TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 376.488 | Formula: C25H28O3
H donors: 1 H acceptors: 3 LogP: 6.71 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: OC(=O)/C=C/c1ccc(cc1C)C(=O)c1ccc2c(c1)C(C)(C)CCC2(C)C
InChi: 1S/C25H28O3/c1-16-14-18(7-6-17(16)9-11-22(26)27)23(28)19-8-10-20-21(15-19)25(4,5)13-12-24(20,2)3/h6-11,14-15H,12-13H2,1-5H3,(H,26,27)/b11-9+
InChiKey: OBKHFYXYYSPOHD-PKNBQFBNSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	tyrosine kinase	0.0271	0.1237	0.1237
Brugia malayi	Papain family cysteine protease containing protein	0.0123	0.0371	0.0539
Brugia malayi	nuclear hormone receptor	0.0067	0.0035	0.0051
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0123	0.0371	0.0515
Brugia malayi	cathepsin L-like precursor	0.0083	0.013	0.0189
Onchocerca volvulus		0.0123	0.0371	0.0491
Loa Loa (eye worm)	SRC-1	0.0253	0.1131	0.11
Brugia malayi	Cathepsin L-like precursor	0.0123	0.0371	0.0539
Loa Loa (eye worm)	hypothetical protein	0.0093	0.0193	0.0159
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0083	0.013	0.0164
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0123	0.0371	0.1151
Onchocerca volvulus	Cathepsin L homolog	0.0123	0.0371	0.0491
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0253	0.1131	0.1131
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0217	0.092	0.092
Brugia malayi	nuclear receptor NHR-88	0.0067	0.0035	0.0051
Schistosoma mansoni	tyrosine kinase	0.0438	0.2227	0.2227
Trypanosoma brucei	Aminopeptidase M1, putative	0.0093	0.0193	0.0256
Brugia malayi	Cathepsin L-like precursor	0.0083	0.013	0.0189
Entamoeba histolytica	cysteine proteinase, putative	0.0123	0.0371	0.4276
Trypanosoma cruzi	mitogen activated protein kinase 4, putative	0.0388	0.1928	0.2788
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0093	0.0193	0.0193
Trypanosoma cruzi	dihydrofolate reductase-thymidylate synthase	0.1227	0.6872	1
Brugia malayi	hypothetical protein	0.0093	0.0193	0.0281
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0228	0.0989	0.0989
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0067	0.0035	0.0035
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0217	0.092	0.092
Schistosoma mansoni	retinoic acid receptor RXR	0.0067	0.0035	0.0035
Trichomonas vaginalis	CMGC family protein kinase	0.0388	0.1928	0.6235
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0256	0.1152	0.1152
Loa Loa (eye worm)	hypothetical protein	0.0083	0.013	0.0095
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0253	0.1131	0.1131
Brugia malayi	Cathepsin L-like precursor	0.0083	0.013	0.0189
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0067	0.0035	0.0035
Echinococcus multilocularis	mitogen activated protein kinase	0.0388	0.1928	0.1928
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0064	0.0018	0.0018
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0123	0.0371	0.1151
Schistosoma mansoni	tyrosine kinase	0.045	0.2295	0.2295
Loa Loa (eye worm)	hypothetical protein	0.0083	0.013	0.0095
Loa Loa (eye worm)	hypothetical protein	0.0123	0.0371	0.0337
Trypanosoma brucei	mitogen activated protein kinase 4, putative	0.0388	0.1928	0.2788
Loa Loa (eye worm)	peptidase family M1 containing protein	0.0093	0.0193	0.0159
Echinococcus granulosus	mitogen activated protein kinase	0.0388	0.1928	0.1928
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0093	0.0193	0.0193
Brugia malayi	hypothetical protein	0.0584	0.3082	0.4485
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0067	0.0035	0.0035
Leishmania major	cathepsin L-like protease	0.0123	0.0371	0.0265
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0123	0.0371	0.0515
Schistosoma mansoni	tyrosine kinase	0.0253	0.1131	0.1131
Mycobacterium ulcerans	thymidylate synthase	0.1227	0.6872	1
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0271	0.1237	0.1237
Echinococcus multilocularis	aminopeptidase N	0.0093	0.0193	0.0193
Leishmania major	cathepsin L-like protease	0.0123	0.0371	0.0265
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0253	0.1131	0.1131
Schistosoma mansoni	aminopeptidase PILS (M01 family)	0.0093	0.0193	0.0193
