Detailed information for compound 161029

Basic information

Technical information
  • TDR Targets ID: 161029
  • Name: (E)-3-[4-(5,5,8,8-tetramethyl-6,7-dihydronaph thalene-2-carbonyl)phenyl]prop-2-enoic acid
  • MW: 362.461 | Formula: C24H26O3
  • H donors: 1 H acceptors: 3 LogP: 6.34 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(=O)/C=C/c1ccc(cc1)C(=O)c1ccc2c(c1)C(C)(C)CCC2(C)C
  • InChi: 1S/C24H26O3/c1-23(2)13-14-24(3,4)20-15-18(10-11-19(20)23)22(27)17-8-5-16(6-9-17)7-12-21(25)26/h5-12,15H,13-14H2,1-4H3,(H,25,26)/b12-7+
  • InChiKey: PKXWKCWUBFDHSQ-KPKJPENVSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (E)-3-[4-(1,1,4,4-tetramethyltetralin-6-carbonyl)phenyl]prop-2-enoic acid
  • (E)-3-[4-[oxo-(1,1,4,4-tetramethyl-6-tetralinyl)methyl]phenyl]-2-propenoic acid
  • (E)-3-[4-[(5,5,8,8-tetramethyl-6,7-dihydronaphthalen-2-yl)carbonyl]phenyl]prop-2-enoic acid
  • (E)-3-[4-(1,1,4,4-tetramethyltetralin-6-carbonyl)phenyl]acrylic acid
  • (E)-3-[4-(5,5,8,8-tetramethyl6,7-dihydronaphthalene-2-carbonyl)phenyl]prop-2-enoic acid
  • (E)-3-[4-[oxo-(1,1,4,4-tetramethyl-6-tetralinyl)methyl]phenyl]prop-2-enoic acid

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens cytochrome P450, family 26, subfamily B, polypeptide 1 Starlite/ChEMBL References
Homo sapiens cytochrome P450, family 26, subfamily A, polypeptide 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 cytochrome P450, family 26, subfamily B, polypeptide 1 437 aa 352 aa 26.4 %
Trypanosoma brucei cytochrome P450, putative cytochrome P450, family 26, subfamily A, polypeptide 1 497 aa 515 aa 21.9 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major cathepsin L-like protease 0.0121 0.0512 0.0265
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0048 0.008 0.008
Schistosoma mansoni tyrosine kinase 0.0514 0.2839 0.2839
Echinococcus granulosus tissue type plasminogen activator 0.0139 0.062 0.062
Trichomonas vaginalis conserved hypothetical protein 0.0572 0.3184 1
Trypanosoma cruzi aminopeptidase, putative 0.0092 0.0337 0.0443
Onchocerca volvulus Cathepsin L homolog 0.0121 0.0512 0.0723
Schistosoma mansoni retinoic acid receptor RXR 0.0065 0.0183 0.0183
Loa Loa (eye worm) hypothetical protein 0.004 0.0032 0.0032
Brugia malayi SEA domain containing protein 0.0046 0.0066 0.0095
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0121 0.0512 0.0515
Echinococcus multilocularis growth factor receptor bound protein 2 0.0048 0.008 0.008
Trypanosoma brucei metallo-peptidase, Clan MA(E) Family M1 0.0092 0.0337 0.0256
Mycobacterium ulcerans aminopeptidase N PepN 0.0092 0.0337 0.0089
Echinococcus granulosus Mastin 0.0082 0.0278 0.0278
Echinococcus multilocularis tyrosine kinase 0.0037 0.0013 0.0013
Onchocerca volvulus 0.0256 0.1314 0.1885
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0065 0.0183 0.0183
Echinococcus granulosus insulin receptor 0.0316 0.1665 0.1665
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0065 0.0183 0.0265
Loa Loa (eye worm) hypothetical protein 0.0082 0.0278 0.0278
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0121 0.0512 0.1151
Brugia malayi Protein kinase domain containing protein 0.0037 0.0013 0.0018
Brugia malayi Trypsin family protein 0.0082 0.0278 0.0402
Onchocerca volvulus 0.0121 0.0512 0.0723
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0037 0.0013 0.0013
Echinococcus multilocularis tyrosine protein kinase Abl 0.0061 0.0153 0.0153
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0061 0.0153 0.0153
Brugia malayi Peptidase family M1 containing protein 0.0092 0.0337 0.0487
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0061 0.0153 0.0153
Brugia malayi Protein kinase domain containing protein 0.0152 0.0693 0.1002
Loa Loa (eye worm) hypothetical protein 0.0065 0.0183 0.0183
Schistosoma mansoni cercarial elastase (S01 family) 0.0082 0.0278 0.0278
Loa Loa (eye worm) fibroinase 0.0121 0.0512 0.0512
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0092 0.0337 0.0337
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0121 0.0512 0.0515
Loa Loa (eye worm) TK/EGFR protein kinase 0.0973 0.5561 0.5561
Schistosoma mansoni cercarial elastase (S01 family) 0.0082 0.0278 0.0278
Schistosoma mansoni coup transcription factor 0.0065 0.0183 0.0183
Onchocerca volvulus 0.0046 0.0066 0.0077
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0062 0.0164 0.0164
Schistosoma mansoni tyrosine kinase 0.0061 0.0153 0.0153
Onchocerca volvulus 0.0046 0.0066 0.0077
Entamoeba histolytica cysteine protease, putative 0.0062 0.0164 0.1556
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0526 0.2912 0.2912
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0121 0.0512 0.1151
Echinococcus granulosus tyrosine protein kinase Srms 0.0037 0.0013 0.0013
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0173 0.0821 0.0821
