Detailed information for compound 1613639

Basic information

Technical information
  • TDR Targets ID: 1613639
  • Name: (4,6-diacetyloxy-8-methoxynaphthalen-1-yl) ac etate
  • MW: 332.305 | Formula: C17H16O7
  • H donors: 0 H acceptors: 3 LogP: 2.4 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(OC(=O)C)cc2c1c(ccc2OC(=O)C)OC(=O)C
  • InChi: 1S/C17H16O7/c1-9(18)22-12-7-13-14(23-10(2)19)5-6-15(24-11(3)20)17(13)16(8-12)21-4/h5-8H,1-4H3
  • InChiKey: SGPSIWQGVAAPDH-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (4,6-diacetoxy-8-methoxy-1-naphthyl) acetate
  • acetic acid (4,6-diacetoxy-8-methoxy-1-naphthyl) ester
  • (4,6-diacetyloxy-8-methoxy-naphthalen-1-yl) ethanoate
  • NSC620516
  • NCI60_006061

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0148 0.1856 0.1829
Mycobacterium tuberculosis Probable dehydrogenase 0.0209 0.2761 0.8837
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0166 0.2117 0.2232
Schistosoma mansoni hypothetical protein 0.0095 0.1071 0.1129
Schistosoma mansoni jumonji/arid domain-containing protein 0.0069 0.0688 0.0725
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0314 0.4293 0.4908
Loa Loa (eye worm) hypothetical protein 0.0148 0.1856 0.1631
Entamoeba histolytica hypothetical protein 0.007 0.0708 0.5
Brugia malayi jmjC domain containing protein 0.0185 0.2407 0.2752
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0023 0.0024 0.0027
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0314 0.4293 0.4591
Plasmodium falciparum glutathione reductase 0.0092 0.1031 0.457
Brugia malayi hypothetical protein 0.0148 0.1856 0.2122
Echinococcus multilocularis peregrin 0.0057 0.0513 0.0391
Brugia malayi jmjC domain containing protein 0.0069 0.0688 0.0786
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0314 0.4293 0.4591
Brugia malayi nuclear receptor NHR-88 0.0148 0.1856 0.2122
Brugia malayi Nuclear hormone receptor E75 0.0148 0.1856 0.2122
Loa Loa (eye worm) hypothetical protein 0.0148 0.1856 0.1631
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0299 0.4075 0.4326
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0627 0.5428
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0163 0.2079 0.2069
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0314 0.4293 0.4908
Giardia lamblia PHD finger protein 15 0.0057 0.0513 1
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0314 0.4293 0.4439
Loa Loa (eye worm) glutathione reductase 0.0092 0.1031 0.0629
Brugia malayi Pre-SET motif family protein 0.0617 0.8747 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0088 0.0981 0.1034
Mycobacterium tuberculosis Probable reductase 0.0209 0.2761 0.8837
Leishmania major cathepsin L-like protease 0.0064 0.0627 0.5428
Mycobacterium tuberculosis Probable oxidoreductase 0.0233 0.3105 1
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0185 0.2407 0.242
Leishmania major cathepsin L-like protease 0.0064 0.0627 0.5428
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0314 0.4293 0.4526
Echinococcus multilocularis ecdysone induced protein 78C 0.0314 0.4293 0.4439
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0314 0.4293 0.4439
Plasmodium falciparum thioredoxin reductase 0.0092 0.1031 0.457
Schistosoma mansoni nuclear receptor 0.0148 0.1856 0.1957
Echinococcus multilocularis thyroid hormone receptor alpha 0.0314 0.4293 0.4439
Brugia malayi nuclear hormone receptor 0.0314 0.4293 0.4908
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0233 0.3105 1
Schistosoma mansoni hypothetical protein 0.007 0.0708 0.0746
Loa Loa (eye worm) hypothetical protein 0.0148 0.1856 0.1631
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0314 0.4293 0.4439
Trypanosoma brucei trypanothione reductase 0.0092 0.1031 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0627 0.5428
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0163 0.2079 1
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0314 0.4293 0.4439
Schistosoma mansoni hypothetical protein 0.0095 0.1071 0.1129
Brugia malayi nuclear hormone receptor family member odr-7 0.0148 0.1856 0.2122
Brugia malayi Nuclear hormone receptor-like 1 0.0314 0.4293 0.4908
