Detailed information for compound 161417

Basic information

Technical information
  • TDR Targets ID: 161417
  • Name: 4-(aminomethyl)-N-[(2S)-1-[[(3S)-1-hydroxy-2- oxo-5-phenylpentan-3-yl]amino]-4-methyl-1-oxo pentan-2-yl]benzamide
  • MW: 439.547 | Formula: C25H33N3O4
  • H donors: 4 H acceptors: 4 LogP: 2.57 Rotable bonds: 14
    Rule of 5 violations (Lipinski): 1
  • SMILES: OCC(=O)[C@@H](NC(=O)[C@@H](NC(=O)c1ccc(cc1)CN)CC(C)C)CCc1ccccc1
  • InChi: 1S/C25H33N3O4/c1-17(2)14-22(28-24(31)20-11-8-19(15-26)9-12-20)25(32)27-21(23(30)16-29)13-10-18-6-4-3-5-7-18/h3-9,11-12,17,21-22,29H,10,13-16,26H2,1-2H3,(H,27,32)(H,28,31)/t21-,22-/m0/s1
  • InChiKey: LLNRGZBDXFVPFY-VXKWHMMOSA-N  


Substructure search Similarity search

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Synonyms

  • 4-(aminomethyl)-N-[(1S)-1-[[(1S)-3-hydroxy-2-oxo-1-phenethyl-propyl]carbamoyl]-3-methyl-butyl]benzamide
  • 4-(aminomethyl)-N-[(1S)-1-[[[(1S)-3-hydroxy-2-oxo-1-phenethylpropyl]amino]-oxomethyl]-3-methylbutyl]benzamide
  • 4-(aminomethyl)-N-[(2S)-1-[[(3S)-1-hydroxy-2-oxo-5-phenyl-pentan-3-yl]amino]-4-methyl-1-oxo-pentan-2-yl]benzamide
  • 4-(aminomethyl)-N-[(1S)-1-[[(1S)-3-hydroxy-2-keto-1-phenethyl-propyl]carbamoyl]-3-methyl-butyl]benzamide
  • 4-(aminomethyl)-N-[(1S)-1-[[(1S)-3-hydroxy-2-oxo-1-(2-phenylethyl)propyl]carbamoyl]-3-methyl-butyl]benzamide
  • 4-(aminomethyl)-N-[(1S)-1-[[[(1S)-3-hydroxy-2-oxo-1-(2-phenylethyl)propyl]amino]-oxomethyl]-3-methylbutyl]benzamide
  • 4-(aminomethyl)-N-[(1S)-1-[[(1S)-3-hydroxy-2-keto-1-(2-phenylethyl)propyl]carbamoyl]-3-methyl-butyl]benzamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens cathepsin L Starlite/ChEMBL References
Homo sapiens cathepsin S Starlite/ChEMBL References
Homo sapiens cathepsin B Starlite/ChEMBL References
Homo sapiens cathepsin K Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Plasmodium falciparum cysteine proteinase falcipain 3 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase C (CPC), putative Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2b Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii cathepsin B Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium berghei berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei gambiense cysteine peptidase C (CPC), putative,CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like, putative Get druggable targets OG5_127800 All targets in OG5_127800
Plasmodium knowlesi knowpain-4 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-3 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Cathepsin B-like protease (Precursor), related Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01363 cathepsin B [EC3.4.22.1], putative Get druggable targets OG5_127800 All targets in OG5_127800
Loa Loa (eye worm) ctsf protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni SmCB2 peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) fibroinase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Giardia lamblia Cathepsin B precursor Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Brugia malayi cathepsin B-like cysteine proteinase Get druggable targets OG5_127800 All targets in OG5_127800
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii cathepsin CPL Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2a Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01373 cathepsin F [EC3.4.22.41], putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Giardia lamblia Cathepsin B precursor Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania mexicana cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin L-like proteinase precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase C (CPC), putative Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin L cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Giardia lamblia Cathepsin B precursor Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Cathepsin L, related Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin F homolog Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania braziliensis cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma cruzi cruzipain precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium parvum cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cathepsin B Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium hominis cryptopain precursor Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum cysteine proteinase falcipain 1 cathepsin S 281 aa 226 aa 34.1 %
Plasmodium falciparum cysteine proteinase falcipain 1 cathepsin L 333 aa 359 aa 30.1 %
Plasmodium falciparum dipeptidyl aminopeptidase 1 cathepsin B 339 aa 368 aa 26.9 %
Plasmodium falciparum cysteine proteinase falcipain 1 cathepsin K 329 aa 349 aa 33.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus potassium voltage gated channel protein 0.0058 0.1198 0.1198
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0086 0.1847 1
Toxoplasma gondii preprocathepsin c precursor, putative 0.002 0.0292 0.0236
Echinococcus multilocularis geminin 0.0344 0.7939 0.7939
Echinococcus granulosus sodium leak channel non selective protein 0.0058 0.1198 0.1198
Brugia malayi TAR-binding protein 0.0067 0.1399 0.3357
Giardia lamblia Hypothetical protein 0.002 0.0292 0.031
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0058 0.1198 0.286
Plasmodium falciparum cysteine proteinase falcipain 3 0.0086 0.1847 1
Schistosoma mansoni voltage-gated potassium channel 0.0058 0.1198 0.1198
Loa Loa (eye worm) hypothetical protein 0.0034 0.0619 0.1424
Giardia lamblia Cathepsin B precursor 0.007 0.1465 1
Giardia lamblia Cysteine protease 0.002 0.0292 0.031
Schistosoma mansoni voltage-gated potassium channel 0.0058 0.1198 0.1198
Echinococcus multilocularis cathepsin b 0.0181 0.4086 0.4086
Entamoeba histolytica cysteine protease, putative 0.0047 0.0922 0.4194
Schistosoma mansoni hypothetical protein 0.0016 0.0191 0.0191
Schistosoma mansoni two-pore calcium channel 0.0058 0.1198 0.1198
