Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | cysteinyl leukotriene receptor 1 | References | |
Homo sapiens | cysteinyl leukotriene receptor 2 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | zinc finger protein | 0.0021 | 0.0333 | 0.0188 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.002 | 0.0199 | 0.5 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.002 | 0.0199 | 0.5 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.002 | 0.0199 | 0.5 |
Schistosoma mansoni | zinc finger protein | 0.0021 | 0.0333 | 0.0173 |
Echinococcus granulosus | zinc finger protein | 0.0021 | 0.0333 | 0.0188 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.002 | 0.0199 | 0.5 |
Toxoplasma gondii | exonuclease III APE | 0.002 | 0.0199 | 0.5 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.002 | 0.0199 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.9254 | 1 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0022 | 0.0518 | 0.0559 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0024 | 0.0851 | 0.0914 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.002 | 0.0199 | 0.5 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.002 | 0.0199 | 0.5 |
Trichomonas vaginalis | ap endonuclease, putative | 0.002 | 0.0199 | 0.5 |
Trichomonas vaginalis | ap endonuclease, putative | 0.002 | 0.0199 | 0.5 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.002 | 0.0199 | 0.5 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.002 | 0.0199 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.4357 | 0.4709 |
Schistosoma mansoni | bromodomain containing protein | 0.0068 | 0.7956 | 1 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0038 | 0.3186 | 0.4188 |
Brugia malayi | Bromodomain containing protein | 0.0041 | 0.3599 | 0.3469 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.4024 | 0.4348 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.3611 | 0.3902 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0064 | 0.7332 | 1 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0024 | 0.0851 | 0.0914 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.002 | 0.0199 | 0.5 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0024 | 0.0851 | 0.084 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.002 | 0.0199 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0022 | 0.0518 | 0.0411 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.002 | 0.0199 | 0.5 |
Brugia malayi | PHD-finger family protein | 0.0027 | 0.1264 | 0.1086 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.002 | 0.0199 | 0.0215 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0064 | 0.7332 | 1 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0038 | 0.3186 | 0.4188 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 70 nM | Inhibition of leukotriene-induced contractions of peripheral guinea pig lung strip | ChEMBL. | 2170649 |
Ki (binding) | = 50 nM | In vitro binding affinity against cysteinyl leukotriene D4 receptor from guinea pig lung membrane | ChEMBL. | 2170649 |
Ki (binding) | = 50 nM | In vitro binding affinity against cysteinyl leukotriene D4 receptor from guinea pig lung membrane | ChEMBL. | 2170649 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.