Trypanosoma cruzi cruzipain precursor, putative 0.0064 0.0627 0.5428
Schistosoma mansoni nuclear hormone receptor 0.0148 0.1856 0.1957
Brugia malayi Latrophilin receptor protein 2 0.0095 0.1071 0.1224
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0209 0.2761 0.8837
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0059 0.0545 0.4497
Loa Loa (eye worm) hypothetical protein 0.0148 0.1856 0.1631
Echinococcus granulosus jumonji domain containing protein 0.0079 0.0839 0.074
Loa Loa (eye worm) hypothetical protein 0.0314 0.4293 0.4591
Brugia malayi orphan nuclear receptor NR2E1 0.0148 0.1856 0.2122
Brugia malayi nuclear receptor RXR 0.0166 0.2117 0.242
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0148 0.1856 0.1829
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0095 0.1071 0.0988
Schistosoma mansoni coup transcription factor 0.0314 0.4293 0.4526
Loa Loa (eye worm) hypothetical protein 0.0148 0.1856 0.1631
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0148 0.1856 0.1957
Plasmodium falciparum phd finger protein, putative 0.0057 0.0513 0.1888
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0627 0.5428
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0314 0.4293 0.3984
Loa Loa (eye worm) hypothetical protein 0.0314 0.4293 0.4591
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0314 0.4293 0.4908
Entamoeba histolytica hypothetical protein 0.007 0.0708 0.5
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0163 0.2079 1
Echinococcus granulosus microtubule associated protein 2 0.0667 0.9485 1
Schistosoma mansoni hypothetical protein 0.0095 0.1071 0.1129
Echinococcus granulosus lysine specific demethylase 5A 0.0069 0.0688 0.0578
Schistosoma mansoni nuclear hormone receptor 0.0314 0.4293 0.4526
Entamoeba histolytica hypothetical protein 0.007 0.0708 0.5
Loa Loa (eye worm) hypothetical protein 0.0166 0.2117 0.1948
Schistosoma mansoni jumonji domain containing protein 0.0147 0.1847 0.1947
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0056 0.0507 0.1857
Echinococcus granulosus Nuclear hormone receptor HR96 0.0148 0.1856 0.1829
Loa Loa (eye worm) hypothetical protein 0.0148 0.1856 0.1631
Trypanosoma cruzi major cysteine proteinase, putative 0.0051 0.0424 0.3131
Entamoeba histolytica hypothetical protein 0.007 0.0708 0.5
Echinococcus multilocularis jumonji domain containing protein 0.0079 0.0839 0.074
Brugia malayi glutathione reductase 0.0092 0.1031 0.1178
Toxoplasma gondii PHD-finger domain-containing protein 0.0057 0.0513 0.1888
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0163 0.2079 1
Loa Loa (eye worm) hypothetical protein 0.0166 0.2117 0.1948
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0314 0.4293 0.4591
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0148 0.1856 0.1416
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0032 0.0148 0.0156
Loa Loa (eye worm) hypothetical protein 0.0314 0.4293 0.4591
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0107 0.1253 0.3736
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0148 0.1856 0.1416
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0032 0.0148 0.0169
Loa Loa (eye worm) hypothetical protein 0.0314 0.4293 0.4591
Onchocerca volvulus Bile acid receptor homolog 0.0314 0.4293 0.3984
Brugia malayi Nuclear hormone receptor-like 1 0.0166 0.2117 0.242
Echinococcus multilocularis lysine specific demethylase 5A 0.0069 0.0688 0.0578
Brugia malayi nuclear receptor RXR 0.0148 0.1856 0.2122
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0163 0.2079 0.2069
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0314 0.4293 0.4908
Brugia malayi hypothetical protein 0.0148 0.1856 0.2122
Trypanosoma cruzi trypanothione reductase, putative 0.0092 0.1031 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0627 0.5428
Brugia malayi nuclear receptor NHR-67 0.0148 0.1856 0.2122
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0627 0.5428
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0314 0.4293 0.4908
Brugia malayi Nuclear hormone receptor E75 0.0148 0.1856 0.2122
Schistosoma mansoni hypothetical protein 0.0204 0.2684 0.283
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0148 0.1856 0.2122