Leishmania major	mitogen activated protein kinase, putative,map kinase, putative	0.0388	0.1928	0.2598
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0123	0.0371	0.1151
Onchocerca volvulus		0.0123	0.0371	0.0491
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0067	0.0035	0.0035
Loa Loa (eye worm)	hypothetical protein	0.0093	0.0193	0.0159
Echinococcus granulosus	epidermal growth factor receptor	0.0832	0.4544	0.4544
Brugia malayi	thymidylate synthase	0.1227	0.6872	1
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0067	0.0035	0.0035
Trypanosoma brucei	protein kinase, putative	0.0388	0.1928	0.2788
Echinococcus granulosus	tyrosine kinase	0.0228	0.0989	0.0989
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0067	0.0035	0.0051
Plasmodium vivax	vivapain-2	0.0123	0.0371	0.0515
Trypanosoma cruzi	metallo-peptidase, Clan MA(E) Family M1	0.0093	0.0193	0.0256
Plasmodium vivax	bifunctional dihydrofolate reductase-thymidylate synthase, putative	0.1227	0.6872	1
Echinococcus granulosus	tyrosine protein kinase HCK	0.0204	0.0843	0.0843
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0123	0.0371	0.0515
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0123	0.0371	0.1151
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0123	0.0371	0.1151
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0093	0.0193	0.0193
Brugia malayi	photoreceptor-specific nuclear receptor	0.0067	0.0035	0.0051
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0093	0.0193	0.0193
Trypanosoma brucei	metallo-peptidase, Clan MA(E) Family M1	0.0093	0.0193	0.0256
Brugia malayi	steroid hormone receptor	0.0067	0.0035	0.0051
Schistosoma mansoni	cathepsin F (C01 family)	0.0123	0.0371	0.0371
Schistosoma mansoni	tyrosine kinase	0.0832	0.4544	0.4544
Loa Loa (eye worm)	cysteine protease	0.0123	0.0371	0.0337
Loa Loa (eye worm)	ctsf protein	0.0123	0.0371	0.0337
Echinococcus granulosus	epidermal growth factor receptor	0.045	0.2295	0.2295
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0123	0.0371	0.1151
Brugia malayi	Furin-like cysteine rich region family protein	0.0832	0.4544	0.6613
Echinococcus granulosus	cathepsin L	0.0064	0.0018	0.0018
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0093	0.0193	0.0193
Schistosoma mansoni	Tata binding protein associated factor (M01 family)	0.0093	0.0193	0.0193
Schistosoma mansoni	cathepsin F (C01 family)	0.0083	0.013	0.013
Echinococcus multilocularis	leukotriene A 4 hydrolase	0.1758	1	1
Schistosoma mansoni	aminopeptidase A (M01 family)	0.0093	0.0193	0.0193
Onchocerca volvulus		0.0123	0.0371	0.0491
Entamoeba histolytica	cysteine proteinase, putative	0.0123	0.0371	0.4276
Echinococcus multilocularis	ecdysone induced protein 78C	0.0067	0.0035	0.0035
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0093	0.0193	0.0193
Onchocerca volvulus	Cathepsin F homolog	0.0123	0.0371	0.0491
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0067	0.0035	0.0051
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0123	0.0371	0.0515
Schistosoma mansoni	RAR-like nuclear receptor	0.0067	0.0035	0.0035
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0123	0.0371	0.1151
Schistosoma mansoni	tyrosine kinase	0.0438	0.2227	0.2227
Trypanosoma cruzi	cysteine peptidase, putative	0.0123	0.0371	0.0515
Onchocerca volvulus		0.0123	0.0371	0.0491
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0123	0.0371	0.0515
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0123	0.0371	0.0515
Trichomonas vaginalis	conserved hypothetical protein	0.0584	0.3082	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0083	0.013	0.0366
Schistosoma mansoni	nuclear hormone receptor	0.0067	0.0035	0.0035
Trypanosoma cruzi	puromycin-sensitive aminopeptidase-like protein, putative	0.0093	0.0193	0.0256
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0067	0.0035	0.0051
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0067	0.0035	0.0051
Schistosoma mansoni	tyrosine kinase	0.0271	0.1237	0.1237
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0253	0.1131	0.1131
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0123	0.0371	0.1151
Trypanosoma cruzi	cysteine peptidase, putative	0.0123	0.0371	0.0515