Onchocerca volvulus 0.0139 0.062 0.088
Loa Loa (eye worm) hypothetical protein 0.0081 0.0275 0.0275
Trypanosoma cruzi aminopeptidase, putative 0.0092 0.0337 0.0443
Schistosoma mansoni tyrosine kinase 0.0973 0.5561 0.5561
Echinococcus granulosus FTZ F1 alpha 0.0065 0.0183 0.0183
Echinococcus multilocularis thyroid hormone receptor alpha 0.0065 0.0183 0.0183
Schistosoma mansoni hypothetical protein 0.0139 0.062 0.062
Brugia malayi hypothetical protein 0.0092 0.0337 0.0487
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0121 0.0512 0.0515
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.1722 1 1
Echinococcus multilocularis aminopeptidase N 0.0092 0.0337 0.0337
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0081 0.0275 0.0353
Brugia malayi hypothetical protein 0.0092 0.0337 0.0487
Onchocerca volvulus 0.0051 0.0095 0.012
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0082 0.0278 0.0278
Echinococcus granulosus tyrosine protein kinase shark 0.0037 0.0013 0.0013
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0121 0.0512 0.1151
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0048 0.008 0.008
Schistosoma mansoni cercarial elastase (S01 family) 0.0082 0.0278 0.0278
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0121 0.0512 0.1151
Echinococcus multilocularis cathepsin L cysteine protease 0.0121 0.0512 0.0512
Loa Loa (eye worm) TK protein kinase 0.0201 0.0987 0.0987
Echinococcus granulosus glycoprotein Antigen 5 0.0082 0.0278 0.0278
Plasmodium falciparum cysteine proteinase falcipain 3 0.0121 0.0512 0.0515
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.038 0.2047 0.2926
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0121 0.0512 0.0512
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0121 0.0512 0.1151
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0092 0.0337 0.0573
Echinococcus granulosus tyrosine protein kinase Lyn 0.0253 0.1293 0.1293
Loa Loa (eye worm) thymidylate synthase 0.1202 0.6918 0.6918
Loa Loa (eye worm) hypothetical protein 0.0082 0.0278 0.0278
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0065 0.0183 0.0183
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0121 0.0512 0.0512
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.1202 0.6918 0.5
Echinococcus granulosus enteropeptidase 0.0082 0.0278 0.0278
Echinococcus multilocularis c src tyrosine kinase 0.0061 0.0153 0.0153
Mycobacterium ulcerans thymidylate synthase 0.1202 0.6918 1
Schistosoma mansoni tyrosine kinase 0.0526 0.2912 0.2912
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0249 0.1273 0.1273
Brugia malayi Cathepsin L-like precursor 0.0121 0.0512 0.074
Trypanosoma cruzi cruzipain precursor, putative 0.0121 0.0512 0.0697
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.004 0.0032 0.0046
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0065 0.0183 0.0183
Entamoeba histolytica cysteine protease, putative 0.0062 0.0164 0.1556
Echinococcus multilocularis epidermal growth factor receptor 0.0973 0.5561 0.5561
Loa Loa (eye worm) TK/FER protein kinase 0.0037 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0092 0.0337 0.0337
Trypanosoma cruzi cysteine peptidase, putative 0.0121 0.0512 0.0697
Plasmodium falciparum M1-family alanyl aminopeptidase, putative 0.0092 0.0337 0.0256
Trypanosoma cruzi cysteine peptidase, putative 0.0121 0.0512 0.0697
Brugia malayi Tyrosine-protein kinase abl-1 0.0061 0.0153 0.0222
Echinococcus granulosus cathepsin l cysteine peptidase 0.0121 0.0512 0.0512
Loa Loa (eye worm) hypothetical protein 0.0082 0.0278 0.0278
Brugia malayi Papain family cysteine protease containing protein 0.0062 0.0164 0.0237
Trypanosoma cruzi cysteine proteinase, putative 0.0062 0.0164 0.0192
Schistosoma mansoni adapter molecule crk 0.0048 0.008 0.008
Schistosoma mansoni cathepsin F (C01 family) 0.0081 0.0275 0.0275
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0139 0.062 0.0854
Schistosoma mansoni tyrosine kinase 0.0249 0.1273 0.1273
Loa Loa (eye worm) TK protein kinase 0.0226 0.1132 0.1132
Leishmania major hypothetical protein, conserved 0.0139 0.062 0.043
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0121 0.0512 0.1151
Brugia malayi Trypsin family protein 0.0082 0.0278 0.0402
Echinococcus multilocularis epidermal growth factor receptor 0.0526 0.2912 0.2912
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0065 0.0183 0.0265
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0249 0.1273 0.1273
Echinococcus granulosus tyrosine protein kinase Src42A 0.0249 0.1273 0.1273
Onchocerca volvulus 0.0338 0.1797 0.2585
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0085 0.0301 0.0301
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0121 0.0512 0.1151
Loa Loa (eye worm) hypothetical protein 0.0082 0.0278 0.0278
