TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 474.681 | Formula: C28H30N2OS2
H donors: 0 H acceptors: 1 LogP: 7.05 Rotable bonds: 11
Rule of 5 violations (Lipinski): 1
SMILES: CN(CCCCN(c1ccccc1SCc1ccccc1)C(=O)c1cc2c(s1)cccc2)C
InChi: 1S/C28H30N2OS2/c1-29(2)18-10-11-19-30(28(31)27-20-23-14-6-8-16-25(23)33-27)24-15-7-9-17-26(24)32-21-22-12-4-3-5-13-22/h3-9,12-17,20H,10-11,18-19,21H2,1-2H3
InChiKey: YPKZZQXDAZSUPY-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	neuropeptide Y receptor Y2	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus multilocularis	neuropeptide receptor	Get druggable targets OG5_127863	All targets in OG5_127863
Echinococcus granulosus	neuropeptide receptor	Get druggable targets OG5_127863	All targets in OG5_127863
Echinococcus multilocularis	G protein coupled receptor 139	Get druggable targets OG5_127863	All targets in OG5_127863
Schistosoma japonicum	ko:K04209 neuropeptide Y receptor, invertebrate, putative	Get druggable targets OG5_127863	All targets in OG5_127863
Schistosoma mansoni	neuropeptide receptor	Get druggable targets OG5_127863	All targets in OG5_127863

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	neuropeptide Y receptor Y2	381 aa	388 aa	20.4 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	tubulin gamma chain, putative	0.0045	0.0051	0.0104
Schistosoma mansoni	serine/threonine protein kinase	0.0096	0.0405	0.0658
Brugia malayi	endoprotease bli-4 precursor	0.0921	0.6148	0.6143
Echinococcus multilocularis	beta tubulin	0.0045	0.0051	0.0047
Echinococcus granulosus	tubulin beta 4A class IVa	0.0045	0.0051	0.0047
Brugia malayi	hypothetical protein	0.006	0.0158	0.0144
Entamoeba histolytica	tubulin family protein	0.0045	0.0051	0.0801
Brugia malayi	proprotein convertase 2	0.0579	0.3767	0.3758
Schistosoma mansoni	tripeptidyl-peptidase II (S08 family)	0.0039	0.0014	0.0022
Trichomonas vaginalis	hypothetical protein	0.0178	0.0979	0.2667
Wolbachia endosymbiont of Brugia malayi	fructose-1,6-bisphosphatase	0.0043	0.0039	0.5
Echinococcus multilocularis	neuropeptide receptor	0.0217	0.1249	0.1532
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.1199	0.8083	1
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0128	0.0627	0.0627
Leishmania major	beta tubulin	0.0045	0.0051	0.1384
Trypanosoma brucei	beta tubulin	0.0045	0.0051	0.0892
Brugia malayi	Ets-domain containing protein	0.0084	0.0326	0.0313
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0206	0.0206
Echinococcus multilocularis	integrin alpha ps	0.0072	0.024	0.028
Echinococcus granulosus	c4b binding protein beta chain	0.006	0.0158	0.0179
Trichomonas vaginalis	conserved hypothetical protein	0.0178	0.0979	0.2667
Leishmania major	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0043	0.0039	0.0918
Giardia lamblia	Furin precursor putative serine protease	0.0178	0.0979	0.4484
Trichomonas vaginalis	conserved hypothetical protein	0.0178	0.0979	0.2667
Toxoplasma gondii	beta-1 tubulin, putative	0.0045	0.0051	0.1921
Brugia malayi	endochitinase	0.0079	0.0286	0.0273
Echinococcus multilocularis	proprotein convertase subtilisin:kexin type 5	0.056	0.3635	0.4488
Brugia malayi	Endochitinase	0.0079	0.0286	0.0273
Trypanosoma brucei	inositol-1(or 4)-monophosphatase 1, putative	0.0043	0.0039	0.0592
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0217	0.1253	0.3423
Echinococcus multilocularis	GA binding protein alpha chain	0.0084	0.0326	0.0387