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0314 0.4293 0.4526
Brugia malayi nuclear hormone receptor family member nhr-6 0.0148 0.1856 0.2122
Loa Loa (eye worm) hypothetical protein 0.0148 0.1856 0.1631
Schistosoma mansoni microtubule-associated protein tau 0.0667 0.9485 1
Onchocerca volvulus 0.0148 0.1856 0.1416
Loa Loa (eye worm) MH2 domain-containing protein 0.0115 0.1376 0.1049
Brugia malayi conserved hypotetical protein 0.0148 0.1856 0.2122
Toxoplasma gondii PHD-finger domain-containing protein 0.0057 0.0513 0.1888
Schistosoma mansoni nuclear receptor 0.0148 0.1856 0.1957
Schistosoma mansoni nuclear receptor nhr-48 0.0148 0.1856 0.1957
Plasmodium vivax hypothetical protein, conserved 0.0057 0.0513 0.1888
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0163 0.2079 1
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0233 0.3105 1
Trypanosoma cruzi cysteine peptidase, putative 0.0064 0.0627 0.5428
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0314 0.4293 0.4526
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0233 0.3105 1
Loa Loa (eye worm) hypothetical protein 0.0314 0.4293 0.4591
Onchocerca volvulus 0.0148 0.1856 0.1416
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0163 0.2079 0.6054
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0314 0.4293 0.4591
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0163 0.2079 1
Brugia malayi Steroid receptor seven-up type 2 0.0314 0.4293 0.4908
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0166 0.2117 0.2109
Toxoplasma gondii thioredoxin reductase 0.0092 0.1031 0.457
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0088 0.0981 0.1034
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0299 0.4075 0.4659
Echinococcus granulosus peregrin 0.0057 0.0513 0.0391
Schistosoma mansoni nuclear hormone receptor 0.0148 0.1856 0.1957
Loa Loa (eye worm) hypothetical protein 0.0148 0.1856 0.1631
Leishmania major cathepsin L-like protease 0.0064 0.0627 0.5428
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0185 0.2407 0.242
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0166 0.2117 0.1948
Loa Loa (eye worm) hypothetical protein 0.0204 0.2684 0.2637
Echinococcus multilocularis PHD finger protein rhinoceros 0.0057 0.0513 0.0391
Loa Loa (eye worm) hypothetical protein 0.0314 0.4293 0.4591
Loa Loa (eye worm) transcription factor SMAD2 0.0115 0.1376 0.1049
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0314 0.4293 0.4908
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0314 0.4293 0.4591
Echinococcus multilocularis thioredoxin glutathione reductase 0.0092 0.1031 0.0945
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0107 0.1253 0.2872
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0148 0.1856 0.1631
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0314 0.4293 0.4439
Loa Loa (eye worm) hypothetical protein 0.0095 0.1071 0.0677
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0088 0.0981 0.0892
Brugia malayi steroid hormone receptor 0.0314 0.4293 0.4908
Loa Loa (eye worm) hypothetical protein 0.0148 0.1856 0.1631
Loa Loa (eye worm) hypothetical protein 0.0148 0.1856 0.1631
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0107 0.1253 0.3736
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0314 0.4293 0.4439
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0314 0.4293 0.4908
Loa Loa (eye worm) hypothetical protein 0.0314 0.4293 0.4591
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0314 0.4293 0.4439
Echinococcus granulosus ecdysone induced protein 78C 0.0314 0.4293 0.4439
Brugia malayi tailless protein 0.0148 0.1856 0.2122
Brugia malayi Probable ClpP-like protease 0.0163 0.2079 0.2377
Echinococcus granulosus PHD finger protein rhinoceros 0.0057 0.0513 0.0391
Brugia malayi Calcitonin receptor-like protein seb-1 0.0299 0.4075 0.4659
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0163 0.2079 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0069 0.0688 0.0725
Brugia malayi PHD-finger family protein 0.0057 0.0513 0.0586
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0209 0.2761 0.8837
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0163 0.2079 1
