Detailed information for compound 1609255

Basic information

Technical information
  • TDR Targets ID: 1609255
  • Name: AIDS-150011
  • MW: 437.378 | Formula: C16H25F6N3O4
  • H donors: 2 H acceptors: 3 LogP: 3.05 Rotable bonds: 16
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(N(CCCNC(=O)C(F)(F)F)CCCCNC(=O)C(F)(F)F)OC(C)(C)C
  • InChi: 1S/C16H25F6N3O4/c1-14(2,3)29-13(28)25(10-6-8-24-12(27)16(20,21)22)9-5-4-7-23-11(26)15(17,18)19/h4-10H2,1-3H3,(H,23,26)(H,24,27)
  • InChiKey: HEKUJOZWBBJHNW-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • AIDS150011
  • N-[4-[(2,2,2-trifluoro-1-oxoethyl)amino]butyl]-N-[3-[(2,2,2-trifluoro-1-oxoethyl)amino]propyl]carbamic acid tert-butyl ester
  • N-[4-[(2,2,2-trifluoroacetyl)amino]butyl]-N-[3-[(2,2,2-trifluoroacetyl)amino]propyl]carbamic acid tert-butyl ester
  • NCI60_030942
  • NSC685960
  • tert-butyl N-[4-[(2,2,2-trifluoroacetyl)amino]butyl]-N-[3-[(2,2,2-trifluoroacetyl)amino]propyl]carbamate
  • tert-butyl N-[4-(2,2,2-trifluoroethanoylamino)butyl]-N-[3-(2,2,2-trifluoroethanoylamino)propyl]carbamate
  • tert-Butyl 4-((trifluoroacetyl)amino)butyl(3-((trifluoroacetyl)amino)propyl)carbamate

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) RNA binding protein 0.0202 0.2807 0.4391
Onchocerca volvulus 0.003 0.0114 0.0429
Leishmania major hypothetical protein, conserved 0.0035 0.0195 0.3894
Brugia malayi beta-lactamase 0.0035 0.0195 0.0304
Echinococcus multilocularis PH interacting protein 0.003 0.0114 0.0089
Loa Loa (eye worm) hypothetical protein 0.0034 0.0171 0.0267
Onchocerca volvulus 0.0054 0.0492 0.1848
Loa Loa (eye worm) hypothetical protein 0.0025 0.0035 0.0055
Brugia malayi intermediate filament protein 0.0054 0.0492 0.077
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0195 0.061
Echinococcus granulosus peregrin 0.003 0.0114 0.0089
Trichomonas vaginalis histone acetyltransferase gcn5, putative 0.0193 0.2664 0.4061
Brugia malayi Bromodomain containing protein 0.003 0.0114 0.0179
Entamoeba histolytica bromodomain-containing protein 0.0193 0.2664 1
Loa Loa (eye worm) hypothetical protein 0.0431 0.6393 1
Brugia malayi cytoplasmic intermediate filament protein 0.0029 0.0096 0.015
Onchocerca volvulus 0.0097 0.1155 0.4337
Echinococcus granulosus bromodomain containing protein 8 0.003 0.0114 0.0089
Echinococcus multilocularis lamin dm0 0.0054 0.0492 0.0469
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0194 0.017
Brugia malayi ATPase, AAA family protein 0.003 0.0114 0.0179
Onchocerca volvulus 0.003 0.0114 0.0429
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0194 0.0266
Trichomonas vaginalis bromodomain-containing protein, putative 0.0268 0.3844 0.5939
Echinococcus multilocularis tar DNA binding protein 0.0202 0.2807 0.2789
Trichomonas vaginalis conserved hypothetical protein 0.0268 0.3844 0.5939
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0195 0.061
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0417 0.0652
Brugia malayi Bromodomain containing protein 0.003 0.0114 0.0179
Leishmania major hypothetical protein, conserved 0.0055 0.05 1
Echinococcus multilocularis protein kinase C binding protein 1 0.003 0.0114 0.0089
Brugia malayi Bromodomain containing protein 0.003 0.0114 0.0179
Brugia malayi RNA binding protein 0.0202 0.2807 0.4391
Echinococcus granulosus PH interacting protein 0.003 0.0114 0.0089
Brugia malayi TAR-binding protein 0.0202 0.2807 0.4391
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0195 0.2085
Loa Loa (eye worm) CBP-B 0.01 0.1206 0.1887
Trichomonas vaginalis bromodomain-containing protein, putative 0.0431 0.6393 1
Mycobacterium ulcerans beta-lactamase 0.0035 0.0195 1