Echinococcus granulosus	proprotein convertase subtilisin:kexin type 5	0.056	0.3635	0.4488
Loa Loa (eye worm)	hypothetical protein	0.006	0.0158	0.0158
Echinococcus granulosus	Tubulin beta 2C chain	0.0045	0.0051	0.0047
Mycobacterium tuberculosis	Probable alanine and proline rich membrane-anchored mycosin MycP2 (serine protease) (subtilisin-like protease) (subtilase-like)	0.0039	0.0014	0.0317
Schistosoma mansoni	ets-related	0.0256	0.1519	0.2471
Schistosoma mansoni	site-1 peptidase (S08 family)	0.0039	0.0014	0.0022
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0217	0.1253	0.3423
Trichomonas vaginalis	conserved hypothetical protein	0.0178	0.0979	0.2667
Schistosoma mansoni	site-1 peptidase (S08 family)	0.0039	0.0014	0.0022
Schistosoma mansoni	subfamily S8B unassigned peptidase (S08 family)	0.0039	0.0014	0.0022
Loa Loa (eye worm)	subtilase	0.0039	0.0014	0.0014
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.1199	0.8083	1
Echinococcus multilocularis	beta tubulin	0.0045	0.0051	0.0047
Schistosoma mansoni	hypothetical protein	0.0275	0.1657	0.2695
Echinococcus granulosus	beta-adrenergic receptor kinase	0.0096	0.0405	0.0484
Echinococcus granulosus	beta tubulin	0.0045	0.0051	0.0047
Schistosoma mansoni	hypothetical protein	0.01	0.0437	0.0711
Echinococcus granulosus	tubulin subunit beta	0.0045	0.0051	0.0047
Echinococcus multilocularis	tubulin beta 1 chain	0.0045	0.0051	0.0047
Loa Loa (eye worm)	AGC/GRK/BARK protein kinase	0.0096	0.0405	0.0405
Leishmania major	beta tubulin	0.0045	0.0051	0.1384
Trichomonas vaginalis	conserved hypothetical protein	0.0178	0.0979	0.2667
Echinococcus multilocularis	histone lysine n methyltransferase setd8	0.0068	0.021	0.0244
Brugia malayi	Integrin alpha cytoplasmic region family protein	0.0121	0.0583	0.057
Loa Loa (eye worm)	hypothetical protein	0.006	0.0158	0.0158
Trypanosoma brucei	RNA helicase, putative	0.01	0.0437	1
Loa Loa (eye worm)	chitinase I	0.0079	0.0286	0.0286
Brugia malayi	neuroendocrine convertase 1 precursor	0.0579	0.3767	0.3758
Onchocerca volvulus		0.0286	0.1733	1
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0217	0.1253	0.3423
Schistosoma mansoni	hypothetical protein	0.0178	0.0979	0.1593
Trichomonas vaginalis	tubulin alpha chain, putative	0.0045	0.0051	0.0104
Toxoplasma gondii	inositol(myo)-1(or 4)-monophosphatase 2, putative	0.0043	0.0039	0.1274
Mycobacterium leprae	Possible secreted protease	0.0039	0.0014	1
Onchocerca volvulus	Putative endochitinase	0.0079	0.0286	0.1586
Schistosoma mansoni	gabp alpha	0.0084	0.0326	0.053
Loa Loa (eye worm)	hypothetical protein	0.0361	0.2253	0.2253
Loa Loa (eye worm)	microfilarial chitinase	0.0067	0.0206	0.0206
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0043	0.0039	0.6632
Loa Loa (eye worm)	hypothetical protein	0.006	0.0158	0.0158
Toxoplasma gondii	beta-tubulin, putative	0.0045	0.0051	0.1921
Trichomonas vaginalis	inositol monophosphatase, putative	0.0043	0.0039	0.0069
Echinococcus granulosus	tubulin beta 1 chain	0.0045	0.0051	0.0047
Onchocerca volvulus		0.006	0.0158	0.0838
Plasmodium falciparum	tubulin beta chain	0.0045	0.0051	0.1921
Echinococcus multilocularis	G protein coupled receptor 139	0.0217	0.1249	0.1532
Loa Loa (eye worm)	hypothetical protein	0.1474	1	1
Brugia malayi	hypothetical protein	0.006	0.0158	0.0144
Echinococcus granulosus	Tubulin beta 2C chain	0.0045	0.0051	0.0047
