Detailed information for compound 1613638

Basic information

Technical information
  • TDR Targets ID: 1613638
  • Name: ethyl 1-cyclopropyl-4-oxopiperidine-3-carboxy late
  • MW: 211.258 | Formula: C11H17NO3
  • H donors: 0 H acceptors: 2 LogP: 0.76 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=O)C1CN(CCC1=O)C1CC1
  • InChi: 1S/C11H17NO3/c1-2-15-11(14)9-7-12(8-3-4-8)6-5-10(9)13/h8-9H,2-7H2,1H3
  • InChiKey: CYTHCMOPAYRQRJ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • ethyl 1-cyclopropyl-4-oxo-piperidine-3-carboxylate
  • 1-cyclopropyl-4-oxo-3-piperidinecarboxylic acid ethyl ester
  • 1-cyclopropyl-4-keto-nipecotic acid ethyl ester
  • NCI60_029916
  • AIDS-149261
  • AIDS149261
  • Ethyl 1-cyclopropyl-4-oxo-3-piperidinecarboxylate
  • NSC683443

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Nuclear hormone receptor E75 0.0134 0.2588 0.296
Onchocerca volvulus 0.0134 0.2588 0.2588
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0283 0.5894 0.6742
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0059 0.0942 0.1598
Brugia malayi hypothetical protein 0.0134 0.2588 0.296
Loa Loa (eye worm) hypothetical protein 0.0048 0.0697 0.0797
Loa Loa (eye worm) hypothetical protein 0.0283 0.5894 0.6742
Loa Loa (eye worm) hypothetical protein 0.0134 0.2588 0.296
Schistosoma mansoni retinoic acid receptor RXR 0.0283 0.5894 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0283 0.5894 1
Brugia malayi Latrophilin receptor protein 2 0.0048 0.0697 0.0797
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0161 0.3182 1
Loa Loa (eye worm) hypothetical protein 0.0134 0.2588 0.296
Loa Loa (eye worm) hypothetical protein 0.0283 0.5894 0.6742
Schistosoma mansoni retinoid-x-receptor (RXR) 0.015 0.2942 0.4991
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0134 0.2588 0.4391
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0283 0.5894 0.6742
Brugia malayi Nuclear hormone receptor E75 0.0134 0.2588 0.296
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0161 0.3182 1
Loa Loa (eye worm) hypothetical protein 0.0152 0.2989 0.342
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.1024 0.5
Schistosoma mansoni thyroid hormone receptor 0.0283 0.5894 1
Brugia malayi nuclear receptor RXR 0.015 0.2942 0.3365
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0283 0.5894 1
Trypanosoma cruzi cysteine peptidase, putative 0.0063 0.1024 1
Brugia malayi nuclear hormone receptor 0.0283 0.5894 0.6742
Loa Loa (eye worm) hypothetical protein 0.015 0.2942 0.3365
Loa Loa (eye worm) hypothetical protein 0.0283 0.5894 0.6742
Loa Loa (eye worm) hypothetical protein 0.0059 0.0942 0.1077
Brugia malayi nuclear receptor RXR 0.0134 0.2588 0.296
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0283 0.5894 1
Brugia malayi hypothetical protein 0.015 0.2942 0.3365
Loa Loa (eye worm) hypothetical protein 0.0134 0.2588 0.296
Echinococcus granulosus peptidase Clp S14 family 0.0105 0.196 0.3326
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0283 0.5894 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0283 0.5894 0.6742
Brugia malayi nuclear hormone receptor 0.0134 0.2588 0.296
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0283 0.5894 0.6742
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0283 0.5894 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0059 0.0942 0.1598
Onchocerca volvulus Protein ultraspiracle homolog 0.0283 0.5894 0.5894
Echinococcus granulosus Nuclear hormone receptor HR96 0.0134 0.2588 0.4391
Loa Loa (eye worm) hypothetical protein 0.0161 0.3182 0.364
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0161 0.3182 0.5
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0134 0.2588 0.4391
Schistosoma mansoni nuclear hormone receptor 0.0283 0.5894 1
Brugia malayi nuclear receptor NHR-67 0.0134 0.2588 0.296
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0134 0.2588 0.4391
Trypanosoma cruzi cysteine peptidase, putative 0.0063 0.1024 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.1024 0.5
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0283 0.5894 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.1024 0.5
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0283 0.5894 1
Leishmania major cathepsin L-like protease 0.0063 0.1024 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0283 0.5894 1
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0283 0.5894 0.6742
Loa Loa (eye worm) hypothetical protein 0.0134 0.2588 0.296
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0283 0.5894 0.6742
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0283 0.5894 0.6742
Loa Loa (eye worm) hypothetical protein 0.0104 0.1928 0.2206
Echinococcus granulosus GPCR family 2 0.0048 0.0697 0.1182
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0105 0.196 0.5
Onchocerca volvulus 0.0283 0.5894 0.5894
Echinococcus multilocularis nuclear receptor nhr 48 0.0134 0.2588 0.4391
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0283 0.5894 1
Loa Loa (eye worm) hypothetical protein 0.0283 0.5894 0.6742
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0283 0.5894 1
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0134 0.2588 0.4391
