Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Nuclear receptor subfamily 6 group A member 1 homolog | 0.0269 | 0.1782 | 0.4331 |
Loa Loa (eye worm) | hypothetical protein | 0.0571 | 0.4115 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0269 | 0.1782 | 0.4331 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0571 | 0.4115 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0571 | 0.4115 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0571 | 0.4115 | 1 |
Brugia malayi | nuclear receptor RXR | 0.0302 | 0.2032 | 0.4938 |
Schistosoma mansoni | nuclear receptor | 0.0269 | 0.1782 | 0.1782 |
Loa Loa (eye worm) | hypothetical protein | 0.0571 | 0.4115 | 1 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.0269 | 0.1782 | 0.4254 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.0269 | 0.1782 | 0.4254 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0302 | 0.2032 | 0.2032 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0571 | 0.4115 | 1 |
Schistosoma mansoni | hepatocyte nuclear factor 4-alpha (hnf-4-alpha) | 0.0269 | 0.1782 | 0.1782 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0571 | 0.4115 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0269 | 0.1782 | 0.4331 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0571 | 0.4115 | 0.4115 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0571 | 0.4115 | 1 |
Brugia malayi | orphan nuclear receptor NR2E1 | 0.0269 | 0.1782 | 0.4331 |
Echinococcus granulosus | thyroid hormone receptor alpha | 0.0269 | 0.1782 | 0.4254 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0571 | 0.4115 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0302 | 0.2032 | 0.4938 |
Loa Loa (eye worm) | hypothetical protein | 0.0571 | 0.4115 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0302 | 0.2032 | 0.4938 |
Loa Loa (eye worm) | nuclear hormone receptor | 0.0269 | 0.1782 | 0.4331 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0571 | 0.4115 | 1 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0571 | 0.4115 | 0.4115 |
Loa Loa (eye worm) | hypothetical protein | 0.0302 | 0.2032 | 0.4938 |
Loa Loa (eye worm) | hypothetical protein | 0.0302 | 0.2032 | 0.4938 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0571 | 0.4115 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0571 | 0.4115 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0571 | 0.4115 | 1 |
Onchocerca volvulus | 0.0571 | 0.4115 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0269 | 0.1782 | 0.4331 |
Loa Loa (eye worm) | hypothetical protein | 0.0269 | 0.1782 | 0.4331 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0571 | 0.4115 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0571 | 0.4115 | 1 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0571 | 0.4115 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0571 | 0.4115 | 1 |
Brugia malayi | nuclear hormone receptor family member nhr-6 | 0.0269 | 0.1782 | 0.4331 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0571 | 0.4115 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0571 | 0.4115 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0269 | 0.1782 | 0.4331 |
Schistosoma mansoni | thyroid hormone receptor | 0.0571 | 0.4115 | 0.4115 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0269 | 0.1782 | 0.4254 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0302 | 0.2032 | 0.4869 |
Loa Loa (eye worm) | hypothetical protein | 0.0302 | 0.2032 | 0.4938 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0571 | 0.4115 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0571 | 0.4115 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0269 | 0.1782 | 0.4331 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0571 | 0.4115 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0571 | 0.4115 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0571 | 0.4115 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0571 | 0.4115 | 1 |
Brugia malayi | nuclear hormone receptor family member odr-7 | 0.0269 | 0.1782 | 0.4331 |
Loa Loa (eye worm) | nuclear receptor NHR-67 | 0.0269 | 0.1782 | 0.4331 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0571 | 0.4115 | 1 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.0269 | 0.1782 | 0.4254 |
Schistosoma mansoni | coup transcription factor | 0.0571 | 0.4115 | 0.4115 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0571 | 0.4115 | 1 |
Echinococcus multilocularis | nuclear receptor subfamily 4 group A | 0.0269 | 0.1782 | 0.4254 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0571 | 0.4115 | 0.4115 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0269 | 0.1782 | 0.4331 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0571 | 0.4115 | 1 |
Brugia malayi | nuclear receptor NHR-88 | 0.0269 | 0.1782 | 0.4331 |
Loa Loa (eye worm) | hypothetical protein | 0.0571 | 0.4115 | 1 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.0269 | 0.1782 | 0.4331 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0269 | 0.1782 | 0.4254 |
Echinococcus granulosus | nuclear receptor subfamily 4 group A | 0.0269 | 0.1782 | 0.4254 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0571 | 0.4115 | 1 |
Brugia malayi | ecdysone receptor | 0.0269 | 0.1782 | 0.4331 |
