Detailed information for compound 1612636

Basic information

Technical information
  • TDR Targets ID: 1612636
  • Name: 2-[[(4-chlorophenyl)amino]methyl]-5-[(4-hydro xyphenyl)methylidene]cyclopentan-1-one
  • MW: 327.805 | Formula: C19H18ClNO2
  • H donors: 2 H acceptors: 2 LogP: 4.44 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Oc1ccc(cc1)/C=C/1\CCC(C1=O)CNc1ccc(cc1)Cl
  • InChi: 1S/C19H18ClNO2/c20-16-5-7-17(8-6-16)21-12-15-4-3-14(19(15)23)11-13-1-9-18(22)10-2-13/h1-2,5-11,15,21-22H,3-4,12H2/b14-11+
  • InChiKey: KRNGWPMSMWJZKZ-SDNWHVSQSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (5E)-2-[[(4-chlorophenyl)amino]methyl]-5-[(4-hydroxyphenyl)methylidene]cyclopentan-1-one
  • (5E)-2-[[(4-chlorophenyl)amino]methyl]-5-[(4-hydroxyphenyl)methylene]cyclopentan-1-one
  • 2-[[(4-chlorophenyl)amino]methyl]-5-[(4-hydroxyphenyl)methylene]cyclopentan-1-one
  • (5E)-2-[[(4-chlorophenyl)amino]methyl]-5-[(4-hydroxyphenyl)methylene]-1-cyclopentanone
  • 2-[[(4-chlorophenyl)amino]methyl]-5-[(4-hydroxyphenyl)methylene]-1-cyclopentanone
  • (5E)-2-[[(4-chlorophenyl)amino]methyl]-5-(4-hydroxybenzylidene)cyclopentan-1-one
  • 2-[[(4-chlorophenyl)amino]methyl]-5-(4-hydroxybenzylidene)cyclopentan-1-one
  • NCI60_013108
  • Cyclopentanone, 2-[(4-chlorophenyl)aminomethyl]-5-[(4- hydroxyphenyl)methylene]-
  • NSC639541

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0053 0.1943 0.2518
Schistosoma mansoni tyrosine-protein kinase fps85d 0.003 0.0684 0.0684
Echinococcus multilocularis transfer RNA-Thr 0.003 0.0684 0.0684
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.003 0.0684 0.0684
Loa Loa (eye worm) hypothetical protein 0.003 0.0684 0.0886
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.003 0.0684 0.4732
Trichomonas vaginalis TK family protein kinase 0.003 0.0684 1
Onchocerca volvulus 0.003 0.0684 0.0675
Entamoeba histolytica tyrosine kinase, putative 0.003 0.0684 0.4732
Echinococcus granulosus tyrosine protein kinase Src42A 0.003 0.0684 0.0684
Trichomonas vaginalis TKL family protein kinase 0.003 0.0684 1
Schistosoma mansoni serine/threonine RGC 0.003 0.0684 0.0684
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.0175 0.0227
Loa Loa (eye worm) TK/ALK protein kinase 0.003 0.0684 0.0886
Trichomonas vaginalis TKL family protein kinase 0.003 0.0684 1
Entamoeba histolytica tyrosine kinase, putative 0.003 0.0684 0.4732
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.003 0.0684 0.4732
Echinococcus multilocularis ephrin type A receptor 4 A 0.003 0.0684 0.0684
Echinococcus multilocularis dual specificity testis specific protein kinase 0.003 0.0684 0.0684
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.0175 0.0175
Schistosoma mansoni protein kinase 0.003 0.0684 0.0684
Brugia malayi bone morphogenetic protein type 1 receptor 0.003 0.0684 0.0886
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.678 0.8787
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0175 0.0227
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0175 0.0227
Loa Loa (eye worm) hypothetical protein 0.003 0.0684 0.0886
Entamoeba histolytica tyrosine kinase, putative 0.003 0.0684 0.4732
Loa Loa (eye worm) TK/FER protein kinase 0.003 0.0684 0.0886
Trichomonas vaginalis TKL family protein kinase 0.003 0.0684 1
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0684 1
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.003 0.0684 0.0684
Loa Loa (eye worm) hypothetical protein 0.002 0.0175 0.0227
Brugia malayi nuclear receptor NHR-88 0.002 0.0175 0.0227
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.0175 0.0175
Entamoeba histolytica tyrosin kinase, putative 0.003 0.0684 0.4732
Trichomonas vaginalis TKL family protein kinase 0.003 0.0684 1
Schistosoma mansoni tar DNA-binding protein 0.0076 0.3175 0.3175
Echinococcus granulosus epidermal growth factor receptor 0.003 0.0684 0.0684
Entamoeba histolytica tyrosine kinase, putative 0.003 0.0684 0.4732
Schistosoma mansoni tyrosine protein kinase 0.003 0.0684 0.0684
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.003 0.0684 1
Trichomonas vaginalis TKL family protein kinase 0.003 0.0684 1
Loa Loa (eye worm) TK/FER protein kinase 0.003 0.0684 0.0886
Brugia malayi Protein kinase domain containing protein 0.003 0.0684 0.0886
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.003 0.0684 0.0684
Trichomonas vaginalis TKL family protein kinase 0.003 0.0684 1
Schistosoma mansoni tyrosine kinase 0.003 0.0684 0.0684
Entamoeba histolytica hypothetical protein 0.003 0.0684 0.4732
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.003 0.0684 0.4732
Echinococcus multilocularis c src tyrosine kinase 0.003 0.0684 0.0684
Trichomonas vaginalis TKL family protein kinase 0.003 0.0684 1
Loa Loa (eye worm) TK protein kinase 0.003 0.0684 0.0886
Echinococcus granulosus tyrosine protein kinase Fyn 0.003 0.0684 0.0684
Plasmodium falciparum tyrosine kinase-like protein 0.003 0.0684 1
Onchocerca volvulus 0.003 0.0684 0.0675
Loa Loa (eye worm) TK protein kinase 0.003 0.0684 0.0886
Entamoeba histolytica protein kinase, putative 0.003 0.0684 0.4732
Trichomonas vaginalis TKL family protein kinase 0.003 0.0684 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0175 0.0227
Echinococcus multilocularis tyrosine protein kinase Fgr 0.003 0.0684 0.0684
Trichomonas vaginalis TKL family protein kinase 0.003 0.0684 1
Trichomonas vaginalis TKL family protein kinase 0.003 0.0684 1
Schistosoma mansoni tyrosine kinase 0.003 0.0684 0.0684
Entamoeba histolytica hypothetical protein 0.0033 0.0864 0.6034
Trichomonas vaginalis TKL family protein kinase 0.003 0.0684 1