Schistosoma mansoni	hypothetical protein	0.0128	0.0627	0.102
Mycobacterium ulcerans	chitinase/cellulase	0.0067	0.0206	1
Leishmania major	beta tubulin	0.0045	0.0051	0.1384
Plasmodium falciparum	SET domain protein, putative	0.0068	0.021	1
Loa Loa (eye worm)	tubulin beta-1 chain	0.0045	0.0051	0.0051
Schistosoma mansoni	subfamily S8B non-peptidase homologue (S08 family)	0.0217	0.1253	0.2038
Leishmania major	beta tubulin	0.0045	0.0051	0.1384
Schistosoma mansoni	subfamily S8B unassigned peptidase (S08 family)	0.0921	0.6148	1
Echinococcus granulosus	Furin 1	0.0217	0.1253	0.1536
Echinococcus multilocularis	integrin alpha 3	0.0123	0.0595	0.072
Echinococcus granulosus	Tubulin beta 2C chain	0.0045	0.0051	0.0047
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0042	0.0031	0.0021
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0042	0.0031	0.0021
Onchocerca volvulus		0.006	0.0158	0.0838
Brugia malayi	Will die slowly protein	0.0286	0.1733	0.1722
Toxoplasma gondii	histone lysine methyltransferase SET8	0.0068	0.021	1
Echinococcus multilocularis	Tubulin beta 2C chain	0.0045	0.0051	0.0047
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0014	0.0014
Plasmodium vivax	tubulin beta chain, putative	0.0045	0.0051	0.1921
Leishmania major	beta tubulin	0.0045	0.0051	0.1384
Onchocerca volvulus	Putative endochitinase	0.0079	0.0286	0.1586
Leishmania major	beta tubulin	0.0045	0.0051	0.1384
Onchocerca volvulus		0.006	0.0158	0.0838
Echinococcus multilocularis	Furin 1	0.0217	0.1253	0.1536
Trichomonas vaginalis	conserved hypothetical protein	0.0178	0.0979	0.2667
Schistosoma mansoni	integrin alpha	0.016	0.0855	0.139
Schistosoma mansoni	tubulin subunit beta	0.0045	0.0051	0.0084
Echinococcus multilocularis	Tubulin beta 2C chain	0.0045	0.0051	0.0047
Loa Loa (eye worm)	tubulin beta-2A chain	0.0045	0.0051	0.0051
Schistosoma mansoni	tubulin subunit beta	0.0045	0.0051	0.0084
Loa Loa (eye worm)	hypothetical protein	0.006	0.0158	0.0158
Schistosoma mansoni	serine/threonine protein kinase	0.0096	0.0405	0.0658
Trichomonas vaginalis	conserved hypothetical protein	0.0178	0.0979	0.2667
Onchocerca volvulus		0.006	0.0158	0.0838
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0403	0.2545	0.2545
Leishmania major	beta tubulin	0.0045	0.0051	0.1384
Brugia malayi	Inositol-1	0.0043	0.0039	0.0025
Loa Loa (eye worm)	BEN-1 protein	0.0045	0.0051	0.0051
Schistosoma mansoni	c4b-binding protein beta chain	0.006	0.0158	0.0257
Toxoplasma gondii	beta tubulin	0.0045	0.0051	0.1921
Echinococcus multilocularis	Tubulin beta 2C chain	0.0045	0.0051	0.0047
Loa Loa (eye worm)	cuticular endochitinase	0.0079	0.0286	0.0286
Echinococcus multilocularis	Tubulin beta 2C chain	0.0045	0.0051	0.0047
Echinococcus granulosus	Tubulin beta 2C chain	0.0045	0.0051	0.0047
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0241	0.0241
Loa Loa (eye worm)	tubulin beta chain	0.0045	0.0051	0.0051
Loa Loa (eye worm)	beta-tubulin	0.0045	0.0051	0.0051
Loa Loa (eye worm)	proprotein convertase 2	0.0217	0.1253	0.1253
Leishmania major	beta tubulin	0.0045	0.0051	0.1384
Echinococcus granulosus	beta tubulin	0.0045	0.0051	0.0047
Trypanosoma brucei	beta tubulin	0.0045	0.0051	0.0892
Brugia malayi	Fli-1 protein	0.0256	0.1519	0.1508
Brugia malayi	endochitinase	0.0079	0.0286	0.0273
Schistosoma mansoni	serine-type protease inhibitor	0.0429	0.2724	0.443
Mycobacterium ulcerans	chitinase/cellulase	0.0067	0.0206	1
