Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0924 | 0.5252 | 1 |
Trichomonas vaginalis | cyclin B, putative | 0.0256 | 0.0961 | 0.183 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0355 | 0.1594 | 0.3034 |
Trypanosoma cruzi | cdc2-related kinase 3 | 0.0355 | 0.1594 | 0.1474 |
Trypanosoma cruzi | cdc2-related kinase 3 | 0.0355 | 0.1594 | 0.1474 |
Loa Loa (eye worm) | hypothetical protein | 0.0256 | 0.0961 | 0.183 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0355 | 0.1594 | 0.3034 |
Plasmodium falciparum | protein kinase 5 | 0.0355 | 0.1594 | 1 |
Echinococcus granulosus | mitogen activated protein kinase | 0.0924 | 0.5252 | 1 |
Trichomonas vaginalis | cyclins, putative | 0.0256 | 0.0961 | 0.183 |
Leishmania major | cell division related protein kinase 2,cdc2-related kinase | 0.0355 | 0.1594 | 0.1474 |
Loa Loa (eye worm) | CMGC/CDK/CDC2 protein kinase | 0.0355 | 0.1594 | 0.3034 |
Loa Loa (eye worm) | hypothetical protein | 0.0256 | 0.0961 | 0.183 |
Trypanosoma brucei | cdc2-related kinase 1 | 0.0355 | 0.1594 | 0.1474 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0924 | 0.5252 | 1 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.0924 | 0.5252 | 1 |
Echinococcus multilocularis | cyclin dependent kinase 1 | 0.0355 | 0.1594 | 0.3034 |
Giardia lamblia | Kinase, CMGC MAPK | 0.0924 | 0.5252 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0355 | 0.1594 | 0.3034 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0924 | 0.5252 | 1 |
Trichomonas vaginalis | cyclin A, putative | 0.0256 | 0.0961 | 0.183 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.0924 | 0.5252 | 1 |
Leishmania major | cell division protein kinase 2,cdc2-related kinase | 0.0355 | 0.1594 | 0.1474 |
Echinococcus multilocularis | cyclin dependent kinase 1 | 0.0355 | 0.1594 | 0.3034 |
Brugia malayi | Cyclin, N-terminal domain containing protein | 0.0256 | 0.0961 | 0.183 |
Trichomonas vaginalis | cyclin B, putative | 0.0256 | 0.0961 | 0.183 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.0924 | 0.5252 | 1 |
Trichomonas vaginalis | cyclin B, putative | 0.0256 | 0.0961 | 0.183 |
Trypanosoma brucei | cdc2-related kinase 3 | 0.0355 | 0.1594 | 0.1474 |
Giardia lamblia | Kinase, CMGC CDK | 0.0355 | 0.1594 | 0.3034 |
Trichomonas vaginalis | cyclin B, putative | 0.0256 | 0.0961 | 0.183 |
Echinococcus multilocularis | cyclin B | 0.0256 | 0.0961 | 0.183 |
Echinococcus multilocularis | cyclin dependent kinase 5 | 0.0355 | 0.1594 | 0.3034 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.0924 | 0.5252 | 1 |
Echinococcus granulosus | cyclin dependent kinase 1 | 0.0355 | 0.1594 | 0.3034 |
Echinococcus granulosus | cyclin B | 0.0256 | 0.0961 | 0.183 |
Entamoeba histolytica | cell division protein kinase 2, putative | 0.0355 | 0.1594 | 1 |
Entamoeba histolytica | cell division protein kinase 2, putative | 0.0355 | 0.1594 | 1 |
Echinococcus granulosus | cyclin dependent kinase 5 | 0.0355 | 0.1594 | 0.3034 |
Loa Loa (eye worm) | CMGC/CDK/CDK5 protein kinase | 0.0355 | 0.1594 | 0.3034 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0355 | 0.1594 | 0.3034 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0924 | 0.5252 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.015 | 0.0274 | 0.0522 |
Plasmodium vivax | protein kinase Crk2 | 0.0355 | 0.1594 | 0.5 |
Echinococcus granulosus | cyclin dependent kinase | 0.0355 | 0.1594 | 0.3034 |
Trichomonas vaginalis | cyclins, putative | 0.0256 | 0.0961 | 0.183 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0924 | 0.5252 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0924 | 0.5252 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0924 | 0.5252 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0924 | 0.5252 | 1 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.0924 | 0.5252 | 0.4352 |
Brugia malayi | cell division control protein 2 homolog | 0.0355 | 0.1594 | 0.3034 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.0924 | 0.5252 | 1 |
Onchocerca volvulus | 0.0256 | 0.0961 | 0.5 | |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.0924 | 0.5252 | 1 |
Echinococcus granulosus | 5'partial|cyclin dependent kinase 1 | 0.0355 | 0.1594 | 0.3034 |
Loa Loa (eye worm) | hypothetical protein | 0.0343 | 0.1516 | 0.2887 |
Entamoeba histolytica | cyclin, putative | 0.0256 | 0.0961 | 0.6032 |
Trichomonas vaginalis | cyclins, putative | 0.0256 | 0.0961 | 0.183 |
Loa Loa (eye worm) | CMGC/CDK/CDC2 protein kinase | 0.0355 | 0.1594 | 0.3034 |
Trypanosoma cruzi | cdc2-related kinase 1 | 0.0355 | 0.1594 | 0.1474 |
Trypanosoma cruzi | cdc2-related kinase 1 | 0.0355 | 0.1594 | 0.1474 |
Trypanosoma brucei | protein kinase, putative | 0.0924 | 0.5252 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.0355 | 0.1594 | 0.3034 |
Trichomonas vaginalis | cyclins, putative | 0.0175 | 0.044 | 0.0838 |
Brugia malayi | MAP kinase sur-1 | 0.0924 | 0.5252 | 1 |
Trichomonas vaginalis | cyclins, putative | 0.0256 | 0.0961 | 0.183 |
Giardia lamblia | G2/mitotic-specific cyclin B | 0.0256 | 0.0961 | 0.183 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.0924 | 0.5252 | 1 |
Schistosoma mansoni | cyclin B | 0.0256 | 0.0961 | 0.183 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.0924 | 0.5252 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0355 | 0.1594 | 0.3034 |
Echinococcus multilocularis | cyclin dependent kinase | 0.0355 | 0.1594 | 0.3034 |
Giardia lamblia | Kinase, CMGC CDK | 0.0355 | 0.1594 | 0.3034 |
Brugia malayi | Cyclin, N-terminal domain containing protein | 0.0256 | 0.0961 | 0.183 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.