Trichomonas vaginalis TKL family protein kinase 0.003 0.0684 1
Loa Loa (eye worm) TK/FER protein kinase 0.003 0.0684 0.0886
Loa Loa (eye worm) TK/FER protein kinase 0.003 0.0684 0.0886
Trichomonas vaginalis TKL family protein kinase 0.003 0.0684 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0175 0.0227
Echinococcus multilocularis epidermal growth factor receptor 0.003 0.0684 0.0684
Trichomonas vaginalis br serine/threonine-protein kinase, putative 0.003 0.0684 1
Loa Loa (eye worm) RGC/RGC protein kinase 0.003 0.0684 0.0886
Onchocerca volvulus 0.003 0.0684 0.0675
Trypanosoma brucei Pseudokinase, putative 0.003 0.0684 1
Leishmania major protein kinase, putative 0.003 0.0684 1
Loa Loa (eye worm) TK/KIN16 protein kinase 0.003 0.0684 0.0886
Brugia malayi Raf kinase 0.003 0.0684 0.0886
Entamoeba histolytica protein kinase, putative 0.003 0.0684 0.4732
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.0175 0.0175
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.0175 0.0227
Schistosoma mansoni tyrosine kinase 0.003 0.0684 0.0684
Schistosoma mansoni protein tyrosine kinase 0.003 0.0684 0.0684
Brugia malayi SRC-1 0.003 0.0684 0.0886
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.0175 0.0175
Loa Loa (eye worm) TK/ACK protein kinase 0.003 0.0684 0.0886
Echinococcus granulosus tyrosine kinase 0.003 0.0684 0.0684
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.0175 0.0227
Onchocerca volvulus Tyrosine kinase receptor Cad96Ca homolog 0.003 0.0684 0.0675
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.003 0.0684 1
Entamoeba histolytica protein kinase domain containing protein 0.003 0.0684 0.4732
Trichomonas vaginalis TKL family protein kinase 0.003 0.0684 1
Trichomonas vaginalis TKL family protein kinase 0.003 0.0684 1
Trichomonas vaginalis TKL family protein kinase 0.003 0.0684 1
Trichomonas vaginalis TKL family protein kinase 0.003 0.0684 1
Entamoeba histolytica protein kinase domain containing protein 0.003 0.0684 0.4732
Brugia malayi Protein kinase domain containing protein 0.003 0.0684 0.0886
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.003 0.0684 0.0684
Loa Loa (eye worm) TK protein kinase 0.003 0.0684 0.0886
Entamoeba histolytica serine/threonine kinase, putative 0.003 0.0684 0.4732
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.003 0.0684 0.4732
Schistosoma mansoni tyrosine kinase 0.003 0.0684 0.0684
Schistosoma mansoni hypothetical protein 0.0205 1 1
Trichomonas vaginalis TKL family protein kinase 0.003 0.0684 1
Echinococcus granulosus tyrosine protein kinase Fes:Fps 0.003 0.0684 0.0684
Echinococcus granulosus raf serine:threonine protein kinase 0.003 0.0684 0.0684
Giardia lamblia Kinase 0.003 0.0684 1
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0684 1
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.0175 0.0227
Brugia malayi Protein kinase domain containing protein 0.003 0.0684 0.0886
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 0.3175 0.4115
Brugia malayi Protein kinase domain containing protein 0.003 0.0684 0.0886
Entamoeba histolytica serine/threonine kinase, putative 0.003 0.0684 0.4732
Trichomonas vaginalis serine-threonine protein kinase, putative 0.003 0.0684 1
Echinococcus granulosus tyrosine kinase 0.003 0.0684 0.0684
Brugia malayi Calcitonin receptor-like protein seb-1 0.0053 0.1943 0.2518
Entamoeba histolytica tyrosine kinase, putative 0.003 0.0684 0.4732
Trichomonas vaginalis TKL family protein kinase 0.003 0.0684 1
Trichomonas vaginalis TKL family protein kinase 0.003 0.0684 1
Loa Loa (eye worm) hypothetical protein 0.0162 0.7716 1
Trichomonas vaginalis AGC family protein kinase 0.003 0.0684 1
Echinococcus multilocularis retinal guanylyl cyclase 2 0.003 0.0684 0.0684
Echinococcus multilocularis kinase suppressor of Ras 1 0.003 0.0684 0.0684
Schistosoma mansoni tar DNA-binding protein 0.0076 0.3175 0.3175
Plasmodium falciparum protein kinase, putative 0.003 0.0684 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0175 0.0175
Trichomonas vaginalis TKL family protein kinase 0.003 0.0684 1
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.0175 0.0175
Brugia malayi Protein kinase domain containing protein 0.003 0.0684 0.0886
Entamoeba histolytica tyrosine kinase, putative 0.003 0.0684 0.4732
Loa Loa (eye worm) hypothetical protein 0.002 0.0175 0.0227
Loa Loa (eye worm) TK/FER protein kinase 0.003 0.0684 0.0886
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.1415 0.1415
Echinococcus granulosus tyrosine protein kinase ABL1 0.003 0.0684 0.0684
Brugia malayi Protein kinase domain containing protein 0.003 0.0684 0.0886
Entamoeba histolytica protein kinase, putative 0.003 0.0684 0.4732
Entamoeba histolytica hypothetical protein, conserved 0.003 0.0684 0.4732
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0175 0.0227
Schistosoma mansoni tyrosine kinase 0.003 0.0684 0.0684
Echinococcus multilocularis tyrosine kinase 0.003 0.0684 0.0684
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.0175 0.0175
Loa Loa (eye worm) TK/ABL protein kinase 0.003 0.0684 0.0886
Echinococcus multilocularis tyrosine protein kinase Fyn 0.003 0.0684 0.0684
Entamoeba histolytica protein kinase domain containing protein 0.003 0.0684 0.4732
Loa Loa (eye worm) hypothetical protein 0.003 0.0684 0.0886
Loa Loa (eye worm) TK/FER protein kinase 0.003 0.0684 0.0886
Echinococcus multilocularis epidermal growth factor receptor 0.003 0.0684 0.0684
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.003 0.0684 0.0684
Loa Loa (eye worm) TK/FER protein kinase 0.003 0.0684 0.0886
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0175 0.0227