Leishmania major	beta tubulin	0.0045	0.0051	0.1384
Echinococcus granulosus	G protein coupled receptor kinase 1	0.0086	0.0336	0.0399
Trypanosoma brucei	beta tubulin	0.0045	0.0051	0.0892
Echinococcus multilocularis	beta adrenergic receptor kinase	0.0096	0.0405	0.0484
Echinococcus granulosus	integrin alpha 3	0.0123	0.0595	0.072
Echinococcus multilocularis		0.0743	0.4909	0.6067
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.056	0.3635	1
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0128	0.0627	0.076
Toxoplasma gondii	rhoptry neck protein RON9	0.006	0.0158	0.7334
Echinococcus granulosus	integrin alpha ps	0.0072	0.024	0.028
Leishmania major	beta tubulin	0.0045	0.0051	0.1384
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0128	0.0627	0.0614
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0217	0.1253	0.3423
Brugia malayi	Latrophilin receptor protein 2	0.0128	0.0627	0.0614
Trichomonas vaginalis	tubulin beta chain, putative	0.0045	0.0051	0.0104
Echinococcus multilocularis	c4b binding protein beta chain	0.006	0.0158	0.0179
Loa Loa (eye worm)	hypothetical protein	0.0126	0.0615	0.0615
Loa Loa (eye worm)	tubulin beta-4 chain	0.0045	0.0051	0.0051
Brugia malayi	hypothetical protein	0.006	0.0158	0.0144
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0043	0.0039	0.0069
Echinococcus multilocularis	integrin alpha ps	0.0072	0.024	0.028
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0217	0.1253	0.3423
Schistosoma mansoni	hypothetical protein	0.0128	0.0627	0.102
Schistosoma mansoni	hypothetical protein	0.0128	0.0627	0.102
Mycobacterium tuberculosis	Probable membrane-anchored mycosin MycP3 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-3)	0.0039	0.0014	0.0317
Echinococcus granulosus	histone lysine n methyltransferase setd8	0.0068	0.021	0.0244
Mycobacterium tuberculosis	Probable proline rich membrane-anchored mycosin MycP5 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-5)	0.0039	0.0014	0.0317
Schistosoma mansoni	neuropeptide receptor	0.0217	0.1249	0.2032
Brugia malayi	latrophilin 2 splice variant baaae	0.0275	0.1657	0.1646
Echinococcus granulosus	neuroendocrine convertase 2	0.0579	0.3767	0.4652
Brugia malayi	Protein set-1	0.0068	0.021	0.0197
Schistosoma mansoni	furin-1 (S08 family)	0.0401	0.2527	0.4111
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0128	0.0627	0.076
Echinococcus granulosus	GPCR family 2	0.0128	0.0627	0.076
Echinococcus granulosus	GA binding protein alpha chain	0.0084	0.0326	0.0387
Loa Loa (eye worm)	fli-1 protein	0.0256	0.1519	0.1519
Onchocerca volvulus	Putative endochitinase	0.0079	0.0286	0.1586
Echinococcus granulosus	Tubulin beta 2C chain	0.0045	0.0051	0.0047
Echinococcus multilocularis	inositol monophosphatase 1	0.0043	0.0039	0.0031
Entamoeba histolytica	chitinase, putative	0.0079	0.0286	1
Schistosoma mansoni	histone-lysine n-methyltransferase seto7	0.0068	0.021	0.0342
Trypanosoma brucei	beta tubulin	0.0045	0.0051	0.0892
Brugia malayi	hypothetical protein	0.006	0.0158	0.0144
Mycobacterium ulcerans	extragenic suppressor protein SuhB	0.0043	0.0039	0.1303
Schistosoma mansoni	tubulin subunit beta	0.0045	0.0051	0.0084
Brugia malayi	Ets-domain containing protein	0.0084	0.0326	0.0313
Brugia malayi	Tubulin beta-1 chain	0.0045	0.0051	0.0038
Echinococcus multilocularis	GPCR, family 2	0.0128	0.0627	0.076
Plasmodium falciparum	apical sushi protein	0.006	0.0158	0.7334
