Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | pyruvate carboxylase | 0.1891 | 0.2653 | 0.183 |
Loa Loa (eye worm) | AUR protein kinase | 0.1676 | 0.214 | 0.1321 |
Entamoeba histolytica | protein kinase , putative | 0.1676 | 0.214 | 1 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.365 | 0.6861 | 1 |
Leishmania major | acetyl-CoA carboxylase, putative | 0.4963 | 1 | 1 |
Loa Loa (eye worm) | carboxyl transferase domain-containing protein | 0.4789 | 0.9584 | 1 |
Brugia malayi | Carboxyl transferase domain containing protein | 0.4789 | 0.9584 | 1 |
Toxoplasma gondii | acetyl-CoA carboxylase ACC1 | 0.4963 | 1 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.1676 | 0.214 | 1 |
Echinococcus granulosus | serine:threonine protein kinase 12 B | 0.1676 | 0.214 | 0.214 |
Giardia lamblia | Acetyl-CoA carboxylase/pyruvate carboxylase fusion protein, putative | 0.0846 | 0.0156 | 0.049 |
Plasmodium vivax | biotin carboxylase subunit of acetyl CoA carboxylase, putative | 0.3592 | 0.672 | 1 |
Plasmodium vivax | serine/threonine protein kinase 6, putative | 0.1676 | 0.214 | 0.3129 |
Trypanosoma brucei | 3-methylcrotonyl-CoA carboxylase alpha subunit, putative | 0.1891 | 0.2653 | 0.183 |
Entamoeba histolytica | acetyl-coA carboxylase, putative | 0.0846 | 0.0156 | 0.049 |
Trypanosoma cruzi | 3-methylcrotonyl-CoA carboxylase, putative | 0.1891 | 0.2653 | 0.479 |
Leishmania major | carboxylase, putative | 0.1891 | 0.2653 | 0.0652 |
Echinococcus granulosus | calcium:calmodulin dependent protein kinase | 0.0804 | 0.0054 | 0.0054 |
Trichomonas vaginalis | AGC family protein kinase | 0.1676 | 0.214 | 1 |
Loa Loa (eye worm) | AUR protein kinase | 0.1676 | 0.214 | 0.1321 |
Schistosoma mansoni | protein kinase | 0.1676 | 0.214 | 0.2097 |
Leishmania major | methylcrotonoyl-coa carboxylase biotinylated subunitprotein-like protein | 0.1891 | 0.2653 | 0.0652 |
Schistosoma mansoni | acetyl-CoA carboxylase | 0.4963 | 1 | 1 |
Trypanosoma brucei | 3-methylcrotonyl-CoA carboxylase alpha subunit, putative | 0.1891 | 0.2653 | 0.183 |
Entamoeba histolytica | protein kinase, putative | 0.1676 | 0.214 | 1 |
Echinococcus granulosus | serine/threonine protein kinase | 0.0804 | 0.0054 | 0.0054 |
Loa Loa (eye worm) | AUR protein kinase | 0.1676 | 0.214 | 0.1321 |
Trypanosoma cruzi | aurora B kinase, putative | 0.1676 | 0.214 | 0.3845 |
Toxoplasma gondii | acetyl-coA carboxylase ACC2 | 0.4963 | 1 | 1 |
Echinococcus granulosus | serine threonine protein kinase nrc | 0.0804 | 0.0054 | 0.0054 |
Echinococcus granulosus | aurora kinase A | 0.1676 | 0.214 | 0.214 |
Entamoeba histolytica | protein kinase, putative | 0.1202 | 0.1006 | 0.4568 |
Schistosoma mansoni | serine/threonine protein kinase | 0.1676 | 0.214 | 0.2097 |
Echinococcus multilocularis | acetyl coenzyme A carboxylase 1 | 0.4963 | 1 | 1 |
Entamoeba histolytica | protein kinase domain containing protein | 0.1676 | 0.214 | 1 |
Echinococcus multilocularis | aurora kinase A | 0.1676 | 0.214 | 0.214 |
Echinococcus multilocularis | propionyl coenzyme A carboxylase alpha chain | 0.1891 | 0.2653 | 0.2653 |
Schistosoma mansoni | pyruvate carboxylase | 0.1891 | 0.2653 | 0.2613 |
Plasmodium falciparum | biotin carboxylase subunit of acetyl CoA carboxylase, putative | 0.3592 | 0.672 | 1 |
Schistosoma mansoni | methylcrotonyl-CoA carboxylase | 0.1891 | 0.2653 | 0.2613 |
Echinococcus multilocularis | rac serine:threonine kinase | 0.0804 | 0.0054 | 0.0054 |
Entamoeba histolytica | protein kinase, putative | 0.1202 | 0.1006 | 0.4568 |
Trypanosoma brucei | aurora B kinase | 0.1676 | 0.214 | 0.126 |
Trichomonas vaginalis | AGC family protein kinase | 0.1676 | 0.214 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.1676 | 0.214 | 1 |
Chlamydia trachomatis | biotin carboxylase | 0.1717 | 0.2237 | 0.5 |
Trypanosoma brucei | acetyl-CoA carboxylase | 0.4963 | 1 | 1 |
Mycobacterium ulcerans | short chain dehydrogenase | 0.365 | 0.6861 | 1 |
Wolbachia endosymbiont of Brugia malayi | Acetyl/propionyl-CoA carboxylase, alpha subunit | 0.1891 | 0.2653 | 0.5 |
Toxoplasma gondii | aurora kinase | 0.1676 | 0.214 | 0.126 |
Entamoeba histolytica | serine/threonine protein kinase 6, putative | 0.1676 | 0.214 | 1 |
Brugia malayi | serine/threonine protein kinase 6 | 0.1676 | 0.214 | 0.1321 |
Echinococcus granulosus | propionyl coenzyme A carboxylase alpha chain | 0.1891 | 0.2653 | 0.2653 |
Trichomonas vaginalis | AGC family protein kinase | 0.1676 | 0.214 | 1 |
Trypanosoma brucei | unspecified product | 0.1243 | 0.1104 | 0.0108 |
Giardia lamblia | Aurora kinase | 0.1676 | 0.214 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.1202 | 0.1006 | 0.4568 |
Mycobacterium leprae | Probable bifunctional protein acetyl-/propionyl-coenzyme A carboxylase, alpha chain AccA3 (BccP) | 0.1891 | 0.2653 | 0.5 |
Echinococcus multilocularis | serine:threonine protein kinase 12 B | 0.1676 | 0.214 | 0.214 |
Schistosoma mansoni | methylcrotonyl-CoA carboxylase | 0.1891 | 0.2653 | 0.2613 |
Echinococcus multilocularis | serine threonine protein kinase nrc serine threonine protein kinase gad | 0.0804 | 0.0054 | 0.0054 |
Trypanosoma cruzi | acetyl-CoA carboxylase | 0.3073 | 0.5479 | 1 |
Plasmodium falciparum | serine/threonine protein kinase, putative | 0.1676 | 0.214 | 0.3129 |
Entamoeba histolytica | serine/threonine- protein kinase 6 , putative | 0.1676 | 0.214 | 1 |
Brugia malayi | serine/threonine kinase 12 | 0.1676 | 0.214 | 0.1321 |
Entamoeba histolytica | serine/threonine- protein kinase 6, putative | 0.1676 | 0.214 | 1 |
Brugia malayi | serine/threonine-protein kinase 6 | 0.1676 | 0.214 | 0.1321 |
Trypanosoma cruzi | 3-methylcrotonyl-CoA carboxylase, putative | 0.1891 | 0.2653 | 0.479 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.