Echinococcus granulosus ecdysone induced protein 78C 0.0065 0.0183 0.0183
Loa Loa (eye worm) hypothetical protein 0.0082 0.0278 0.0278
Brugia malayi Nuclear hormone receptor-like 1 0.0065 0.0183 0.0265
Echinococcus granulosus tyrosine protein kinase Fyn 0.0249 0.1273 0.1273
Onchocerca volvulus 0.0092 0.0337 0.047
Entamoeba histolytica cysteine protease, putative 0.0062 0.0164 0.1556
Plasmodium falciparum M1-family alanyl aminopeptidase 0.0092 0.0337 0.0256
Loa Loa (eye worm) TK/ROR protein kinase 0.0152 0.0693 0.0693
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0121 0.0512 0.1151
Schistosoma mansoni tyrosine kinase 0.0514 0.2839 0.2839
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.038 0.2047 0.2598
Leishmania major cathepsin L-like protease 0.0121 0.0512 0.0265
Echinococcus multilocularis leukotriene A 4 hydrolase 0.1722 1 1
Echinococcus granulosus cathepsin l1 0.0121 0.0512 0.0512
Loa Loa (eye worm) TK/FER protein kinase 0.0037 0.0013 0.0013
Echinococcus granulosus cathepsin l1 0.0081 0.0275 0.0275
Echinococcus multilocularis tyrosine protein kinase shark 0.0037 0.0013 0.0013
Onchocerca volvulus Protein ultraspiracle homolog 0.0065 0.0183 0.0247
Onchocerca volvulus 0.0121 0.0512 0.0723
Echinococcus multilocularis insulin receptor 0.0316 0.1665 0.1665
Loa Loa (eye worm) papain family cysteine protease containing protein 0.004 0.0032 0.0032
Leishmania major cathepsin L-like protease 0.0121 0.0512 0.0265
Echinococcus granulosus tyrosine kinase 0.0226 0.1132 0.1132
Echinococcus granulosus c src tyrosine kinase 0.0061 0.0153 0.0153
Loa Loa (eye worm) steroid hormone receptor 0.0065 0.0183 0.0183
Echinococcus granulosus growth factor receptor bound protein 2 0.0048 0.008 0.008
Leishmania major cathepsin L-like protease 0.0121 0.0512 0.0265
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0065 0.0183 0.0183
Schistosoma mansoni hypothetical protein 0.0082 0.0278 0.0278
Leishmania major cathepsin L-like protease 0.0121 0.0512 0.0265
Brugia malayi Cathepsin L-like precursor 0.0121 0.0512 0.074
Echinococcus multilocularis cysteine protease 0.0121 0.0512 0.0512
Loa Loa (eye worm) hypothetical protein 0.0065 0.0183 0.0183
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0249 0.1273 0.1273
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0082 0.0278 0.0278
Entamoeba histolytica aminopeptidase, putative 0.0092 0.0337 0.333
Echinococcus granulosus thymidylate synthase 0.1202 0.6918 0.6918
Brugia malayi Cathepsin L-like precursor 0.0121 0.0512 0.074
Entamoeba histolytica cysteine protease, putative 0.0062 0.0164 0.1556
Entamoeba histolytica cysteine protease, putative 0.0062 0.0164 0.1556
Schistosoma mansoni tyrosine kinase 0.0316 0.1665 0.1665
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.038 0.2047 0.2047
Schistosoma mansoni thyroid hormone receptor 0.0065 0.0183 0.0183
Trypanosoma brucei Aminopeptidase M1, putative 0.0092 0.0337 0.0256
Echinococcus multilocularis tyrosine protein kinase Blk 0.0226 0.1132 0.1132
Echinococcus granulosus tyrosine protein kinase Fyn 0.0249 0.1273 0.1273
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0092 0.0337 0.0337
Loa Loa (eye worm) TK/FER protein kinase 0.0037 0.0013 0.0013
Trypanosoma brucei Aminopeptidase M1, putative 0.0092 0.0337 0.0256
Entamoeba histolytica cysteine protease, putative 0.0062 0.0164 0.1556
Loa Loa (eye worm) TK/ABL protein kinase 0.0037 0.0013 0.0013
Brugia malayi Cathepsin L-like precursor 0.0081 0.0275 0.0397
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.038 0.2047 0.2598
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0048 0.008 0.008
Entamoeba histolytica cysteine proteinase, putative 0.0062 0.0164 0.1556
Loa Loa (eye worm) trypsin family protein 0.0082 0.0278 0.0278
Schistosoma mansoni tyrosine kinase 0.0526 0.2912 0.2912
Schistosoma mansoni RAR-like nuclear receptor 0.0065 0.0183 0.0183
Entamoeba histolytica cysteine proteinase, putative 0.0121 0.0512 0.5121
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0065 0.0183 0.0247
Entamoeba histolytica cysteine proteinase, putative 0.0081 0.0275 0.269
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0121 0.0512 0.0515
Loa Loa (eye worm) hypothetical protein 0.0051 0.0095 0.0095
Schistosoma mansoni tyrosine kinase 0.0037 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0046 0.0066 0.0066
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0316 0.1665 0.1665
Brugia malayi Cathepsin L-like precursor 0.0081 0.0275 0.0397
Schistosoma mansoni Tata binding protein associated factor (M01 family) 0.0092 0.0337 0.0337
Trypanosoma cruzi cysteine peptidase, putative 0.0121 0.0512 0.0697
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0065 0.0183 0.0183
Onchocerca volvulus 0.0046 0.0066 0.0077