Brugia malayi Thioredoxin reductase 0.0092 0.1031 0.1178
Brugia malayi Nuclear hormone receptor-like 1 0.0166 0.2117 0.242
Echinococcus granulosus Nuclear hormone receptor HR96 0.0148 0.1856 0.1829
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0166 0.2117 0.2232
Plasmodium vivax glutathione reductase, putative 0.0092 0.1031 0.457
Schistosoma mansoni zinc finger protein 0.0148 0.1856 0.1957
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0056 0.0507 0.1857
Loa Loa (eye worm) hypothetical protein 0.0148 0.1856 0.1631
Brugia malayi Bromodomain containing protein 0.0057 0.0513 0.0586
Brugia malayi MH2 domain containing protein 0.0115 0.1376 0.1573
Brugia malayi latrophilin 2 splice variant baaae 0.0204 0.2684 0.3069
Schistosoma mansoni thyroid hormone receptor 0.0314 0.4293 0.4526
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0148 0.1856 0.1829
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0148 0.1856 0.1829
Echinococcus granulosus GPCR family 2 0.0095 0.1071 0.0988
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0627 0.5428
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0627 0.5428
Brugia malayi nuclear receptor NHR-88 0.0314 0.4293 0.4908
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0314 0.4293 0.4526
Loa Loa (eye worm) hypothetical protein 0.0166 0.2117 0.1948
Schistosoma mansoni thyroid hormone receptor 0.0314 0.4293 0.4526
Schistosoma mansoni retinoic acid receptor RXR 0.0314 0.4293 0.4526
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0314 0.4293 0.4439
Plasmodium vivax thioredoxin reductase, putative 0.0092 0.1031 0.457
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.007 0.0708 0.0599
Onchocerca volvulus 0.0088 0.0981 0.0493
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0314 0.4293 0.4908
Echinococcus multilocularis FTZ F1 alpha 0.0314 0.4293 0.4439
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0314 0.4293 0.4908
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0163 0.2079 1
Toxoplasma gondii hypothetical protein 0.0056 0.0507 0.1857
Loa Loa (eye worm) hypothetical protein 0.0166 0.2117 0.1948
Schistosoma mansoni hypothetical protein 0.0095 0.1071 0.1129
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0314 0.4293 0.4439
Echinococcus granulosus nuclear receptor nhr 48 0.0148 0.1856 0.1829
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0148 0.1856 0.1829
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0627 0.5428
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0627 0.5428
Loa Loa (eye worm) hypothetical protein 0.0088 0.0981 0.0568
Echinococcus granulosus thioredoxin glutathione reductase 0.0092 0.1031 0.0945
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0088 0.0981 0.1034
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0314 0.4293 0.4908
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0085 0.0933 0.084
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0314 0.4293 0.4908
Loa Loa (eye worm) hypothetical protein 0.0299 0.4075 0.4326
Onchocerca volvulus 0.0314 0.4293 0.3984
Schistosoma mansoni RAR-like nuclear receptor 0.0314 0.4293 0.4526
Loa Loa (eye worm) jmjC domain-containing protein 0.0117 0.1399 0.1077
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0095 0.1071 0.0988
Loa Loa (eye worm) hypothetical protein 0.0148 0.1856 0.1631
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0314 0.4293 0.4439
Echinococcus multilocularis microtubule associated protein 2 0.0667 0.9485 1
Leishmania major trypanothione reductase 0.0092 0.1031 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0095 0.1071 0.0988
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0209 0.2761 0.8837
Loa Loa (eye worm) hypothetical protein 0.0163 0.2079 0.1903
Plasmodium vivax SET domain protein, putative 0.0088 0.0981 0.431
Loa Loa (eye worm) steroid hormone receptor 0.0314 0.4293 0.4591
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0314 0.4293 0.4526
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0088 0.0981 0.431
Schistosoma mansoni peptidase Clp (S14 family) 0.0163 0.2079 0.2192
Brugia malayi hypothetical protein 0.0166 0.2117 0.242