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0191 0.0191
Entamoeba histolytica hypothetical protein 0.0038 0.0718 0.2909
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.1847 1
Onchocerca volvulus 0.0086 0.1847 1
Trypanosoma brucei inositol 1,4,5-trisphosphate receptor 0.0058 0.1198 0.5922
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.1847 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.1847 1
Plasmodium vivax vivapain-2 0.0086 0.1847 1
Schistosoma mansoni voltage-gated potassium channel 0.0058 0.1198 0.1198
Brugia malayi Voltage-gated calcium channel, P/Q-type, alpha subunit. C. elegans unc-2 ortholog 0.0058 0.1198 0.286
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0181 0.4086 0.4086
Loa Loa (eye worm) hypothetical protein 0.002 0.0292 0.0614
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.002 0.0292 0.0236
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0058 0.1198 0.1198
Plasmodium vivax vivapain-3 0.0047 0.0922 0.4194
Schistosoma mansoni voltage-gated potassium channel 0.0058 0.1198 0.1198
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0058 0.1198 0.286
Entamoeba histolytica cysteine protease, putative 0.0047 0.0922 0.4194
Leishmania major cathepsin L-like protease 0.0086 0.1847 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0086 0.1847 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0988 0.2341
Toxoplasma gondii cathepsin CPC1 0.002 0.0292 0.0236
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0058 0.1198 0.1198
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0047 0.0922 0.4947
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit. C. elegans exp-2 ortholog 0.0058 0.1198 0.286
Echinococcus granulosus voltage dependent calcium channel 0.0058 0.1198 0.1198
Onchocerca volvulus 0.0086 0.1847 1
Echinococcus multilocularis voltage gated potassium channel 0.0058 0.1198 0.1198
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0086 0.1847 1
Brugia malayi Cathepsin L-like precursor 0.0086 0.1847 0.4466
Loa Loa (eye worm) hypothetical protein 0.0058 0.1198 0.2855
Entamoeba histolytica cysteine protease, putative 0.0047 0.0922 0.4194
Trypanosoma cruzi cysteine proteinase, putative 0.0047 0.0922 0.1744
Giardia lamblia Cathepsin L-like protease 0.002 0.0292 0.031
Loa Loa (eye worm) hypothetical protein 0.002 0.0292 0.0614
Loa Loa (eye worm) hypothetical protein 0.0058 0.1198 0.2855
Trypanosoma cruzi major cysteine proteinase, putative 0.002 0.0292 0.0098
Echinococcus granulosus voltage dependent calcium channel 0.0058 0.1198 0.1198
Echinococcus multilocularis voltage dependent calcium channel 0.0058 0.1198 0.1198
Schistosoma mansoni hypothetical protein 0.0344 0.7939 0.7939
Echinococcus granulosus voltage gated potassium channel 0.0058 0.1198 0.1198
Trypanosoma cruzi cysteine peptidase, putative 0.0086 0.1847 0.4158
Entamoeba histolytica papain family cysteine protease domain containing protein 0.002 0.0292 0.0236
Entamoeba histolytica cysteine protease, putative 0.002 0.0292 0.0236
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.2028 0.2028
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0191 0.0191
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0254 0.0254
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0058 0.1198 0.1198
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0086 0.1847 1
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit 0.0058 0.1198 0.286
Schistosoma mansoni ryanodine receptor related 0.0058 0.1198 0.1198
Toxoplasma gondii cathepsin CPL 0.0086 0.1847 1
Schistosoma mansoni apoferritin-2 0.0008 0.0017 0.0017
Schistosoma mansoni hypothetical protein 0.0058 0.1198 0.1198
Echinococcus granulosus transient receptor potential gamma protein 0.0058 0.1198 0.1198
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0059 0.1217 0.6554
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0058 0.1198 0.1198
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0058 0.1198 0.1198
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0058 0.1198 0.1198
Echinococcus multilocularis potassium voltage gated channel protein 0.0058 0.1198 0.1198
Schistosoma mansoni voltage-gated potassium channel 0.0058 0.1198 0.1198
Plasmodium vivax unspecified product 0.002 0.0292 0.0236
Giardia lamblia Dipeptidyl-peptidase I precursor 0.002 0.0292 0.031
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0058 0.1198 0.1198
Echinococcus multilocularis voltage dependent calcium channel 0.0058 0.1198 0.1198
Brugia malayi Papain family cysteine protease containing protein 0.002 0.0292 0.0621
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0191 0.0365
Echinococcus granulosus potassium large conductance calcium activated 0.0058 0.1198 0.1198
Echinococcus multilocularis tar DNA binding protein 0.0067 0.1399 0.1399
Onchocerca volvulus 0.0059 0.1217 0.5946
Echinococcus multilocularis potassium voltage gated channel protein 0.0058 0.1198 0.1198
Brugia malayi CXXC zinc finger family protein 0.003 0.0537 0.1227
Schistosoma mansoni voltage-dependent calcium channel 0.0058 0.1198 0.1198
Echinococcus granulosus ferritin 0.0008 0.0017 0.0017
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0292 0.1501
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0086 0.1847 1
Loa Loa (eye worm) fibroinase 0.0086 0.1847 0.4462
Giardia lamblia Cathepsin L precursor 0.002 0.0292 0.031
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.002 0.0292 0.0236
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0058 0.1198 0.1198
Loa Loa (eye worm) voltage-gated potassium channel 0.0058 0.1198 0.2855
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0058 0.1198 0.1198
Brugia malayi cation channel family protein 0.0058 0.1198 0.286
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0058 0.1198 0.1198
Brugia malayi voltage-dependent calcium channel 0.0058 0.1198 0.286
Echinococcus granulosus potassium voltage gated channel protein 0.0058 0.1198 0.1198