Brugia malayi Immunoglobulin I-set domain containing protein 0.003 0.0684 0.0886
Schistosoma mansoni tyrosine kinase 0.003 0.0684 0.0684
Entamoeba histolytica protein kinase domain containing protein 0.003 0.0684 0.4732
Echinococcus multilocularis activin receptor type 0.003 0.0684 0.0684
Echinococcus multilocularis geminin 0.0205 1 1
Entamoeba histolytica tyrosine kinase, putative 0.003 0.0684 0.4732
Echinococcus multilocularis tyrosine protein kinase csk 0.003 0.0684 0.0684
Echinococcus granulosus tyrosine protein kinase pr2 0.003 0.0684 0.0684
Echinococcus granulosus tyrosine protein kinase Src64B 0.003 0.0684 0.0684
Loa Loa (eye worm) TK/INSR protein kinase 0.003 0.0684 0.0886
Schistosoma mansoni ephrin receptor 0.003 0.0684 0.0684
Brugia malayi hypothetical protein 0.0043 0.1415 0.1834
Echinococcus multilocularis tyrosine protein kinase Src64B 0.003 0.0684 0.0684
Onchocerca volvulus 0.003 0.0684 0.0675
Loa Loa (eye worm) TK/FER protein kinase 0.003 0.0684 0.0886
Entamoeba histolytica tyrosine kinase, putative 0.003 0.0684 0.4732
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.1415 0.1415
Trichomonas vaginalis TKL family protein kinase 0.003 0.0684 1
Entamoeba histolytica protein kinase, putative 0.003 0.0684 0.4732
Schistosoma mansoni ephrin receptor 0.003 0.0684 0.0684
Brugia malayi Protein kinase domain containing protein 0.003 0.0684 0.0886
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.0175 0.0227
Entamoeba histolytica protein kinase domain containing protein 0.003 0.0684 0.4732
Brugia malayi Protein kinase domain containing protein 0.003 0.0684 0.0886
Trichomonas vaginalis STE family protein kinase 0.003 0.0684 1
Schistosoma mansoni protein kinase 0.003 0.0684 0.0684
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0017 0.0027 0.5
Entamoeba histolytica receptor protein kinase, putative 0.003 0.0684 0.4732
Echinococcus granulosus protein kinase 0.003 0.0684 0.0684
Brugia malayi Protein kinase domain containing protein 0.003 0.0684 0.0886
Entamoeba histolytica protein kinase domain containing protein 0.003 0.0684 0.4732
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.003 0.0684 1
Schistosoma mansoni tyrosine kinase 0.003 0.0684 0.0684
Loa Loa (eye worm) RGC/RGC protein kinase 0.003 0.0684 0.0886
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0175 0.0227
Echinococcus granulosus protein tyrosine kinase 0.003 0.0684 0.0684
Brugia malayi Protein kinase domain containing protein 0.003 0.0684 0.0886
Brugia malayi Protein kinase domain containing protein 0.003 0.0684 0.0886
Onchocerca volvulus 0.003 0.0684 0.0675
Echinococcus multilocularis natriuretic peptide receptor 1 0.003 0.0684 0.0684
Entamoeba histolytica cysteine surface protein, putative 0.003 0.0684 0.4732
Schistosoma mansoni tar DNA-binding protein 0.0076 0.3175 0.3175
Entamoeba histolytica protein kinase domain containing protein 0.003 0.0684 0.4732
Plasmodium falciparum protein kinase, putative 0.003 0.0684 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0684 0.0886
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0684 1
Brugia malayi Immunoglobulin I-set domain containing protein 0.003 0.0684 0.0886
Brugia malayi Guanylyl cyclase protein 23 0.003 0.0684 0.0886
Entamoeba histolytica protein kinase domain containing protein 0.003 0.0684 0.4732
Brugia malayi Protein kinase domain containing protein 0.003 0.0684 0.0886
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.0175 0.0227
Brugia malayi ephrin receptor 1 precursor 0.003 0.0684 0.0886
Schistosoma mansoni src-type protein tyrosine kinase-related 0.003 0.0684 0.0684
Echinococcus granulosus tyrosine protein kinase Srms 0.003 0.0684 0.0684
Trichomonas vaginalis serine/threonine-protein kinase wnk, putative 0.003 0.0684 1
Echinococcus multilocularis macrophage colony stimulating factor 1 receptor 0.003 0.0684 0.0684
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.003 0.0684 0.0684
Schistosoma mansoni hypothetical protein 0.0205 1 1
Entamoeba histolytica protein kinase, putative 0.003 0.0684 0.4732
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0017 0.0027 0.0035
Trichomonas vaginalis TKL family protein kinase 0.003 0.0684 1
Schistosoma mansoni tyrosine kinase 0.003 0.0684 0.0684
Trichomonas vaginalis TKL family protein kinase 0.003 0.0684 1
Toxoplasma gondii protein kinase 0.003 0.0684 1
Treponema pallidum exodeoxyribonuclease (exoA) 0.0017 0.0027 0.5
Trichomonas vaginalis TKL family protein kinase 0.003 0.0684 1
Schistosoma mansoni protein kinase 0.003 0.0684 0.0684
Brugia malayi TAR-binding protein 0.0076 0.3175 0.4115
Onchocerca volvulus 0.003 0.0684 0.0675
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.0175 0.0227
Onchocerca volvulus 0.003 0.0684 0.0675
Entamoeba histolytica protein kinase, putative 0.003 0.0684 0.4732
Entamoeba histolytica tyrosine kinase, putative 0.003 0.0684 0.4732
Entamoeba histolytica protein kinase domain containing protein 0.003 0.0684 0.4732
Schistosoma mansoni thyroid hormone receptor 0.002 0.0175 0.0175
Trichomonas vaginalis TKL family protein kinase 0.003 0.0684 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0684 0.0886
Brugia malayi hypothetical protein 0.003 0.0684 0.0886
Entamoeba histolytica receptor protein kinase, putative 0.003 0.0684 0.4732
Echinococcus granulosus tyrosine protein kinase Fyn 0.003 0.0684 0.0684
Loa Loa (eye worm) TKL/MLK/ILK protein kinase 0.003 0.0684 0.0886
Trichomonas vaginalis TKL family protein kinase 0.003 0.0684 1
Brugia malayi Probable tyrosine-protein kinase kin-31 0.003 0.0684 0.0886
Entamoeba histolytica serine/threonine kinase, putative 0.003 0.0684 0.4732