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0043	0.0039	0.0069
Echinococcus granulosus	C type lectin domian containing protein	0.006	0.0158	0.0179
Brugia malayi	beta-tubulin, identical	0.0045	0.0051	0.0038
Echinococcus multilocularis	tubulin subunit beta	0.0045	0.0051	0.0047
Trichomonas vaginalis	tubulin, putative	0.0045	0.0051	0.0104
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0045	0.0051	0.0104
Leishmania major	beta tubulin	0.0045	0.0051	0.1384
Schistosoma mansoni	tubulin subunit beta	0.0045	0.0051	0.0084
Loa Loa (eye worm)	pregnancy-associated plasma protein-E	0.006	0.0158	0.0158
Echinococcus multilocularis	neuroendocrine convertase 2	0.0579	0.3767	0.4652
Trichomonas vaginalis	WD repeat domain, putative	0.0286	0.1733	0.4749
Entamoeba histolytica	tubulin family protein	0.0045	0.0051	0.0801
Brugia malayi	GCC2 and GCC3 family protein	0.006	0.0158	0.0144
Brugia malayi	pregnancy-associated plasma protein-A	0.006	0.0158	0.0144
Leishmania major	beta tubulin	0.0045	0.0051	0.1384
Echinococcus granulosus	furin	0.0921	0.6148	0.7603
Schistosoma mansoni	hypothetical protein	0.0128	0.0627	0.102
Leishmania major	beta tubulin	0.0045	0.0051	0.1384
Loa Loa (eye worm)	inositol-1	0.0043	0.0039	0.0039
Schistosoma mansoni	integrin alpha-ps	0.0072	0.024	0.039
Schistosoma mansoni	transcription factor LCR-F1	0.0042	0.0031	0.005
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0355	0.0355
Leishmania major	beta tubulin	0.0045	0.0051	0.1384
Loa Loa (eye worm)	hypothetical protein	0.0068	0.021	0.021
Brugia malayi	Sushi domain	0.006	0.0158	0.0144
Plasmodium vivax	apical sushi protein, putative	0.006	0.0158	0.7334
Brugia malayi	hypothetical protein	0.006	0.0158	0.0144
Onchocerca volvulus		0.006	0.0158	0.0838
Loa Loa (eye worm)	WD40 repeat protein	0.0286	0.1733	0.1733
Brugia malayi	hypothetical protein	0.006	0.0158	0.0144
Trichomonas vaginalis	conserved hypothetical protein	0.0178	0.0979	0.2667
Onchocerca volvulus		0.006	0.0158	0.0838
Trichomonas vaginalis	conserved hypothetical protein	0.0178	0.0979	0.2667
Echinococcus multilocularis	G protein coupled receptor kinase 1	0.0086	0.0336	0.0399
Loa Loa (eye worm)	hypothetical protein	0.0275	0.1657	0.1657
Trichomonas vaginalis	proprotein convertase subtilisin/kexin type, putative	0.0178	0.0979	0.2667
Onchocerca volvulus	Putative endochitinase	0.0079	0.0286	0.1586
Mycobacterium leprae	PROBABLE MEMBRANE-ANCHORED MYCOSIN MYCP3 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-3)	0.0039	0.0014	1
Loa Loa (eye worm)	hypothetical protein	0.006	0.0158	0.0158
Plasmodium vivax	SET domain protein, putative	0.0068	0.021	1
Mycobacterium tuberculosis	Possible chitinase	0.0067	0.0206	1
Brugia malayi	celfurPC protein	0.0743	0.4909	0.4902
Loa Loa (eye worm)	endoprotease bli-4	0.0921	0.6148	0.6148
Schistosoma mansoni	tubulin subunit beta	0.0045	0.0051	0.0084
Loa Loa (eye worm)	hypothetical protein	0.0921	0.6148	0.6148
Schistosoma mansoni	tubulin subunit beta	0.0045	0.0051	0.0084
Trypanosoma cruzi	beta tubulin, putative	0.0045	0.0051	1
Loa Loa (eye worm)	hypothetical protein	0.006	0.0158	0.0158
Schistosoma mansoni	inositol monophosphatase	0.0043	0.0039	0.0063
Loa Loa (eye worm)	integrin alpha pat-2	0.0247	0.1459	0.1459
Echinococcus granulosus	inositol monophosphatase 1	0.0043	0.0039	0.0031
Trichomonas vaginalis	neuroendocrine convertase 2 precursor, putative	0.0178	0.0979	0.2667
Schistosoma mansoni	serine-type protease inhibitor	0.0429	0.2724	0.443
