Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Bromodomain containing protein | 0.0037 | 0.1803 | 0.2724 |
Loa Loa (eye worm) | hypothetical protein | 0.0095 | 0.6507 | 0.9832 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0096 | 0.6618 | 0.6618 |
Schistosoma mansoni | transient receptor potential channel 4 | 0.0095 | 0.6507 | 0.9654 |
Entamoeba histolytica | Niemann-Pick C1 protein, putative | 0.0096 | 0.6618 | 1 |
Schistosoma mansoni | transient receptor potential channel | 0.0095 | 0.6507 | 0.9654 |
Echinococcus multilocularis | short transient receptor potential channel 6 | 0.0063 | 0.3876 | 0.3876 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0049 | 0.2728 | 0.4122 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0018 | 0.0243 | 0.5 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0025 | 0.0766 | 1 |
Echinococcus multilocularis | transient receptor potential gamma protein | 0.0095 | 0.6507 | 0.6507 |
Brugia malayi | CHE-14 protein | 0.0041 | 0.2119 | 0.3202 |
Echinococcus granulosus | TRP transient receptor potential channel | 0.0035 | 0.1627 | 0.1627 |
Schistosoma mansoni | hypothetical protein | 0.004 | 0.1997 | 0.2963 |
Echinococcus multilocularis | methyl CpG binding domain protein 2 | 0.0017 | 0.0102 | 0.0102 |
Brugia malayi | PHD-finger family protein | 0.0024 | 0.0731 | 0.1105 |
Leishmania major | hypothetical protein, conserved | 0.0025 | 0.0766 | 1 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0018 | 0.0243 | 0.0243 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0017 | 0.0102 | 0.0102 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0022 | 0.0542 | 0.0542 |
Brugia malayi | hypothetical protein | 0.0016 | 0.0047 | 0.0071 |
Schistosoma mansoni | ap endonuclease | 0.0018 | 0.0243 | 0.036 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0058 | 0.3516 | 0.3516 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0018 | 0.0243 | 0.0367 |
Echinococcus multilocularis | protein dispatched 1 | 0.0047 | 0.2597 | 0.2597 |
Echinococcus granulosus | Protein patched homolog 1 | 0.0041 | 0.2119 | 0.2119 |
Schistosoma mansoni | transient receptor potential channel | 0.0063 | 0.3876 | 0.5751 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0049 | 0.2728 | 0.4122 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0025 | 0.0766 | 1 |
Schistosoma mansoni | hypothetical protein | 0.002 | 0.0389 | 0.0577 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.0098 | 0.674 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.0766 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0069 | 0.4398 | 0.6646 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0033 | 0.1465 | 0.2214 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.1465 | 0.2174 |
Schistosoma mansoni | transient receptor potential channel | 0.0063 | 0.3876 | 0.5751 |
Echinococcus granulosus | short transient receptor potential channel 6 | 0.0063 | 0.3876 | 0.3876 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0018 | 0.0243 | 0.5 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0018 | 0.0243 | 0.5 |
Schistosoma mansoni | ap endonuclease | 0.0018 | 0.0243 | 0.036 |
Loa Loa (eye worm) | bromodomain containing protein | 0.0017 | 0.0152 | 0.0229 |
Loa Loa (eye worm) | PHD-finger family protein | 0.002 | 0.0389 | 0.0588 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0102 | 0.0155 |
Echinococcus multilocularis | dnaJ subfamily C 6 | 0.006 | 0.3641 | 0.3641 |
Schistosoma mansoni | bromodomain containing protein | 0.0062 | 0.3803 | 0.5642 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0017 | 0.0102 | 0.0152 |
Brugia malayi | hypothetical protein | 0.0025 | 0.0766 | 0.1158 |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.6618 | 1 |
Echinococcus granulosus | methyl CpG binding domain protein 2 | 0.0017 | 0.0102 | 0.0102 |
Schistosoma mansoni | hypothetical protein | 0.004 | 0.1997 | 0.2963 |
Schistosoma mansoni | methyl-cpg binding protein mbd | 0.0017 | 0.0102 | 0.0152 |
Brugia malayi | Transient-receptor-potential like protein | 0.0035 | 0.1627 | 0.2458 |