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0067	0.0035	0.0051
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0123	0.0371	0.0371
Echinococcus granulosus	cathepsin l1	0.0083	0.013	0.013
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0067	0.0035	0.0051
Schistosoma mansoni	tyrosine kinase	0.045	0.2295	0.2295
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0123	0.0371	0.1151
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0123	0.0371	0.1151
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0123	0.0371	0.1151
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0067	0.0035	0.0051
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0253	0.1131	0.1131
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0067	0.0035	0.0035
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0271	0.1237	0.1237
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0253	0.1131	0.1131
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0253	0.1131	0.1131
Echinococcus granulosus	FTZ F1 alpha	0.0067	0.0035	0.0035
Trichomonas vaginalis	CMGC family protein kinase	0.0388	0.1928	0.6235
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0123	0.0371	0.1151
Schistosoma mansoni	tyrosine kinase	0.0438	0.2227	0.2227
Echinococcus multilocularis	Peptidase M1, membrane alanine aminopeptidase, N terminal	0.0093	0.0193	0.0193
Echinococcus multilocularis	cathepsin L cysteine protease	0.0123	0.0371	0.0371
Plasmodium vivax	M1-family alanyl aminopeptidase, putative	0.0093	0.0193	0.0256
Toxoplasma gondii	cathepsin CPL	0.0123	0.0371	0.0265
Brugia malayi	SRC-1	0.0253	0.1131	0.1646
Brugia malayi	Cathepsin L-like precursor	0.0123	0.0371	0.0539
Schistosoma mansoni	leukotriene A4 hydrolase (M01 family)	0.1758	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0123	0.0371	0.1151
Trypanosoma cruzi	cruzipain precursor, putative	0.0123	0.0371	0.0515
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0228	0.0989	0.0989
Brugia malayi	Cathepsin L-like precursor	0.0123	0.0371	0.0539
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0067	0.0035	0.0035
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0123	0.0371	0.0515
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0123	0.0371	0.0515
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0123	0.0371	0.0515
Loa Loa (eye worm)	thymidylate synthase	0.1227	0.6872	0.6861
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0253	0.1131	0.1131
Trypanosoma cruzi	metallo-peptidase, clan MA(E), family M1, putative	0.0093	0.0193	0.0256
Entamoeba histolytica	cysteine protease, putative	0.0123	0.0371	0.4276
Trypanosoma cruzi	cysteine peptidase, putative	0.0123	0.0371	0.0515
Brugia malayi	MAP kinase sur-1	0.0388	0.1928	0.2806
Brugia malayi	TATA binding protein associated factor	0.0093	0.0193	0.0281
Brugia malayi	Papain family cysteine protease containing protein	0.0064	0.0018	0.0026
Toxoplasma gondii	bifunctional dihydrofolate reductase-thymidylate synthase	0.1227	0.6872	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0123	0.0371	0.0515
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0067	0.0035	0.0035
Leishmania major	cathepsin L-like protease	0.0123	0.0371	0.0265
Loa Loa (eye worm)	TATA binding protein associated factor	0.0093	0.0193	0.0159
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0253	0.1131	0.1131
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.045	0.2295	0.2295
Trypanosoma brucei	dihydrofolate reductase-thymidylate synthase	0.1227	0.6872	1
Echinococcus multilocularis	epidermal growth factor receptor	0.0832	0.4544	0.4544
Leishmania major	cysteine peptidase A (CPA)	0.0123	0.0371	0.0265
Trypanosoma cruzi	puromycin-sensitive aminopeptidase-like protein, putative	0.0093	0.0193	0.0256
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0123	0.0371	0.1151
Leishmania major	cathepsin L-like protease	0.0123	0.0371	0.0265
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0083	0.013	0.0189
Schistosoma mansoni	thyroid hormone receptor	0.0067	0.0035	0.0035
Echinococcus multilocularis	tyrosine protein kinase HCK	0.0204	0.0843	0.0843
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0228	0.0989	0.0989