Entamoeba histolytica protein kinase, putative 0.003 0.0684 0.4732
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0684 1
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0017 0.0027 0.5
Trichomonas vaginalis TKL family protein kinase 0.003 0.0684 1
Schistosoma mansoni tyrosine kinase 0.003 0.0684 0.0684
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.003 0.0684 1
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.003 0.0684 0.0684
Echinococcus granulosus tyrosine protein kinase csk 0.003 0.0684 0.0684
Schistosoma mansoni protein kinase 0.003 0.0684 0.0684
Echinococcus multilocularis tar DNA binding protein 0.0076 0.3175 0.3175
Brugia malayi Protein kinase domain containing protein 0.003 0.0684 0.0886
Brugia malayi Tyrosine-protein kinase PR2 0.003 0.0684 0.0886
Echinococcus multilocularis heat shock protein 70 0.003 0.0684 0.0684
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.0175 0.0227
Echinococcus multilocularis integrin linked protein kinase 0.003 0.0684 0.0684
Loa Loa (eye worm) TK/FAK protein kinase 0.003 0.0684 0.0886
Loa Loa (eye worm) SRC-1 0.003 0.0684 0.0886
Brugia malayi Protein kinase domain containing protein 0.003 0.0684 0.0886
Brugia malayi Furin-like cysteine rich region family protein 0.003 0.0684 0.0886
Brugia malayi Protein kinase domain containing protein 0.003 0.0684 0.0886
Echinococcus multilocularis tyrosine protein kinase Srms 0.003 0.0684 0.0684
Schistosoma mansoni hypothetical protein 0.003 0.0684 0.0684
Loa Loa (eye worm) RNA binding protein 0.0076 0.3175 0.4115
Schistosoma mansoni tar DNA-binding protein 0.0076 0.3175 0.3175
Loa Loa (eye worm) hypothetical protein 0.002 0.0175 0.0227
Trichomonas vaginalis TKL family protein kinase 0.003 0.0684 1
Brugia malayi Probable tyrosine-protein kinase kin-31 0.003 0.0684 0.0886
Schistosoma mansoni tar DNA-binding protein 0.0076 0.3175 0.3175
Giardia lamblia Protein 21.1 0.003 0.0684 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0175 0.0227
Entamoeba histolytica hypothetical protein 0.0033 0.0864 0.6034
Entamoeba histolytica tyrosine kinase, putative 0.003 0.0684 0.4732
Brugia malayi protein-tyrosine kinase 0.003 0.0684 0.0886
Trichomonas vaginalis TKL family protein kinase 0.003 0.0684 1
Trichomonas vaginalis TKL family protein kinase 0.003 0.0684 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0175 0.0227
Echinococcus multilocularis tyrosine protein kinase Blk 0.003 0.0684 0.0684
Entamoeba histolytica tyrosin kinase, putative 0.003 0.0684 0.4732
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.003 0.0684 1
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.0175 0.0175
Entamoeba histolytica protein kinase domain containing protein 0.003 0.0684 0.4732
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.003 0.0684 0.0684
Schistosoma mansoni tyrosine kinase 0.003 0.0684 0.0684
Trichomonas vaginalis TKL family protein kinase 0.003 0.0684 1
Onchocerca volvulus 0.003 0.0684 0.0675
Brugia malayi Protein kinase domain containing protein 0.003 0.0684 0.0886
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.0175 0.0227
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0175 0.0227
Loa Loa (eye worm) TK protein kinase 0.003 0.0684 0.0886
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.003 0.0684 1
Loa Loa (eye worm) TK/Met protein kinase 0.003 0.0684 0.0886
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.003 0.0684 0.0684
Loa Loa (eye worm) hypothetical protein 0.003 0.0684 0.0886
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.003 0.0684 0.4732
Echinococcus granulosus insulin growth factor 1 receptor beta 0.003 0.0684 0.0684
Plasmodium vivax tyrosine kinase-like protein, putative 0.003 0.0684 1
Entamoeba histolytica protein kinase, putative 0.0033 0.0864 0.6034
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.003 0.0684 0.0684
Onchocerca volvulus 0.003 0.0684 0.0675
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0175 0.0175
Loa Loa (eye worm) hypothetical protein 0.002 0.0175 0.0227
Echinococcus granulosus tyrosine protein kinase Btk29A 0.003 0.0684 0.0684
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.003 0.0684 0.4732
Loa Loa (eye worm) hypothetical protein 0.003 0.0684 0.0886
Schistosoma mansoni tyrosine kinase 0.003 0.0684 0.0684
Schistosoma mansoni protein kinase 0.003 0.0684 0.0684
Entamoeba histolytica protein kinase with ankyrin repeats, putative 0.003 0.0684 0.4732
Entamoeba histolytica ankyrin repeat protein 0.003 0.0684 0.4732
Schistosoma mansoni hypothetical protein 0.0036 0.1044 0.1044
Entamoeba histolytica SH2-protein kinase domain containing protein 0.003 0.0684 0.4732
Toxoplasma gondii STE kinase 0.003 0.0684 1
Schistosoma mansoni tyrosine kinase 0.003 0.0684 0.0684
Loa Loa (eye worm) TKL/MLK/HH498 protein kinase 0.003 0.0684 0.0886
Entamoeba histolytica tyrosine- protein kinase 2, putative 0.003 0.0684 0.4732
Trichomonas vaginalis protein kinase atn1, putative 0.003 0.0684 1
Echinococcus granulosus tyrosine protein kinase Lyn 0.003 0.0684 0.0684
Trichomonas vaginalis TKL family protein kinase 0.003 0.0684 1
Schistosoma mansoni protein kinase 0.003 0.0684 0.0684
Toxoplasma gondii protein kinase domain-containing protein 0.003 0.0684 1
Echinococcus granulosus tyrosine protein kinase Blk 0.003 0.0684 0.0684
Loa Loa (eye worm) TK/FER protein kinase 0.003 0.0684 0.0886
Entamoeba histolytica protein kinase domain containing protein 0.003 0.0684 0.4732
Trichomonas vaginalis TKL family protein kinase 0.003 0.0684 1
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.003 0.0684 0.0684
Echinococcus granulosus tyrosine protein kinase Btk29A 0.003 0.0684 0.0684