Echinococcus multilocularis | protein patched | 0.0041 | 0.2119 | 0.2119 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.2728 | 0.4122 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.1809 | 0.2733 |
Schistosoma mansoni | hypothetical protein | 0.004 | 0.1997 | 0.2963 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0017 | 0.0102 | 0.0152 |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.0041 | 0.2119 | 0.2119 |
Echinococcus multilocularis | zinc finger protein | 0.0019 | 0.0304 | 0.0304 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.1368 | 0.2067 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0096 | 0.6618 | 0.6618 |
Echinococcus granulosus | zinc finger protein | 0.0019 | 0.0304 | 0.0304 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.0041 | 0.2119 | 0.2119 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0035 | 0.1614 | 0.1614 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.2119 | 0.3202 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0058 | 0.3516 | 0.3516 |
Schistosoma mansoni | methyl-cpg binding protein mbd | 0.0017 | 0.0102 | 0.0152 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0017 | 0.0102 | 0.0102 |
Echinococcus granulosus | transient receptor potential gamma protein | 0.0095 | 0.6507 | 0.6507 |
Echinococcus granulosus | dnaJ subfamily C 6 | 0.006 | 0.3641 | 0.3641 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0018 | 0.0243 | 0.0367 |
Brugia malayi | Niemann-Pick C1 protein precursor | 0.0096 | 0.6618 | 1 |
Echinococcus multilocularis | transient receptor potential ion channel A | 0.0092 | 0.6248 | 0.6248 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.0766 | 1 |
Echinococcus granulosus | expressed conserved protein | 0.009 | 0.614 | 0.614 |
Loa Loa (eye worm) | DnaJ domain-containing protein | 0.006 | 0.3641 | 0.5501 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0766 | 0.1158 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0022 | 0.0542 | 0.0804 |
Brugia malayi | Bromodomain containing protein | 0.0073 | 0.4741 | 0.7163 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0018 | 0.0243 | 0.5 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0035 | 0.1614 | 0.1614 |
Trichomonas vaginalis | protein kinase inhibitor, putative | 0.006 | 0.3641 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.2151 | 0.325 |
Echinococcus multilocularis | expressed conserved protein | 0.009 | 0.614 | 0.614 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.1465 | 0.2214 |
Schistosoma mansoni | patched 1 | 0.0041 | 0.2119 | 0.3144 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.0766 | 1 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0018 | 0.0243 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.006 | 0.3641 | 0.5402 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0025 | 0.0766 | 1 |
Schistosoma mansoni | zinc finger protein | 0.0019 | 0.0304 | 0.0452 |
Echinococcus multilocularis | TRP (transient receptor potential) channel | 0.0035 | 0.1627 | 0.1627 |
Brugia malayi | DnaJ domain containing protein | 0.006 | 0.3641 | 0.5501 |
Echinococcus granulosus | short transient receptor potential channel 6 | 0.0063 | 0.3876 | 0.3876 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0022 | 0.0542 | 0.0542 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.1627 | 0.2458 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0049 | 0.2728 | 0.4122 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.1998 | 0.3019 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0041 | 0.2119 | 0.5523 |
Echinococcus multilocularis | short transient receptor potential channel 6 | 0.0063 | 0.3876 | 0.3876 |
Loa Loa (eye worm) | hypothetical protein | 0.0059 | 0.3617 | 0.5466 |
Echinococcus granulosus | transient receptor potential ion channel A | 0.0092 | 0.6248 | 0.6248 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.288 | 0.4352 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.0766 | 1 |
Schistosoma mansoni | hypothetical protein | 0.004 | 0.1997 | 0.2963 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0018 | 0.0243 | 0.0243 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.0041 | 0.2119 | 0.3202 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.