protein kinase, putative 0.0026 0.0041 0.0327
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.3076 1 1
Schistosoma mansoni serine/threonine protein kinase 0.0215 0.0656 0.0656
Echinococcus multilocularis C2 calcium dependent membrane targeting 0.0017 0.0012 0.0012
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0144 0.0426 0.0426
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0021 0.0021
Trypanosoma brucei isocitrate dehydrogenase, putative 0.3076 1 1
Brugia malayi SH2 domain containing protein 0.0017 0.001 0.0007
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0144 0.0426 0.0426
Loa Loa (eye worm) hypothetical protein 0.0016 0.0007 0.0005
Echinococcus granulosus tyrosine protein kinase Fyn 0.0021 0.0024 0.0024
Schistosoma mansoni serine/threonine protein kinase 0.0026 0.0041 0.0041
Echinococcus multilocularis tyrosine protein kinase Abl 0.0021 0.0024 0.0024
Echinococcus granulosus mitogen activated protein kinase 11 0.0298 0.0929 0.0929
Onchocerca volvulus 0.0162 0.0483 0.941
Echinococcus granulosus tyrosine kinase 0.0017 0.001 0.001
Echinococcus granulosus growth factor receptor bound protein 2 0.0015 0.0003 0.0003
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0026 0.0041 0.0041
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0021 0.0024 0.0024
Brugia malayi Probable isocitrate dehydrogenase 0.0374 0.1175 0.1173
Onchocerca volvulus 0.0017 0.001 0.0046
Schistosoma mansoni cell adhesion molecule 0.0014 0.0003 0.0003
Brugia malayi Pleckstrin Homology Domain 0.0016 0.0007 0.0004
Trichomonas vaginalis AGC family protein kinase 0.0026 0.0041 0.0116
Entamoeba histolytica tartrate dehydrogenase, putative 0.0374 0.1175 1
Brugia malayi hypothetical protein 0.0017 0.001 0.0007
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0026 0.0041 0.0041
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.0298 0.0929 0.0892
Brugia malayi protein-tyrosine kinase 0.0017 0.001 0.0007
Schistosoma mansoni serine/threonine protein kinase 0.0044 0.0097 0.0097
Echinococcus multilocularis myotubularin protein 13 0.0016 0.0007 0.0007
Trichomonas vaginalis AGC family protein kinase 0.0144 0.0426 0.3469
Echinococcus multilocularis growth factor receptor bound protein 2 0.0015 0.0003 0.0003
Schistosoma mansoni serine/threonine protein kinase 0.0144 0.0426 0.0426
Loa Loa (eye worm) hypothetical protein 0.0016 0.0007 0.0005
Schistosoma mansoni serine/threonine protein kinase 0.009 0.0248 0.0248
Echinococcus multilocularis unc 13 (munc13) 0.0017 0.0012 0.0012
Trichomonas vaginalis AGC family protein kinase 0.0026 0.0041 0.0116
Brugia malayi Protein kinase domain containing protein 0.0017 0.001 0.0007
Trichomonas vaginalis AGC family protein kinase 0.0026 0.0041 0.0116
Loa Loa (eye worm) hypothetical protein 0.0188 0.0569 0.0566
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.002 0.0021 0.0021
Onchocerca volvulus 0.0017 0.001 0.0046
Echinococcus multilocularis NCK adaptor protein 0.0015 0.0003 0.0003
Echinococcus granulosus protein kinase c iota type 0.0042 0.0093 0.0093
Schistosoma mansoni serine/threonine kinase 0.0026 0.0041 0.0041
Brugia malayi Tyrosine-protein kinase abl-1 0.0021 0.0024 0.0021
Loa Loa (eye worm) TK/FER protein kinase 0.0017 0.001 0.0007
Echinococcus granulosus MAP kinase activated protein kinase 2 0.0215 0.0656 0.0656
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0026 0.0041 0.0041
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0026 0.0041 0.0041
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0021 0.0024 0.0024
Toxoplasma gondii isocitrate dehydrogenase 0.3076 1 1
