Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Methionine aminopeptidase MapB (map) (peptidase M) | 0.0224 | 0.8442 | 0.5 |
Trypanosoma cruzi | metallo- peptidase, Clan MG, Family M24 | 0.0256 | 1 | 0.5 |
Plasmodium vivax | methionine aminopeptidase 1b, putative | 0.0256 | 1 | 1 |
Plasmodium falciparum | methionine aminopeptidase 1b, putative | 0.0256 | 1 | 1 |
Treponema pallidum | methionine aminopeptidase (map) | 0.0224 | 0.8442 | 0.5 |
Mycobacterium ulcerans | methionine aminopeptidase | 0.0224 | 0.8442 | 0.5 |
Mycobacterium leprae | PROBABLE METHIONINE AMINOPEPTIDASE MAPB (MAP) (PEPTIDASE M) | 0.0224 | 0.8442 | 0.5 |
Loa Loa (eye worm) | glutamate receptor | 0.0128 | 0.3782 | 0.3782 |
Echinococcus granulosus | metabotropic glutamate receptor 5 | 0.0158 | 0.5223 | 0.3393 |
Schistosoma mansoni | methionyl aminopeptidase 1 (M24 family) | 0.0224 | 0.8442 | 1 |
Wolbachia endosymbiont of Brugia malayi | methionine aminopeptidase | 0.0224 | 0.8442 | 0.5 |
Mycobacterium tuberculosis | Methionine aminopeptidase MapA (map) (peptidase M) (MetAP) | 0.0224 | 0.8442 | 0.5 |
Loa Loa (eye worm) | methionine aminopeptidase type I | 0.0256 | 1 | 1 |
Trypanosoma brucei | metallo- peptidase, Clan MG, Family M24 | 0.0256 | 1 | 0.5 |
Brugia malayi | metabotropic glutamate receptor subtype 5a (mGluR5a), putative | 0.0116 | 0.3196 | 0.2772 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0107 | 0.277 | 0.278 |
Mycobacterium ulcerans | methionine aminopeptidase MapB | 0.0224 | 0.8442 | 0.5 |
Chlamydia trachomatis | methionine aminopeptidase | 0.0224 | 0.8442 | 0.5 |
Trypanosoma brucei | methionine aminopeptidase, putative | 0.0256 | 1 | 0.5 |
Brugia malayi | Metabotropic glutamate receptor precursor. | 0.0128 | 0.3782 | 0.3395 |
Echinococcus multilocularis | methionyl aminopeptidase 1 (M24 family) | 0.0256 | 1 | 1 |
Trypanosoma brucei | methionine aminopeptidase, type I, putative | 0.0256 | 1 | 0.5 |
Toxoplasma gondii | methionine aminopeptidase | 0.0256 | 1 | 1 |
Echinococcus multilocularis | methionyl aminopeptidase 1 (M24 family) | 0.0224 | 0.8442 | 0.7845 |
Echinococcus granulosus | methionyl aminopeptidase 1 M24 family | 0.0256 | 1 | 1 |
Mycobacterium leprae | PROBABLE METHIONINE AMINOPEPTIDASE MAPA (MAP) (PEPTIDASE M) (MetAP) | 0.0224 | 0.8442 | 0.5 |
Trypanosoma cruzi | metallo- peptidase, Clan MG, Family M24 | 0.0256 | 1 | 0.5 |
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.0146 | 0.4637 | 0.5156 |
Leishmania major | methionine aminopeptidase, putative,metallo-peptidase, Clan MG, Family M24 | 0.0256 | 1 | 0.5 |
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 0.0158 | 0.5223 | 0.3393 |
Schistosoma mansoni | methionyl aminopeptidase 1 (M24 family) | 0.0224 | 0.8442 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0158 | 0.5223 | 0.5223 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 25.1189 uM | PubChem BioAssay. qHTS for Inhibitors of Vif-A3G Interactions: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.