Echinococcus multilocularis	cysteine protease	0.0123	0.0371	0.0371
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0064	0.0018	0.0018
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0067	0.0035	0.0035
Loa Loa (eye worm)	TK protein kinase	0.0228	0.0989	0.0957
Echinococcus multilocularis	cathepsin L cysteine protease	0.0123	0.0371	0.0371
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0083	0.013	0.0366
Onchocerca volvulus		0.0123	0.0371	0.0491
Echinococcus granulosus	cathepsin L cysteine protease	0.0064	0.0018	0.0018
Trypanosoma cruzi	aminopeptidase, putative	0.0093	0.0193	0.0256
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0123	0.0371	0.0371
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0123	0.0371	0.1151
Onchocerca volvulus		0.0093	0.0193	0.0231
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0123	0.0371	0.0371
Echinococcus granulosus	mitogen activated protein kinase 3	0.0388	0.1928	0.1928
Echinococcus multilocularis	insulin receptor	0.0271	0.1237	0.1237
Trypanosoma cruzi	cysteine peptidase, putative	0.0123	0.0371	0.0515
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0123	0.0371	0.1151
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0253	0.1131	0.1131
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0067	0.0035	0.0035
Leishmania major	dihydrofolate reductase-thymidylate synthase	0.1227	0.6872	1
Schistosoma mansoni	serine/threonine protein kinase	0.0388	0.1928	0.1928
Echinococcus multilocularis	FTZ F1 alpha	0.0067	0.0035	0.0035
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0067	0.0035	0.0051
Schistosoma mansoni	cytosol alanyl aminopeptidase (M01 family)	0.0093	0.0193	0.0193
Trypanosoma brucei	aminopeptidase, putative	0.0093	0.0193	0.0256
Loa Loa (eye worm)	TK protein kinase	0.0204	0.0843	0.0811
Schistosoma mansoni	tyrosine kinase	0.0253	0.1131	0.1131
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0253	0.1131	0.1131
Trypanosoma cruzi	Aminopeptidase M1, putative	0.0093	0.0193	0.0256
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	0.0388	0.1928	0.19
Onchocerca volvulus	Cathepsin L homolog	0.0123	0.0371	0.0491
Schistosoma mansoni	coup transcription factor	0.0067	0.0035	0.0035
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0123	0.0371	0.0515
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0067	0.0035	0.0035
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0123	0.0371	0.0515
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0067	0.0035	0.0051
Brugia malayi	Peptidase family M1 containing protein	0.0093	0.0193	0.0281
Echinococcus granulosus	cysteine protease	0.0064	0.0018	0.0018
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0228	0.0989	0.0989
Echinococcus multilocularis	thymidylate synthase	0.1227	0.6872	0.6872
Leishmania major	cathepsin L-like protease	0.0123	0.0371	0.0265
Onchocerca volvulus		0.0123	0.0371	0.0491
Trypanosoma cruzi	aminopeptidase, putative	0.0093	0.0193	0.0256
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0067	0.0035	0.0051
Brugia malayi	Cathepsin L-like precursor	0.0123	0.0371	0.0539
Loa Loa (eye worm)	hypothetical protein	0.0083	0.013	0.0095
Schistosoma mansoni	thyroid hormone receptor	0.0067	0.0035	0.0035
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0093	0.0193	0.0193
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0093	0.0193	0.0193
Brugia malayi	hypothetical protein	0.0808	0.4405	0.641
Brugia malayi	Steroid receptor seven-up type 2	0.0067	0.0035	0.0051
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0067	0.0035	0.0051
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0388	0.1928	0.2788
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0253	0.1131	0.1131
Trichomonas vaginalis	Clan MA, family M1, aminopeptidase N-like metallopeptidase	0.0093	0.0193	0.0573
Echinococcus granulosus	thymidylate synthase	0.1227	0.6872	0.6872
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0123	0.0371	0.1151
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0832	0.4544	0.4525
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0067	0.0035	0.0051