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.3076 1 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.3076 1 1
Echinococcus granulosus tyrosine protein kinase Fyn 0.0021 0.0024 0.0024
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0026 0.0041 0.0038
Echinococcus multilocularis mitogen activated protein kinase 14 0.0298 0.0929 0.0929
Echinococcus granulosus twitchin 0.0018 0.0013 0.0013
Echinococcus multilocularis Diacylglycerol kinase theta 0.0016 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0062 0.0158 0.0156
Loa Loa (eye worm) camk/mapkapk/mapkapk protein kinase 0.0215 0.0656 0.0653
Onchocerca volvulus 0.0162 0.0483 0.941
Brugia malayi Variant SH3 domain containing protein 0.0026 0.0041 0.0038
Echinococcus multilocularis tyrosine protein kinase Srms 0.0017 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0016 0.0007 0.0005
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.0298 0.0929 0.0926
Brugia malayi Isocitrate dehydrogenase 0.3076 1 1
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0026 0.0041 0.0041
Entamoeba histolytica diacylglycerol kinase, putative 0.0016 0.0007 0.0043
Echinococcus granulosus Rac GTPase activating protein 1 0.0016 0.0007 0.0007
Echinococcus multilocularis Rac GTPase activating protein 1 0.0016 0.0007 0.0007
Schistosoma mansoni vav2 0.0026 0.0041 0.0041
Brugia malayi Protein kinase domain containing protein 0.002 0.0021 0.0018
Echinococcus multilocularis tyrosine protein kinase shark 0.0265 0.0822 0.0822
Echinococcus granulosus tyrosine protein kinase Blk 0.0017 0.001 0.001
Trypanosoma brucei protein kinase A catalytic subunit, putative 0.0144 0.0426 0.0386
Loa Loa (eye worm) hypothetical protein 0.0374 0.1175 0.1173
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0021 0.0024 0.0024
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.0052 0.0124 0.0122
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0017 0.001 0.001
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0021 0.0024 0.0024
Loa Loa (eye worm) SRC-1 0.0021 0.0024 0.0021
Echinococcus multilocularis isocitrate dehydrogenase (NAD) subunit 0.0374 0.1175 0.1175
Loa Loa (eye worm) TK/FER protein kinase 0.0017 0.001 0.0007
Echinococcus granulosus C2 calcium dependent membrane targeting 0.0017 0.0012 0.0012
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0017 0.001 0.0063
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0026 0.0041 0.0041
Echinococcus granulosus tyrosine kinase 0.0017 0.001 0.001
Brugia malayi Ras association domain family 1 isoform A 0.0016 0.0007 0.0004
Brugia malayi p70 ribosomal S6 kinase beta 0.0026 0.0041 0.0038
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0026 0.0041 0.0041
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0183 0.0551 0.0549
Echinococcus multilocularis raf serine:threonine protein kinase 0.0022 0.0028 0.0028
Entamoeba histolytica PH domain containing protein kinase, putative 0.0144 0.0426 0.3608
Schistosoma mansoni serine/threonine protein kinase 0.0026 0.0041 0.0041
Echinococcus multilocularis serine threonine protein kinase 0.0074 0.0196 0.0196
Toxoplasma gondii protein kinase, cAMP-dependent, catalytic chain 0.0144 0.0426 0.0419
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0026 0.0041 0.0038
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0021 0.0024 0.0024
Loa Loa (eye worm) TK/FER protein kinase 0.0017 0.001 0.0007
Echinococcus multilocularis mitogen activated protein kinase 14 0.0298 0.0929 0.0929
Loa Loa (eye worm) TK/FER protein kinase 0.0017 0.001 0.0007
Echinococcus multilocularis serine:threonine protein kinase N2 0.0026 0.0041 0.0041
