Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | nitric oxide synthase 1 (neuronal) | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | NADPH fad oxidoreductase, putative | 0.0024 | 0.8159 | 0.8159 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0027 | 1 | 1 |
Giardia lamblia | Nitric oxide synthase, inducible | 0.0024 | 0.8159 | 0.5 |
Brugia malayi | FAD binding domain containing protein | 0.0017 | 0.3805 | 0.3805 |
Treponema pallidum | flavodoxin | 0.001 | 0 | 0.5 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0027 | 1 | 1 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.0027 | 1 | 1 |
Entamoeba histolytica | type A flavoprotein, putative | 0.001 | 0 | 0.5 |
Brugia malayi | FAD binding domain containing protein | 0.0027 | 1 | 1 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0013 | 0.1841 | 0.5 |
Chlamydia trachomatis | sulfite reductase | 0.0017 | 0.3805 | 0.5 |
Entamoeba histolytica | type A flavoprotein, putative | 0.001 | 0 | 0.5 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0027 | 1 | 1 |
Leishmania major | p450 reductase, putative | 0.0027 | 1 | 1 |
Entamoeba histolytica | type A flavoprotein, putative | 0.001 | 0 | 0.5 |
Trypanosoma cruzi | p450 reductase, putative | 0.0027 | 1 | 1 |
Entamoeba histolytica | type A flavoprotein, putative | 0.001 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 1 | 1 |
Schistosoma mansoni | cytochrome P450 reductase | 0.0027 | 1 | 1 |
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.0027 | 1 | 1 |
Entamoeba histolytica | type A flavoprotein, putative | 0.001 | 0 | 0.5 |
Plasmodium falciparum | nitric oxide synthase, putative | 0.0027 | 1 | 1 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0017 | 0.3805 | 0.3805 |
Plasmodium vivax | flavodoxin domain containing protein | 0.0024 | 0.8159 | 0.8159 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.0027 | 1 | 1 |
Trypanosoma brucei | NADPH-dependent diflavin oxidoreductase 1 | 0.0027 | 1 | 1 |
Trichomonas vaginalis | sulfite reductase, putative | 0.0027 | 1 | 1 |
Leishmania major | cytochrome P450 reductase, putative | 0.0024 | 0.8159 | 0.8159 |
Giardia lamblia | Hypothetical protein | 0.0024 | 0.8159 | 0.5 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0013 | 0.1841 | 0.5 |
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.0027 | 1 | 0.5 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.0027 | 1 | 1 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.0027 | 1 | 1 |
Trypanosoma brucei | NADPH-cytochrome p450 reductase, putative | 0.0027 | 1 | 1 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.0027 | 1 | 1 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.0027 | 1 | 1 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.0017 | 0.3805 | 0.2407 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0027 | 1 | 1 |
Schistosoma mansoni | NADPH flavin oxidoreductase | 0.0014 | 0.1964 | 0.0151 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0027 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 18.8 uM | Inhibition of human recombinant nNOS expressed in baculovirus infected insect Sf9 cells assessed as conversion of [3H]L-arginine to [3H]L-citrulline incubated for 15 mins prior to substrate addition measured after 45 mins by liquid scintillation counting | ChEMBL. | 22175766 |
IC50 (binding) | = 243 uM | Inhibition of human recombinant eNOS expressed in baculovirus infected insect Sf9 cells assessed as conversion of [3H]L-arginine to [3H]L-citrulline incubated for 15 mins prior to substrate addition measured after 45 mins by liquid scintillation counting | ChEMBL. | 22175766 |
IC50 (binding) | = 481 uM | Inhibition of human recombinant iNOS expressed in baculovirus infected insect Sf9 cells assessed as conversion of [3H]L-arginine to [3H]L-citrulline incubated for 15 mins prior to substrate addition measured after 45 mins by liquid scintillation counting | ChEMBL. | 22175766 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.