Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | cell division cycle 7 | Starlite/ChEMBL | No references |
Homo sapiens | WEE1 G2 checkpoint kinase | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0069 | 0 | 0.5 | |
Trypanosoma brucei | isocitrate dehydrogenase, putative | 0.0644 | 1 | 1 |
Loa Loa (eye worm) | isocitrate dehydrogenase gamma subunit | 0.0078 | 0.0155 | 0.0155 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0644 | 1 | 1 |
Brugia malayi | isocitrate dehydrogenase [NAD] subunit beta, mitochondrial | 0.0078 | 0.0155 | 0.0155 |
Trichomonas vaginalis | isocitrate dehydrogenase, putative | 0.0078 | 0.0155 | 1 |
Schistosoma mansoni | isocitrate dehydrogenase | 0.0078 | 0.0155 | 0.0155 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0644 | 1 | 1 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0644 | 1 | 0.5 |
Trypanosoma cruzi | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0644 | 1 | 1 |
Giardia lamblia | Kinase, CDC7 | 0.0069 | 0 | 0.5 |
Brugia malayi | isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial | 0.0078 | 0.0155 | 0.0155 |
Mycobacterium ulcerans | 3-isopropylmalate dehydrogenase | 0.0078 | 0.0155 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.0155 | 0.0155 |
Trypanosoma brucei | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0644 | 1 | 1 |
Brugia malayi | Isocitrate dehydrogenase subunit gamma, mitochondrial precursor | 0.0078 | 0.0155 | 0.0155 |
Entamoeba histolytica | tartrate dehydrogenase, putative | 0.0078 | 0.0155 | 0.5 |
Brugia malayi | Isocitrate dehydrogenase | 0.0644 | 1 | 1 |
Brugia malayi | Probable isocitrate dehydrogenase | 0.0078 | 0.0155 | 0.0155 |
Onchocerca volvulus | 0.0069 | 0 | 0.5 | |
Plasmodium vivax | isocitrate dehydrogenase [NADP], mitochondrial, putative | 0.0644 | 1 | 0.5 |
Echinococcus multilocularis | isocitrate dehydrogenase (NAD+) | 0.0078 | 0.0155 | 0.0155 |
Schistosoma mansoni | unc-13 (munc13) | 0.0078 | 0.0155 | 0.0155 |
Echinococcus granulosus | isocitrate dehydrogenase NAD | 0.0078 | 0.0155 | 0.0155 |
Leishmania major | isocitrate dehydrogenase, putative | 0.0078 | 0.0155 | 0.0155 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0644 | 1 | 1 |
Brugia malayi | Probable isocitrate dehydrogenase | 0.0078 | 0.0155 | 0.0155 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0644 | 1 | 0.5 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.0644 | 1 | 1 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0644 | 1 | 1 |
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.0644 | 1 | 0.5 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0644 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | isocitrate dehydrogenase | 0.0078 | 0.0155 | 0.5 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.0644 | 1 | 1 |
Trypanosoma cruzi | isocitrate dehydrogenase, putative | 0.0644 | 1 | 1 |
Echinococcus multilocularis | isocitrate dehydrogenase (NAD) subunit | 0.0078 | 0.0155 | 0.0155 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.0644 | 1 | 1 |
Echinococcus granulosus | isocitrate dehydrogenase NAD subunit | 0.0078 | 0.0155 | 0.0155 |
Schistosoma mansoni | Isocitrate dehydrogenase [NAD] subunit gamma mitochondrial | 0.0078 | 0.0155 | 0.0155 |
Leishmania major | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0644 | 1 | 1 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.0644 | 1 | 1 |
Mycobacterium leprae | PROBABLE 3-ISOPROPYLMALATE DEHYDROGENASE LEUB (BETA-IPM DEHYDROGENASE) (IMDH) (3-IPM-DH) | 0.0078 | 0.0155 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (functional) | = 5.7 | PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: CDC7 | ChEMBL. | No reference |
Ki (functional) | = 6 | PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: WEE1 | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.