Schistosoma mansoni Isocitrate dehydrogenase [NAD] subunit gamma mitochondrial 0.0374 0.1175 0.1175
Echinococcus multilocularis tyrosine protein kinase Blk 0.0017 0.001 0.001
Echinococcus multilocularis enhancer of mRNA decapping protein 4 0.014 0.0412 0.0412
Schistosoma mansoni protein kinase C mu 0.0016 0.0007 0.0007
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0017 0.001 0.001
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 2 0.0144 0.0426 0.0386
Schistosoma mansoni growth factor receptor-bound protein 0.0015 0.0003 0.0003
Loa Loa (eye worm) CAMK/PKD protein kinase 0.002 0.0021 0.0018
Toxoplasma gondii isocitrate dehydrogenase 0.3076 1 1
Loa Loa (eye worm) TK/FER protein kinase 0.0017 0.001 0.0007
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0144 0.0426 0.0426
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0298 0.0929 0.0525
Onchocerca volvulus Tyrosine kinase homolog 0.0171 0.0513 1
Echinococcus granulosus enhancer of mRNA decapping protein 4 0.014 0.0412 0.0412
Loa Loa (eye worm) TK/FER protein kinase 0.0017 0.001 0.0007
Loa Loa (eye worm) hypothetical protein 0.0017 0.0012 0.0009
Trichomonas vaginalis AGC family protein kinase 0.0026 0.0041 0.0116
Mycobacterium ulcerans 3-isopropylmalate dehydrogenase 0.0374 0.1175 0.5
Brugia malayi P38 map kinase family protein 2 0.0298 0.0929 0.0926
Brugia malayi RhoGEF domain containing protein 0.0016 0.0007 0.0004
Echinococcus granulosus tyrosine protein kinase shark 0.0265 0.0822 0.0822
Onchocerca volvulus 0.0017 0.0012 0.0095
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0021 0.0021
Loa Loa (eye worm) TK/FER protein kinase 0.0017 0.001 0.0007
Echinococcus multilocularis protein kinase c iota type 0.0042 0.0093 0.0093
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0298 0.0929 0.0525
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0026 0.0041 0.0041
Loa Loa (eye worm) TK/FER protein kinase 0.0017 0.001 0.0007
Brugia malayi isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial 0.0374 0.1175 0.1173
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.002 0.0021 0.0021
Brugia malayi map kinase activated protein kinase protein 2 0.0215 0.0656 0.0653
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0144 0.0426 0.0426
Echinococcus multilocularis isocitrate dehydrogenase 0.3076 1 1
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0021 0.0024 0.0024
Loa Loa (eye worm) TK/FER protein kinase 0.0017 0.001 0.0007
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 1 0.0144 0.0426 0.0386
Toxoplasma gondii AGC kinase 0.0026 0.0041 0.0033
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.002 0.0021 0.0018
Loa Loa (eye worm) AGC/NDR protein kinase 0.0026 0.0041 0.0038
Echinococcus granulosus myotubularin protein 13 0.0016 0.0007 0.0007
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.0298 0.0929 0.0525
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0026 0.0041 0.0038
Schistosoma mansoni tyrosine kinase 0.0255 0.0788 0.0788
Loa Loa (eye worm) TK/ABL protein kinase 0.0017 0.001 0.0007
Schistosoma mansoni isocitrate dehydrogenase 0.0374 0.1175 0.1175
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.3076 1 1
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0026 0.0041 0.0038
Loa Loa (eye worm) AGC/PKC/IOTA protein kinase 0.002 0.0021 0.0018
Toxoplasma gondii AGC kinase 0.0144 0.0426 0.0419
Entamoeba histolytica diacylglycerol kinase, putative 0.0016 0.0007 0.0043
Echinococcus multilocularis tyrosine kinase 0.0017 0.001 0.001
Schistosoma mansoni serine/threonine protein kinase 0.0026 0.0041 0.0041
