Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | enteropeptidase | 0.0129 | 0.6675 | 0.6675 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0129 | 0.6675 | 0.6545 |
Trypanosoma cruzi | transcription factor btf3, putative | 0.0076 | 0.2619 | 0.5 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0129 | 0.6675 | 0.6545 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0129 | 0.6675 | 0.6545 |
Entamoeba histolytica | hypothetical protein | 0.0076 | 0.2619 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0076 | 0.2619 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0129 | 0.6675 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0047 | 0.0378 | 0.0378 |
Brugia malayi | Trypsin family protein | 0.0129 | 0.6675 | 1 |
Schistosoma mansoni | transient receptor potential channel 4 | 0.0112 | 0.537 | 0.5189 |
Brugia malayi | Trypsin family protein | 0.0129 | 0.6675 | 1 |
Echinococcus multilocularis | short transient receptor potential channel 6 | 0.0074 | 0.2475 | 0.2475 |
Echinococcus granulosus | enteropeptidase | 0.0129 | 0.6675 | 0.6675 |
Echinococcus multilocularis | transmembrane protease serine 3 | 0.0129 | 0.6675 | 0.6675 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.219 | 0.3281 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0047 | 0.0378 | 0.0378 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0129 | 0.6675 | 0.6545 |
Brugia malayi | hypothetical protein | 0.0129 | 0.6675 | 1 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0129 | 0.6675 | 0.6545 |
Loa Loa (eye worm) | ICD-1 protein | 0.0076 | 0.2619 | 0.3924 |
Echinococcus granulosus | Peptidase S1 S6 chymotrypsin Hap | 0.0129 | 0.6675 | 0.6675 |
Echinococcus granulosus | short transient receptor potential channel 6 | 0.0074 | 0.2475 | 0.2475 |
Echinococcus granulosus | transient receptor potential ion channel A | 0.0108 | 0.5085 | 0.5085 |
Brugia malayi | Chymotrypsin-like protease CTRL-1 precursor | 0.0129 | 0.6675 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0047 | 0.0378 | 0.0566 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0129 | 0.6675 | 0.6545 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.1747 | 0.1423 |
Loa Loa (eye worm) | hypothetical protein | 0.0129 | 0.6675 | 1 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0129 | 0.6675 | 0.6545 |
Schistosoma mansoni | hypothetical protein | 0.0129 | 0.6675 | 0.6545 |
Loa Loa (eye worm) | hypothetical protein | 0.0129 | 0.6675 | 1 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0129 | 0.6675 | 0.6545 |
Loa Loa (eye worm) | trypsin family protein | 0.0129 | 0.6675 | 1 |
Brugia malayi | Trypsin family protein | 0.0129 | 0.6675 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.1747 | 0.1423 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0129 | 0.6675 | 0.6545 |
Trypanosoma cruzi | transcription factor btf3, putative | 0.0076 | 0.2619 | 0.5 |
Onchocerca volvulus | 0.0129 | 0.6675 | 0.5 | |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0129 | 0.6675 | 0.6545 |
Echinococcus multilocularis | short transient receptor potential channel 6 | 0.0074 | 0.2475 | 0.2475 |
Trypanosoma brucei | transcription factor BTF3, putative | 0.0076 | 0.2619 | 0.5 |
Echinococcus multilocularis | subfamily S1A unassigned peptidase (S01 family) | 0.0129 | 0.6675 | 0.6675 |
Echinococcus multilocularis | tar DNA binding protein | 0.0064 | 0.1747 | 0.1747 |
Schistosoma mansoni | transcription factor btf3 | 0.0076 | 0.2619 | 0.233 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0129 | 0.6675 | 0.6545 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0129 | 0.6675 | 0.6545 |
Loa Loa (eye worm) | hypothetical protein | 0.0129 | 0.6675 | 1 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0129 | 0.6675 | 0.6545 |
Schistosoma mansoni | transient receptor potential channel | 0.0112 | 0.537 | 0.5189 |
Entamoeba histolytica | transcription factor BTF3, putative | 0.0076 | 0.2619 | 0.5 |
Echinococcus granulosus | transient receptor potential gamma protein | 0.0112 | 0.537 | 0.537 |
Mycobacterium ulcerans | hypothetical protein | 0.0129 | 0.6675 | 0.5 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0129 | 0.6675 | 0.6545 |
Echinococcus multilocularis | Peptidase S1 S6, chymotrypsin Hap | 0.0129 | 0.6675 | 0.6675 |