Brugia malayi Bromodomain containing protein 0.003 0.0114 0.0179
Schistosoma mansoni CREB-binding protein 1 (SmCBP1) 0.0131 0.1699 0.2629
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0195 0.061
Brugia malayi Bromodomain containing protein 0.003 0.0114 0.0179
Echinococcus multilocularis peregrin 0.003 0.0114 0.0089
Loa Loa (eye worm) hypothetical protein 0.003 0.0114 0.0179
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0054 0.0492 0.077
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0417 0.0652
Trichomonas vaginalis bromodomain-containing protein, putative 0.0193 0.2664 0.4061
Loa Loa (eye worm) MH2 domain-containing protein 0.0239 0.3388 0.5299
Brugia malayi Bromodomain containing protein 0.003 0.0114 0.0179
Brugia malayi polybromodomain protein 0.003 0.0114 0.0179
Loa Loa (eye worm) hypothetical protein 0.003 0.0114 0.0179
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0195 0.061
Trichomonas vaginalis bromodomain-containing protein, putative 0.0193 0.2664 0.4061
Leishmania major hypothetical protein, conserved 0.003 0.0114 0.2285
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0195 1
Mycobacterium ulcerans lipase LipD 0.0035 0.0195 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0195 0.0304
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0195 0.2085
Schistosoma mansoni tar DNA-binding protein 0.0202 0.2807 0.4369
Onchocerca volvulus 0.0193 0.2664 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0055 0.05 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0055 0.05 1
Trichomonas vaginalis bromodomain-containing protein, putative 0.0193 0.2664 0.4061
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0195 1
Echinococcus granulosus ATPase family AAA domain containing protein 2B 0.003 0.0114 0.0089
Brugia malayi hypothetical protein 0.0055 0.05 0.0782
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0195 0.061
Entamoeba histolytica bromodomain-containing protein 0.003 0.0114 0.0429
Echinococcus granulosus histone acetyltransferase KAT2B 0.003 0.0114 0.0089
Loa Loa (eye worm) hypothetical protein 0.003 0.0114 0.0179
Brugia malayi Bromodomain containing protein 0.0431 0.6393 1
Trichomonas vaginalis bromodomain-containing protein, putative 0.0193 0.2664 0.4061
Trichomonas vaginalis conserved hypothetical protein 0.0238 0.3368 0.5182
Trichomonas vaginalis bromodomain containing protein, putative 0.0193 0.2664 0.4061
Trichomonas vaginalis bromodomain-containing protein, putative 0.0268 0.3844 0.5939
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0195 0.0304
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0195 0.061
Trichomonas vaginalis bromodomain-containing protein, putative 0.0193 0.2664 0.4061
Echinococcus multilocularis global transcription activator snf2l2 0.003 0.0114 0.0089
Echinococcus multilocularis Bromodomain containing protein 0.0193 0.2664 0.2646
Loa Loa (eye worm) hypothetical protein 0.0097 0.1155 0.1807
Schistosoma mansoni bromodomain containing 0.003 0.0114 0.014
Brugia malayi hypothetical protein 0.0163 0.2189 0.3423
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0195 0.0128
Brugia malayi beta-lactamase family protein 0.0035 0.0195 0.0304
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0195 0.017
Schistosoma mansoni hypothetical protein 0.003 0.0114 0.014
Loa Loa (eye worm) hypothetical protein 0.003 0.0114 0.0179
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0195 0.061
Brugia malayi hypothetical protein 0.0035 0.0194 0.0304
Echinococcus multilocularis polybromo 1 0.003 0.0114 0.0089
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0026 0.0051 0.0026
Loa Loa (eye worm) hypothetical protein 0.003 0.0114 0.0179