Brugia malayi RhoGAP domain containing protein 0.0026 0.0041 0.0038
Echinococcus granulosus tyrosine protein kinase Src64B 0.0021 0.0024 0.0024
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.3076 1 1
Schistosoma mansoni serine/threonine protein kinase 0.009 0.0248 0.0248
Onchocerca volvulus 0.0017 0.001 0.0046
Schistosoma mansoni protein kinase C mu 0.002 0.0021 0.0021
Echinococcus granulosus Diacylglycerol kinase theta 0.0016 0.0007 0.0007
Brugia malayi isocitrate dehydrogenase [NAD] subunit beta, mitochondrial 0.0374 0.1175 0.1173
Echinococcus granulosus NDR protein kinase 0.0026 0.0041 0.0041
Trichomonas vaginalis AGC family protein kinase 0.0026 0.0041 0.0116
Loa Loa (eye worm) hypothetical protein 0.0046 0.0106 0.0104
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0021 0.0024 0.0024
Schistosoma mansoni unc-13 (munc13) 0.0391 0.1232 0.1232
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0016 0.0007 0.0005
Brugia malayi Protein kinase domain containing protein 0.0017 0.001 0.0007
Schistosoma mansoni atypical protein kinase C 0.0042 0.0093 0.0093
Echinococcus granulosus roundabout 2 0.0017 0.0012 0.0012
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0021 0.0024 0.0024
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.3076 1 1
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0014 0.0003 0.0003
Schistosoma mansoni unc-13 (munc13) 0.0017 0.0012 0.0012
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.3076 1 1
Trichomonas vaginalis AGC family protein kinase 0.0026 0.0041 0.0116
Loa Loa (eye worm) hypothetical protein 0.0016 0.0007 0.0005
Echinococcus granulosus RNA directed DNA polymerase 0.0046 0.0106 0.0106
Echinococcus granulosus NCK adaptor protein 0.0015 0.0003 0.0003
Schistosoma mansoni tyrosine kinase 0.0021 0.0024 0.0024
Echinococcus multilocularis protein kinase c eta type 0.0016 0.0007 0.0007
Brugia malayi SH2 domain containing protein 0.0017 0.001 0.0007
Brugia malayi Protein kinase domain containing protein 0.0026 0.0041 0.0038
Echinococcus multilocularis protein kinase c epsilon type 0.0044 0.0097 0.0097
Leishmania major isocitrate dehydrogenase, putative 0.0374 0.1175 0.0783
Schistosoma mansoni serine/threonine protein kinase 0.0022 0.0028 0.0028
Onchocerca volvulus 0.0017 0.001 0.0046
Loa Loa (eye worm) hypothetical protein 0.0017 0.0012 0.001
Schistosoma mansoni nck2/grb4 0.0015 0.0003 0.0003
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0021 0.0024 0.0024
Echinococcus granulosus isocitrate dehydrogenase NAD subunit 0.0374 0.1175 0.1175
Echinococcus granulosus unc 13 munc13 0.0017 0.0012 0.0012
Brugia malayi SRC-1 0.0021 0.0024 0.0021
Loa Loa (eye worm) AGC/AKT protein kinase 0.0026 0.0041 0.0038
Loa Loa (eye worm) AGC/PKA protein kinase 0.0144 0.0426 0.0423
Schistosoma mansoni diacylglycerol kinase theta 0.0016 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0178 0.0535 0.0533
Loa Loa (eye worm) TK protein kinase 0.0017 0.001 0.0007
Brugia malayi protein kinase C II. 0.0044 0.0097 0.0095
Echinococcus multilocularis serine:threonine protein kinase 38 0.0026 0.0041 0.0041
Loa Loa (eye worm) hypothetical protein 0.0016 0.0007 0.0005
Brugia malayi Immunoglobulin I-set domain containing protein 0.0183 0.0551 0.0548
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0144 0.0426 0.0426
Echinococcus granulosus tyrosine protein kinase Srms 0.0017 0.001 0.001
Entamoeba histolytica PH domain containing protein kinase, putative 0.0144 0.0426 0.3608
Echinococcus granulosus protein kinase c eta type 0.0016 0.0007 0.0007
Trichomonas vaginalis AGC family protein kinase 0.0026 0.0041 0.0116