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0627 0.5428
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0088 0.0981 0.0892
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0148 0.1856 0.1829
Brugia malayi ecdysone receptor 0.0148 0.1856 0.2122
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0314 0.4293 0.4591
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0148 0.1856 0.1829
Brugia malayi hypothetical protein 0.007 0.0708 0.0809
Echinococcus granulosus thyroid hormone receptor alpha 0.0148 0.1856 0.1829
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0095 0.1071 0.0988
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0314 0.4293 0.4908
Brugia malayi Pre-SET motif family protein 0.0088 0.0981 0.1121
Loa Loa (eye worm) hypothetical protein 0.0097 0.1108 0.0722
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0163 0.2079 1
Loa Loa (eye worm) nuclear hormone receptor 0.0148 0.1856 0.1631
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0314 0.4293 0.4439
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0209 0.2761 0.8677
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0166 0.2117 0.2109
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0088 0.0981 0.1034
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0056 0.0507 0.1857
Loa Loa (eye worm) hypothetical protein 0.0166 0.2117 0.1948
Onchocerca volvulus Protein ultraspiracle homolog 0.0314 0.4293 0.3984
Echinococcus multilocularis nuclear receptor nhr 48 0.0148 0.1856 0.1829
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0023 0.0024 0.0027
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.007 0.0708 0.0599
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0314 0.4293 0.4439
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0314 0.4293 0.4526
Schistosoma mansoni hypothetical protein 0.0057 0.0513 0.0541
Schistosoma mansoni steroid hormone receptor ad4bp 0.0314 0.4293 0.4526
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0057 0.0513 0.0541
Brugia malayi nuclear hormone receptor 0.0148 0.1856 0.2122
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0314 0.4293 0.4439
Trypanosoma cruzi cysteine peptidase, putative 0.0064 0.0627 0.5428
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0163 0.2079 1
Loa Loa (eye worm) hypothetical protein 0.0148 0.1856 0.1631
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0617 0.8747 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0314 0.4293 0.4908
Loa Loa (eye worm) nuclear receptor NHR-67 0.0148 0.1856 0.1631
Loa Loa (eye worm) latrophilin receptor protein 2 0.0095 0.1071 0.0677
Brugia malayi ecdysteroid receptor 0.0314 0.4293 0.4908
Brugia malayi photoreceptor-specific nuclear receptor 0.0314 0.4293 0.4908
Echinococcus multilocularis GPCR, family 2 0.0095 0.1071 0.0988
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0092 0.1031 0.2985
Echinococcus granulosus peptidase Clp S14 family 0.0107 0.1253 0.1183
Echinococcus multilocularis peptidase Clp (S14 family) 0.0107 0.1253 0.1183
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0314 0.4293 0.4591
Loa Loa (eye worm) jmjC domain-containing protein 0.0069 0.0688 0.0213
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0148 0.1856 0.1957
Trypanosoma cruzi cysteine peptidase, putative 0.0064 0.0627 0.5428
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0627 0.5428
Loa Loa (eye worm) DR-78 0.0148 0.1856 0.1631
Schistosoma mansoni transcription factor LCR-F1 0.007 0.0708 0.0746
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0209 0.2761 0.8837
Loa Loa (eye worm) thioredoxin reductase 0.0092 0.1031 0.0629
Echinococcus granulosus FTZ F1 alpha 0.0314 0.4293 0.4439
Loa Loa (eye worm) hypothetical protein 0.0314 0.4293 0.4591
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0095 0.1071 0.1224
Brugia malayi hypothetical protein 0.0166 0.2117 0.242
Echinococcus granulosus histone lysine methyltransferase setb 0.0088 0.0981 0.0892

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -4.767 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.361 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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