Onchocerca volvulus 0.0035 0.0195 0.0731
Trichomonas vaginalis bromodomain-containing protein, putative 0.0193 0.2664 0.4061
Brugia malayi polybromodomain protein 0.003 0.0114 0.0179
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0195 0.0128
Schistosoma mansoni tar DNA-binding protein 0.0202 0.2807 0.4369
Leishmania major DNA-binding protein, putative,predicted bromodomain protein 0.003 0.0114 0.2285
Onchocerca volvulus 0.0054 0.0492 0.1848
Brugia malayi bromodomain containing protein 0.003 0.0114 0.0179
Schistosoma mansoni polybromo-1 0.003 0.0114 0.014
Schistosoma mansoni cellular tumor antigen P53 0.0097 0.1155 0.1775
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.003 0.0114 0.0089
Echinococcus granulosus lamin dm0 0.0054 0.0492 0.0469
Trichomonas vaginalis bromodomain-containing protein, putative 0.0193 0.2664 0.4061
Schistosoma mansoni transcription initiation factor tfiid 0.003 0.0114 0.014
Schistosoma mansoni zinc finger protein 0.003 0.0114 0.014
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0226 0.3189 1
Loa Loa (eye worm) BRM protein 0.003 0.0114 0.0179
Echinococcus multilocularis tumor protein p63 0.066 1 1
Loa Loa (eye worm) beta-lactamase 0.0035 0.0195 0.0304
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0194 0.017
Echinococcus multilocularis 0.003 0.0114 0.0089
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0026 0.0051 0.0026
Onchocerca volvulus 0.0035 0.0195 0.0731
Loa Loa (eye worm) hypothetical protein 0.003 0.0114 0.0179
Brugia malayi hypothetical protein 0.0035 0.0195 0.0305
Mycobacterium ulcerans hypothetical protein 0.0035 0.0195 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0195 0.0304
Trichomonas vaginalis conserved hypothetical protein 0.0193 0.2664 0.4061
Onchocerca volvulus 0.0035 0.0195 0.0731
Loa Loa (eye worm) hypothetical protein 0.003 0.0114 0.0179
Leishmania major hypothetical protein, conserved,predicted bromodomain protein 0.003 0.0114 0.2285
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.003 0.0114 0.014
Schistosoma mansoni hypothetical protein 0.003 0.0114 0.014
Brugia malayi RNA recognition motif domain containing protein 0.0202 0.2807 0.4391
Echinococcus multilocularis bromodomain containing protein 8 0.003 0.0114 0.0089
Mycobacterium tuberculosis Conserved protein 0.0035 0.0195 0.061
Schistosoma mansoni tar DNA-binding protein 0.0202 0.2807 0.4369
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0195 0.0128
Loa Loa (eye worm) bromodomain containing protein 0.0193 0.2664 0.4167
Brugia malayi acetyltransferase, GNAT family protein 0.003 0.0114 0.0179
Echinococcus granulosus Bromodomain containing protein 0.003 0.0114 0.0089
Loa Loa (eye worm) hypothetical protein 0.0035 0.0195 0.0304
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0195 0.0128
Loa Loa (eye worm) hypothetical protein 0.0055 0.05 0.0782
Loa Loa (eye worm) intermediate filament protein 0.0054 0.0492 0.077
Schistosoma mansoni hypothetical protein 0.0034 0.0171 0.0229
Loa Loa (eye worm) transcription factor SMAD2 0.0239 0.3388 0.5299
Schistosoma mansoni bromodomain containing protein 0.003 0.0114 0.014
Brugia malayi BRM protein 0.003 0.0114 0.0179
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0195 0.2085
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.003 0.0114 0.0089
Brugia malayi MH2 domain containing protein 0.0239 0.3388 0.5299
Echinococcus granulosus lamin 0.0054 0.0492 0.0469
Leishmania major hypothetical protein, conserved 0.003 0.0114 0.2285
Loa Loa (eye worm) hypothetical protein 0.003 0.0114 0.0179
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0195 0.0266