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0123	0.0371	0.1151
Loa Loa (eye worm)	fibroinase	0.0123	0.0371	0.0337
Loa Loa (eye worm)	aminopeptidase N	0.0093	0.0193	0.0159
Echinococcus granulosus	tyrosine protein kinase Blk	0.0228	0.0989	0.0989
Loa Loa (eye worm)	TK/INSR protein kinase	0.0271	0.1237	0.1206
Loa Loa (eye worm)	leukotriene A4 hydrolase	0.1758	1	1
Onchocerca volvulus		0.0093	0.0193	0.0231
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0067	0.0035	0.0035
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0253	0.1131	0.1131
Brugia malayi	Peptidase family M1 containing protein	0.0093	0.0193	0.0281
Plasmodium falciparum	bifunctional dihydrofolate reductase-thymidylate synthase	0.1227	0.6872	1
Echinococcus multilocularis	mitogen activated protein kinase 3	0.0388	0.1928	0.1928
Echinococcus multilocularis		0.0255	0.1147	0.1147
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0123	0.0371	0.0515
Loa Loa (eye worm)	hypothetical protein	0.0093	0.0193	0.0159
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0123	0.0371	0.1151
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0067	0.0035	0.0035
Brugia malayi	Papain family cysteine protease containing protein	0.0064	0.0018	0.0026
Trypanosoma brucei	Aminopeptidase M1, putative	0.0093	0.0193	0.0256
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0064	0.0018	0.0018
Leishmania major	cathepsin L-like protease	0.0123	0.0371	0.0265
Plasmodium vivax	vivapain-2	0.0123	0.0371	0.0515
Trichomonas vaginalis	CMGC family protein kinase	0.0388	0.1928	0.6235
Echinococcus granulosus	aminopeptidase N	0.0093	0.0193	0.0193
Toxoplasma gondii	CMGC kinase, MAPK family (ERK) MAPK-1	0.0388	0.1928	0.2598
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0123	0.0371	0.1151
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0067	0.0035	0.0035
Echinococcus multilocularis	cysteine protease	0.0123	0.0371	0.0371
Leishmania major	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	0.0388	0.1928	0.2598
Trichomonas vaginalis	Clan MA, family M1, aminopeptidase N-like metallopeptidase	0.0093	0.0193	0.0573
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0123	0.0371	0.0337
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0067	0.0035	0.0035
Entamoeba histolytica	protein kinase, putative	0.0204	0.0843	1
Brugia malayi	hypothetical protein	0.0093	0.0193	0.0281
Brugia malayi	Nuclear hormone receptor-like 1	0.0067	0.0035	0.0051
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0067	0.0035	0.0035
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0253	0.1131	0.1131
Brugia malayi	protein-tyrosine kinase	0.0228	0.0989	0.1439
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0093	0.0193	0.0193
Echinococcus granulosus	insulin receptor	0.0271	0.1237	0.1237
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0123	0.0371	0.1151
Brugia malayi	Peptidase family M1 containing protein	0.0093	0.0193	0.0281
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0123	0.0371	0.1151
Trypanosoma cruzi	metallo-peptidase, clan MA(E), family M1, putative	0.0093	0.0193	0.0256
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0123	0.0371	0.0371
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0123	0.0371	0.1151
Echinococcus multilocularis	cathepsin L	0.0064	0.0018	0.0018
Entamoeba histolytica	aminopeptidase, putative	0.0093	0.0193	0.2127
Onchocerca volvulus		0.0123	0.0371	0.0491
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0123	0.0371	0.1151
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0067	0.0035	0.0035
Brugia malayi	Protein kinase domain containing protein	0.0271	0.1237	0.18
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0067	0.0035	0.0035
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0093	0.0193	0.0193
Mycobacterium tuberculosis	Probable thymidylate synthase ThyA (ts) (TSASE)	0.1227	0.6872	1
Schistosoma mansoni	bifunctional dihydrofolate reductase-thymidylate synthase	0.1227	0.6872	0.6872
Mycobacterium leprae	PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE)	0.1227	0.6872	0.5
Plasmodium falciparum	M1-family alanyl aminopeptidase, putative	0.0093	0.0193	0.0256
