Detailed information for compound 1609630

Basic information

Technical information
  • TDR Targets ID: 1609630
  • Name: N'-(2H-pyrazol-3-yl)-N-(3,4,5-trimethoxypheny l)-1,3,5-triazine-2,4-diamine
  • MW: 343.341 | Formula: C15H17N7O3
  • H donors: 3 H acceptors: 4 LogP: 2.26 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(Nc2ncnc(n2)Nc2n[nH]cc2)cc(c1OC)OC
  • InChi: 1S/C15H17N7O3/c1-23-10-6-9(7-11(24-2)13(10)25-3)19-14-16-8-17-15(21-14)20-12-4-5-18-22-12/h4-8H,1-3H3,(H3,16,17,18,19,20,21,22)
  • InChiKey: BFENEDRNBGYKMO-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • [4-(2H-pyrazol-3-ylamino)-s-triazin-2-yl]-(3,4,5-trimethoxyphenyl)amine

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens aurora kinase B Starlite/ChEMBL No references
Homo sapiens kinase insert domain receptor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Neospora caninum hypothetical protein Get druggable targets OG5_127024 All targets in OG5_127024
Trypanosoma congolense aurora B kinase Get druggable targets OG5_127024 All targets in OG5_127024
Brugia malayi Immunoglobulin I-set domain containing protein Get druggable targets OG5_130320 All targets in OG5_130320
Loa Loa (eye worm) TK/KIN16 protein kinase Get druggable targets OG5_130320 All targets in OG5_130320
Plasmodium knowlesi serine/threonine protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Leishmania donovani Aurora I-related kinase Get druggable targets OG5_127024 All targets in OG5_127024
Trypanosoma cruzi aurora B kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Schistosoma japonicum Serine/threonine-protein kinase 12, putative Get druggable targets OG5_127024 All targets in OG5_127024
Cryptosporidium hominis protein kinase (EC 2.7.1.-) p46XlEg22 Get druggable targets OG5_127024 All targets in OG5_127024
Onchocerca volvulus Tyrosine kinase homolog Get druggable targets OG5_130320 All targets in OG5_130320
Loa Loa (eye worm) AUR protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Entamoeba histolytica serine/threonine protein kinase 6, putative Get druggable targets OG5_127024 All targets in OG5_127024
Leishmania braziliensis protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Entamoeba histolytica protein kinase , putative Get druggable targets OG5_127024 All targets in OG5_127024
Trypanosoma brucei aurora B kinase Get druggable targets OG5_127024 All targets in OG5_127024
Schistosoma mansoni protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Candida albicans likely protein kinase similar to S. cerevisiae IPL1 (YPL209C) Aurora protein kinase involved in regulating kinetochore-microtubu Get druggable targets OG5_127024 All targets in OG5_127024
Loa Loa (eye worm) AUR protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus multilocularis serine:threonine protein kinase 12 B Get druggable targets OG5_127024 All targets in OG5_127024
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Entamoeba histolytica serine/threonine- protein kinase 6, putative Get druggable targets OG5_127024 All targets in OG5_127024
Leishmania major protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_127024 All targets in OG5_127024
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Plasmodium falciparum serine/threonine protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Leishmania mexicana protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Loa Loa (eye worm) AUR protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Entamoeba histolytica serine/threonine- protein kinase 6 , putative Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus granulosus serine:threonine protein kinase 12 B Get druggable targets OG5_127024 All targets in OG5_127024
Plasmodium berghei serine/threonine protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Plasmodium yoelii Protein kinase domain, putative Get druggable targets OG5_127024 All targets in OG5_127024
Plasmodium vivax serine/threonine protein kinase 6, putative Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus multilocularis aurora kinase A Get druggable targets OG5_127024 All targets in OG5_127024
Toxoplasma gondii aurora kinase Get druggable targets OG5_127024 All targets in OG5_127024