Loa Loa (eye worm)	D-ets-4 DNA binding domain-containing protein	0.0084	0.0326	0.0326
Trichomonas vaginalis	conserved hypothetical protein	0.0178	0.0979	0.2667
Leishmania major	beta tubulin	0.0045	0.0051	0.1384
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0403	0.2545	0.2534
Onchocerca volvulus	Putative endochitinase	0.0079	0.0286	0.1586
Leishmania major	chitinase	0.0079	0.0286	1
Leishmania major	beta tubulin	0.0045	0.0051	0.1384
Giardia lamblia	High cysteine membrane protein Group 2	0.0342	0.2121	1
Onchocerca volvulus		0.006	0.0158	0.0838
Toxoplasma gondii	rhoptry neck protein RON1	0.006	0.0158	0.7334
Brugia malayi	Integrin alpha pat-2 precursor	0.016	0.0855	0.0842
Echinococcus multilocularis	protein will die slowly	0.0286	0.1733	0.2131
Mycobacterium leprae	PROBABLE PROLINE RICH MEMBRANE-ANCHORED MYCOSIN MYCP5 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-5)	0.0039	0.0014	1
Loa Loa (eye worm)	BEN-1 protein	0.0045	0.0051	0.0051
Echinococcus granulosus	protein will die slowly	0.0286	0.1733	0.2131
Mycobacterium tuberculosis	Probable membrane-anchored mycosin MycP4 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-4)	0.0039	0.0014	0.0317
Trichomonas vaginalis	conserved hypothetical protein	0.0178	0.0979	0.2667
Onchocerca volvulus		0.006	0.0158	0.0838
Loa Loa (eye worm)	hypothetical protein	0.006	0.0158	0.0158
Loa Loa (eye worm)	hypothetical protein	0.0128	0.0627	0.0627
Echinococcus multilocularis	Tubulin beta 2C chain	0.0045	0.0051	0.0047
Entamoeba histolytica	myo-inositol monophosphatase, putative	0.0043	0.0039	0.0304
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.056	0.3635	1
Loa Loa (eye worm)	hypothetical protein	0.006	0.0158	0.0158
Trichomonas vaginalis	leucine-rich repeat protein, BspA family	0.0178	0.0979	0.2667
Leishmania major	beta tubulin	0.0045	0.0051	0.1384
Echinococcus multilocularis	tubulin, beta 4A class IVa	0.0045	0.0051	0.0047
Brugia malayi	hypothetical protein	0.0042	0.0031	0.0017
Echinococcus multilocularis	C type lectin domian containing protein	0.006	0.0158	0.0179
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0043	0.0039	0.6632
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0045	0.0051	0.0104
Onchocerca volvulus		0.006	0.0158	0.0838
Loa Loa (eye worm)	hypothetical protein	0.0121	0.0583	0.0583
Brugia malayi	hypothetical protein	0.006	0.0158	0.0144
Leishmania major	beta tubulin	0.0045	0.0051	0.1384
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0217	0.1253	0.3423
Schistosoma mansoni	inositol monophosphatase	0.0043	0.0039	0.0063
Schistosoma mansoni	hypothetical protein	0.0286	0.1733	0.2819
Onchocerca volvulus		0.006	0.0158	0.0838
Echinococcus granulosus	neuropeptide receptor	0.0217	0.1249	0.1532
Schistosoma mansoni	hypothetical protein	0.0042	0.0031	0.005
Loa Loa (eye worm)	hypothetical protein	0.006	0.0158	0.0158
Trichomonas vaginalis	conserved hypothetical protein	0.0178	0.0979	0.2667

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	> 10000 nM	Binding affinity against SMS-KAN cell membranes endogenously expressing Neuropeptide Y receptor type 2 using [125I]-PYY as radioligand	ChEMBL.	14611849
IC50 (binding)	> 10000 nM	Binding affinity against SMS-KAN cell membranes endogenously expressing Neuropeptide Y receptor type 2 using [125I]-PYY as radioligand	ChEMBL.	14611849

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 161005