Schistosoma mansoni cercarial elastase (S01 family) 0.0082 0.0278 0.0278
Schistosoma mansoni tyrosine kinase 0.0037 0.0013 0.0013
Echinococcus granulosus tyrosine protein kinase Fyn 0.0249 0.1273 0.1273
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0121 0.0512 0.1151
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0065 0.0183 0.0183
Leishmania major cysteine peptidase A (CPA) 0.0121 0.0512 0.0265
Schistosoma mansoni cathepsin s 0.004 0.0032 0.0032
Brugia malayi Peptidase family M1 containing protein 0.0092 0.0337 0.0487
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0121 0.0512 0.0515
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0062 0.0164 0.0164
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0249 0.1273 0.1273
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0037 0.0013 0.0013
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0213 0.1059 0.1059
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0081 0.0275 0.0366
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0121 0.0512 0.1151
Entamoeba histolytica cysteine protease, putative 0.0062 0.0164 0.1556
Mycobacterium ulcerans aminopeptidase N PepN 0.0092 0.0337 0.0089
Entamoeba histolytica cysteine proteinase, putative 0.0062 0.0164 0.1556
Schistosoma mansoni tyrosine kinase 0.0514 0.2839 0.2839
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0037 0.0013 0.0013
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0082 0.0278 0.0278
Loa Loa (eye worm) TK/FER protein kinase 0.0037 0.0013 0.0013
Echinococcus granulosus tyrosine protein kinase Blk 0.0226 0.1132 0.1132
Loa Loa (eye worm) hypothetical protein 0.0065 0.0183 0.0183
Trichomonas vaginalis CMGC family protein kinase 0.038 0.2047 0.6235
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0121 0.0512 0.1151
Trypanosoma cruzi Aminopeptidase M1, putative 0.0092 0.0337 0.0443
Schistosoma mansoni cercarial elastase (S01 family) 0.0082 0.0278 0.0278
Leishmania major cathepsin L-like protease 0.0121 0.0512 0.0265
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0121 0.0512 0.1151
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.038 0.2047 0.2598
Echinococcus multilocularis cysteine protease 0.0121 0.0512 0.0512
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0065 0.0183 0.0265
Schistosoma mansoni steroid hormone receptor ad4bp 0.0065 0.0183 0.0183
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.1202 0.6918 1
Brugia malayi cathepsin F-like cysteine proteinase 0.004 0.0032 0.0046
Echinococcus granulosus cathepsin L 0.0062 0.0164 0.0164
Echinococcus granulosus epidermal growth factor receptor 0.0973 0.5561 0.5561
Brugia malayi Protein kinase domain containing protein 0.0037 0.0013 0.0018
Onchocerca volvulus 0.0046 0.0066 0.0077
Loa Loa (eye worm) TK/FER protein kinase 0.0037 0.0013 0.0013
Brugia malayi MAP kinase sur-1 0.038 0.2047 0.2959
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0092 0.0337 0.0443
Plasmodium vivax vivapain-3 0.0062 0.0164 0.0192
Brugia malayi Trypsin family protein 0.0082 0.0278 0.0402
Loa Loa (eye worm) TK/FER protein kinase 0.0037 0.0013 0.0013
Echinococcus multilocularis cathepsin L 0.0062 0.0164 0.0164
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0249 0.1273 0.1273
Loa Loa (eye worm) ctsf protein 0.0121 0.0512 0.0512
Brugia malayi Cathepsin L-like precursor 0.0121 0.0512 0.074
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0065 0.0183 0.0183
Entamoeba histolytica cysteine proteinase, putative 0.0121 0.0512 0.5121
Onchocerca volvulus 0.0121 0.0512 0.0723
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.1202 0.6918 1
Echinococcus multilocularis NCK adaptor protein 0.0048 0.008 0.008
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0226 0.1132 0.1132
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0092 0.0337 0.0337
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0065 0.0183 0.0183
Loa Loa (eye worm) hypothetical protein 0.004 0.0032 0.0032
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0065 0.0183 0.0265
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0121 0.0512 0.1151
Schistosoma mansoni nck2/grb4 0.0048 0.008 0.008
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0121 0.0512 0.0512
Plasmodium falciparum cysteine repeat modular protein 1 0.0139 0.062 0.0675
Echinococcus multilocularis mitogen activated protein kinase 3 0.038 0.2047 0.2047
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0092 0.0337 0.0443
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0065 0.0183 0.0183
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0065 0.0183 0.0265
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0092 0.0337 0.0337
Trypanosoma brucei protein kinase, putative 0.038 0.2047 0.2788
Brugia malayi steroid hormone receptor 0.0065 0.0183 0.0265
Brugia malayi hypothetical protein 0.0572 0.3184 0.4602