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0283 0.5894 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0283 0.5894 1
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0161 0.3182 1
Echinococcus granulosus FTZ F1 alpha 0.0283 0.5894 1
Echinococcus multilocularis FTZ F1 alpha 0.0283 0.5894 1
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.015 0.2942 0.4991
Brugia malayi Nuclear hormone receptor-like 1 0.015 0.2942 0.3365
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0283 0.5894 0.6742
Brugia malayi photoreceptor-specific nuclear receptor 0.0283 0.5894 0.6742
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.1024 0.5
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0161 0.3182 0.5
Schistosoma mansoni nuclear receptor 0.0134 0.2588 0.4391
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0161 0.3182 1
Schistosoma mansoni hypothetical protein 0.0104 0.1928 0.3272
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0059 0.0942 0.1598
Loa Loa (eye worm) hypothetical protein 0.0283 0.5894 0.6742
Schistosoma mansoni nuclear hormone receptor 0.0134 0.2588 0.4391
Brugia malayi nuclear receptor NHR-88 0.0134 0.2588 0.296
Loa Loa (eye worm) hypothetical protein 0.0283 0.5894 0.6742
Loa Loa (eye worm) hypothetical protein 0.0134 0.2588 0.296
Loa Loa (eye worm) hypothetical protein 0.0134 0.2588 0.296
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0283 0.5894 1
Schistosoma mansoni nuclear receptor 0.0134 0.2588 0.4391
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0152 0.2989 0.342
Loa Loa (eye worm) hypothetical protein 0.0134 0.2588 0.296
Loa Loa (eye worm) hypothetical protein 0.0134 0.2588 0.296
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0283 0.5894 0.6742
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0105 0.196 0.5
Loa Loa (eye worm) nuclear hormone receptor 0.0134 0.2588 0.296
Schistosoma mansoni thyroid hormone receptor 0.0283 0.5894 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.1024 0.5
Schistosoma mansoni hypothetical protein 0.0048 0.0697 0.1182
Echinococcus multilocularis GPCR, family 2 0.0048 0.0697 0.1182
Brugia malayi Calcitonin receptor-like protein seb-1 0.0152 0.2989 0.342
Toxoplasma gondii hypothetical protein 0.0055 0.0858 0.2695
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0283 0.5894 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0048 0.0697 0.1182
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0048 0.0697 0.0797
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0048 0.0697 0.1182
Schistosoma mansoni nuclear hormone receptor 0.0134 0.2588 0.4391
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0161 0.3182 1
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0134 0.2588 0.296
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.1024 0.5
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0134 0.2588 0.4391
Loa Loa (eye worm) hypothetical protein 0.0134 0.2588 0.296
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0161 0.3182 1
Echinococcus multilocularis peptidase Clp (S14 family) 0.0105 0.196 0.3326
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0283 0.5894 0.6742
Echinococcus multilocularis ecdysone induced protein 78C 0.0283 0.5894 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.1024 0.5
Echinococcus granulosus thyroid hormone receptor alpha 0.0134 0.2588 0.4391
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.015 0.2942 0.4991
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0283 0.5894 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0059 0.0942 0.1598
Schistosoma mansoni steroid hormone receptor ad4bp 0.0283 0.5894 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.1024 0.5
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0055 0.0858 0.2695
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0134 0.2588 0.296
Brugia malayi latrophilin 2 splice variant baaae 0.0104 0.1928 0.2206
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0283 0.5894 0.6742
Brugia malayi Probable ClpP-like protease 0.0161 0.3182 0.364
Brugia malayi nuclear receptor NHR-88 0.0283 0.5894 0.6742
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0134 0.2588 0.4391
Schistosoma mansoni coup transcription factor 0.0283 0.5894 1
Onchocerca volvulus 0.0134 0.2588 0.2588
Brugia malayi Nuclear hormone receptor-like 1 0.015 0.2942 0.3365
Loa Loa (eye worm) hypothetical protein 0.0134 0.2588 0.296
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0283 0.5894 0.5894
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0283 0.5894 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.1024 0.5
Loa Loa (eye worm) hypothetical protein 0.0134 0.2588 0.296
Echinococcus granulosus nuclear receptor nhr 48 0.0134 0.2588 0.4391
Onchocerca volvulus Bile acid receptor homolog 0.0283 0.5894 0.5894
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0283 0.5894 1
Schistosoma mansoni hypothetical protein 0.0048 0.0697 0.1182
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0048 0.0697 0.1182
Schistosoma mansoni RAR-like nuclear receptor 0.0283 0.5894 1
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0283 0.5894 0.6742