Leishmania major	cathepsin L-like protease	0.0123	0.0371	0.0265
Trichomonas vaginalis	CMGC family protein kinase	0.0388	0.1928	0.6235
Plasmodium falciparum	M1-family alanyl aminopeptidase	0.0093	0.0193	0.0256
Leishmania major	cathepsin L-like protease	0.0123	0.0371	0.0265
Brugia malayi	ecdysteroid receptor	0.0067	0.0035	0.0051
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0093	0.0193	0.0193
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0253	0.1131	0.1131
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0123	0.0371	0.0337
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0388	0.1928	0.2788
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0067	0.0035	0.0035
Onchocerca volvulus		0.1227	0.6872	1
Brugia malayi	Cathepsin L-like precursor	0.0123	0.0371	0.0539
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0067	0.0035	0.0035
Giardia lamblia	Kinase, CMGC MAPK	0.0388	0.1928	0.5
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0253	0.1131	0.1131
Onchocerca volvulus		0.0083	0.013	0.0139
Onchocerca volvulus		0.0093	0.0193	0.0231
Trypanosoma cruzi	mitogen activated protein kinase 2, putative	0.0388	0.1928	0.2788
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0123	0.0371	0.1151
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0067	0.0035	0.0035
Echinococcus granulosus	cathepsin l1	0.0123	0.0371	0.0371
Plasmodium vivax	M1-family alanyl aminopeptidase, putative	0.0093	0.0193	0.0256
Trichomonas vaginalis	Clan MA, family M1, aminopeptidase N-like metallopeptidase	0.0093	0.0193	0.0573
Trypanosoma cruzi	dihydrofolate reductase-thymidylate synthase, putative	0.0584	0.3082	0.4471
Echinococcus multilocularis	epidermal growth factor receptor	0.045	0.2295	0.2295
Schistosoma mansoni	cathepsin F (C01 family)	0.0123	0.0371	0.0371
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0123	0.0371	0.0515
Brugia malayi	Cathepsin L-like precursor	0.0123	0.0371	0.0539
Echinococcus granulosus	ecdysone induced protein 78C	0.0067	0.0035	0.0035
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0067	0.0035	0.0051
Entamoeba histolytica	cysteine proteinase, putative	0.0083	0.013	0.1361

Activities

Activity type	Activity value	Assay description	Source	Reference
EC50 ratio (binding)		Transcriptional activation of retinoic acid RAR-alpha receptor; Not active	ChEMBL.	No reference
EC50 ratio (binding)	= 17	Transcriptional activation of retinoic acid RAR-gamma receptor	ChEMBL.	No reference
EC50 ratio (binding)	= 100	Transcriptional activation of retinoic acid RAR-beta receptor	ChEMBL.	No reference
EC50 ratio (binding)	0	Transcriptional activation of retinoic acid RAR-alpha receptor; Not active	ChEMBL.	No reference
EC50 ratio (binding)	= 17	Transcriptional activation of retinoic acid RAR-gamma receptor	ChEMBL.	No reference
EC50 ratio (binding)	= 100	Transcriptional activation of retinoic acid RAR-beta receptor	ChEMBL.	No reference
ED30 (functional)	= 0.184 mM	Concentration of the compound that induces 30% utriculi reduction in rhino mouse.	ChEMBL.	No reference
ED30 (functional)	= 0.184 mM	Concentration of the compound that induces 30% utriculi reduction in rhino mouse.	ChEMBL.	No reference
Max (functional)	= 0 %	Maximal transcriptional activation of RAR-alpha relative to retinoic acid at 10e-6 M	ChEMBL.	No reference
Max (functional)	= 0 %	Maximal transcriptional activation of RAR-alpha relative to retinoic acid at 10e-6 M	ChEMBL.	No reference
Max (functional)	= 66 %	Maximal trascriptional activation of RAR-beta relative to retinoic acid at 10e-6 M	ChEMBL.	No reference
Max (functional)	= 66 %	Maximal trascriptional activation of RAR-gamma relative to retinoic acid at 10e-6 M	ChEMBL.	No reference
Max (functional)	= 66 %	Maximal trascriptional activation of RAR-beta relative to retinoic acid at 10e-6 M	ChEMBL.	No reference
Max (functional)	= 66 %	Maximal trascriptional activation of RAR-gamma relative to retinoic acid at 10e-6 M	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL97668

Bibliographic References

No literature references available for this target.

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Detailed information for compound 161028