Schistosoma mansoni cercarial elastase (S01 family) 0.0082 0.0278 0.0278
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0121 0.0512 0.0515
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0065 0.0183 0.0265
Brugia malayi thymidylate synthase 0.1202 0.6918 1
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0249 0.1273 0.1273
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0121 0.0512 0.0515
Entamoeba histolytica cysteine proteinase, putative 0.0062 0.0164 0.1556
Brugia malayi Cathepsin L-like precursor 0.0121 0.0512 0.074
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0338 0.1797 0.1797
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0065 0.0183 0.0183
Leishmania major cathepsin L-like protease 0.0121 0.0512 0.0265
Loa Loa (eye worm) hypothetical protein 0.0037 0.0013 0.0013
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0065 0.0183 0.0183
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0092 0.0337 0.0443
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0065 0.0183 0.0183
Brugia malayi SRC-1 0.0249 0.1273 0.184
Brugia malayi Sex muscle abnormal protein 5 0.0048 0.008 0.0116
Brugia malayi nuclear receptor NHR-88 0.0065 0.0183 0.0265
Brugia malayi nuclear hormone receptor 0.0065 0.0183 0.0265
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0082 0.0278 0.0278
Schistosoma mansoni cercarial elastase (S01 family) 0.0082 0.0278 0.0278
Onchocerca volvulus 0.0092 0.0337 0.047
Brugia malayi protein-tyrosine kinase 0.0226 0.1132 0.1636
Loa Loa (eye worm) TK/FER protein kinase 0.0037 0.0013 0.0013
Schistosoma mansoni tyrosine kinase 0.0249 0.1273 0.1273
Onchocerca volvulus 0.0082 0.0278 0.0385
Echinococcus multilocularis 0.0299 0.1567 0.1567
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0065 0.0183 0.0183
Brugia malayi Trypsin family protein 0.0338 0.1797 0.2598
Echinococcus multilocularis cathepsin L cysteine protease 0.0121 0.0512 0.0512
Echinococcus granulosus NCK adaptor protein 0.0048 0.008 0.008
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.0164 0.0192
Loa Loa (eye worm) hypothetical protein 0.0065 0.0183 0.0183
Schistosoma mansoni cathepsin F (C01 family) 0.0121 0.0512 0.0512
Loa Loa (eye worm) TATA binding protein associated factor 0.0092 0.0337 0.0337
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0121 0.0512 0.1151
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0121 0.0512 0.1151
Toxoplasma gondii kringle domain-containing protein 0.0139 0.062 0.043
Toxoplasma gondii cathepsin CPL 0.0121 0.0512 0.0265
Schistosoma mansoni thyroid hormone receptor 0.0065 0.0183 0.0183
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0092 0.0337 0.0337
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0065 0.0183 0.0183
Echinococcus multilocularis Mastin 0.0082 0.0278 0.0278
Brugia malayi Protein kinase domain containing protein 0.0037 0.0013 0.0018
Loa Loa (eye worm) DOMON domain-containing protein 0.0046 0.0066 0.0066
Echinococcus granulosus tyrosine protein kinase ABL1 0.0037 0.0013 0.0013
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0082 0.0278 0.0278
Trypanosoma brucei aminopeptidase, putative 0.0092 0.0337 0.0256
Leishmania major cathepsin L-like protease 0.0121 0.0512 0.0265
Trichomonas vaginalis CMGC family protein kinase 0.038 0.2047 0.6235
Onchocerca volvulus 0.0121 0.0512 0.0723
Loa Loa (eye worm) hypothetical protein 0.0081 0.0275 0.0275
Loa Loa (eye worm) hypothetical protein 0.0092 0.0337 0.0337
Trichomonas vaginalis CMGC family protein kinase 0.038 0.2047 0.6235
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0065 0.0183 0.0265
Echinococcus granulosus tyrosine kinase 0.0037 0.0013 0.0013
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0065 0.0183 0.0183
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0092 0.0337 0.0337
Echinococcus multilocularis glycoprotein Antigen 5 0.0082 0.0278 0.0278
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0121 0.0512 0.1151
Schistosoma mansoni nuclear hormone receptor 0.0065 0.0183 0.0183
Loa Loa (eye worm) hypothetical protein 0.0139 0.062 0.062
Entamoeba histolytica cysteine protease, putative 0.0062 0.0164 0.1556
Brugia malayi photoreceptor-specific nuclear receptor 0.0065 0.0183 0.0265
Echinococcus multilocularis tissue type plasminogen activator 0.0139 0.062 0.062
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0092 0.0337 0.0337
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.038 0.2047 0.2926
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.038 0.2047 0.2788
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0092 0.0337 0.0337
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0249 0.1273 0.1273
Loa Loa (eye worm) hypothetical protein 0.0065 0.0183 0.0183
Loa Loa (eye worm) hypothetical protein 0.0065 0.0183 0.0183
