Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0544 | 0.1828 | 0.8189 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0544 | 0.1828 | 0.1828 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0379 | 0.0582 | 0.3182 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0544 | 0.1828 | 0.8189 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0544 | 0.1828 | 1 |
Onchocerca volvulus | 0.0544 | 0.1828 | 1 | |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0544 | 0.1828 | 0.8189 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0544 | 0.1828 | 0.8189 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0379 | 0.0582 | 0.2606 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0544 | 0.1828 | 0.8189 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0544 | 0.1828 | 0.8189 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0544 | 0.1828 | 0.8189 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0544 | 0.1828 | 0.8189 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0544 | 0.1828 | 0.8189 |
Plasmodium vivax | vivapain-2 | 0.0544 | 0.1828 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0544 | 0.1828 | 0.8189 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0544 | 0.1828 | 0.8189 |
Loa Loa (eye worm) | fibroinase | 0.0544 | 0.1828 | 0.1323 |
Brugia malayi | Cathepsin L-like precursor | 0.0544 | 0.1828 | 0.1828 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0379 | 0.0582 | 0.0582 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.1623 | 1 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0597 | 0.2232 | 0.2232 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0544 | 0.1828 | 0.1828 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0544 | 0.1828 | 0.1828 |
Echinococcus granulosus | cathepsin l1 | 0.0544 | 0.1828 | 0.1828 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0544 | 0.1828 | 0.8189 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0544 | 0.1828 | 0.8189 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0544 | 0.1828 | 0.1828 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0544 | 0.1828 | 0.1828 |
Onchocerca volvulus | Cathepsin F homolog | 0.0544 | 0.1828 | 1 |
Onchocerca volvulus | 0.0544 | 0.1828 | 1 | |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0544 | 0.1828 | 0.8189 |
Brugia malayi | Cathepsin L-like precursor | 0.0544 | 0.1828 | 0.1828 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0544 | 0.1828 | 0.1828 |
Entamoeba histolytica | cysteine protease, putative | 0.0544 | 0.1828 | 1 |
Onchocerca volvulus | 0.0544 | 0.1828 | 1 | |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0544 | 0.1828 | 0.1323 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0544 | 0.1828 | 0.8189 |
Loa Loa (eye worm) | hypothetical protein | 0.0544 | 0.1828 | 0.1323 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.1623 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0544 | 0.1828 | 0.8189 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0544 | 0.1828 | 0.1828 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0544 | 0.1828 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0544 | 0.1828 | 0.8189 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.1623 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0379 | 0.0582 | 0.2606 |
Brugia malayi | Cathepsin L-like precursor | 0.0379 | 0.0582 | 0.0582 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0544 | 0.1828 | 0.8189 |
Echinococcus granulosus | cathepsin l1 | 0.0379 | 0.0582 | 0.0582 |
Loa Loa (eye worm) | cathepsin B | 0.0597 | 0.2232 | 0.1752 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0544 | 0.1828 | 0.8189 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0544 | 0.1828 | 0.8189 |
Brugia malayi | Cathepsin L-like precursor | 0.0544 | 0.1828 | 0.1828 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0544 | 0.1828 | 0.8189 |
Brugia malayi | cathepsin L-like precursor | 0.0379 | 0.0582 | 0.0582 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0544 | 0.1828 | 0.1323 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0544 | 0.1828 | 0.8189 |
Giardia lamblia | Cathepsin B precursor | 0.0597 | 0.2232 | 0.5 |
Echinococcus granulosus | cathepsin b | 0.1623 | 1 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0544 | 0.1828 | 0.1828 |
Onchocerca volvulus | 0.0544 | 0.1828 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.0597 | 0.2232 | 1 |
Loa Loa (eye worm) | cysteine protease | 0.0544 | 0.1828 | 0.1323 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0544 | 0.1828 | 1 |
Onchocerca volvulus | 0.0544 | 0.1828 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0544 | 0.1828 | 0.8189 |
Brugia malayi | Cathepsin L-like precursor | 0.0544 | 0.1828 | 0.1828 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0544 | 0.1828 | 0.1828 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0544 | 0.1828 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0379 | 0.0582 | 0.0582 |
Giardia lamblia | Cathepsin B precursor | 0.0597 | 0.2232 | 0.5 |
Giardia lamblia | Cathepsin B precursor | 0.0597 | 0.2232 | 0.5 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0379 | 0.0582 | 0.0582 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0544 | 0.1828 | 0.8189 |
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.0597 | 0.2232 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0544 | 0.1828 | 0.1828 |
Onchocerca volvulus | 0.0544 | 0.1828 | 1 | |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0544 | 0.1828 | 0.8189 |
Echinococcus multilocularis | cathepsin b | 0.1623 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1623 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0544 | 0.1828 | 0.8189 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0544 | 0.1828 | 0.8189 |
Brugia malayi | Cathepsin L-like precursor | 0.0544 | 0.1828 | 0.1828 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0544 | 0.1828 | 0.8189 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0544 | 0.1828 | 0.1828 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0597 | 0.2232 | 0.2232 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0544 | 0.1828 | 0.8189 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.1623 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0544 | 0.1828 | 0.8189 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0544 | 0.1828 | 0.8189 |
Loa Loa (eye worm) | ctsf protein | 0.0544 | 0.1828 | 0.1323 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0544 | 0.1828 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0544 | 0.1828 | 0.8189 |
Echinococcus multilocularis | cathepsin b | 0.1623 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0544 | 0.1828 | 0.8189 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.1623 | 1 | 1 |
Echinococcus granulosus | cathepsin b | 0.1623 | 1 | 1 |
Leishmania major | cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like | 0.0597 | 0.2232 | 1 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.0379 | 0.0582 | 0.0582 |
Echinococcus multilocularis | cysteine protease | 0.0544 | 0.1828 | 0.1828 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0544 | 0.1828 | 0.8189 |
Plasmodium vivax | vivapain-2 | 0.0544 | 0.1828 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0544 | 0.1828 | 0.1828 |
Onchocerca volvulus | 0.0544 | 0.1828 | 1 | |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0544 | 0.1828 | 0.1828 |
Onchocerca volvulus | Cathepsin L homolog | 0.0544 | 0.1828 | 1 |
Echinococcus multilocularis | cysteine protease | 0.0544 | 0.1828 | 0.1828 |
Toxoplasma gondii | cathepsin B | 0.0597 | 0.2232 | 1 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0544 | 0.1828 | 0.1828 |
Onchocerca volvulus | Cathepsin L homolog | 0.0544 | 0.1828 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0544 | 0.1828 | 0.8189 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0544 | 0.1828 | 0.1828 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0544 | 0.1828 | 0.8189 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.