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.003 0.0684 0.4732
Trichomonas vaginalis TKL family protein kinase 0.003 0.0684 1
Entamoeba histolytica tyrosine kinase, putative 0.003 0.0684 0.4732
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.003 0.0684 0.0684
Echinococcus granulosus epidermal growth factor receptor 0.003 0.0684 0.0684
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.003 0.0684 0.0684
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.003 0.0684 0.0684
Loa Loa (eye worm) TKL/RAF/RAF protein kinase 0.003 0.0684 0.0886
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.003 0.0684 1
Entamoeba histolytica tyrosin kinase, putative 0.003 0.0684 0.4732
Schistosoma mansoni tyrosine kinase 0.003 0.0684 0.0684
Entamoeba histolytica protein kinase domain containing protein 0.003 0.0684 0.4732
Echinococcus multilocularis thyroid hormone receptor alpha 0.002 0.0175 0.0175
Brugia malayi Protein kinase domain containing protein 0.003 0.0684 0.0886
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.0175 0.0175
Schistosoma mansoni protein kinase 0.003 0.0684 0.0684
Trichomonas vaginalis TKL family protein kinase 0.003 0.0684 1
Entamoeba histolytica protein kinase, putative 0.003 0.0684 0.4732
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.003 0.0684 0.0886
Echinococcus multilocularis protein KINase family member (kin 25) 0.003 0.0684 0.0684
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.678 0.8787
Trypanosoma brucei protein kinase, putative 0.003 0.0684 1
Trichomonas vaginalis TKL family protein kinase 0.003 0.0684 1
Schistosoma mansoni tyrosine kinase 0.003 0.0684 0.0684
Entamoeba histolytica tyrosin kinase, putative 0.003 0.0684 0.4732
Loa Loa (eye worm) TAR-binding protein 0.0076 0.3175 0.4115
Echinococcus granulosus tyrosine protein kinase csk 0.003 0.0684 0.0684
Trichomonas vaginalis CAMK family protein kinase 0.003 0.0684 1
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.003 0.0684 0.0684
Echinococcus granulosus tyrosine protein kinase Fyn 0.003 0.0684 0.0684
Echinococcus granulosus activated cdc42 kinase 1 0.003 0.0684 0.0684
Echinococcus granulosus activated cdc42 kinase 1 0.003 0.0684 0.0684
Schistosoma mansoni serine/threonine protein kinase 0.003 0.0684 0.0684
Brugia malayi exodeoxyribonuclease III family protein 0.0017 0.0027 0.0035
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.0175 0.0175
Echinococcus multilocularis tyrosine kinase 0.003 0.0684 0.0684
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.0175 0.0175
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.003 0.0684 0.0684
Echinococcus multilocularis insulin receptor 0.003 0.0684 0.0684
Trichomonas vaginalis TKL family protein kinase 0.003 0.0684 1
Entamoeba histolytica hypothetical protein 0.003 0.0684 0.4732
Echinococcus granulosus c src tyrosine kinase 0.003 0.0684 0.0684
Plasmodium falciparum tyrosine kinase-like protein 0.003 0.0684 1
Giardia lamblia Kinase, NEK 0.003 0.0684 1
Echinococcus granulosus fibroblast growth factor receptor 4 0.003 0.0684 0.0684
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.0175 0.0227
Entamoeba histolytica tyrosine kinase, putative 0.003 0.0684 0.4732
Trichomonas vaginalis TKL family protein kinase 0.003 0.0684 1
Trichomonas vaginalis TKL family protein kinase 0.003 0.0684 1
Brugia malayi Protein kinase domain containing protein 0.003 0.0684 0.0886
Echinococcus granulosus retinal guanylyl cyclase 2 0.003 0.0684 0.0684
Trichomonas vaginalis TKL family protein kinase 0.003 0.0684 1
Loa Loa (eye worm) TK/KIN6 protein kinase 0.003 0.0684 0.0886
Echinococcus granulosus tyrosine protein kinase 0.003 0.0684 0.0684
Entamoeba histolytica hypothetical protein 0.003 0.0684 0.4732
Schistosoma mansoni serine/threonine protein kinase 0.003 0.0684 0.0684
Entamoeba histolytica hypothetical protein 0.0043 0.1415 1
Schistosoma mansoni tyrosine kinase 0.003 0.0684 0.0684
Echinococcus multilocularis tyrosine protein kinase Abl 0.003 0.0684 0.0684
Trichomonas vaginalis TKL family protein kinase 0.003 0.0684 1
Entamoeba histolytica hypothetical protein 0.0033 0.0864 0.6034
Echinococcus granulosus natriuretic peptide receptor 1 0.003 0.0684 0.0684
Brugia malayi Protein kinase domain containing protein 0.003 0.0684 0.0886
Loa Loa (eye worm) TK/FER protein kinase 0.003 0.0684 0.0886
Schistosoma mansoni tyrosine-protein kinase fps85d 0.003 0.0684 0.0684
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.003 0.0684 0.4732
Entamoeba histolytica protein kinase domain containing protein 0.003 0.0684 0.4732
Trypanosoma brucei AGC/RSK family serine/threonine kinase, putative 0.003 0.0684 1
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.0175 0.0175
Entamoeba histolytica ankyrin repeat protein 0.003 0.0684 0.4732
Entamoeba histolytica hypothetical protein 0.003 0.0684 0.4732
Schistosoma mansoni tyrosine kinase 0.003 0.0684 0.0684
Onchocerca volvulus 0.0162 0.7716 1
Schistosoma mansoni coup transcription factor 0.002 0.0175 0.0175
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.003 0.0684 0.4732
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0684 1
Loa Loa (eye worm) TK protein kinase 0.003 0.0684 0.0886
Schistosoma mansoni tyrosine kinase 0.003 0.0684 0.0684
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.1415 0.1415
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.003 0.0684 0.0684
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.0175 0.0227
Loa Loa (eye worm) hypothetical protein 0.003 0.0684 0.0886
Brugia malayi Protein kinase domain containing protein 0.003 0.0684 0.0886