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0092 0.0337 0.0443
Onchocerca volvulus 0.0082 0.0278 0.0385
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0065 0.0183 0.0265
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0121 0.0512 0.1151
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0065 0.0183 0.0183
Onchocerca volvulus 0.0081 0.0275 0.038
Onchocerca volvulus 0.0092 0.0337 0.047
Echinococcus granulosus tyrosine protein kinase HCK 0.0201 0.0987 0.0987
Plasmodium vivax unspecified product 0.0062 0.0164 0.0192
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.0572 0.3184 0.4577
Plasmodium vivax vivapain-2 0.0121 0.0512 0.0697
Echinococcus granulosus epidermal growth factor receptor 0.0526 0.2912 0.2912
Brugia malayi Papain family cysteine protease containing protein 0.0121 0.0512 0.074
Loa Loa (eye worm) cysteine protease 0.0121 0.0512 0.0512
Onchocerca volvulus 0.0065 0.0183 0.0247
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0092 0.0337 0.0337
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0092 0.0337 0.0337
Brugia malayi Cathepsin L-like precursor 0.0121 0.0512 0.074
Brugia malayi Variant SH3 domain containing protein 0.0048 0.008 0.0116
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0065 0.0183 0.0265
Schistosoma mansoni aminopeptidase A (M01 family) 0.0092 0.0337 0.0337
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0121 0.0512 0.1151
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0121 0.0512 0.1151
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0061 0.0153 0.0153
Brugia malayi Protein kinase domain containing protein 0.0037 0.0013 0.0018
Loa Loa (eye worm) hypothetical protein 0.0338 0.1797 0.1797
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0092 0.0337 0.0443
Entamoeba histolytica cysteine protease, putative 0.0062 0.0164 0.1556
Loa Loa (eye worm) peptidase family M1 containing protein 0.0092 0.0337 0.0337
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0065 0.0183 0.0183
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0065 0.0183 0.0265
Echinococcus multilocularis enteropeptidase 0.0082 0.0278 0.0278
Brugia malayi Protein kinase domain containing protein 0.0037 0.0013 0.0018
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0121 0.0512 0.0515
Echinococcus multilocularis thymidylate synthase 0.1202 0.6918 0.6918
Onchocerca volvulus 0.0121 0.0512 0.0723
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.038 0.2047 0.2926
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0121 0.0512 0.0515
Onchocerca volvulus 0.1202 0.6918 1
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.1202 0.6918 1
Schistosoma mansoni tyrosine kinase 0.0316 0.1665 0.1665
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0082 0.0278 0.0278
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.0092 0.0337 0.0337
Onchocerca volvulus 0.0121 0.0512 0.0723
Echinococcus multilocularis FTZ F1 alpha 0.0065 0.0183 0.0183
Giardia lamblia Kinase, CMGC MAPK 0.038 0.2047 0.5
Entamoeba histolytica cysteine protease, putative 0.0062 0.0164 0.1556
Echinococcus multilocularis tyrosine protein kinase HCK 0.0201 0.0987 0.0987
Brugia malayi SH2 domain containing protein 0.0037 0.0013 0.0018
Trypanosoma cruzi cysteine peptidase, putative 0.0121 0.0512 0.0697
Schistosoma mansoni cercarial elastase (S01 family) 0.0082 0.0278 0.0278
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.1202 0.6918 1
Schistosoma mansoni hypothetical protein 0.0082 0.0278 0.0278
Echinococcus granulosus mitogen activated protein kinase 3 0.038 0.2047 0.2047
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0065 0.0183 0.0183
Trichomonas vaginalis CMGC family protein kinase 0.038 0.2047 0.6235
Leishmania major dihydrofolate reductase-thymidylate synthase 0.1202 0.6918 1
Schistosoma mansoni cercarial elastase (S01 family) 0.0082 0.0278 0.0278
Brugia malayi Peptidase family M1 containing protein 0.0092 0.0337 0.0487
Entamoeba histolytica cysteine proteinase, putative 0.0062 0.0164 0.1556
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0065 0.0183 0.0183
Loa Loa (eye worm) aminopeptidase N 0.0092 0.0337 0.0337
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0092 0.0337 0.0443
Brugia malayi ecdysteroid receptor 0.0065 0.0183 0.0265
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0065 0.0183 0.0265
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0316 0.1665 0.1665
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.038 0.2047 0.2926
Loa Loa (eye worm) hypothetical protein 0.0092 0.0337 0.0337
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0249 0.1273 0.1273
Echinococcus multilocularis tyrosine protein kinase Srms 0.0226 0.1132 0.1132
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0121 0.0512 0.0515
