Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0697 | 1 | 1 |
Echinococcus multilocularis | cysteine protease | 0.0697 | 1 | 1 |
Leishmania major | cathepsin L-like protease | 0.0697 | 1 | 0.5 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0361 | 0.2137 | 0.2137 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0697 | 1 | 1 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0697 | 1 | 1 |
Echinococcus granulosus | cathepsin l1 | 0.0697 | 1 | 1 |
Toxoplasma gondii | cathepsin CPL | 0.0697 | 1 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0697 | 1 | 1 |
Brugia malayi | cathepsin L-like precursor | 0.0468 | 0.4639 | 0.4639 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0697 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0697 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0697 | 1 | 1 |
Leishmania major | cathepsin L-like protease | 0.0697 | 1 | 0.5 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0697 | 1 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.0697 | 1 | 1 |
Trypanosoma cruzi | cysteine proteinase, putative | 0.0361 | 0.2137 | 0.2137 |
Onchocerca volvulus | Cathepsin L homolog | 0.0697 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0697 | 1 | 1 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0697 | 1 | 1 |
Leishmania major | cathepsin L-like protease | 0.0697 | 1 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0697 | 1 | 1 |
Loa Loa (eye worm) | fibroinase | 0.0697 | 1 | 1 |
Onchocerca volvulus | 0.0697 | 1 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0697 | 1 | 1 |
Onchocerca volvulus | 0.0697 | 1 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0697 | 1 | 1 |
Loa Loa (eye worm) | ctsf protein | 0.0697 | 1 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0697 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0697 | 1 | 1 |
Leishmania major | cathepsin L-like protease | 0.0697 | 1 | 0.5 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0697 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0468 | 0.4639 | 0.4639 |
Onchocerca volvulus | 0.0697 | 1 | 1 | |
Brugia malayi | Cathepsin L-like precursor | 0.0468 | 0.4639 | 0.4639 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0697 | 1 | 1 |
Leishmania major | cathepsin L-like protease | 0.0697 | 1 | 0.5 |
Onchocerca volvulus | 0.0697 | 1 | 1 | |
Echinococcus multilocularis | cysteine protease | 0.0697 | 1 | 1 |
Echinococcus granulosus | cathepsin L cysteine protease | 0.0361 | 0.2137 | 0.2137 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0361 | 0.2137 | 0.2137 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0697 | 1 | 1 |
Leishmania major | cathepsin L-like protease | 0.0697 | 1 | 0.5 |
Plasmodium vivax | vivapain-2 | 0.0697 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0697 | 1 | 1 |
Onchocerca volvulus | 0.0697 | 1 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0468 | 0.4639 | 0.4639 |
Leishmania major | cathepsin L-like protease | 0.0697 | 1 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0697 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0697 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0697 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0697 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0697 | 1 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0697 | 1 | 1 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.0468 | 0.4639 | 0.4639 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0697 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0697 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0697 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase (N-terminal), putative | 0.0361 | 0.2137 | 0.2137 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0697 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0697 | 1 | 1 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0697 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0697 | 1 | 1 |
Leishmania major | cathepsin L-like protease | 0.0697 | 1 | 0.5 |
Onchocerca volvulus | 0.0697 | 1 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0697 | 1 | 1 |
Loa Loa (eye worm) | cysteine protease | 0.0697 | 1 | 1 |
Onchocerca volvulus | Cathepsin F homolog | 0.0697 | 1 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0697 | 1 | 1 |
Plasmodium vivax | vivapain-2 | 0.0697 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0697 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0697 | 1 | 1 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0697 | 1 | 1 |
Echinococcus multilocularis | cathepsin L | 0.0361 | 0.2137 | 0.2137 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0697 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0697 | 1 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0697 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0697 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0468 | 0.4639 | 0.3182 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0468 | 0.4639 | 0.3182 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.0361 | 0.2137 | 0.2137 |
Brugia malayi | Cathepsin L-like precursor | 0.0697 | 1 | 1 |
Echinococcus granulosus | cathepsin L | 0.0361 | 0.2137 | 0.2137 |
Trypanosoma cruzi | cysteine protease, putative | 0.0361 | 0.2137 | 0.2137 |
Echinococcus granulosus | cathepsin l1 | 0.0468 | 0.4639 | 0.4639 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0697 | 1 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0468 | 0.4639 | 0.4639 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0697 | 1 | 1 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0697 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0697 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0468 | 0.4639 | 0.4639 |
Leishmania major | cysteine peptidase A (CPA) | 0.0697 | 1 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0697 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0697 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0697 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0697 | 1 | 1 |
Trypanosoma cruzi | cysteine proteinase, putative | 0.0361 | 0.2137 | 0.2137 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0697 | 1 | 1 |
Onchocerca volvulus | Cathepsin L homolog | 0.0697 | 1 | 1 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.0361 | 0.2137 | 0.2137 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0697 | 1 | 1 |
Echinococcus granulosus | cysteine protease | 0.0361 | 0.2137 | 0.2137 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0697 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0468 | 0.4639 | 0.4639 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0697 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0697 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0697 | 1 | 1 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0697 | 1 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0468 | 0.4639 | 0.3182 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0697 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0697 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0697 | 1 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0468 | 0.4639 | 0.4639 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0697 | 1 | 1 |
Onchocerca volvulus | 0.0697 | 1 | 1 | |
Brugia malayi | Cathepsin L-like precursor | 0.0697 | 1 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0697 | 1 | 1 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0361 | 0.2137 | 0.2137 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.0361 | 0.2137 | 0.2137 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.