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.002 0.0292 0.0236
Brugia malayi olfactory channel protein osm-9 0.0058 0.1198 0.286
Echinococcus granulosus sodium channel protein 0.0058 0.1198 0.1198
Entamoeba histolytica cysteine proteinase, putative 0.0086 0.1847 1
Loa Loa (eye worm) hypothetical protein 0.0058 0.1198 0.2855
Brugia malayi cathepsin L-like cysteine proteinase 0.002 0.0292 0.0621
Brugia malayi Papain family cysteine protease containing protein 0.0047 0.0922 0.218
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0292 0.1501
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0047 0.0922 0.4947
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0988 0.2341
Brugia malayi Cyclic-nucleotide gated cation channel 0.0058 0.1198 0.286
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.002 0.0292 0.0236
Echinococcus granulosus cysteine protease 0.0047 0.0922 0.0922
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0058 0.1198 0.1198
Echinococcus multilocularis potassium large conductance calcium activated 0.0058 0.1198 0.1198
Toxoplasma gondii transporter, cation channel family protein 0.0058 0.1198 0.5922
Loa Loa (eye worm) hypothetical protein 0.0058 0.1198 0.2855
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0058 0.1198 0.1198
Echinococcus multilocularis potassium voltage gated channel subfamily C 0.0058 0.1198 0.1198
Brugia malayi cathepsin B-like cysteine proteinase 0.0181 0.4086 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0086 0.1847 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.007 0.1465 0.1465
Entamoeba histolytica cysteine protease, putative 0.002 0.0292 0.0236
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0086 0.1847 1
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0058 0.1198 0.1198
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.002 0.0292 0.1501
Entamoeba histolytica hypothetical protein 0.0038 0.0718 0.2909
Schistosoma mansoni voltage-gated potassium channel 0.0058 0.1198 0.1198
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0058 0.1198 0.5922
Giardia lamblia Dipeptidyl-peptidase I precursor 0.002 0.0292 0.031
Toxoplasma gondii cathepsin B 0.007 0.1465 0.7601
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0191 0.0191
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0619 0.143
Plasmodium falciparum serine repeat antigen 5 0.002 0.0292 0.0236
Giardia lamblia Cathepsin B precursor 0.002 0.0292 0.031
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0058 0.1198 0.1198
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.002 0.0292 0.0236
Brugia malayi Cathepsin L-like precursor 0.0059 0.1217 0.2907
Leishmania major cathepsin L-like protease 0.0086 0.1847 1
Entamoeba histolytica cysteine protease, putative 0.0047 0.0922 0.4194
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0086 0.1847 1
Echinococcus multilocularis cpg binding protein 0.0032 0.0578 0.0578
Echinococcus granulosus two pore calcium channel protein 1 0.0058 0.1198 0.1198
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.007 0.1465 0.7912
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0027 0.0453 0.1019
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.1847 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0067 0.1399 0.3353
Brugia malayi RNA binding protein 0.0067 0.1399 0.3357
Giardia lamblia Cysteine protease 0.002 0.0292 0.031
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.002 0.0292 0.0292
Entamoeba histolytica cysteine proteinase, putative 0.0059 0.1217 0.6042
Brugia malayi Papain family cysteine protease containing protein 0.0086 0.1847 0.4466
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0292 0.1501
Schistosoma mansoni voltage-gated potassium channel 0.0058 0.1198 0.1198
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0058 0.1198 0.1198
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0086 0.1847 0.1847
Echinococcus granulosus cathepsin b 0.0181 0.4086 0.4086
Loa Loa (eye worm) hypothetical protein 0.0058 0.1198 0.2855
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.0254 1
Echinococcus multilocularis voltage gated hydrogen channel 1 0.0058 0.1198 0.1198
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.0254 1
Plasmodium falciparum serine repeat antigen 8 0.002 0.0292 0.0236
Schistosoma mansoni ferritin 0.0008 0.0017 0.0017
Plasmodium vivax serine-repeat antigen (SERA), putative 0.002 0.0292 0.0236
Schistosoma mansoni tar DNA-binding protein 0.0067 0.1399 0.1399
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0191 0.0191
Schistosoma mansoni cathepsin F (C01 family) 0.0086 0.1847 0.1847
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.002 0.0292 0.0292
Loa Loa (eye worm) hypothetical protein 0.0059 0.1217 0.2902
Schistosoma mansoni cpg binding protein 0.0032 0.0578 0.0578
Trypanosoma cruzi cruzipain precursor, putative 0.0027 0.0453 0.0519
Entamoeba histolytica cysteine protease, putative 0.0047 0.0922 0.4194
Echinococcus multilocularis potassium voltage gated channel protein 0.0058 0.1198 0.1198
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0086 0.1847 1
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.002 0.0292 0.1501
Brugia malayi Cathepsin L-like precursor 0.0086 0.1847 0.4466
Loa Loa (eye worm) hypothetical protein 0.0058 0.1198 0.2855
Entamoeba histolytica cysteine protease, putative 0.0047 0.0922 0.4194
Entamoeba histolytica cysteine protease, putative 0.002 0.0292 0.0236
Schistosoma mansoni hypothetical protein 0.0016 0.0191 0.0191
Entamoeba histolytica cysteine protease, putative 0.0047 0.0922 0.4194
Schistosoma mansoni voltage-gated potassium channel 0.0058 0.1198 0.1198
Echinococcus multilocularis short transient receptor potential channel 6 0.0058 0.1198 0.1198
Plasmodium falciparum serine repeat antigen 3 0.002 0.0292 0.0236
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0058 0.1198 0.1198