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus granulosus aurora kinase A Get druggable targets OG5_127024 All targets in OG5_127024
Schistosoma japonicum ko:K08850 aurora kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Trypanosoma brucei gambiense protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Giardia lamblia Aurora kinase Get druggable targets OG5_127024 All targets in OG5_127024
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Brugia malayi serine/threonine protein kinase 6 Get druggable targets OG5_127024 All targets in OG5_127024
Candida albicans likely protein kinase similar to S. cerevisiae IPL1 (YPL209C) Aurora protein kinase involved in regulating kinetochore-microtubu Get druggable targets OG5_127024 All targets in OG5_127024
Cryptosporidium parvum protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Brugia malayi serine/threonine kinase 12 Get druggable targets OG5_127024 All targets in OG5_127024
Plasmodium yoelii putative protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Onchocerca volvulus Get druggable targets OG5_130320 All targets in OG5_130320
Brugia malayi serine/threonine-protein kinase 6 Get druggable targets OG5_127024 All targets in OG5_127024
Leishmania infantum protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei mitogen-activated protein kinase 5 aurora kinase B 303 aa 299 aa 22.1 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus GPCR family 3 C terminal 0.0022 0.0389 0.0389
Echinococcus granulosus C2 calcium dependent membrane targeting 0.0033 0.0852 0.0852
Onchocerca volvulus 0.0167 0.6493 0.9754
Loa Loa (eye worm) raf kinase 0.0027 0.0614 0.0756
Brugia malayi RhoGEF domain containing protein 0.0027 0.0614 0.073
Loa Loa (eye worm) AUR protein kinase 0.0069 0.2372 0.2924
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0166 0.648 0.648
Schistosoma mansoni serine/threonine protein kinase 0.0039 0.1113 0.1113
Echinococcus granulosus raf serine:threonine protein kinase 0.0028 0.0657 0.0657
Brugia malayi Protein kinase domain containing protein 0.0039 0.1113 0.1324
Echinococcus granulosus N chimaerin 0.0027 0.0614 0.0614
Brugia malayi p70 ribosomal S6 kinase beta 0.0039 0.1113 0.1324
Echinococcus granulosus Rac GTPase activating protein 1 0.0027 0.0614 0.0614
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0069 0.2372 0.5
Schistosoma mansoni metabotropic glutamate receptor 0.0113 0.4238 0.4238
Trichomonas vaginalis AGC family protein kinase 0.0039 0.1113 0.0444
Echinococcus multilocularis protein kinase c iota type 0.0066 0.2263 0.2263
Echinococcus multilocularis protein kinase c epsilon type 0.0072 0.2501 0.2501
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0072 0.2501 0.3084
Schistosoma mansoni protein kinase 0.0014 0.0043 0.0043
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0027 0.0614 0.0614
Loa Loa (eye worm) hypothetical protein 0.0033 0.0852 0.1051
Brugia malayi Hr1 repeat family protein 0.0039 0.1113 0.1324
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0029 0.0672 0.0829
Trichomonas vaginalis AGC family protein kinase 0.0039 0.1113 0.0444
Loa Loa (eye worm) hypothetical protein 0.0205 0.8112 1
Loa Loa (eye worm) AUR protein kinase 0.0069 0.2372 0.2924
Plasmodium falciparum serine/threonine protein kinase, putative 0.0069 0.2372 0.5
Echinococcus multilocularis Rac GTPase activating protein 1 0.0027 0.0614 0.0614
Entamoeba histolytica protein kinase, putative 0.0039 0.1113 0.4693
Echinococcus granulosus neuroglian 0.0014 0.0059 0.0059
Brugia malayi Protein kinase c protein 2 0.0212 0.8409 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0614 0.0756
Echinococcus multilocularis neuroglian 0.0014 0.0059 0.0059
Loa Loa (eye worm) hypothetical protein 0.0027 0.0614 0.0756
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0069 0.2372 0.2372
Trichomonas vaginalis AGC family protein kinase 0.0069 0.2372 1
Schistosoma mansoni protein kinase C 0.0033 0.0852 0.0852
Loa Loa (eye worm) hypothetical protein 0.0027 0.0614 0.0756
Echinococcus granulosus tyrosine kinase 0.0014 0.0043 0.0043
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0039 0.1113 0.1113