Schistosoma mansoni tyrosine kinase 0.003 0.0684 0.0684
Trichomonas vaginalis TKL family protein kinase 0.003 0.0684 1
Entamoeba histolytica protein kinase domain containing protein 0.003 0.0684 0.4732
Echinococcus multilocularis tyrosine protein kinase Fes:Fps 0.003 0.0684 0.0684
Brugia malayi latrophilin 2 splice variant baaae 0.0036 0.1044 0.1353
Entamoeba histolytica hypothetical protein 0.0043 0.1415 1
Entamoeba histolytica protein kinase, putative 0.003 0.0684 0.4732
Entamoeba histolytica protein kinase domain containing protein 0.003 0.0684 0.4732
Entamoeba histolytica protein kinase, putative 0.003 0.0684 0.4732
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0017 0.0027 0.5
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.003 0.0684 0.0684
Brugia malayi SH2 domain containing protein 0.003 0.0684 0.0886
Loa Loa (eye worm) protein kinase domain-containing protein 0.003 0.0684 0.0886
Entamoeba histolytica hypothetical protein 0.0043 0.1415 1
Loa Loa (eye worm) TK/FER protein kinase 0.003 0.0684 0.0886
Echinococcus multilocularis tyrosine protein kinase csk 0.003 0.0684 0.0684
Entamoeba histolytica hypothetical protein 0.003 0.0684 0.4732
Echinococcus multilocularis protein kinase 0.003 0.0684 0.0684
Entamoeba histolytica protein kinase domain containing protein 0.003 0.0684 0.4732
Trichomonas vaginalis TKL family protein kinase 0.003 0.0684 1
Trichomonas vaginalis TKL family protein kinase 0.003 0.0684 1
Schistosoma mansoni tyrosine kinase 0.003 0.0684 0.0684
Brugia malayi Protein kinase domain containing protein 0.003 0.0684 0.0886
Brugia malayi proto-oncogene tyrosine-protein kinase FER 0.003 0.0684 0.0886
Entamoeba histolytica hypothetical protein 0.0043 0.1415 1
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.0175 0.0175
Brugia malayi steroid hormone receptor 0.002 0.0175 0.0227
Echinococcus multilocularis receptor type guanylyl cyclase 0.003 0.0684 0.0684
Brugia malayi Protein kinase domain containing protein 0.003 0.0684 0.0886
Onchocerca volvulus 0.003 0.0684 0.0675
Trypanosoma cruzi protein kinase, putative 0.003 0.0684 1
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.003 0.0684 0.0684
Onchocerca volvulus 0.003 0.0684 0.0675
Trichomonas vaginalis TKL family protein kinase 0.003 0.0684 1
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.003 0.0684 0.0886
Brugia malayi Protein kinase domain containing protein 0.003 0.0684 0.0886
Loa Loa (eye worm) TK protein kinase 0.003 0.0684 0.0886
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.0175 0.0227
Loa Loa (eye worm) hypothetical protein 0.003 0.0684 0.0886
Schistosoma mansoni serine/threonine protein kinase 0.003 0.0684 0.0684
Brugia malayi SH2 domain containing protein 0.003 0.0684 0.0886
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.0175 0.0175
Loa Loa (eye worm) TK protein kinase 0.003 0.0684 0.0886
Trichomonas vaginalis TKL family protein kinase 0.003 0.0684 1
Entamoeba histolytica protein kinase domain containing protein 0.003 0.0684 0.4732
Trichomonas vaginalis TKL family protein kinase 0.003 0.0684 1
Loa Loa (eye worm) TK/FER protein kinase 0.003 0.0684 0.0886
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.0175 0.0175
Echinococcus multilocularis retinal guanylyl cyclase 2 0.003 0.0684 0.0684
Echinococcus granulosus tar DNA binding protein 0.0076 0.3175 0.3175
Brugia malayi Protein kinase domain containing protein 0.003 0.0684 0.0886
Plasmodium falciparum protein kinase, putative 0.003 0.0684 1
Loa Loa (eye worm) steroid hormone receptor 0.002 0.0175 0.0227
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.003 0.0684 0.0684
Brugia malayi Protein kinase domain containing protein 0.003 0.0684 0.0886
Entamoeba histolytica tyrosine kinase, putative 0.003 0.0684 0.4732
Entamoeba histolytica protein kinase domain containing protein 0.003 0.0684 0.4732
Schistosoma mansoni protein kinase 0.003 0.0684 0.0684
Echinococcus granulosus tyrosine protein kinase csk 0.003 0.0684 0.0684
Loa Loa (eye worm) TK/EGFR protein kinase 0.003 0.0684 0.0886
Echinococcus multilocularis tyrosine protein kinase csk 0.003 0.0684 0.0684
Brugia malayi Protein kinase domain containing protein 0.003 0.0684 0.0886
Echinococcus granulosus retinal guanylyl cyclase 2 0.003 0.0684 0.0684
Brugia malayi Tyrosine-protein kinase abl-1 0.003 0.0684 0.0886
Entamoeba histolytica tyrosine kinase, putative 0.003 0.0684 0.4732
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.003 0.0684 0.4732
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.0175 0.0175
Brugia malayi RNA recognition motif domain containing protein 0.0076 0.3175 0.4115
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.003 0.0684 0.0684
Trichomonas vaginalis TKL family protein kinase 0.003 0.0684 1
Echinococcus granulosus tyrosine protein kinase shark 0.003 0.0684 0.0684
Echinococcus multilocularis tyrosine protein kinase pr2 0.003 0.0684 0.0684
Brugia malayi Protein kinase domain containing protein 0.003 0.0684 0.0886
Loa Loa (eye worm) RGC/RGC protein kinase 0.003 0.0684 0.0886
Entamoeba histolytica tyrosine kinase, putative 0.003 0.0684 0.4732
Echinococcus granulosus 3'partial|retinal guanylyl cyclase 2 0.003 0.0684 0.0684
Trichomonas vaginalis TKL family protein kinase 0.003 0.0684 1
Echinococcus multilocularis tyrosine protein kinase csk 0.003 0.0684 0.0684
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.003 0.0684 0.0886
Brugia malayi C-terminal src kinase protein 1 0.003 0.0684 0.0886
Loa Loa (eye worm) TK protein kinase 0.003 0.0684 0.0886
Loa Loa (eye worm) serine/threonine protein kinase 0.003 0.0684 0.0886