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0058 0.1198 0.6451
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.002 0.0292 0.0292
Schistosoma mansoni voltage-gated potassium channel 0.0058 0.1198 0.1198
Loa Loa (eye worm) hypothetical protein 0.0027 0.0453 0.1013
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0058 0.1198 0.6451
Schistosoma mansoni voltage-gated potassium channel 0.0058 0.1198 0.1198
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.002 0.0292 0.0236
Echinococcus granulosus potassium voltage gated channel subfamily C 0.0058 0.1198 0.1198
Echinococcus granulosus voltage gated hydrogen channel 1 0.0058 0.1198 0.1198
Brugia malayi Cathepsin L-like precursor 0.0086 0.1847 0.4466
Loa Loa (eye worm) RNA binding protein 0.0067 0.1399 0.3353
Plasmodium vivax unspecified product 0.0047 0.0922 0.4194
Echinococcus multilocularis cysteine protease 0.0086 0.1847 0.1847
Loa Loa (eye worm) hypothetical protein 0.0058 0.1198 0.2855
Loa Loa (eye worm) hypothetical protein 0.0058 0.1198 0.2855
Loa Loa (eye worm) TAR-binding protein 0.0067 0.1399 0.3353
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0058 0.1198 0.1198
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.007 0.1465 0.3161
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0047 0.0922 0.0922
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0254 0.1296
Loa Loa (eye worm) hypothetical protein 0.0058 0.1198 0.2855
Echinococcus granulosus transient receptor potential cation channel 0.0058 0.1198 0.1198
Brugia malayi cation channel family protein 0.0058 0.1198 0.286
Loa Loa (eye worm) hypothetical protein 0.0058 0.1198 0.2855
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0537 0.1221
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit. C. elegans egl-36 ortholog 0.0058 0.1198 0.286
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0292 0.1501
Loa Loa (eye worm) papain family cysteine protease containing protein 0.002 0.0292 0.0614
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0058 0.1198 0.1198
Plasmodium falciparum serine repeat antigen 1 0.002 0.0292 0.0236
Brugia malayi Large-conductance calcium-activated potassium channel Slo-1 (KCNMA) alpha subunit. C. elegans slo-1 ortholog 0.0058 0.1198 0.286
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0058 0.1198 0.2855
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.2028 0.2028
Brugia malayi cathepsin L precursor 0.002 0.0292 0.0621
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0058 0.1198 0.1198
Loa Loa (eye worm) hypothetical protein 0.0058 0.1198 0.2855
Plasmodium vivax unspecified product 0.0027 0.0453 0.1248
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0094 0.2028 0.2028
Onchocerca volvulus 0.0086 0.1847 1
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0058 0.1198 0.1198
Schistosoma mansoni transient receptor potential channel 4 0.0058 0.1198 0.1198
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0086 0.1847 1
Schistosoma mansoni voltage-gated cation channel 0.0058 0.1198 0.1198
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0047 0.0922 0.0922
Schistosoma mansoni calcium channel voltage-dependent p/q type alpha 1a-related 0.0058 0.1198 0.1198
Toxoplasma gondii transporter, cation channel family protein 0.0058 0.1198 0.5922
Loa Loa (eye worm) hypothetical protein 0.0059 0.1217 0.2902
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.007 0.1465 0.7601
Echinococcus multilocularis short transient receptor potential channel 6 0.0058 0.1198 0.1198
Brugia malayi cathepsin Z-like cysteine proteinase 0.002 0.0292 0.0621
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.1847 1
Giardia lamblia Cathepsin B precursor 0.002 0.0292 0.031
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0086 0.1847 1
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0086 0.1847 1
Onchocerca volvulus Transient receptor potential cation channel trpm homolog 0.0058 0.1198 0.5824
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0058 0.1198 0.1198
Echinococcus multilocularis potassium voltage gated channel subfamily A 0.0058 0.1198 0.1198
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0086 0.1847 0.1847
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.002 0.0292 0.1501
Onchocerca volvulus Transient receptor potential cation channel trpm homolog 0.0058 0.1198 0.5824
Onchocerca volvulus 0.0086 0.1847 1
Echinococcus granulosus calcium activated potassium channel 0.0058 0.1198 0.1198
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0181 0.4086 0.4086
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0094 0.2028 0.4909
Trypanosoma cruzi cruzipain precursor, putative 0.0086 0.1847 0.4158
Echinococcus granulosus transient receptor potential cation channel 0.0058 0.1198 0.1198
Schistosoma mansoni tar DNA-binding protein 0.0067 0.1399 0.1399
Onchocerca volvulus 0.0086 0.1847 1
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0047 0.0922 0.1744
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.1847 1
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.002 0.0292 0.1501
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.002 0.0292 0.0236
Echinococcus multilocularis potassium voltage gated channel protein 0.0058 0.1198 0.1198
Loa Loa (eye worm) hypothetical protein 0.0049 0.0988 0.2336
Schistosoma mansoni ap endonuclease 0.0018 0.0254 0.0254
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0058 0.1198 0.286
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0254 0.0521
Schistosoma mansoni calcium-activated potassium channel 0.0058 0.1198 0.1198
Loa Loa (eye worm) ion channel NompC 0.0058 0.1198 0.2855
Echinococcus granulosus hypothetical protein 0.0058 0.1198 0.1198
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0086 0.1847 1
Leishmania major cathepsin L-like protease 0.0086 0.1847 1
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0086 0.1847 0.4462
Brugia malayi Ryanodine Receptor TM 4-6 family protein 0.0058 0.1198 0.286