Echinococcus multilocularis transmembrane protease serine 3 0.0082 0.0278 0.0278
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0121 0.0512 0.1151
Brugia malayi Trypsin-like protease protein 5 0.0082 0.0278 0.0402
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0062 0.0164 0.0164
Entamoeba histolytica cysteine protease, putative 0.0062 0.0164 0.1556
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0121 0.0512 0.0515
Onchocerca volvulus 0.0082 0.0278 0.0385
Loa Loa (eye worm) hypothetical protein 0.0048 0.008 0.008
Brugia malayi Muscle positioning protein 4 0.0051 0.0095 0.0138
Onchocerca volvulus 0.0082 0.0278 0.0385
Loa Loa (eye worm) TK/FER protein kinase 0.0037 0.0013 0.0013
Onchocerca volvulus Cathepsin F homolog 0.0121 0.0512 0.0723
Loa Loa (eye worm) hypothetical protein 0.0081 0.0275 0.0275
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0121 0.0512 0.1151
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0121 0.0512 0.1151
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.1202 0.6918 0.6918
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0065 0.0183 0.0183
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0249 0.1273 0.1273
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0065 0.0183 0.0265
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0249 0.1273 0.1273
Echinococcus granulosus cathepsin L cysteine protease 0.0062 0.0164 0.0164
Schistosoma mansoni cercarial elastase (S01 family) 0.0082 0.0278 0.0278
Trypanosoma cruzi cysteine protease, putative 0.0062 0.0164 0.0192
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0092 0.0337 0.0443
Trypanosoma cruzi hypothetical protein, conserved 0.0139 0.062 0.0854
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0226 0.1132 0.1132
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0092 0.0337 0.0573
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0081 0.0275 0.0366
Entamoeba histolytica cysteine protease, putative 0.0121 0.0512 0.5121
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0065 0.0183 0.0183
Echinococcus granulosus tyrosine protein kinase Src42A 0.0213 0.1059 0.1059
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0121 0.0512 0.0515
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0121 0.0512 0.1151
Onchocerca volvulus Cathepsin L homolog 0.0121 0.0512 0.0723
Brugia malayi Papain family cysteine protease containing protein 0.0062 0.0164 0.0237
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.035 0.1869 0.1869
Echinococcus granulosus mitogen activated protein kinase 0.038 0.2047 0.2047
Brugia malayi hypothetical protein 0.0037 0.0013 0.0018
Schistosoma mansoni hypothetical protein 0.0046 0.0066 0.0066
Echinococcus granulosus cysteine protease 0.0062 0.0164 0.0164
Echinococcus granulosus tyrosine protein kinase Src64B 0.0249 0.1273 0.1273
Loa Loa (eye worm) TK/FER protein kinase 0.0037 0.0013 0.0013
Brugia malayi hypothetical protein 0.0082 0.0278 0.0402
Schistosoma mansoni serine/threonine protein kinase 0.0036 0.0009 0.0009
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0062 0.0164 0.0192
Schistosoma mansoni cathepsin F (C01 family) 0.0121 0.0512 0.0512
Loa Loa (eye worm) hypothetical protein 0.004 0.0032 0.0032
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0249 0.1273 0.1273
Onchocerca volvulus 0.0121 0.0512 0.0723
Echinococcus granulosus aminopeptidase N 0.0092 0.0337 0.0337
Loa Loa (eye worm) hypothetical protein 0.0338 0.1797 0.1797
Loa Loa (eye worm) leukotriene A4 hydrolase 0.1722 1 1
Trypanosoma cruzi cysteine proteinase, putative 0.0062 0.0164 0.0192
Plasmodium vivax vivapain-1 0.0062 0.0164 0.0192
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0065 0.0183 0.0183
Onchocerca volvulus Bile acid receptor homolog 0.0065 0.0183 0.0247
Schistosoma mansoni growth factor receptor-bound protein 0.0048 0.008 0.008
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0065 0.0183 0.0183
Schistosoma mansoni growth factor receptor-bound protein 0.0048 0.008 0.008
Loa Loa (eye worm) SRC-1 0.0249 0.1273 0.1273
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0065 0.0183 0.0183
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0082 0.0278 0.0402
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.1202 0.6918 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0065 0.0183 0.0265
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0092 0.0337 0.0337
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0121 0.0512 0.1151
Brugia malayi SH2 domain containing protein 0.0037 0.0013 0.0018
Loa Loa (eye worm) hypothetical protein 0.0121 0.0512 0.0512
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0121 0.0512 0.0512
Brugia malayi Protein kinase domain containing protein 0.0316 0.1665 0.2407
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0065 0.0183 0.0183