Echinococcus multilocularis receptor type guanylyl cyclase 0.0014 0.0043 0.0043
Loa Loa (eye worm) RGC/RGC protein kinase 0.0014 0.0043 0.0053
Echinococcus multilocularis raf serine:threonine protein kinase 0.0028 0.0657 0.0657
Schistosoma mansoni serine/threonine kinase 0.0039 0.1113 0.1113
Entamoeba histolytica protein kinase, putative 0.0069 0.2372 1
Trichomonas vaginalis AGC family protein kinase 0.0039 0.1113 0.0444
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.0029 0.0672 0.0672
Echinococcus granulosus serine:threonine protein kinase N2 0.0039 0.1113 0.1113
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0039 0.1113 0.1372
Loa Loa (eye worm) hypothetical protein 0.0027 0.0614 0.0756
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0113 0.4238 0.4238
Loa Loa (eye worm) AGC/NDR protein kinase 0.0039 0.1113 0.1372
Entamoeba histolytica protein kinase , putative 0.0069 0.2372 1
Echinococcus granulosus Diacylglycerol kinase theta 0.0027 0.0614 0.0614
Brugia malayi metabotropic glutamate receptor type 2 0.0066 0.2242 0.2666
Echinococcus multilocularis serine:threonine protein kinase N2 0.0039 0.1113 0.1113
Schistosoma mansoni protein kinase 0.0069 0.2372 0.2372
Brugia malayi serine/threonine protein kinase 6 0.0069 0.2372 0.2821
Echinococcus multilocularis C2 calcium dependent membrane targeting 0.0033 0.0852 0.0852
Brugia malayi C1-like domain containing protein 0.0029 0.0672 0.0799
Trichomonas vaginalis AGC family protein kinase 0.0039 0.1113 0.0444
Entamoeba histolytica protein kinase, putative 0.0039 0.1113 0.4693
Brugia malayi RhoGAP domain containing protein 0.0027 0.0614 0.073
Echinococcus granulosus protein kinase c iota type 0.0066 0.2263 0.2263
Schistosoma mansoni serine/threonine protein kinase 0.0039 0.1113 0.1113
Schistosoma mansoni serine/threonine protein kinase 0.0072 0.2501 0.2501
Schistosoma mansoni unc-13 (munc13) 0.0033 0.0852 0.0852
Loa Loa (eye worm) hypothetical protein 0.0178 0.6963 0.8583
Trypanosoma cruzi aurora B kinase, putative 0.0069 0.2372 1
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.0035 0.0925 0.114
Schistosoma mansoni diacylglycerol kinase theta 0.0027 0.0614 0.0614
Loa Loa (eye worm) hypothetical protein 0.0018 0.0213 0.0263
Loa Loa (eye worm) hypothetical protein 0.0014 0.0043 0.0053
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0027 0.0614 0.0756
Schistosoma mansoni serine/threonine protein kinase 0.0069 0.2372 0.2372
Schistosoma mansoni rac gtpase activating protein 0.0027 0.0614 0.0614
Echinococcus multilocularis serine:threonine protein kinase N2 0.0039 0.1113 0.1113
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0069 0.2372 1
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0027 0.0614 0.0756
Toxoplasma gondii AGC kinase 0.0039 0.1113 0.2842
Onchocerca volvulus 0.0033 0.0852 0.128
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative 0.0122 0.4627 0.5502
Echinococcus multilocularis serine threonine protein kinase 0.0223 0.8851 0.8851
Echinococcus multilocularis Diacylglycerol kinase theta 0.0027 0.0614 0.0614
Trichomonas vaginalis AGC family protein kinase 0.0039 0.1113 0.0444
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0039 0.1113 0.1113
Schistosoma mansoni diacylglycerol kinase theta 0.0027 0.0614 0.0614
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.0185 0.726 0.895
Schistosoma mansoni hypothetical protein 0.0022 0.0389 0.0389
Onchocerca volvulus 0.0027 0.0614 0.0922
Echinococcus multilocularis GPCR, family 3, C terminal 0.0022 0.0389 0.0389
Brugia malayi Ras association domain family 1 isoform A 0.0027 0.0614 0.073
Entamoeba histolytica protein kinase, putative 0.0069 0.2372 1
Brugia malayi Variant SH3 domain containing protein 0.0027 0.0614 0.073
Entamoeba histolytica protein kinase, putative 0.0039 0.1113 0.4693
Echinococcus multilocularis roundabout 2 0.0018 0.0213 0.0213
Trypanosoma brucei aurora B kinase 0.0069 0.2372 1
Entamoeba histolytica hypothetical protein 0.0027 0.0614 0.2587
Loa Loa (eye worm) AGC/PKC/IOTA protein kinase 0.0029 0.0672 0.0829
Schistosoma mansoni serine/threonine protein kinase 0.0039 0.1113 0.1113