Trypanosoma cruzi cysteine proteinase, putative 0.0047 0.0922 0.1744
Echinococcus granulosus potassium voltage gated channel protein 0.0058 0.1198 0.1198
Brugia malayi Cathepsin L-like precursor 0.0086 0.1847 0.4466
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0086 0.1847 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0292 0.1501
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0292 0.1501
Trypanosoma cruzi cysteine peptidase, putative 0.0086 0.1847 0.4158
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.002 0.0292 0.0292
Schistosoma mansoni voltage-gated potassium channel 0.0058 0.1198 0.1198
Brugia malayi hypothetical protein 0.0038 0.0718 0.1674
Echinococcus multilocularis cysteine protease 0.0086 0.1847 0.1847
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.1847 1
Echinococcus granulosus cathepsin l1 0.0059 0.1217 0.1217
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0086 0.1847 1
Giardia lamblia Dipeptidyl-peptidase I precursor 0.002 0.0292 0.031
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.002 0.0292 0.0292
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0058 0.1198 0.1198
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0292 0.1501
Echinococcus multilocularis expressed protein 0.0008 0.0017 0.0017
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0044 0.0044
Schistosoma mansoni tar DNA-binding protein 0.0067 0.1399 0.1399
Brugia malayi cathepsin L-like precursor 0.0059 0.1217 0.2907
Schistosoma mansoni ferritin light chain 0.0008 0.0017 0.0017
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0058 0.1198 0.1198
Echinococcus granulosus cathepsin l cysteine peptidase 0.0086 0.1847 0.1847
Echinococcus multilocularis transient receptor potential gamma protein 0.0058 0.1198 0.1198
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0058 0.1198 0.1198
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0094 0.2028 0.2028
Loa Loa (eye worm) hypothetical protein 0.0058 0.1198 0.2855
Echinococcus multilocularis sodium leak channel non selective protein 0.0058 0.1198 0.1198
Giardia lamblia Cathepsin L precursor 0.002 0.0292 0.031
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0058 0.1198 0.1198
Plasmodium falciparum cysteine proteinase falcipain 1 0.0047 0.0922 0.4194
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.1847 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0086 0.1847 0.4462
Brugia malayi Cathepsin L-like precursor 0.0059 0.1217 0.2907
Schistosoma mansoni voltage-gated potassium channel 0.0058 0.1198 0.1198
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0058 0.1198 0.1198
Echinococcus granulosus cathepsin L cysteine proteinase 0.0086 0.1847 0.1847
Loa Loa (eye worm) hypothetical protein 0.0181 0.4086 1
Brugia malayi Cathepsin L-like precursor 0.0027 0.0453 0.1019
Trypanosoma cruzi inositol 1,4,5-trisphosphate receptor, putative 0.0058 0.1198 0.2462
Onchocerca volvulus 0.0086 0.1847 1
Trypanosoma cruzi cysteine peptidase, putative 0.0086 0.1847 0.4158
Echinococcus multilocularis cathepsin L cysteine protease 0.0086 0.1847 0.1847
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0058 0.1198 0.1198
Echinococcus multilocularis transient receptor potential cation channel 0.0058 0.1198 0.1198
Echinococcus granulosus cpg binding protein 0.0032 0.0578 0.0578
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.1847 1
Schistosoma mansoni apoferritin-2 0.0008 0.0017 0.0017
Schistosoma mansoni voltage-gated potassium channel KCNQ 0.0058 0.1198 0.1198
Loa Loa (eye worm) hypothetical protein 0.0058 0.1198 0.2855
Loa Loa (eye worm) voltage-gated calcium channel 0.0058 0.1198 0.2855
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0058 0.1198 0.1198
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0059 0.1217 0.2512
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.002 0.0292 0.1501
Brugia malayi cahepsin L-like non-peptiedase homolog 0.002 0.0292 0.0621
Entamoeba histolytica cysteine proteinase 1, putative 0.0047 0.0922 0.4194
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0181 0.4086 1
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.002 0.0292 0.1501
Schistosoma mansoni voltage-gated potassium channel 0.0058 0.1198 0.1198
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0058 0.1198 0.1198
Leishmania major cysteine peptidase A (CPA) 0.0086 0.1847 1
Entamoeba histolytica cysteine proteinase 2 0.0047 0.0922 0.4194
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.002 0.0292 0.0292
Echinococcus multilocularis shaker cognate 0.0058 0.1198 0.1198
Echinococcus multilocularis transient receptor potential cation channel 0.0058 0.1198 0.1198
Entamoeba histolytica cysteine proteinase, putative 0.0047 0.0922 0.4194
Echinococcus granulosus potassium voltage gated channel subfamily A 0.0058 0.1198 0.1198
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0047 0.0922 0.4194
Giardia lamblia Encystation-specific protease 0.002 0.0292 0.031
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0058 0.1198 0.1198
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0292 0.1501
Entamoeba histolytica cysteine protease, putative 0.0047 0.0922 0.4194
Echinococcus granulosus transient receptor potential cation channel 0.0058 0.1198 0.1198
Leishmania major cathepsin L-like protease 0.0086 0.1847 1
Schistosoma mansoni voltage-gated potassium channel 0.0058 0.1198 0.1198
Schistosoma mansoni cpg binding protein 0.003 0.0537 0.0537
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0086 0.1847 1
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0058 0.1198 0.1198
Giardia lamblia Cathepsin B precursor 0.002 0.0292 0.031
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.002 0.0292 0.0292
Echinococcus multilocularis transient receptor potential cation channel 0.0058 0.1198 0.1198
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.0008 0.0017 0.5
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0086 0.1847 1