Loa Loa (eye worm) | hypothetical protein | 0.0269 | 0.1782 | 0.4331 |
Brugia malayi | tailless protein | 0.0269 | 0.1782 | 0.4331 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0302 | 0.2032 | 0.4869 |
Brugia malayi | nuclear hormone receptor | 0.0571 | 0.4115 | 1 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0571 | 0.4115 | 0.4115 |
Brugia malayi | nuclear hormone receptor | 0.0269 | 0.1782 | 0.4331 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0571 | 0.4115 | 1 |
Brugia malayi | nuclear receptor NHR-67 | 0.0269 | 0.1782 | 0.4331 |
Schistosoma mansoni | thyroid hormone receptor | 0.0571 | 0.4115 | 0.4115 |
Brugia malayi | nuclear receptor subfamily 1, group D, member 1, putative | 0.0269 | 0.1782 | 0.4331 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.0269 | 0.1782 | 0.4254 |
Loa Loa (eye worm) | hypothetical protein | 0.0571 | 0.4115 | 1 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0571 | 0.4115 | 1 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0571 | 0.4115 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0302 | 0.2032 | 0.4938 |
Schistosoma mansoni | nuclear hormone receptor | 0.0269 | 0.1782 | 0.1782 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0302 | 0.2032 | 0.4938 |
Brugia malayi | hypothetical protein | 0.0269 | 0.1782 | 0.4331 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0302 | 0.2032 | 0.4938 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0269 | 0.1782 | 0.4331 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0571 | 0.4115 | 0.4115 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0571 | 0.4115 | 1 |
Brugia malayi | hypothetical protein | 0.0302 | 0.2032 | 0.4938 |
Schistosoma mansoni | zinc finger protein | 0.0269 | 0.1782 | 0.1782 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0571 | 0.4115 | 0.4115 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0571 | 0.4115 | 1 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0571 | 0.4115 | 0.4115 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0571 | 0.4115 | 1 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0571 | 0.4115 | 1 |
Brugia malayi | hypothetical protein | 0.0269 | 0.1782 | 0.4331 |
Echinococcus multilocularis | nuclear receptor nhr 48 | 0.0269 | 0.1782 | 0.4254 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0571 | 0.4115 | 1 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0571 | 0.4115 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0269 | 0.1782 | 0.4331 |
Schistosoma mansoni | nuclear hormone receptor | 0.0571 | 0.4115 | 0.4115 |
Schistosoma mansoni | nuclear receptor nhr-48 | 0.0269 | 0.1782 | 0.1782 |
Brugia malayi | steroid hormone receptor | 0.0571 | 0.4115 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0571 | 0.4115 | 1 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0571 | 0.4115 | 1 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0571 | 0.4115 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0269 | 0.1782 | 0.4331 |
Loa Loa (eye worm) | plexin A | 0.0046 | 0.0055 | 0.0134 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.0269 | 0.1782 | 0.4254 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0571 | 0.4115 | 1 |
Onchocerca volvulus | 0.0269 | 0.1782 | 0.4331 | |
Loa Loa (eye worm) | hypothetical protein | 0.0269 | 0.1782 | 0.4331 |
Schistosoma mansoni | nuclear receptor | 0.0269 | 0.1782 | 0.1782 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0571 | 0.4115 | 1 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0571 | 0.4115 | 0.4115 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0571 | 0.4115 | 1 |
Brugia malayi | hypothetical protein | 0.0302 | 0.2032 | 0.4938 |
Echinococcus granulosus | nuclear receptor nhr 48 | 0.0269 | 0.1782 | 0.4254 |
Loa Loa (eye worm) | hypothetical protein | 0.0269 | 0.1782 | 0.4331 |
Onchocerca volvulus | 0.0269 | 0.1782 | 0.4331 | |
Brugia malayi | nuclear receptor NHR-88 | 0.0571 | 0.4115 | 1 |
Brugia malayi | conserved hypotetical protein | 0.0269 | 0.1782 | 0.4331 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0571 | 0.4115 | 1 |
Brugia malayi | nuclear receptor RXR | 0.0269 | 0.1782 | 0.4331 |
Onchocerca volvulus | Nuclear receptor subfamily 6 group A member 1 homolog | 0.0269 | 0.1782 | 0.4331 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0571 | 0.4115 | 1 |
Brugia malayi | plexin A | 0.0046 | 0.0055 | 0.0134 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0571 | 0.4115 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0269 | 0.1782 | 0.4331 |
Echinococcus granulosus | FTZ F1 alpha | 0.0571 | 0.4115 | 1 |
Schistosoma mansoni | nuclear hormone receptor | 0.0269 | 0.1782 | 0.1782 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0571 | 0.4115 | 0.4115 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0571 | 0.4115 | 1 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0571 | 0.4115 | 1 |
Loa Loa (eye worm) | DR-78 | 0.0269 | 0.1782 | 0.4331 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0302 | 0.2032 | 0.2032 |
Brugia malayi | ecdysteroid receptor | 0.0571 | 0.4115 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0269 | 0.1782 | 0.4331 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.