Brugia malayi Protein kinase domain containing protein 0.0026 0.0041 0.0038
Trichomonas vaginalis AGC family protein kinase 0.0026 0.0041 0.0116
Brugia malayi diacylglycerol kinase 0.0016 0.0007 0.0004
Echinococcus granulosus isocitrate dehydrogenase NAD 0.0374 0.1175 0.1175
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0017 0.001 0.001
Echinococcus multilocularis RNA directed DNA polymerase 0.0046 0.0106 0.0106
Echinococcus multilocularis roundabout 2 0.0017 0.0012 0.0012
Wolbachia endosymbiont of Brugia malayi isocitrate dehydrogenase 0.0374 0.1175 0.5
Trichomonas vaginalis isocitrate dehydrogenase, putative 0.0374 0.1175 1
Trichomonas vaginalis AGC family protein kinase 0.0026 0.0041 0.0116
Loa Loa (eye worm) hypothetical protein 0.0016 0.0007 0.0005
Schistosoma mansoni serine/threonine protein kinase 0.0144 0.0426 0.0426
Toxoplasma gondii AGC kinase 0.0144 0.0426 0.0419
Echinococcus granulosus tyrosine protein kinase Lyn 0.0025 0.0037 0.0037
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.3076 1 1
Trichomonas vaginalis AGC family protein kinase 0.0026 0.0041 0.0116
Loa Loa (eye worm) hypothetical protein 0.0162 0.0483 0.0481
Echinococcus multilocularis c src tyrosine kinase 0.0021 0.0024 0.0024
Echinococcus granulosus N chimaerin 0.0026 0.0041 0.0041
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0021 0.0024 0.0024
Echinococcus granulosus tyrosine protein kinase Src42A 0.0021 0.0024 0.0024
Brugia malayi Protein kinase domain containing protein 0.0026 0.0041 0.0038
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0021 0.0024 0.0024
Schistosoma mansoni diacylglycerol kinase theta 0.0016 0.0007 0.0007
Schistosoma mansoni tyrosine kinase 0.0021 0.0024 0.0024
Schistosoma mansoni adapter molecule crk 0.0015 0.0003 0.0003
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.3076 1 1
Schistosoma mansoni growth factor receptor-bound protein 0.0015 0.0003 0.0003
Echinococcus granulosus mitogen activated protein kinase 14 0.0298 0.0929 0.0929
Echinococcus granulosus c src tyrosine kinase 0.0021 0.0024 0.0024
Loa Loa (eye worm) isocitrate dehydrogenase 0.3076 1 1
Giardia lamblia Kinase, AGC PKA 0.0144 0.0426 0.5
Onchocerca volvulus 0.0017 0.001 0.0046
Schistosoma mansoni tyrosine kinase 0.0021 0.0024 0.0024
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0026 0.0041 0.0038
Brugia malayi Hr1 repeat family protein 0.0026 0.0041 0.0038
Brugia malayi Protein kinase domain containing protein 0.0017 0.001 0.0007
Brugia malayi Isocitrate dehydrogenase subunit gamma, mitochondrial precursor 0.0374 0.1175 0.1173
Mycobacterium leprae PROBABLE 3-ISOPROPYLMALATE DEHYDROGENASE LEUB (BETA-IPM DEHYDROGENASE) (IMDH) (3-IPM-DH) 0.0374 0.1175 0.5
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.3076 1 1
Echinococcus granulosus serine:threonine protein kinase N2 0.0026 0.0041 0.0041
Loa Loa (eye worm) hypothetical protein 0.0144 0.0426 0.0423
Schistosoma mansoni tyrosine kinase 0.0021 0.0024 0.0024
Schistosoma mansoni serine/threonine protein kinase 0.0026 0.0041 0.0041
Echinococcus multilocularis N chimaerin 0.0026 0.0041 0.0041
Loa Loa (eye worm) hypothetical protein 0.0017 0.001 0.0007
Echinococcus granulosus Protein kinase C brain isozyme 0.009 0.0248 0.0248
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0144 0.0426 0.0426
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0044 0.0097 0.0095
Loa Loa (eye worm) Ras association domain family 1 isoform A 0.0016 0.0007 0.0005

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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