Brugia malayi Cathepsin L-like precursor 0.0086 0.1847 0.4466
Plasmodium vivax vivapain-1 0.0047 0.0922 0.4194
Loa Loa (eye worm) voltage-dependent calcium channel 0.0058 0.1198 0.2855
Schistosoma mansoni transient receptor potential channel 0.0058 0.1198 0.1198
Leishmania major cathepsin L-like protease 0.0086 0.1847 1
Brugia malayi Voltage-gated calcium channel, alpha subunit 0.0058 0.1198 0.286
Echinococcus multilocularis conserved hypothetical protein 0.0058 0.1198 0.1198
Echinococcus granulosus hyperpolarization activated cyclic 0.0058 0.1198 0.1198
Leishmania major cathepsin L-like protease 0.0086 0.1847 1
Loa Loa (eye worm) hypothetical protein 0.0058 0.1198 0.2855
Toxoplasma gondii transporter, cation channel family protein 0.0058 0.1198 0.5922
Entamoeba histolytica cysteine proteinase, putative 0.0047 0.0922 0.4194
Loa Loa (eye worm) hypothetical protein 0.0016 0.0191 0.0365
Entamoeba histolytica cysteine protease, putative 0.0086 0.1847 1
Schistosoma mansoni cathepsin F (C01 family) 0.0059 0.1217 0.1217
Echinococcus granulosus short transient receptor potential channel 6 0.0058 0.1198 0.1198
Echinococcus multilocularis cathepsin L 0.0047 0.0922 0.0922
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0044 0.0044
Trypanosoma cruzi cysteine peptidase, putative 0.0027 0.0453 0.0519
Schistosoma mansoni hypothetical protein 0.0016 0.0191 0.0191
Loa Loa (eye worm) ctsf protein 0.0086 0.1847 0.4462
Echinococcus granulosus cathepsin L cysteine protease 0.0047 0.0922 0.0922
Entamoeba histolytica cysteine protease, putative 0.0047 0.0922 0.4194
Entamoeba histolytica cysteine proteinase, putative 0.0047 0.0922 0.4194
Onchocerca volvulus Cathepsin L homolog 0.0086 0.1847 1
Echinococcus granulosus two pore calcium channel protein 2 0.0058 0.1198 0.1198
Schistosoma mansoni cathepsin F (C01 family) 0.0086 0.1847 0.1847
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0058 0.1198 0.2855
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.002 0.0292 0.031
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0058 0.1198 0.1198
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0094 0.2028 0.4912
Trypanosoma cruzi major cysteine proteinase, putative 0.002 0.0292 0.0098
Loa Loa (eye worm) hypothetical protein 0.0058 0.1198 0.2855
Entamoeba histolytica hypothetical protein 0.0038 0.0718 0.2909
Schistosoma mansoni tar DNA-binding protein 0.0067 0.1399 0.1399
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0181 0.4086 0.4086
Loa Loa (eye worm) hypothetical protein 0.0058 0.1198 0.2855
Schistosoma mansoni hypothetical protein 0.0038 0.0718 0.0718
Entamoeba histolytica cysteine protease, putative 0.0047 0.0922 0.4194
Loa Loa (eye worm) hypothetical protein 0.0058 0.1198 0.2855
Plasmodium falciparum serine repeat antigen 6 0.002 0.0292 0.0236
Giardia lamblia Cathepsin L precursor 0.002 0.0292 0.031
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.1847 1
Onchocerca volvulus Cathepsin L homolog 0.0086 0.1847 1
Leishmania major cathepsin L-like protease 0.0086 0.1847 1
Echinococcus granulosus transient receptor potential cation channel 0.0058 0.1198 0.1198
Echinococcus granulosus potassium voltage gated channel protein 0.0058 0.1198 0.1198
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0058 0.1198 0.1198
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0027 0.0453 0.1013
Plasmodium falciparum serine repeat antigen 4 0.002 0.0292 0.0236
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.1847 1
Loa Loa (eye worm) hypothetical protein 0.0058 0.1198 0.2855
Leishmania major hypothetical protein, conserved 0.0058 0.1198 0.5922
Echinococcus granulosus GPCR family 2 0.0016 0.0191 0.0191
Echinococcus multilocularis dnaJ subfamily B 0.0432 1 1
Entamoeba histolytica cysteine protease, putative 0.002 0.0292 0.0236
Onchocerca volvulus 0.0086 0.1847 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.1847 1
Brugia malayi cathepsin Z-like cysteine proteinase 0.002 0.0292 0.0621
Schistosoma mansoni tar DNA-binding protein 0.0067 0.1399 0.1399
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.002 0.0292 0.0236
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0058 0.1198 0.2855
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0058 0.1198 0.1198
Loa Loa (eye worm) hypothetical protein 0.0027 0.0453 0.1013
Schistosoma mansoni hypothetical protein 0.0016 0.0191 0.0191
Schistosoma mansoni cathepsin s 0.0027 0.0453 0.0453
Schistosoma mansoni cathepsin S (C01 family) 0.002 0.0292 0.0292
Brugia malayi Cathepsin L-like precursor 0.0086 0.1847 0.4466
Giardia lamblia Hypothetical protein 0.002 0.0292 0.031
Echinococcus granulosus transient receptor potential cation channel 0.0058 0.1198 0.1198
Brugia malayi RNA recognition motif domain containing protein 0.0067 0.1399 0.3357
Echinococcus multilocularis hyperpolarization activated cyclic 0.0058 0.1198 0.1198
Entamoeba histolytica hypothetical protein 0.002 0.0292 0.0236
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.0058 0.1198 0.5922
Loa Loa (eye worm) hypothetical protein 0.0027 0.0453 0.1013
Brugia malayi cathepsin F-like cysteine proteinase 0.0027 0.0453 0.1019
Echinococcus multilocularis transient receptor potential cation channel 0.0058 0.1198 0.1198
Schistosoma mansoni cathepsin B (C01 family) 0.002 0.0292 0.0292
Schistosoma mansoni ap endonuclease 0.0018 0.0254 0.0254
Loa Loa (eye worm) voltage-gated potassium channel 0.0058 0.1198 0.2855
Echinococcus granulosus potassium voltage gated channel protein 0.0058 0.1198 0.1198
Echinococcus granulosus TRP transient receptor potential channel 0.0058 0.1198 0.1198
Echinococcus multilocularis potassium voltage gated channel subfamily KQT 0.0058 0.1198 0.1198
Schistosoma mansoni 60S ribosomal protein L21 0.0058 0.1198 0.1198
Brugia malayi Voltage-gated potassium channel, KCNQ (Kv7-like) alpha-subunit. C. elegans kqt-1 ortholog 0.0058 0.1198 0.286
Toxoplasma gondii hypothetical protein 0.0058 0.1198 0.5922