Echinococcus multilocularis mitogen activated protein kinase 0.038 0.2047 0.2047
Entamoeba histolytica cysteine proteinase 2 0.0062 0.0164 0.1556
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0082 0.0278 0.0278
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0121 0.0512 0.0515
Brugia malayi Steroid receptor seven-up type 2 0.0065 0.0183 0.0265
Brugia malayi cathepsin L-like precursor 0.0081 0.0275 0.0397
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0092 0.0337 0.0573
Echinococcus granulosus cathepsin L cysteine proteinase 0.0121 0.0512 0.0512
Brugia malayi TATA binding protein associated factor 0.0092 0.0337 0.0487
Entamoeba histolytica cysteine protease, putative 0.0062 0.0164 0.1556
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0082 0.0278 0.0278
Loa Loa (eye worm) TK/FER protein kinase 0.0037 0.0013 0.0013
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0065 0.0183 0.0183
Brugia malayi hypothetical protein 0.0792 0.4487 0.6486
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.0092 0.0337 0.0337
Loa Loa (eye worm) hypothetical protein 0.0065 0.0183 0.0183
Loa Loa (eye worm) hypothetical protein 0.0065 0.0183 0.0183
Echinococcus multilocularis ecdysone induced protein 78C 0.0065 0.0183 0.0183
Echinococcus granulosus transmembrane protease serine 3 0.0082 0.0278 0.0278
Entamoeba histolytica cysteine proteinase 1, putative 0.0062 0.0164 0.1556
Onchocerca volvulus 0.0082 0.0278 0.0385
Brugia malayi Cathepsin L-like cysteine proteinase 0.0081 0.0275 0.0397
Loa Loa (eye worm) TK/INSR protein kinase 0.0316 0.1665 0.1665
Schistosoma mansoni serine/threonine protein kinase 0.038 0.2047 0.2047
Brugia malayi Variant SH3 domain containing protein 0.0048 0.008 0.0116
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0121 0.0512 0.1151
Entamoeba histolytica cysteine protease, putative 0.0062 0.0164 0.1556
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.1202 0.6918 1
Plasmodium vivax vivapain-2 0.0121 0.0512 0.0697
Entamoeba histolytica protein kinase, putative 0.0201 0.0987 1
Brugia malayi Kringle domain containing protein 0.0139 0.062 0.0896
Schistosoma mansoni cercarial elastase (S01 family) 0.0082 0.0278 0.0278
Brugia malayi Cathepsin L-like precursor 0.004 0.0032 0.0046
Brugia malayi Furin-like cysteine rich region family protein 0.0973 0.5561 0.8039
Schistosoma mansoni tyrosine kinase 0.0061 0.0153 0.0153

Activities

Activity type Activity value Assay description Source Reference
EC50 ratio (binding) = 63 Transcriptional activation of retinoic acid RAR-alpha receptor ChEMBL. No reference
EC50 ratio (binding) = 67 Transcriptional activation of retinoic acid RAR-gamma receptor ChEMBL. No reference
EC50 ratio (binding) = 100 Transcriptional activation of retinoic acid RAR-beta receptor ChEMBL. No reference
EC50 ratio (binding) = 63 Transcriptional activation of retinoic acid RAR-alpha receptor ChEMBL. No reference
EC50 ratio (binding) = 67 Transcriptional activation of retinoic acid RAR-gamma receptor ChEMBL. No reference
EC50 ratio (binding) = 100 Transcriptional activation of retinoic acid RAR-beta receptor ChEMBL. No reference
ED30 (functional) = 0.054 mM Concentration of the compound that induces 30% utriculi reduction in rhino mouse. ChEMBL. No reference
ED30 (functional) = 0.054 mM Concentration of the compound that induces 30% utriculi reduction in rhino mouse. ChEMBL. No reference
IC50 (binding) = 4.7 uM Inhibition of microsomal fraction of human CYP26A1 expressed in Sf9 cells using 9-cis-RA as substrate preincubated for 5 mins followed by NADPH addition measured after 1 min by HPLC analysis in presence of rat P450 reductase ChEMBL. 26918322
IC50 (binding) > 5 uM Inhibition of microsomal fraction of human CYP26B1 expressed in Sf9 cells using 9-cis-RA as substrate preincubated for 5 mins followed by NADPH addition measured after 5 mins by HPLC analysis in presence of rat P450 reductase ChEMBL. 26918322
Max (functional) = 63 % Maximal transcriptional activation of RAR-alpha relative to retinoic acid at 10e-6 M ChEMBL. No reference
Max (functional) = 63 % Maximal transcriptional activation of RAR-alpha relative to retinoic acid at 10e-6 M ChEMBL. No reference
Max (functional) = 78 % Maximal trascriptional activation of RAR-beta relative to retinoic acid at 10e-6 M ChEMBL. No reference
Max (functional) = 78 % Maximal trascriptional activation of RAR-beta relative to retinoic acid at 10e-6 M ChEMBL. No reference
Max (functional) = 86 % Maximal trascriptional activation of RAR-gamma relative to retinoic acid at 10e-6 M ChEMBL. No reference
Max (functional) = 86 % Maximal trascriptional activation of RAR-gamma relative to retinoic acid at 10e-6 M ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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