Entamoeba histolytica bromodomain-containing protein 0.003 0.0114 0.0429
Trichomonas vaginalis bromodomain-containing protein, putative 0.0193 0.2664 0.4061
Brugia malayi beta-lactamase family protein 0.0035 0.0195 0.0304
Schistosoma mansoni CREB-binding protein 2 0.0131 0.1699 0.2629
Entamoeba histolytica hypothetical protein 0.0035 0.0194 0.0729
Echinococcus multilocularis musashi 0.0054 0.0492 0.0469
Echinococcus granulosus global transcription activator snf2l2 0.003 0.0114 0.0089
Trichomonas vaginalis bromodomain-containing protein, putative 0.0193 0.2664 0.4061
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0195 1
Echinococcus granulosus zinc finger protein 0.003 0.0114 0.0089
Echinococcus granulosus protein kinase C binding protein 1 0.003 0.0114 0.0089
Trichomonas vaginalis bromodomain-containing protein, putative 0.0431 0.6393 1
Trichomonas vaginalis bromodomain-containing protein, putative 0.0193 0.2664 0.4061
Loa Loa (eye worm) TAR-binding protein 0.0202 0.2807 0.4391
Echinococcus multilocularis bromodomain containing 2 0.0431 0.6393 0.6384
Trichomonas vaginalis bromodomain-containing protein, putative 0.0193 0.2664 0.4061
Echinococcus granulosus CREB binding protein 0.0092 0.1081 0.1059
Schistosoma mansoni bromodomain-containing protein 3 brd3 0.0431 0.6393 1
Echinococcus multilocularis zinc finger protein 0.003 0.0114 0.0089
Echinococcus multilocularis CREB binding protein 0.0099 0.1192 0.117
Schistosoma mansoni helicase 0.003 0.0114 0.014
Trichomonas vaginalis bromodomain-containing protein, putative 0.0193 0.2664 0.4061
Toxoplasma gondii bromodomain-containing protein 0.0193 0.2664 1
Entamoeba histolytica hypothetical protein 0.0035 0.0194 0.0729
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.003 0.0114 0.0089
Trichomonas vaginalis bromodomain-containing protein, putative 0.0268 0.3844 0.5939
Loa Loa (eye worm) hypothetical protein 0.0035 0.0195 0.0304
Loa Loa (eye worm) acetyltransferase 0.003 0.0114 0.0179
Loa Loa (eye worm) hypothetical protein 0.0048 0.0396 0.062
Schistosoma mansoni tar DNA-binding protein 0.0202 0.2807 0.4369
Trypanosoma cruzi PAB1-binding protein , putative 0.0055 0.05 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0195 0.0304
Echinococcus granulosus polybromo 1 0.003 0.0114 0.0089
Schistosoma mansoni bromodomain containing protein 0.003 0.0114 0.014
Trichomonas vaginalis bromodomain-containing protein, putative 0.0193 0.2664 0.4061
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0195 0.0128
Entamoeba histolytica hypothetical protein 0.0035 0.0194 0.0729
Schistosoma mansoni hypothetical protein 0.003 0.0114 0.014
Trichomonas vaginalis bromodomain-containing protein 4, brd4, putative 0.0193 0.2664 0.4061
Entamoeba histolytica ankyrin repeat protein, putative 0.003 0.0114 0.0429
Echinococcus granulosus tar DNA binding protein 0.0202 0.2807 0.2789
Schistosoma mansoni tar DNA-binding protein 0.0202 0.2807 0.4369
Loa Loa (eye worm) hypothetical protein 0.003 0.0114 0.0179
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0171 0.0267
Toxoplasma gondii ABC1 family protein 0.0035 0.0195 0.0315
Onchocerca volvulus Brd8 homolog 0.003 0.0114 0.0429
Echinococcus multilocularis ATPase family AAA domain containing protein 2B 0.003 0.0114 0.0089
Entamoeba histolytica bromodomain-containing protein 0.0193 0.2664 1
Onchocerca volvulus Bromodomain adjacent to zinc finger domain protein 1A homolog 0.003 0.0114 0.0429
Mycobacterium tuberculosis Conserved protein 0.0035 0.0195 0.061
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0195 0.0304
Trichomonas vaginalis esterase, putative 0.0035 0.0195 0.0128
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0202 0.2807 0.4391