Trichomonas vaginalis protein tyrosine kinase, putative 0.003 0.0684 1
Echinococcus granulosus tyrosine protein kinase Fps85D 0.003 0.0684 0.0684
Entamoeba histolytica hypothetical protein 0.003 0.0684 0.4732
Loa Loa (eye worm) hypothetical protein 0.0053 0.1943 0.2518
Entamoeba histolytica serine/threonine kinase, putative 0.003 0.0684 0.4732
Echinococcus multilocularis tyrosine protein kinase shark 0.003 0.0684 0.0684
Schistosoma mansoni tyrosine kinase 0.003 0.0684 0.0684
Schistosoma mansoni tyrosine kinase 0.003 0.0684 0.0684
Echinococcus multilocularis activated cdc42 kinase 1 0.003 0.0684 0.0684
Loa Loa (eye worm) TK/FER protein kinase 0.003 0.0684 0.0886
Loa Loa (eye worm) hypothetical protein 0.003 0.0684 0.0886
Trichomonas vaginalis TKL family protein kinase 0.003 0.0684 1
Schistosoma mansoni tyrosine kinase 0.003 0.0684 0.0684
Brugia malayi RNA binding protein 0.0076 0.3175 0.4115
Leishmania major hypothetical protein, conserved 0.003 0.0684 1
Entamoeba histolytica protein kinase domain containing protein 0.003 0.0684 0.4732
Entamoeba histolytica protein kinase domain containing protein 0.003 0.0684 0.4732
Brugia malayi Receptor family ligand binding region containing protein 0.003 0.0684 0.0886
Echinococcus granulosus retinal guanylyl cyclase 2 0.003 0.0684 0.0684
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.0175 0.0175
Entamoeba histolytica serine/threonine kinase, putative 0.003 0.0684 0.4732
Loa Loa (eye worm) TKL/RAF/KSR protein kinase 0.003 0.0684 0.0886
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.0175 0.0227
Loa Loa (eye worm) TK/FER protein kinase 0.003 0.0684 0.0886
Brugia malayi Protein kinase domain containing protein 0.003 0.0684 0.0886
Echinococcus granulosus integrin linked protein kinase 0.003 0.0684 0.0684
Loa Loa (eye worm) hypothetical protein 0.0036 0.1044 0.1353
Schistosoma mansoni tyrosine kinase 0.003 0.0684 0.0684
Entamoeba histolytica hypothetical protein 0.003 0.0684 0.4732
Echinococcus granulosus dual specificity testis-specific protein kinase 0.003 0.0684 0.0684
Onchocerca volvulus Tyrosine kinase homolog 0.003 0.0684 0.0675
Trichomonas vaginalis TKL family protein kinase 0.003 0.0684 1
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.003 0.0684 0.4732
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.003 0.0684 0.0684
Trichomonas vaginalis TKL family protein kinase 0.003 0.0684 1
Echinococcus granulosus tyrosine kinase 0.003 0.0684 0.0684
Echinococcus multilocularis atrial natriuretic peptide receptor 1 0.003 0.0684 0.0684
Brugia malayi hypothetical protein 0.003 0.0684 0.0886
Echinococcus multilocularis protein tyrosine kinase 0.003 0.0684 0.0684
Echinococcus multilocularis FL cytokine receptor 0.003 0.0684 0.0684
Loa Loa (eye worm) TK/ROR protein kinase 0.003 0.0684 0.0886
Entamoeba histolytica protein kinase, putative 0.003 0.0684 0.4732
Entamoeba histolytica serine/threonine kinase, putative 0.003 0.0684 0.4732
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.0175 0.0227
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.003 0.0684 0.0684
Schistosoma mansoni tyrosine kinase 0.003 0.0684 0.0684
Schistosoma mansoni tyrosine kinase 0.003 0.0684 0.0684
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0175 0.0175
Echinococcus multilocularis tyrosine protein kinase Fyn 0.003 0.0684 0.0684
Brugia malayi integrin-linked kinase 0.003 0.0684 0.0886
Trypanosoma cruzi protein kinase, putative 0.003 0.0684 1
Trichomonas vaginalis TKL family protein kinase 0.003 0.0684 1
Brugia malayi hypothetical protein 0.003 0.0684 0.0886
Echinococcus granulosus tyrosine protein kinase HCK 0.003 0.0684 0.0684
Entamoeba histolytica hypothetical protein 0.003 0.0684 0.4732
Echinococcus granulosus insulin receptor 0.003 0.0684 0.0684
Onchocerca volvulus 0.003 0.0684 0.0675
Echinococcus multilocularis tyrosine protein kinase HCK 0.003 0.0684 0.0684
Onchocerca volvulus 0.003 0.0684 0.0675
Trichomonas vaginalis TKL family protein kinase 0.003 0.0684 1
Schistosoma mansoni tyrosine kinase 0.003 0.0684 0.0684
Trichomonas vaginalis TKL family protein kinase 0.003 0.0684 1
Trichomonas vaginalis TKL family protein kinase 0.003 0.0684 1
Schistosoma mansoni ap endonuclease 0.0017 0.0027 0.0027
Trichomonas vaginalis TKL family protein kinase 0.003 0.0684 1
Loa Loa (eye worm) RGC/RGC protein kinase 0.003 0.0684 0.0886
Loa Loa (eye worm) TK/RYK protein kinase 0.003 0.0684 0.0886
Loa Loa (eye worm) TKL/MLK/TAK1 protein kinase 0.003 0.0684 0.0886
Echinococcus granulosus receptor type guanylyl cyclase 0.003 0.0684 0.0684
Echinococcus granulosus atrial natriuretic peptide receptor 1 0.003 0.0684 0.0684
Trichomonas vaginalis TKL family protein kinase 0.003 0.0684 1
Trichomonas vaginalis TKL family protein kinase 0.003 0.0684 1
Schistosoma mansoni protein kinase 0.003 0.0684 0.0684
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0017 0.0027 0.0027
Trichomonas vaginalis TKL family protein kinase 0.003 0.0684 1
Brugia malayi MH2 domain containing protein 0.0144 0.678 0.8787
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.003 0.0684 0.4732
Brugia malayi Protein kinase domain containing protein 0.003 0.0684 0.0886
Trichomonas vaginalis TKL family protein kinase 0.003 0.0684 1
Echinococcus multilocularis raf serine:threonine protein kinase 0.003 0.0684 0.0684
Loa Loa (eye worm) TK/FER protein kinase 0.003 0.0684 0.0886
Leishmania major protein kinase, putative 0.003 0.0684 1
Schistosoma mansoni tyrosine kinase 0.003 0.0684 0.0684
Onchocerca volvulus 0.003 0.0684 0.0675
Echinococcus multilocularis tyrosine protein kinase Src42A 0.003 0.0684 0.0684