Loa Loa (eye worm) | hypothetical protein | 0.0112 | 0.537 | 0.8045 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.1747 | 0.1423 |
Plasmodium vivax | basic transcription factor 3b, putative | 0.0076 | 0.2619 | 0.5 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0129 | 0.6675 | 0.6545 |
Schistosoma mansoni | transient receptor potential channel | 0.0074 | 0.2475 | 0.218 |
Onchocerca volvulus | 0.0129 | 0.6675 | 0.5 | |
Echinococcus granulosus | tar DNA binding protein | 0.0064 | 0.1747 | 0.1747 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.1747 | 0.1423 |
Echinococcus multilocularis | transient receptor potential ion channel A | 0.0108 | 0.5085 | 0.5085 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0129 | 0.6675 | 0.6545 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0129 | 0.6675 | 0.6545 |
Schistosoma mansoni | hypothetical protein | 0.0129 | 0.6675 | 0.6545 |
Brugia malayi | RNA binding protein | 0.0064 | 0.1747 | 0.2617 |
Loa Loa (eye worm) | TAR-binding protein | 0.0064 | 0.1747 | 0.2617 |
Plasmodium falciparum | basic transcription factor 3b, putative | 0.0076 | 0.2619 | 0.5 |
Leishmania major | basic transcription factor 3a, putative | 0.0076 | 0.2619 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0047 | 0.0378 | 0.0378 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0129 | 0.6675 | 0.6545 |
Onchocerca volvulus | 0.0129 | 0.6675 | 0.5 | |
Echinococcus granulosus | transcription factor btf3 | 0.0076 | 0.2619 | 0.2619 |
Loa Loa (eye worm) | RNA binding protein | 0.0064 | 0.1747 | 0.2617 |
Echinococcus multilocularis | transient receptor potential gamma protein | 0.0112 | 0.537 | 0.537 |
Schistosoma mansoni | aminopeptidase PILS (M01 family) | 0.0129 | 0.6675 | 0.6545 |
Echinococcus granulosus | glycoprotein Antigen 5 | 0.0129 | 0.6675 | 0.6675 |
Echinococcus granulosus | Mastin | 0.0129 | 0.6675 | 0.6675 |
Echinococcus granulosus | subfamily S1A unassigned peptidase S01 family | 0.0129 | 0.6675 | 0.6675 |
Echinococcus granulosus | transmembrane protease serine 3 | 0.0129 | 0.6675 | 0.6675 |
Echinococcus multilocularis | glycoprotein Antigen 5 | 0.0129 | 0.6675 | 0.6675 |
Loa Loa (eye worm) | hypothetical protein | 0.0129 | 0.6675 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0076 | 0.2619 | 0.5 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0047 | 0.0378 | 0.0566 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0064 | 0.1747 | 0.2617 |
Brugia malayi | TAR-binding protein | 0.0064 | 0.1747 | 0.2617 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.1747 | 0.1423 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0047 | 0.0378 | 0.0378 |
Echinococcus granulosus | short transient receptor potential channel 6 | 0.0074 | 0.2475 | 0.2475 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0064 | 0.1747 | 0.2617 |
Toxoplasma gondii | NAC domain-containing protein | 0.0076 | 0.2619 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0129 | 0.6675 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0076 | 0.2619 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0129 | 0.6675 | 1 |
Onchocerca volvulus | 0.0129 | 0.6675 | 0.5 | |
Echinococcus multilocularis | transcription factor btf3 | 0.0076 | 0.2619 | 0.2619 |
Brugia malayi | Trypsin-like protease protein 5 | 0.0129 | 0.6675 | 1 |
Echinococcus multilocularis | Mastin | 0.0129 | 0.6675 | 0.6675 |
Onchocerca volvulus | 0.0129 | 0.6675 | 0.5 | |
Brugia malayi | Trypsin family protein | 0.0129 | 0.6675 | 1 |
Onchocerca volvulus | 0.0129 | 0.6675 | 0.5 | |
Schistosoma mansoni | transient receptor potential channel | 0.0074 | 0.2475 | 0.218 |
Brugia malayi | beta-NAC-like protein | 0.0076 | 0.2619 | 0.3924 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -5.439 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.395 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.379 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.364 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.088 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.938 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.914 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.723 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.