Echinococcus multilocularis myotubularin protein 13 0.0027 0.0614 0.0614
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.0178 0.6963 0.6963
Loa Loa (eye worm) hypothetical protein 0.0022 0.0389 0.048
Echinococcus granulosus aurora kinase A 0.0069 0.2372 0.2372
Loa Loa (eye worm) hypothetical protein 0.0027 0.0614 0.0756
Trichomonas vaginalis AGC family protein kinase 0.0069 0.2372 1
Schistosoma mansoni metabotropic glutamate receptor 0.0066 0.2242 0.2242
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0039 0.1113 0.1372
Echinococcus granulosus twitchin 0.0015 0.0118 0.0118
Echinococcus multilocularis RNA directed DNA polymerase 0.0178 0.6963 0.6963
Loa Loa (eye worm) hypothetical protein 0.0015 0.0092 0.0114
Schistosoma mansoni hypothetical protein 0.0027 0.0614 0.0614
Onchocerca volvulus 0.0027 0.0614 0.0922
Entamoeba histolytica protein kinase domain containing protein 0.0069 0.2372 1
Echinococcus granulosus metabotropic glutamate receptor 2 0.0113 0.4238 0.4238
Echinococcus granulosus protein kinase c epsilon type 0.0072 0.2501 0.2501
Echinococcus granulosus myotubularin protein 13 0.0027 0.0614 0.0614
Toxoplasma gondii aurora kinase 0.0069 0.2372 1
Brugia malayi Guanylyl cyclase protein 23 0.0014 0.0043 0.0051
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0027 0.0614 0.0614
Echinococcus multilocularis tyrosine kinase 0.0014 0.0043 0.0043
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.0014 0.0043 0.0065
Loa Loa (eye worm) RGC/RGC protein kinase 0.0014 0.0043 0.0053
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0039 0.1113 0.1113
Schistosoma mansoni tyrosine kinase 0.0014 0.0043 0.0043
Loa Loa (eye worm) hypothetical protein 0.0027 0.0614 0.0756
Brugia malayi Metabotropic glutamate receptor precursor. 0.0135 0.5163 0.6139
Schistosoma mansoni serine/threonine protein kinase 0.0029 0.0672 0.0672
Schistosoma mansoni nephrin 0.0014 0.0059 0.0059
Brugia malayi Pleckstrin Homology Domain 0.0027 0.0614 0.073
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0027 0.0614 0.0614
Loa Loa (eye worm) AGC/AKT protein kinase 0.0039 0.1113 0.1372
Trichomonas vaginalis AGC family protein kinase 0.0039 0.1113 0.0444
Trichomonas vaginalis AGC family protein kinase 0.0039 0.1113 0.0444
Onchocerca volvulus Metabotropic glutamate receptor homolog 0.0022 0.0389 0.0585
Schistosoma mansoni serine/threonine protein kinase 0.025 1 1
Leishmania major protein kinase, putative 0.0069 0.2372 1
Echinococcus granulosus protein kinase c eta type 0.0027 0.0614 0.0614
Loa Loa (eye worm) glutamate receptor 0.0135 0.5163 0.6364
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0039 0.1113 0.1113
Loa Loa (eye worm) hypothetical protein 0.0027 0.0614 0.0756
Schistosoma mansoni serine/threonine protein kinase 0.0028 0.0657 0.0657
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.0029 0.0672 0.0672
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0015 0.0092 0.0092
Loa Loa (eye worm) AGC/PKN protein kinase 0.0039 0.1113 0.1372
Trichomonas vaginalis AGC family protein kinase 0.0069 0.2372 1
Schistosoma mansoni unc-13 (munc13) 0.0033 0.0852 0.0852
Schistosoma mansoni serine/threonine protein kinase 0.025 1 1
Echinococcus granulosus unc 13 munc13 0.0033 0.0852 0.0852
Loa Loa (eye worm) hypothetical protein 0.0039 0.1113 0.1372
Loa Loa (eye worm) hypothetical protein 0.0027 0.0614 0.0756
Echinococcus multilocularis Protein kinase C, brain isozyme 0.025 1 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0614 0.0756
Brugia malayi serine/threonine-protein kinase 6 0.0069 0.2372 0.2821
Brugia malayi Receptor family ligand binding region containing protein 0.0014 0.0043 0.0051
Echinococcus granulosus roundabout 2 0.0018 0.0213 0.0213
Brugia malayi protein kinase C3,putative 0.0029 0.0672 0.0799
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.0154 0.5944 0.5944
Trichomonas vaginalis AGC family protein kinase 0.0039 0.1113 0.0444
Onchocerca volvulus Tyrosine kinase homolog 0.0171 0.6657 1
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0183 0.7164 0.8831
Trichomonas vaginalis AGC family protein kinase 0.0069 0.2372 1
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0039 0.1113 0.1113
