Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | platelet-derived growth factor receptor, beta polypeptide | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | 3-isopropylmalate dehydrogenase | 0.0036 | 0.0984 | 0.5 |
Trypanosoma brucei | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0296 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0296 | 1 | 1 |
Brugia malayi | Probable isocitrate dehydrogenase | 0.0036 | 0.0984 | 0.0868 |
Trypanosoma cruzi | isocitrate dehydrogenase, putative | 0.0296 | 1 | 0.5 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0016 | 0.029 | 0.0165 |
Schistosoma mansoni | vesicular amine transporter | 0.0011 | 0.0128 | 0.0128 |
Schistosoma mansoni | unc-13 (munc13) | 0.0036 | 0.0984 | 0.0984 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0255 | 0.0129 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.0296 | 1 | 1 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.0016 | 0.029 | 0.0165 |
Echinococcus multilocularis | isocitrate dehydrogenase (NAD) subunit | 0.0036 | 0.0984 | 0.0868 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0296 | 1 | 1 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0296 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0355 | 0.023 |
Schistosoma mansoni | defective proboscis extension response (dpr)-related | 0.0011 | 0.0128 | 0.0128 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0984 | 0.0868 |
Brugia malayi | isocitrate dehydrogenase [NAD] subunit beta, mitochondrial | 0.0036 | 0.0984 | 0.0868 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0296 | 1 | 0.5 |
Schistosoma mansoni | Neurotrimin precursor (hNT) | 0.0011 | 0.0128 | 0.0128 |
Echinococcus granulosus | neurotracting:lsamp:neurotrimin:obcam | 0.0015 | 0.0255 | 0.0129 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.0296 | 1 | 1 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0296 | 1 | 1 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0296 | 1 | 0.5 |
Brugia malayi | Isocitrate dehydrogenase | 0.0296 | 1 | 1 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0296 | 1 | 1 |
Plasmodium vivax | isocitrate dehydrogenase [NADP], mitochondrial, putative | 0.0296 | 1 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | isocitrate dehydrogenase | 0.0036 | 0.0984 | 0.5 |
Trypanosoma brucei | isocitrate dehydrogenase, putative | 0.0296 | 1 | 0.5 |
Schistosoma mansoni | Isocitrate dehydrogenase [NAD] subunit gamma mitochondrial | 0.0036 | 0.0984 | 0.0984 |
Trichomonas vaginalis | isocitrate dehydrogenase, putative | 0.0036 | 0.0984 | 0.5 |
Mycobacterium leprae | PROBABLE 3-ISOPROPYLMALATE DEHYDROGENASE LEUB (BETA-IPM DEHYDROGENASE) (IMDH) (3-IPM-DH) | 0.0036 | 0.0984 | 0.5 |
Brugia malayi | isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial | 0.0036 | 0.0984 | 0.0868 |
Schistosoma mansoni | nephrin | 0.0014 | 0.0227 | 0.0227 |
Echinococcus granulosus | roundabout 2 | 0.0018 | 0.0355 | 0.023 |
Echinococcus granulosus | neuroglian | 0.0014 | 0.0227 | 0.0101 |
Entamoeba histolytica | tartrate dehydrogenase, putative | 0.0036 | 0.0984 | 0.5 |
Loa Loa (eye worm) | isocitrate dehydrogenase gamma subunit | 0.0036 | 0.0984 | 0.0868 |
Trypanosoma cruzi | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0296 | 1 | 0.5 |
Echinococcus multilocularis | neuroglian | 0.0014 | 0.0227 | 0.0101 |
Echinococcus granulosus | isocitrate dehydrogenase NAD subunit | 0.0036 | 0.0984 | 0.0868 |
Echinococcus granulosus | twitchin | 0.0014 | 0.0227 | 0.0101 |
Brugia malayi | Isocitrate dehydrogenase subunit gamma, mitochondrial precursor | 0.0036 | 0.0984 | 0.0868 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.0296 | 1 | 1 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.0296 | 1 | 1 |
Schistosoma mansoni | isocitrate dehydrogenase | 0.0036 | 0.0984 | 0.0984 |
Brugia malayi | Probable isocitrate dehydrogenase | 0.0036 | 0.0984 | 0.0868 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0355 | 0.023 |
Echinococcus multilocularis | isocitrate dehydrogenase (NAD+) | 0.0036 | 0.0984 | 0.0868 |
Schistosoma mansoni | cell adhesion molecule | 0.0015 | 0.0255 | 0.0255 |
Echinococcus granulosus | isocitrate dehydrogenase NAD | 0.0036 | 0.0984 | 0.0868 |
Echinococcus multilocularis | roundabout 2 | 0.0018 | 0.0355 | 0.023 |
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.0296 | 1 | 0.5 |
Leishmania major | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0296 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 1.8 uM | Inhibition of PDGFBB-induced PDGFRbeta autophosphorylation in human SF539 cells incubated for 60 mins prior to PDGFBB-induction measured after 10 mins by phosphotyrosine ELISA | ChEMBL. | 22370340 |
IC50 (binding) | = 25.7 uM | Inhibition of VEGF-induced VEGFR2 autophosphorylation in human U251 cells incubated for 60 mins prior to VEGF-induction measured after 10 mins by phosphotyrosine ELISA | ChEMBL. | 22370340 |
IC50 (functional) | = 39 uM | Cytotoxicity against human A431 cells overexpressing EGFR incubated for 12 hrs measured after 36 hrs by CYQUANT assay | ChEMBL. | 22370340 |
IC50 (binding) | = 156.5 uM | Inhibition of VEGF-induced VEGFR1 autophosphorylation in human A498 cells incubated for 60 mins prior to VEGF-induction measured after 10 mins by phosphotyrosine ELISA | ChEMBL. | 22370340 |
IC50 (binding) | > 200 uM | Inhibition of EGF-induced EGFR autophosphorylation in human A431 cells incubated for 60 mins prior to EGF-induction measured after 10 mins by phosphotyrosine ELISA | ChEMBL. | 22370340 |
Ratio IC50 (binding) | = 3 | Ratio of AG1295 IC50 to compound IC50 for PDGFRbeta autophosphorylation in human SF539 cells | ChEMBL. | 22370340 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.