Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.1322 | 0.7076 | 0.5 |
Trypanosoma brucei | isocitrate dehydrogenase, putative | 0.1322 | 0.7076 | 0.5 |
Trypanosoma brucei | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.1322 | 0.7076 | 0.5 |
Trypanosoma cruzi | isocitrate dehydrogenase, putative | 0.1322 | 0.7076 | 0.5 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.1322 | 0.7076 | 0.5 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.1322 | 0.7076 | 0.5 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.1322 | 0.7076 | 0.7076 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.1322 | 0.7076 | 0.7076 |
Trypanosoma cruzi | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.1322 | 0.7076 | 0.5 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.1322 | 0.7076 | 1 |
Brugia malayi | isocitrate dehydrogenase | 0.1322 | 0.7076 | 0.5 |
Brugia malayi | Isocitrate dehydrogenase | 0.1322 | 0.7076 | 0.5 |
Plasmodium vivax | isocitrate dehydrogenase [NADP], mitochondrial, putative | 0.1322 | 0.7076 | 0.5 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.1322 | 0.7076 | 0.7076 |
Leishmania major | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.1322 | 0.7076 | 0.5 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.1322 | 0.7076 | 0.7076 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.1322 | 0.7076 | 0.7076 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.1322 | 0.7076 | 0.7076 |
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.1322 | 0.7076 | 0.5 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.1322 | 0.7076 | 0.7076 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -4.261 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.