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0094 0.2028 0.2028
Onchocerca volvulus Cathepsin F homolog 0.0086 0.1847 1
Echinococcus granulosus short transient receptor potential channel 6 0.0058 0.1198 0.1198
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0292 0.1501
Schistosoma mansoni voltage-gated potassium channel 0.0058 0.1198 0.1198
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0058 0.1198 0.286
Loa Loa (eye worm) cysteine protease 0.0086 0.1847 0.4462
Schistosoma mansoni voltage-gated potassium channel 0.0058 0.1198 0.1198
Echinococcus multilocularis GPCR, family 2 0.0016 0.0191 0.0191
Echinococcus granulosus shaker cognate 0.0058 0.1198 0.1198
Entamoeba histolytica cysteine protease, putative 0.002 0.0292 0.0236
Entamoeba histolytica papain family cysteine protease domain containing protein 0.002 0.0292 0.0236
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0064 0.1338 0.1338
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0988 0.2336
Onchocerca volvulus 0.0058 0.1198 0.5824
Schistosoma mansoni hypothetical protein 0.0432 1 1
Brugia malayi Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit 0.0058 0.1198 0.286
Echinococcus multilocularis transfer RNA-Gly 0.0058 0.1198 0.1198
Loa Loa (eye worm) hypothetical protein 0.002 0.0292 0.0614
Brugia malayi Papain family cysteine protease containing protein 0.0047 0.0922 0.218
Trypanosoma brucei cysteine peptidase C (CPC) 0.007 0.1465 0.7601
Loa Loa (eye worm) hypothetical protein 0.0058 0.1198 0.2855
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.002 0.0292 0.0292
Trypanosoma cruzi cysteine protease, putative 0.0047 0.0922 0.1744
Echinococcus multilocularis two pore calcium channel protein 2 0.0058 0.1198 0.1198
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0058 0.1198 0.286
Echinococcus granulosus cathepsin b 0.0181 0.4086 0.4086
Onchocerca volvulus 0.003 0.0537 0.1577
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0058 0.1198 0.1198
Schistosoma mansoni ferritin 0.0008 0.0017 0.0017
Plasmodium vivax vivapain-2 0.0086 0.1847 1
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0058 0.1198 0.1198
Echinococcus multilocularis hyperpolarization activated cyclic 0.0058 0.1198 0.1198
Brugia malayi hypothetical protein 0.0058 0.1198 0.286
Entamoeba histolytica cysteine protease, putative 0.0047 0.0922 0.4194
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.002 0.0292 0.1501
Giardia lamblia Cysteine protease 0.002 0.0292 0.031
Loa Loa (eye worm) hypothetical protein 0.002 0.0292 0.0614
Loa Loa (eye worm) hypothetical protein 0.0086 0.1847 0.4462
Loa Loa (eye worm) calcium channel 0.0058 0.1198 0.2855
Echinococcus multilocularis transient receptor potential cation channel 0.0058 0.1198 0.1198
Schistosoma mansoni ferritin light chain 0.0008 0.0017 0.0017
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.002 0.0292 0.0614
Loa Loa (eye worm) hypothetical protein 0.0058 0.1198 0.2855
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0058 0.1198 0.1198
Echinococcus granulosus Potassium voltage gated channel protein Shaw 0.0058 0.1198 0.1198
Loa Loa (eye worm) cathepsin B 0.007 0.1465 0.3517
Brugia malayi cathepsin F-like cysteine proteinase 0.002 0.0292 0.0621
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0038 0.0718 0.0718
Trypanosoma cruzi cysteine peptidase, putative 0.0086 0.1847 0.4158
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0094 0.2028 0.2028
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0086 0.1847 1
Plasmodium falciparum serine repeat antigen 2 0.002 0.0292 0.0236
Entamoeba histolytica cysteine proteinase, putative 0.0047 0.0922 0.4194
Entamoeba histolytica cysteine protease, putative 0.0047 0.0922 0.4194
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0181 0.4086 0.4086
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0059 0.1217 0.6554
Echinococcus multilocularis transient receptor potential cation channel 0.0058 0.1198 0.1198
Plasmodium vivax serine-repeat antigen (SERA), putative 0.002 0.0292 0.0236
Giardia lamblia Cathepsin L precursor 0.002 0.0292 0.031
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0058 0.1198 0.286
Schistosoma mansoni ferritin 0.0008 0.0017 0.0017
Loa Loa (eye worm) papain family cysteine protease containing protein 0.002 0.0292 0.0614
Loa Loa (eye worm) hypothetical protein 0.0058 0.1198 0.2855
Toxoplasma gondii cathepsin CPC2 0.002 0.0292 0.0236
Echinococcus granulosus hyperpolarization activated cyclic 0.0058 0.1198 0.1198
Toxoplasma gondii histone lysine methyltransferase SET1 0.0057 0.1176 0.5788
Echinococcus multilocularis ryanodine receptor 44f 0.0058 0.1198 0.1198
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.002 0.0292 0.0236
Leishmania major hypothetical protein, unknown function 0.0058 0.1198 0.5922
Giardia lamblia Cathepsin B precursor 0.002 0.0292 0.031
Schistosoma mansoni hypothetical protein 0.0034 0.0619 0.0619
Brugia malayi ion channel NompC 0.0058 0.1198 0.286
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.002 0.0292 0.0236
Echinococcus multilocularis ferritin 0.0008 0.0017 0.0017
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0086 0.1847 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0047 0.0922 0.4194
Schistosoma mansoni voltage-gated ion channel 0.0058 0.1198 0.1198
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.002 0.0292 0.0236
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0292 0.1501
Brugia malayi Papain family cysteine protease containing protein 0.002 0.0292 0.0621
Giardia lamblia Cathepsin L precursor 0.002 0.0292 0.031
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0038 0.0718 0.0718
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0086 0.1847 1
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0254 0.0528
Echinococcus multilocularis sodium channel protein 0.0058 0.1198 0.1198
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.002 0.0292 0.0292