Echinococcus multilocularis serine:threonine protein kinase 38 0.0039 0.1113 0.1113
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0027 0.0614 0.0614
Schistosoma mansoni atypical protein kinase C 0.0066 0.2263 0.2263
Brugia malayi Protein kinase domain containing protein 0.0029 0.0672 0.0799
Onchocerca volvulus Poor gastrulation protein homolog 0.0022 0.0389 0.0585
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0069 0.2372 1
Brugia malayi Protein kinase domain containing protein 0.0039 0.1113 0.1324
Echinococcus granulosus RNA directed DNA polymerase 0.0178 0.6963 0.6963
Loa Loa (eye worm) hypothetical protein 0.0035 0.0925 0.114
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0069 0.2372 1
Echinococcus multilocularis unc 13 (munc13) 0.0033 0.0852 0.0852
Entamoeba histolytica diacylglycerol kinase, putative 0.0027 0.0614 0.2587
Echinococcus granulosus protein kinase C gamma type 0.0223 0.8851 0.8851
Loa Loa (eye worm) Ras association domain family 1 isoform A 0.0027 0.0614 0.0756
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.0035 0.0925 0.114
Schistosoma mansoni tyrosine kinase 0.0014 0.0043 0.0043
Brugia malayi protein kinase C II. 0.0072 0.2501 0.2975
Brugia malayi RhoGAP domain containing protein 0.0027 0.0614 0.073
Trichomonas vaginalis AGC family protein kinase 0.0039 0.1113 0.0444
Entamoeba histolytica diacylglycerol kinase, putative 0.0027 0.0614 0.2587
Schistosoma mansoni cell adhesion molecule 0.0015 0.0092 0.0092
Echinococcus multilocularis N chimaerin 0.0027 0.0614 0.0614
Loa Loa (eye worm) RasGEF domain-containing protein 0.0027 0.0614 0.0756
Brugia malayi serine/threonine kinase 12 0.0069 0.2372 0.2821
Giardia lamblia Aurora kinase 0.0069 0.2372 0.5
Brugia malayi Protein kinase domain containing protein 0.0039 0.1113 0.1324
Schistosoma mansoni vav2 0.0027 0.0614 0.0614
Schistosoma mansoni serine/threonine protein kinase 0.0029 0.0672 0.0672
Schistosoma mansoni serine/threonine protein kinase 0.0039 0.1113 0.1113
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0039 0.1113 0.1372
Brugia malayi Receptor family ligand binding region containing protein 0.0035 0.0925 0.11
Entamoeba histolytica protein kinase, putative 0.0039 0.1113 0.4693
Loa Loa (eye worm) hypothetical protein 0.0027 0.0614 0.0756
Echinococcus multilocularis protein kinase c eta type 0.0027 0.0614 0.0614
Echinococcus granulosus metabotropic glutamate receptor 5 0.0166 0.648 0.648
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0069 0.2372 0.2372
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0039 0.1113 0.1113
Schistosoma mansoni protein kinase C mu 0.0029 0.0672 0.0672
Brugia malayi diacylglycerol kinase 0.0027 0.0614 0.073
Loa Loa (eye worm) hypothetical protein 0.0018 0.0213 0.0263
Brugia malayi Immunoglobulin I-set domain containing protein 0.0183 0.7164 0.8519
Onchocerca volvulus 0.0014 0.0043 0.0065
Loa Loa (eye worm) RGC/RGC protein kinase 0.0014 0.0043 0.0053
Schistosoma mansoni protein kinase C mu 0.0027 0.0614 0.0614
Trichomonas vaginalis AGC family protein kinase 0.0039 0.1113 0.0444
Echinococcus granulosus receptor type guanylyl cyclase 0.0014 0.0043 0.0043
Loa Loa (eye worm) hypothetical protein 0.0166 0.648 0.7988
Loa Loa (eye worm) AUR protein kinase 0.0069 0.2372 0.2924
Echinococcus granulosus NDR protein kinase 0.0039 0.1113 0.1113
Trichomonas vaginalis AGC family protein kinase 0.0039 0.1113 0.0444
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0039 0.1113 0.1372
Echinococcus multilocularis aurora kinase A 0.0069 0.2372 0.2372
Loa Loa (eye worm) glutamate receptor 0.0053 0.1706 0.2103
Brugia malayi diacylglycerol kinase 0.0027 0.0614 0.073
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0022 0.0389 0.0463
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.0029 0.0672 0.0799

Activities

Activity type Activity value Assay description Source Reference
Ki (functional) = 5.4 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: KDR ChEMBL. No reference
Ki (functional) = 6.5 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: STK12 ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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