Schistosoma mansoni intermediate filament proteins 0.0054 0.0492 0.0734
Echinococcus granulosus bromodomain containing 2 0.0431 0.6393 0.6384
Brugia malayi Bromodomain containing protein 0.003 0.0114 0.0179
Echinococcus multilocularis lamin 0.0054 0.0492 0.0469
Echinococcus granulosus Bromodomain containing protein 0.003 0.0114 0.0089
Trichomonas vaginalis bromodomain containing protein, putative 0.0268 0.3844 0.5939
Brugia malayi Bromodomain containing protein 0.0431 0.6393 1
Trichomonas vaginalis bromodomain-containing protein, putative 0.0193 0.2664 0.4061
Schistosoma mansoni hypothetical protein 0.003 0.0114 0.014
Entamoeba histolytica bromodomain-containing protein 0.0193 0.2664 1
Echinococcus granulosus CREB binding protein 0.0131 0.1699 0.1678
Schistosoma mansoni lamin 0.0054 0.0492 0.0734
Schistosoma mansoni phd finger protein 0.003 0.0114 0.014
Brugia malayi TAZ zinc finger family protein 0.0131 0.1699 0.2658
Echinococcus granulosus transcription initiation factor TFIID subunit 1 0.003 0.0114 0.0089
Trichomonas vaginalis bromodomain-containing protein, putative 0.0193 0.2664 0.4061
Schistosoma mansoni lamin 0.0054 0.0492 0.0734
Toxoplasma gondii LsmAD domain-containing protein 0.0055 0.05 0.1512
Plasmodium vivax ataxin-2 like protein, putative 0.0055 0.05 1
Trichomonas vaginalis bromodomain-containing protein, putative 0.0193 0.2664 0.4061
Brugia malayi Bromodomain containing protein 0.003 0.0114 0.0179
Echinococcus multilocularis Bromodomain containing protein 0.003 0.0114 0.0089
Trichomonas vaginalis bromodomain-containing protein, putative 0.0193 0.2664 0.4061
Loa Loa (eye worm) hypothetical protein 0.0026 0.0051 0.0079
Loa Loa (eye worm) hypothetical protein 0.0054 0.0492 0.077
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0417 0.0652
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0195 0.0266
Giardia lamblia Kinase, putative 0.0193 0.2664 1
Entamoeba histolytica hypothetical protein 0.003 0.0114 0.0429
Brugia malayi Intermediate filament tail domain containing protein 0.0054 0.0492 0.077
Trypanosoma brucei PAB1-binding protein , putative 0.0055 0.05 1
Trichomonas vaginalis bromodomain-containing protein, putative 0.0193 0.2664 0.4061
Loa Loa (eye worm) bromodomain containing protein 0.003 0.0114 0.0179
Mycobacterium leprae Probable lipase LipE 0.0035 0.0195 1
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0195 0.017
Echinococcus granulosus intermediate filament protein 0.0054 0.0492 0.0469
Brugia malayi PHD-finger family protein 0.003 0.0114 0.0179
Trichomonas vaginalis bromodomain-containing protein, putative 0.0193 0.2664 0.4061
Loa Loa (eye worm) hypothetical protein 0.0025 0.0035 0.0055
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0029 0.0096 0.015
Entamoeba histolytica hypothetical protein 0.0035 0.0194 0.0729
Mycobacterium tuberculosis Conserved protein 0.0035 0.0195 0.061
Plasmodium falciparum ataxin-2 like protein, putative 0.0055 0.05 1
Entamoeba histolytica bromodomain-containing protein 0.003 0.0114 0.0429
Loa Loa (eye worm) hypothetical protein 0.0053 0.0477 0.0746
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0195 0.2085
Schistosoma mansoni hypothetical protein 0.0035 0.0194 0.0266
Schistosoma mansoni bromodomain containing protein 0.003 0.0114 0.014
Loa Loa (eye worm) hypothetical protein 0.005 0.0417 0.0652
Loa Loa (eye worm) hypothetical protein 0.0035 0.0195 0.0304
Loa Loa (eye worm) hypothetical protein 0.003 0.0114 0.0179

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -4.058 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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