Giardia lamblia Cathepsin L precursor 0.002 0.0292 0.031
Schistosoma mansoni cathepsin C 0.002 0.0292 0.0292
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0018 0.0254 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.1847 1
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0254 0.1296
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0058 0.1198 0.1198
Echinococcus multilocularis calcium activated potassium channel 0.0058 0.1198 0.1198
Loa Loa (eye worm) hypothetical protein 0.0058 0.1198 0.2855
Entamoeba histolytica cysteine protease, putative 0.0047 0.0922 0.4194
Echinococcus multilocularis voltage gated potassium channel 0.0058 0.1198 0.1198
Echinococcus granulosus cathepsin L 0.002 0.0292 0.0292
Plasmodium vivax serine-repeat antigen (SERA) 0.002 0.0292 0.0236
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0292 0.1501
Schistosoma mansoni vesicular amine transporter 0.0058 0.1198 0.1198
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.1847 1
Echinococcus granulosus ryanodine receptor 44f 0.0058 0.1198 0.1198
Schistosoma mansoni transient receptor potential channel 0.0058 0.1198 0.1198
Brugia malayi Transient-receptor-potential like protein 0.0058 0.1198 0.286
Schistosoma mansoni voltage-gated potassium channel 0.0058 0.1198 0.1198
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0254 0.0254
Loa Loa (eye worm) hypothetical protein 0.002 0.0292 0.0614
Schistosoma mansoni inositol 145-trisphosphate receptor 0.0058 0.1198 0.1198
Echinococcus multilocularis two pore calcium channel protein 1 0.0058 0.1198 0.1198
Leishmania major cathepsin L-like protease 0.0086 0.1847 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0086 0.1847 1
Trypanosoma cruzi cysteine peptidase, putative 0.0047 0.0922 0.1744
Echinococcus granulosus expressed protein 0.0008 0.0017 0.0017
Echinococcus multilocularis cathepsin L cysteine protease 0.0086 0.1847 0.1847
Giardia lamblia Cathepsin B precursor 0.002 0.0292 0.031
Echinococcus multilocularis cathepsin b 0.0181 0.4086 0.4086
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0047 0.0922 0.0922
Brugia malayi Papain family cysteine protease containing protein 0.002 0.0292 0.0621
Loa Loa (eye worm) ryanodine receptor 0.0058 0.1198 0.2855
Brugia malayi Cathepsin L-like cysteine proteinase 0.0059 0.1217 0.2907
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0058 0.1198 0.1198
Giardia lamblia Cysteine protease 0.002 0.0292 0.031
Plasmodium falciparum serine repeat antigen 9 0.002 0.0292 0.0236
Loa Loa (eye worm) hypothetical protein 0.002 0.0292 0.0614
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0058 0.1198 0.1198
Echinococcus multilocularis cathepsin L 0.002 0.0292 0.0292
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.2028 0.2028
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.0254 1
Loa Loa (eye worm) hypothetical protein 0.0059 0.1217 0.2902
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.0058 0.1198 0.2462
Schistosoma mansoni transcription factor LCR-F1 0.0038 0.0718 0.0718
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0086 0.1847 1
Entamoeba histolytica cysteine proteinase, putative 0.0086 0.1847 1
Giardia lamblia Cathepsin L-like protease 0.002 0.0292 0.031
Schistosoma mansoni hypothetical protein 0.0344 0.7939 0.7939
Toxoplasma gondii hypothetical protein 0.0058 0.1198 0.5922
Entamoeba histolytica hypothetical protein 0.0038 0.0718 0.2909
Schistosoma mansoni cpg binding protein 0.0032 0.0578 0.0578
Giardia lamblia Cathepsin B precursor 0.007 0.1465 1
Giardia lamblia Cathepsin B precursor 0.007 0.1465 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.002 0.0292 0.1501
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0058 0.1198 0.5922
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0191 0.0372
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0086 0.1847 1
Echinococcus granulosus geminin 0.0344 0.7939 0.7939
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0086 0.1847 1
Schistosoma mansoni voltage-gated potassium channel 0.0058 0.1198 0.1198
Entamoeba histolytica cysteine protease, putative 0.002 0.0292 0.0236
Schistosoma mansoni transient receptor potential channel 0.0058 0.1198 0.1198
Leishmania major calcium channel protein, putative,ion transporter, putative 0.0058 0.1198 0.5922
Brugia malayi fibroinase precursor 0.002 0.0292 0.0621
Echinococcus granulosus cathepsin L 0.0047 0.0922 0.0922
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0191 0.0372
Echinococcus granulosus transient receptor potential cation channel 0.0058 0.1198 0.1198
Echinococcus granulosus cathepsin l1 0.0086 0.1847 0.1847
Echinococcus granulosus potassium channel KvQLT family member kqt 1 0.0058 0.1198 0.1198
Plasmodium vivax serine-repeat antigen (SERA) 0.002 0.0292 0.0236
Schistosoma mansoni ferritin 0.0008 0.0017 0.0017
Echinococcus granulosus voltage gated potassium channel 0.0058 0.1198 0.1198
Echinococcus granulosus tar DNA binding protein 0.0067 0.1399 0.1399
Plasmodium falciparum serine repeat antigen 7 0.002 0.0292 0.0236

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 0.017 uM Binding affinity of compound was evaluated against cathepsin L. ChEMBL. 12270170
Ki (binding) = 0.017 uM Binding affinity of compound was evaluated against cathepsin L. ChEMBL. 12270170
Ki (binding) = 0.03 uM Binding affinity against cathepsin K ChEMBL. 12270170
Ki (binding) = 0.03 uM Binding affinity against cathepsin K ChEMBL. 12270170
Ki (binding) = 0.046 uM Binding affinity of compound was evaluated against cathepsin S. ChEMBL. 12270170
Ki (binding) = 0.046 uM Binding affinity of compound was evaluated against cathepsin S. ChEMBL. 12270170
Ki (binding) = 1.95 uM Binding affinity against cathepsin B ChEMBL. 12270170
Ki (binding) = 1.95 uM Binding affinity against cathepsin B ChEMBL. 12270170

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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