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0283 0.5894 1
Leishmania major cathepsin L-like protease 0.0063 0.1024 1
Trypanosoma cruzi major cysteine proteinase, putative 0.0049 0.0727 0.7098
Brugia malayi ecdysone receptor 0.0134 0.2588 0.296
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0134 0.2588 0.4391
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0283 0.5894 0.6742
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0161 0.3182 0.5
Brugia malayi steroid hormone receptor 0.0283 0.5894 0.6742
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.1024 0.5
Schistosoma mansoni zinc finger protein 0.0134 0.2588 0.4391
Brugia malayi Pre-SET motif family protein 0.0059 0.0942 0.1077
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0134 0.2588 0.2588
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0161 0.3182 0.5399
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0161 0.3182 0.5399
Schistosoma mansoni nuclear receptor nhr-48 0.0134 0.2588 0.4391
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0412 0.8742 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0283 0.5894 0.6742
Plasmodium vivax SET domain protein, putative 0.0059 0.0942 0.296
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0152 0.2989 0.342
Loa Loa (eye worm) hypothetical protein 0.015 0.2942 0.3365
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0161 0.3182 0.5
Brugia malayi orphan nuclear receptor NR2E1 0.0134 0.2588 0.296
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0283 0.5894 0.6742
Trypanosoma cruzi cysteine peptidase, putative 0.0063 0.1024 1
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0134 0.2588 0.4391
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0283 0.5894 0.6742
Schistosoma mansoni hypothetical protein 0.0048 0.0697 0.1182
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0048 0.0697 0.1182
Loa Loa (eye worm) hypothetical protein 0.015 0.2942 0.3365
Brugia malayi tailless protein 0.0134 0.2588 0.296
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.015 0.2942 0.4991
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.1024 0.5
Echinococcus granulosus Nuclear hormone receptor HR96 0.0134 0.2588 0.4391
Brugia malayi nuclear hormone receptor family member nhr-6 0.0134 0.2588 0.296
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0105 0.196 0.4744
Loa Loa (eye worm) latrophilin receptor protein 2 0.0048 0.0697 0.0797
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0283 0.5894 1
Schistosoma mansoni hypothetical protein 0.0048 0.0697 0.1182
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0057 0.0894 0.1517
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0055 0.0858 0.2695
Loa Loa (eye worm) steroid hormone receptor 0.0283 0.5894 0.6742
Brugia malayi conserved hypotetical protein 0.0134 0.2588 0.296
Leishmania major cathepsin L-like protease 0.0063 0.1024 1
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0059 0.0942 0.296
Loa Loa (eye worm) hypothetical protein 0.015 0.2942 0.3365
Loa Loa (eye worm) hypothetical protein 0.0283 0.5894 0.6742
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0059 0.0942 0.1598
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0283 0.5894 0.6742
Echinococcus granulosus ecdysone induced protein 78C 0.0283 0.5894 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0283 0.5894 0.6742
Schistosoma mansoni peptidase Clp (S14 family) 0.0161 0.3182 0.5399
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0283 0.5894 0.6742
Loa Loa (eye worm) hypothetical protein 0.0283 0.5894 0.6742
Onchocerca volvulus 0.0059 0.0942 0.0942
Loa Loa (eye worm) hypothetical protein 0.0134 0.2588 0.296
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0134 0.2588 0.4391
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0283 0.5894 0.6742
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0161 0.3182 0.5
Loa Loa (eye worm) DR-78 0.0134 0.2588 0.296
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0059 0.0942 0.1598
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0057 0.0903 0.8824
Brugia malayi ecdysteroid receptor 0.0283 0.5894 0.6742
Brugia malayi hypothetical protein 0.0134 0.2588 0.296
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.015 0.2942 0.3365
Brugia malayi Nuclear hormone receptor-like 1 0.0283 0.5894 0.6742
Brugia malayi hypothetical protein 0.015 0.2942 0.3365
Loa Loa (eye worm) nuclear receptor NHR-67 0.0134 0.2588 0.296
Brugia malayi Pre-SET motif family protein 0.0412 0.8742 1
Trypanosoma cruzi cruzipain precursor, putative 0.0063 0.1024 1
Loa Loa (eye worm) hypothetical protein 0.0134 0.2588 0.296
Brugia malayi nuclear hormone receptor family member odr-7 0.0134 0.2588 0.296
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0134 0.2588 0.2588
Brugia malayi Steroid receptor seven-up type 2 0.0283 0.5894 0.6742
Echinococcus multilocularis thyroid hormone receptor alpha 0.0283 0.5894 1
Loa Loa (eye worm) hypothetical protein 0.015 0.2942 0.3365
Echinococcus granulosus histone lysine methyltransferase setb 0.0059 0.0942 0.1598

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.