Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | cyclin dependent kinase | 0.0135 | 0.2529 | 0.1398 |
Trypanosoma cruzi | cdc2-related kinase 3 | 0.0135 | 0.2529 | 0.1398 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.0365 | 1 | 1 |
Trichomonas vaginalis | cyclin B, putative | 0.0097 | 0.1315 | 0.103 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0365 | 1 | 1 |
Trichomonas vaginalis | cyclin A, putative | 0.0097 | 0.1315 | 0.103 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0135 | 0.2529 | 0.1398 |
Trypanosoma brucei | cdc2-related kinase 1 | 0.0135 | 0.2529 | 0.1398 |
Trypanosoma cruzi | cdc2-related kinase 1 | 0.0135 | 0.2529 | 0.1398 |
Brugia malayi | cell division control protein 2 homolog | 0.0135 | 0.2529 | 0.1398 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.0365 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0135 | 0.2529 | 0.2284 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.0365 | 1 | 1 |
Trichomonas vaginalis | cyclins, putative | 0.0097 | 0.1315 | 0.103 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0365 | 1 | 1 |
Plasmodium vivax | protein kinase Crk2 | 0.0135 | 0.2529 | 0.5 |
Loa Loa (eye worm) | CMGC/CDK/CDK5 protein kinase | 0.0135 | 0.2529 | 0.2529 |
Brugia malayi | Protein kinase domain containing protein | 0.0135 | 0.2529 | 0.1398 |
Trichomonas vaginalis | cyclins, putative | 0.0097 | 0.1315 | 0.103 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.0365 | 1 | 1 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.0365 | 1 | 1 |
Loa Loa (eye worm) | CMGC/CDK/CDC2 protein kinase | 0.0135 | 0.2529 | 0.2529 |
Entamoeba histolytica | cell division protein kinase 2, putative | 0.0135 | 0.2529 | 1 |
Giardia lamblia | Kinase, CMGC CDK | 0.0135 | 0.2529 | 0.1398 |
Echinococcus multilocularis | cyclin dependent kinase 1 | 0.0135 | 0.2529 | 0.1398 |
Loa Loa (eye worm) | hypothetical protein | 0.0097 | 0.1315 | 0.1315 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.0365 | 1 | 1 |
Echinococcus granulosus | cyclin dependent kinase 5 | 0.0135 | 0.2529 | 0.1398 |
Echinococcus multilocularis | cyclin dependent kinase | 0.0135 | 0.2529 | 0.1398 |
Loa Loa (eye worm) | hypothetical protein | 0.0097 | 0.1315 | 0.1315 |
Echinococcus multilocularis | cyclin dependent kinase 5 | 0.0135 | 0.2529 | 0.1398 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0135 | 0.2529 | 0.1398 |
Trichomonas vaginalis | cyclin B, putative | 0.0097 | 0.1315 | 0.103 |
Trichomonas vaginalis | cyclin B, putative | 0.0097 | 0.1315 | 0.103 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.0365 | 1 | 1 |
Giardia lamblia | Kinase, CMGC CDK | 0.0135 | 0.2529 | 0.1398 |
Loa Loa (eye worm) | CMGC/CDK/CDC2 protein kinase | 0.0135 | 0.2529 | 0.2529 |
Giardia lamblia | Kinase, CMGC MAPK | 0.0365 | 1 | 1 |
Trypanosoma cruzi | cdc2-related kinase 1 | 0.0135 | 0.2529 | 0.1398 |
Echinococcus granulosus | 5'partial|cyclin dependent kinase 1 | 0.0135 | 0.2529 | 0.1398 |
Brugia malayi | hypothetical protein | 0.0182 | 0.4084 | 0.3188 |
Trypanosoma brucei | cdc2-related kinase 3 | 0.0135 | 0.2529 | 0.1398 |
Leishmania major | cell division protein kinase 2,cdc2-related kinase | 0.0135 | 0.2529 | 0.1398 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.0365 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.013 | 0.2376 | 0.2376 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0365 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0365 | 1 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0365 | 1 | 1 |
Echinococcus granulosus | mitogen activated protein kinase | 0.0365 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0365 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0135 | 0.2529 | 0.2284 |
Entamoeba histolytica | cell division protein kinase 2, putative | 0.0135 | 0.2529 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0365 | 1 | 1 |
Trichomonas vaginalis | cyclins, putative | 0.0097 | 0.1315 | 0.103 |
Leishmania major | cell division related protein kinase 2,cdc2-related kinase | 0.0135 | 0.2529 | 0.1398 |
Trichomonas vaginalis | cyclin B, putative | 0.0097 | 0.1315 | 0.103 |
Trypanosoma brucei | protein kinase, putative | 0.0365 | 1 | 1 |
Trichomonas vaginalis | cyclins, putative | 0.0097 | 0.1315 | 0.103 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0365 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0182 | 0.4084 | 0.4084 |
Echinococcus granulosus | cyclin dependent kinase 1 | 0.0135 | 0.2529 | 0.1398 |
Trypanosoma cruzi | cdc2-related kinase 3 | 0.0135 | 0.2529 | 0.1398 |
Onchocerca volvulus | 0.0182 | 0.4084 | 1 | |
Plasmodium falciparum | protein kinase 5 | 0.0135 | 0.2529 | 0.5 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.0365 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0135 | 0.2529 | 0.2284 |
Echinococcus multilocularis | cyclin dependent kinase 1 | 0.0135 | 0.2529 | 0.1398 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 19.9526 uM | PubChem BioAssay. qHTS for Inhibitors of Vif-A3G Interactions: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 29.0929 uM | PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.