Echinococcus granulosus ephrin type A receptor 4 A 0.003 0.0684 0.0684
Entamoeba histolytica protein kinase domain containing protein 0.003 0.0684 0.4732
Brugia malayi hypothetical protein 0.0162 0.7716 1
Schistosoma mansoni nuclear hormone receptor 0.002 0.0175 0.0175
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.003 0.0684 0.4732
Entamoeba histolytica leucine-rich repeat domain-containing protein 0.0033 0.0864 0.6034
Echinococcus multilocularis tyrosine protein kinase ABL1 0.003 0.0684 0.0684
Entamoeba histolytica tyrosine kinase, putative 0.003 0.0684 0.4732
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.0175 0.0175
Echinococcus granulosus mitogen-activated protein kinase kinase kinase 9 0.003 0.0684 0.0684
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0684 1
Loa Loa (eye worm) TK/FER protein kinase 0.003 0.0684 0.0886
Entamoeba histolytica protein kinase, putative 0.003 0.0684 0.4732
Schistosoma mansoni thyroid hormone receptor 0.002 0.0175 0.0175
Loa Loa (eye worm) TK/DDR protein kinase 0.003 0.0684 0.0886
Brugia malayi nuclear hormone receptor 0.002 0.0175 0.0227
Loa Loa (eye worm) TK protein kinase 0.003 0.0684 0.0886
Schistosoma mansoni tyrosine kinase 0.003 0.0684 0.0684
Echinococcus granulosus activin receptor type 0.003 0.0684 0.0684
Brugia malayi Steroid receptor seven-up type 2 0.002 0.0175 0.0227
Loa Loa (eye worm) hypothetical protein 0.003 0.0684 0.0886
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0684 1
Schistosoma mansoni tyrosine kinase 0.003 0.0684 0.0684
Plasmodium vivax tyrosine kinase-like protein, putative 0.003 0.0684 1
Entamoeba histolytica protein kinase, putative 0.003 0.0684 0.4732
Entamoeba histolytica tyrosine kinase, putative 0.003 0.0684 0.4732
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0053 0.1943 0.2518
Echinococcus multilocularis protein kinase 0.003 0.0684 0.0684
Brugia malayi Tyrosine-protein kinase F09A5.2 in chromosome X, putative 0.003 0.0684 0.0886
Echinococcus granulosus kinase suppressor of Ras 1 0.003 0.0684 0.0684
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.003 0.0684 0.0675
Entamoeba histolytica protein kinase, putative 0.003 0.0684 0.4732
Trichomonas vaginalis TKL family protein kinase 0.003 0.0684 1
Plasmodium vivax protein kinase, putative 0.003 0.0684 1
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0017 0.0027 0.0027
Trichomonas vaginalis TKL family protein kinase 0.003 0.0684 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0684 0.0886
Giardia lamblia Kinase, NEK 0.003 0.0684 1
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.003 0.0684 0.0684
Schistosoma mansoni tyrosine kinase 0.003 0.0684 0.0684
Schistosoma mansoni hypothetical protein 0.0043 0.1415 0.1415
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.0175 0.0175
Echinococcus multilocularis fibroblast growth factor receptor 4 0.003 0.0684 0.0684
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0175 0.0175
Echinococcus multilocularis retinal guanylyl cyclase 2 0.003 0.0684 0.0684
Echinococcus multilocularis FTZ F1 alpha 0.002 0.0175 0.0175
Brugia malayi ecdysteroid receptor 0.002 0.0175 0.0227
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0175 0.0175
Trichomonas vaginalis TKL family protein kinase 0.003 0.0684 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0684 0.0886
Loa Loa (eye worm) TK/CSK protein kinase 0.003 0.0684 0.0886
Schistosoma mansoni protein kinase 0.003 0.0684 0.0684
Entamoeba histolytica protein kinase, putative 0.003 0.0684 0.4732
Trypanosoma brucei Flagellum attachment zone protein 20 0.003 0.0684 1
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.0175 0.0175
Trichomonas vaginalis TKL family protein kinase 0.003 0.0684 1
Onchocerca volvulus 0.003 0.0684 0.0675
Echinococcus multilocularis tyrosine protein kinase 0.003 0.0684 0.0684
Entamoeba histolytica protein kinase, putative 0.003 0.0684 0.4732
Loa Loa (eye worm) TK/FER protein kinase 0.003 0.0684 0.0886
Echinococcus granulosus FTZ F1 alpha 0.002 0.0175 0.0175
Entamoeba histolytica protein kinase domain containing protein 0.003 0.0684 0.4732
Echinococcus multilocularis tyrosine protein kinase Fyn 0.003 0.0684 0.0684
Loa Loa (eye worm) TK protein kinase 0.003 0.0684 0.0886
Schistosoma mansoni serine/threonine protein kinase 0.003 0.0684 0.0684
Schistosoma mansoni ap endonuclease 0.0017 0.0027 0.0027
Schistosoma mansoni tyrosine kinase 0.003 0.0684 0.0684
Echinococcus multilocularis tyrosine protein kinase Fyn 0.003 0.0684 0.0684
Schistosoma mansoni protein kinase 0.003 0.0684 0.0684
Loa Loa (eye worm) TK/EPH protein kinase 0.003 0.0684 0.0886
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0175 0.0227
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.0175 0.0227
Entamoeba histolytica protein kinase, putative 0.003 0.0684 0.4732
Brugia malayi Protein kinase domain containing protein 0.003 0.0684 0.0886
Entamoeba histolytica protein kinase, putative 0.003 0.0684 0.4732

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -6.119 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -6.065 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.522 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.404 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.369 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.229 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.196 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.185 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.877 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.832 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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